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Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit

Book Description

Amazon LinkCRC Press Link

Author:  Liang-Yin Chu, Wei Wang

ISBN: 978-3-527-34182-5
336 pages
June 2017


An increasing number of technologies are being used to detect minute quantities of biomolecules and cells. However, it can be difficult to determine which technologies show the most promise for high-sensitivity and low-limit detection in different applications.

Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limitdetails proven approaches for the detection of single cells and even single molecules—approaches employed by the world’s foremost microfluidics and nanotechnology laboratories. While similar books concentrate only on microfluidics or nanotechnology, this book focuses on the combination of soft materials (elastomers and other polymers) with hard materials (semiconductors, metals, and glass) to form integrated detection systems for biological and chemical targets. It explores physical and chemical—as well as contact and noncontact—detection methods, using case studies to demonstrate system capabilities. Presenting a snapshot of the current state of the art, the text:

  • Explains the theory behind different detection techniques, from mechanical resonators for detecting cell density to fiber-optic methods for detecting DNA hybridization, and beyond
  • Examines microfluidic advances, including droplet microfluidics, digital microfluidics for manipulating droplets on the microscale, and more
  • Highlights an array of technologies to allow for a comparison of the fundamental advantages and challenges of each, as well as an appreciation of the power of leveraging scalability and integration to achieve sensitivity at low cost

Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit not only serves as a quick reference for the latest achievements in biochemical detection at the single-cell and single-molecule levels, but also provides researchers with inspiration for further innovation and expansion of the field.

Table of Contents




  • Toward Unsupervised Smart Chemical Sensor Arrays
    Leonardo Tomazeli Duarte and Christian Jutten
  • Active CMOS Biochip for Electrochemical DNA Assays
    Peter M. Levine, Ping Gong, Rastislav Levicky, and Kenneth L. Shepard
  • Label-Free DNA Sensor Based on a Surface Long-Period Grating
    Young-Geun Han
  • Measuring the Physical Properties of Cells
    Shirin Mesbah Oskui and William H. Grover
  • Technologies for Low-Cost, Hall Effect-Based Magnetic Immunosensors
    Simone Gambini
  • Two-Dimensional Paper Networks for Automated Multistep Processes in Point-of-Care Diagnostics
    Elain Fu, Barry Lutz, and Paul Yager
  • Droplet-Based Digital Microfluidics for Single-Cell Genetic Analysis
    Yong Zeng and Richard A. Mathies
  • Droplet-Based Microfluidics for Biological Sample Preparation and Analysis
    Xuefei Sun and Ryan T. Kelly
  • A Review of Tubeless Microfluidic Devices
    Pedro J. Resto, David J. Beebe, and Justin C. Williams
  • Index

Product Details

  • Series: Devices, Circuits, and Systems (Book 27)
  • Hardcover: 290 pages
  • Publisher: CRC Press; 1 edition (May 27, 2014)
  • Language: English
  • ISBN-10: 146659490X
  • ISBN-13: 978-1466594906
  • Product Dimensions: 9.2 x 6.1 x 0.8 inches
  • Shipping Weight: 1.2 pounds

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