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no spine minimum. full size. Editor: Nella JEM: Esther RTP: Erin DaltonAnalytical ChemistryJournal_Biomaterials BiomaterialsJournal_BMD Biomedical MicrodevicesJournal_BMF Biomicrofluidics176 spine minimum. full size. Editor: Lingling JEM: Leslie RTP: Michael Reid JACS
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RSC - Lab Chip latest articles RSC - Lab Chip latest articles

  • Engineering reaction-diffusion networks with properties of neural tissue
    by Thomas Litschel on December 15, 2017 at 12:00 am

    Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC01187C, PaperThomas Litschel, Michael Meredith Norton, Vardges Tserunyan, Seth FradenWe present an experimental system of networks of coupled non-linear chemical reactors, which we theoretically model within a reaction-diffusion framework. The networks consist of patterned arrays of diffusively coupled nanoliter-scale...The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Capillary-based Integrated Digital PCR in Picoliter Droplets
    by Jinyu Chen on December 15, 2017 at 12:00 am

    Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC01160A, CommunicationJinyu Chen, Zhaofeng Luo, Lin Li, Jinlong He, Luoquan Li, JianWei Zhu, Ping Wu, Liqun HeA droplet digital polymerase chain reaction (ddPCR) is becoming more and more popular in diagnostic applications in academic institutes or industrial arena. In commercially available ddPCR systems, after they have...The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Microfluidic Bypass Manometry: Highly parallelized measurement of flow resistance of complex channel geometries and trapped droplets
    by Naureen S Suteria on December 14, 2017 at 12:00 am

    Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00889A, PaperNaureen S Suteria, Mehdi Nekouei, Siva A VanapalliCurrent lithography methods allow facile fabrication of microfluidic conduits where not only the shape of the bounding walls can be arbitrarily varied but also the internal conduit space can be...The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Dynamic wettability of polyethylene glycol-modified poly(dimethylsiloxane) surfaces in an aqueous/organic two-phase system
    by MAO FUKUYAMA on December 12, 2017 at 12:00 am

    Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC01121K, PaperMAO FUKUYAMA, Manabu Tokeshi, Mikhail Alekseevich Proskurnin, Akihide HibaraWe herein report the preparation of a surface that behaves in a hydrophobic manner but does not undergo protein adsorption in an aqueous/organic two-phase system. We found that polyethylene-glycol (PEG)-modified...The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Plug-and-actuate on demand: multimodal individual addressability of microarray plates using modular hybrid acoustic wave technology
    by Amgad R. Rezk on December 12, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01099K, CommunicationAmgad R. Rezk, Shwathy Ramesan, Leslie Y. YeoIntegrating versatile microfluidic liquid handling technology with existing drug discovery laboratory formats.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • High-precision modular microfluidics by micromilling of interlocking injection-molded blocks
    by Crystal E Owens on December 12, 2017 at 12:00 am

    Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00951H, PaperCrystal E Owens, A. John HartWider use and adaptation of microfluidics is hindered by the infrastructure, knowledge, and time required to build prototype systems, especially when multiple fluid operations and measurements are required. As a...The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Lab on a Chip in 2017
    on December 7, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC90123B, EditorialThis Editorial summarizes recent news from Lab on a Chip and looks forward to further developments in 2018.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Towards microwave imaging of cells
    by Mehmet Kelleci on December 6, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01251A, PaperMehmet Kelleci, Hande Aydogmus, Levent Aslanbas, Selcuk Oguz Erbil, M. Selim HanayWe have simultaneously used the first two modes of a microwave resonant sensor integrated with microfluidics to size and locate droplets and cells. Higher-order modes can yield further spatial details of cells.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Cancer immunotherapy [small mu ]-environment LabChip: taking advantage of optoelectronic tweezers
    by Ling-Yi Ke on December 6, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00963A, PaperLing-Yi Ke, Zong-Keng Kuo, Yu-Shih Chen, Tsu-Yi Yeh, Minxiang Dong, Hsiang-Wen Tseng, Cheng-Hsien LiuAn OET-based LabChip was developed to provide a stable and static culture [small mu ]-environment for cancer immunotherapy studies. The TiOPc-based OET facilitates the studies of cell-cell interaction resulting in apoptotic progress of cancer cells.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • High-throughput double emulsion-based microfluidic production of hydrogel microspheres with tunable chemical functionalities toward biomolecular conjugation
    by Eric Y. Liu on December 6, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01088E, PaperEric Y. Liu, Sukwon Jung, David A. Weitz, Hyunmin Yi, Chang-Hyung ChoiCapillary microfluidic fabrication of monodisperse and chemically functional hydrogel microspheres with selective conjugation schemes yields improved protein conjugation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Electrochemical biosensor for cancer cell detection based on surface 3D micro-array
    by Shaoqin Liu on December 6, 2017 at 12:00 am

    Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC01117B, PaperShaoqin Liu, Li An, Guangtong Wang, Yu Han, Tianchan Li, Peng JinThe detection of rare circulating tumour cells (CTCs) in the patients' blood is crucial for the early diagnosis of cancer, highly precise cancer therapy and monitoring the therapeutic outcomes in...The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement
    by Andreas R. Thomsen on December 6, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00832E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Andreas R. Thomsen, Christine Aldrian, Peter Bronsert, Yi Thomann, Norbert Nanko, Nicolas Melin, Gerta Rucker, Marie Follo, Anca L. Grosu, Gabriele Niedermann, Paul G. Layer, Anja Heselich, Per G. LundMiniaturised conical measures for cell aggregates.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Impact of complex surfaces on biomicrorheological measurements using optical tweezers
    by Shu Zhang on December 5, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01176H, PaperShu Zhang, Lachlan J. Gibson, Alexander B. Stilgoe, Timo A. Nieminen, Halina Rubinsztein-DunlopThe characterisation of physical properties in biologically relevant processes and the development of novel microfluidic devices for this purpose are experiencing a great resurgence at present.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Converting colour to length based on the coffee-ring effect for quantitative immunoassays using a ruler as readout
    by Dagan Zhang on December 4, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01127J, CommunicationDagan Zhang, Bingbing Gao, Yangtian Chen, Hong LiuWe report a method for converting the colorimetric results of an enzyme-linked immunosorbent assay (ELISA) into length based on the coffee-ring effect, so that the quantitative detection of analytes can be carried out simply using a ruler.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Cyclic olefin copolymer as an X-ray compatible material for microfluidic devices
    by Manuela Denz on December 1, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00824D, PaperManuela Denz, Gerrit Brehm, Clement Y. J. Hemonnot, Heidi Spears, Andrew Wittmeier, Chiara Cassini, Oliva Saldanha, Eleonora Perego, Ana Diaz, Manfred Burghammer, Sarah KosterFabrication of X-ray compatible microfluidic devices by hot embossing, and characterization for small angle X-ray scattering.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Real-time two-photon lithography in controlled flow to create a single-microparticle array and particle-cluster array for optofluidic imaging
    by Bing Xu on December 1, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01080J, PaperBing Xu, Yang Shi, Zhaoxin Lao, Jincheng Ni, Guoqiang Li, Yanlei Hu, Jiawen Li, Jiaru Chu, Dong Wu, Koji SugiokaWe developed a novel method: real-time two-photon-lithography in controlled flow to achieve 100% one-bead-to-one-trap towards optofluidic imaging and biomedical applications.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products
    by Kadi L. Saar on December 1, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00797C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kadi L. Saar, Yingbo Zhang, Thomas Muller, Challa P. Kumar, Sean Devenish, Andrew Lynn, Urszula Lapinska, Xiaoting Yang, Sara Linse, Tuomas P. J. KnowlesSingle-layer lithography microfluidic devices for applying high and stable electric fields on chip.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • On-demand acoustic droplet splitting and steering in a disposable microfluidic chip
    by Jinsoo Park on November 30, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01083D, PaperJinsoo Park, Jin Ho Jung, Kwangseok Park, Ghulam Destgeer, Husnain Ahmed, Raheel Ahmad, Hyung Jin SungAn acoustofluidic device for on-demand droplet splitting and steering in a disposable microfluidic chip.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Subnanometer structure and function from ion beams through complex fluidics to fluorescent particles
    by Kuo-Tang Liao on November 29, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01047H, PaperKuo-Tang Liao, Joshua Schumacher, Henri J. Lezec, Samuel M. StavisAnalytical separation with subnanometer resolution of fluorescent nanoparticles in a nanofluidic device.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Fluorescence-activated droplet sorting of lipolytic microorganisms using a compact optical system
    by Yuxin Qiao on November 29, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00993C, PaperYuxin Qiao, Xiaoyan Zhao, Jun Zhu, Ran Tu, Libing Dong, Li Wang, Zhiyang Dong, Qinhong Wang, Wenbin DuLipases are ubiquitous enzymes of great physiological significance that have been used extensively in multiple industries.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • A robust, portable and backflow-free micromixing device based on both capillary- and vacuum-driven flows
    by Yaguang Zhai on November 29, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01077J, PaperYaguang Zhai, Anyang Wang, Domin Koh, Philip Schneider, Kwang W. OhA robust, portable and backflow-free micromixing device using capillary-driven bypassing and syringe-assisted vacuum-driven pumping shows great promise for a variety of blood typing assays, agglutination-based assays and point-of-care or lab-on-a-chip testing applications.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Wearable sensors: modalities, challenges, and prospects
    by J. Heikenfeld on November 28, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00914C, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.J. Heikenfeld, A. Jajack, J. Rogers, P. Gutruf, L. Tian, T. Pan, R. Li, M. Khine, J. Kim, J. Wang, J. KimNon-invasive wearable sensing technology extracts mechanical, electrical, optical, and chemical information from the human body.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Multi-size spheroid formation using microfluidic funnels
    by M. Marimuthu on November 27, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00970D, PaperM. Marimuthu, N. Rousset, A. St-Georges-Robillard, M. A. Lateef, M. Ferland, A.-M. Mes-Masson, T. GervaisWe present a microfluidic platform for automatic multi-size spheroid formation within constant volume hanging droplets (HDs) from a single inlet loading of a constant cell concentration.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Rapid spheroid clearing on a microfluidic chip
    by Tomas Silva Santisteban on November 24, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01114H, PaperTomas Silva Santisteban, Omid Rabajania, Iana Kalinina, Stephen Robinson, Matthias MeierClearing methods enable deep tissue imaging. This work presents a microfluidic approach for reducing the clearing time of hydrogel embedded spheroids by osmotic pumping.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • A microfluidic chip capable of generating and trapping emulsion droplets for digital loop-mediated isothermal amplification analysis
    by Yu-Dong Ma on November 24, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01004D, PaperYu-Dong Ma, Kang Luo, Wen-Hsin Chang, Gwo-Bin LeeA microfluidic droplet array chip was designed to execute the digital LAMP. This novel device was capable of 1) creating emulsion droplets, 2) sorting them into a trapping array, and 3) executing LAMP for only 40 min. Nucleic acids could be accurately quantified and the limit of detection was only single DNA molecule.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Machine learning to detect signatures of disease in liquid biopsies - a user's guide
    by Jina Ko on November 23, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00955K, Tutorial ReviewJina Ko, Steven N. Baldassano, Po-Ling Loh, Konrad Kording, Brian Litt, David IssadoreNew technologies that measure sparse molecular biomarkers from easily accessible bodily fluids (e.g. blood, urine, and saliva) are revolutionizing disease diagnostics and precision medicine.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Embedding liquid lasers within or around aqueous microfluidic droplets
    by Lu Zheng on November 23, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00701A, PaperLu Zheng, Min Zhi, Yinthai Chan, Saif A. KhanWe demonstrate the incorporation of dye-based liquid lasers within or around flowing aqueous microfluidic droplets, which make them capable of on drop optofluidic sensing.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Upgrading well plates using open microfluidic patterning
    by Samuel B. Berry on November 22, 2017 at 12:00 am

    Lab Chip, 2017, 17,4253-4264DOI: 10.1039/C7LC00878C, PaperSamuel B. Berry, Tianzi Zhang, John H. Day, Xiaojing Su, Ilham Z. Wilson, Erwin Berthier, Ashleigh B. ThebergeWe developed an open microfluidic hydrogel-patterning technology that creates networks of cell culture chambers in well plates for multiculture experiments.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Throughput enhancement of parallel step emulsifier devices by shear-free and efficient nozzle clearance
    by Elad Stolovicki on November 21, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01037K, PaperElad Stolovicki, Roy Ziblat, David A. WeitzOvercrowded drops at the output channels of step emulsifier devices create a bottleneck, thereby limiting the production rate. Here bottlenecks are avoided by using an open collection channel and buoyancy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Geo-material surface modification of microchips using layer-by-layer (LbL) assembly for subsurface energy and environmental applications
    by Y. Q. Zhang on November 17, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00675F, PaperY. Q. Zhang, A. Sanati-Nezhad, S. H. HejaziA key constraint in the application of microfluidic technology to subsurface flow and transport processes is the surface discrepancy between microchips and the actual rocks/soils.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform
    by T. Satoh on November 14, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00952F, PaperT. Satoh, S. Sugiura, K. Shin, R. Onuki-Nagasaki, S. Ishida, K. Kikuchi, M. Kakiki, T. KanamoriA multi-throughput multi-organ-on-a-chip system was formed on a pneumatic pressure-driven medium circulation platform as a novel type of microphysiological system.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Performing multi-step chemical reactions in microliter-sized droplets by leveraging a simple passive transport mechanism
    by Jia Wang on November 14, 2017 at 12:00 am

    Lab Chip, 2017, 17,4342-4355DOI: 10.1039/C7LC01009E, PaperJia Wang, Philip H. Chao, Sebastian Hanet, R. Michael van DamA microdroplet platform, leveraging passive reagent transport, was developed for multi-step synthesis of radiolabeled tracers for positron emission tomography (PET).The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • A compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood-retinal barrier
    by Jose Yeste on November 14, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00795G, PaperJose Yeste, Marta Garcia-Ramirez, Xavi Illa, Anton Guimera, Cristina Hernandez, Rafael Simo, Rosa VillaThis work presents a new microfluidic chip to facilitate multicellular interactions and cell barrier function monitoring in real time.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Multi-functional micromotor: microfluidic fabrication and water treatment application
    by Anqi Chen on November 9, 2017 at 12:00 am

    Lab Chip, 2017, 17,4220-4224DOI: 10.1039/C7LC00950J, CommunicationAnqi Chen, Xue-hui Ge, Jian Chen, Liyuan Zhang, Jian-Hong XuWe developed a microfluidic approach to simultaneously incorporate various catalysts into the micromotor in a one-step process. This provides the micromotor with self-propelled, magnetic and water treatment functions, which should benefit a wide range of applications.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Mask-free fabrication of a versatile microwell chip for multidimensional cellular analysis and drug screening
    by Wenguang Yang on November 9, 2017 at 12:00 am

    Lab Chip, 2017, 17,4243-4252DOI: 10.1039/C7LC01101F, PaperWenguang Yang, Haibo Yu, Gongxin Li, Fanan Wei, Yuechao Wang, Lianqing LiuThree different dimensions (single cell (1D), cell monolayer (2D) and cell spheroid (3D)) of one cell type can be formed using a microwell array and the analyses of biological characteristics are achieved separately.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • An ultra-small, multi-point, and multi-color photo-detection system with high sensitivity and high dynamic range
    by Takashi Anazawa on November 8, 2017 at 12:00 am

    Lab Chip, 2017, 17,4231-4242DOI: 10.1039/C7LC01070B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Takashi Anazawa, Motohiro YamazakiFluorescence from four emission points is collimated by four lenses, split into four-color fluxes by four dichroic mirrors, and directly input into the image sensor.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Lab-on-capillary: a rapid, simple and quantitative genetic analysis platform integrating nucleic acid extraction, amplification and detection
    by Yu Fu on November 8, 2017 at 12:00 am

    Lab Chip, 2017, 17,4334-4341DOI: 10.1039/C7LC01107E, PaperYu Fu, Xiaoming Zhou, Da XingA PDDA-modified functionalized capillary integrated with a liquid-based thermalization system is developed for genetic analysis in a simple and rapid format.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Persistent drought monitoring using a microfluidic-printed electro-mechanical sensor of stomata in planta
    by Volodymyr B. Koman on November 8, 2017 at 12:00 am

    Lab Chip, 2017, 17,4015-4024DOI: 10.1039/C7LC00930E, PaperVolodymyr B. Koman, Tedrick T. S. Lew, Min Hao Wong, Seon-Yeong Kwak, Juan P. Giraldo, Michael S. StranoStomatal function can be used effectively to monitor plant hydraulics, photosensitivity, and gas exchange.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Electrophoretic cytometry of adherent cells
    by Elaine J. Su on November 6, 2017 at 12:00 am

    Lab Chip, 2017, 17,4312-4323DOI: 10.1039/C7LC01012E, PaperElaine J. Su, Amy E. HerrWe design a microfluidic, in situ isoelectric focusing assay that assays adherent cells for targeted, single-cell protein analysis.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Droplet array for screening acute behaviour response to chemicals in Caenorhabditis elegans
    by G. Aubry on November 3, 2017 at 12:00 am

    Lab Chip, 2017, 17,4303-4311DOI: 10.1039/C7LC00945C, PaperG. Aubry, H. LuWe present a droplet platform for on-demand trapping of multiple droplet in series and release that can be applied to chemical screens in C. elegans.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Stereolithographic hydrogel printing of 3D culture chips with biofunctionalized complex 3D perfusion networks
    by Rujing Zhang on November 3, 2017 at 12:00 am

    Lab Chip, 2017, 17,4273-4282DOI: 10.1039/C7LC00926G, PaperRujing Zhang, Niels B. LarsenFree-form mechanically stable 3D perfusion networks traversing and surrounding separate culture volumes are produced by light-induced 3D printing of PEGDA hydrogels.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • An acoustic on-chip goniometer for room temperature macromolecular crystallography
    by C. G. Burton on November 1, 2017 at 12:00 am

    Lab Chip, 2017, 17,4225-4230DOI: 10.1039/C7LC00812K, CommunicationC. G. Burton, D. Axford, A. M. J. Edwards, R. J. Gildea, R. H. Morris, M. I. Newton, A. M. Orville, M. Prince, P. D. Topham, P. T. DockerDevelopment and successful operation of an on-chip goniometer for macromolecular protein crystallography.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Measuring biotherapeutic viscosity and degradation on-chip with particle diffusometry
    by K. N. Clayton on November 1, 2017 at 12:00 am

    Lab Chip, 2017, 17,4148-4159DOI: 10.1039/C7LC00507E, PaperK. N. Clayton, D. Lee, S. T. Wereley, T. L. Kinzer-UrsemA rapid and passive measurement approach for measuring biotherapeutic degradation and viscosity in microfluidic platforms.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Full-angle tomographic phase microscopy of flowing quasi-spherical cells
    by Massimiliano M. Villone on October 31, 2017 at 12:00 am

    Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00943G, PaperMassimiliano M. Villone, Pasquale Memmolo, Francesco Merola, Martina Mugnano, Lisa Miccio, Pier Luca Maffettone, Pietro FerraroWe report a reliable full-angle tomographic phase microscopy (FA-TPM) method for flowing quasi-spherical cells along microfluidic channels.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • A novel microfluidic microelectrode chip for a significantly enhanced monitoring of NPY-receptor activation in live mode
    by Franziska D. Zitzmann on October 31, 2017 at 12:00 am

    Lab Chip, 2017, 17,4294-4302DOI: 10.1039/C7LC00754J, PaperFranziska D. Zitzmann, Heinz-Georg Jahnke, Felix Nitschke, Annette G. Beck-Sickinger, Bernd Abel, Detlev Belder, Andrea A. RobitzkiWe present a FEM simulation based step-by-step development of a microelectrode array integrated into a microfluidic chip for the non-invasive real-time monitoring of living cells.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • A planar dielectrophoresis-based chip for high-throughput cell pairing
    by ChunHui Wu on October 31, 2017 at 12:00 am

    Lab Chip, 2017, 17,4008-4014DOI: 10.1039/C7LC01082F, CommunicationChunHui Wu, RiFei Chen, Yu Liu, ZhenMing Yu, YouWei Jiang, Xing ChengA planar dielectrophoresis-based chip for high-throughput single cell-cell pairing (with a pairing efficiency up to 74.2%) was developed.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • A disposable microfluidic device with a reusable magnetophoretic functional substrate for isolation of circulating tumor cells
    by Hyungseok Cho on October 26, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4113-4123DOI: 10.1039/C7LC00925A, PaperHyungseok Cho, Jinho Kim, Chang-Wan Jeon, Ki-Ho HanWe describe an assembly-disposable microfluidic device based on a silicone-coated release polymer thin film.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Integrated platform for cell culture and dynamic quantification of cell secretion
    by Alicia J. Kaestli on October 26, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4124-4133DOI: 10.1039/C7LC00839B, PaperAlicia J. Kaestli, Michael Junkin, Savas TayWe present an automated platform that integrates antibody patterning, dynamic cell culture, and secretion detection all in the same device.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Development of a microfluidic platform integrating high-resolution microstructured biomaterials to study cell-material interactions
    by D. Barata on October 26, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4134-4147DOI: 10.1039/C7LC00802C, PaperD. Barata, E. Provaggi, C. van Blitterswijk, P. HabibovicMicrofluidic screening platforms offer new possibilities for performing in vitro cell-based assays with higher throughput and in a setting that has the potential to closely mimic the physiological microenvironment.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Dual-mode reconfigurable focusing using the interface of aqueous and dielectric liquids
    by Wonkyoung Kim on October 24, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4031-4039DOI: 10.1039/C7LC00759K, PaperWonkyoung Kim, Changho Lee, Chulhong Kim, Dong Sung KimAn optofluidic lens serves as a highly reconfigurable device to manipulate light by using a smoothly curved interface between immiscible liquids.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Optofluidic marine phosphate detection with enhanced absorption using a Fabry-Perot resonator
    by J. M. Zhu on October 24, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4025-4030DOI: 10.1039/C7LC01016H, PaperJ. M. Zhu, Y. Shi, X. Q. Zhu, Y. Yang, F. H. Jiang, C. J. Sun, W. H. Zhao, X. T. HanAn optofluidic phosphate analysis chip combined with a resonator has been created with enhanced absorption and real-time monitoring. It overcomes the obstacles of traditional methods with macroscale absorption cells, and low representative and time-sensitive detection results.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Color manipulation through microchip tinting for colorimetric detection using hue image analysis
    by Shannon T. Krauss on October 24, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4089-4096DOI: 10.1039/C7LC00796E, PaperShannon T. Krauss, Aeren Q. Nauman, Gavin T. Garner, James P. LandersThree color manipulation (i.e., tinting) techniques can increase colorimetric discrimination and improve detection limits.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Asymmetric nanofluidic grating detector for differential refractive index measurement and biosensing
    by F. Purr on October 23, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4265-4272DOI: 10.1039/C7LC00929A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.F. Purr, M. Bassu, R. D. Lowe, B. Thurmann, A. Dietzel, T. P. BurgAn asymmetric nanofluidic grating is shown to enable simple, robust, and fully differential measurements of refractive index or of surface-adsorbed layers of biomolecules through interferometry.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Staggered trap arrays for robust microfluidic sample digitization
    by A. J. Sposito on October 23, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4105-4112DOI: 10.1039/C7LC00846E, PaperA. J. Sposito, D. L. DeVoeStaggered traps use passive pinning of the advancing fluid interface to optimally fill high aspect ratio microwells in gas impermeable substrates such as thermoplastics.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • High-efficiency single cell encapsulation and size selective capture of cells in picoliter droplets based on hydrodynamic micro-vortices
    by Gopakumar Kamalakshakurup on October 22, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4324-4333DOI: 10.1039/C7LC00972K, PaperGopakumar Kamalakshakurup, Abraham P. LeeSingle cell analysis has emerged as a paradigm shift in cell biology to understand the heterogeneity of individual cells in a clone for pathological interrogation.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Nanowire sensors monitor bacterial growth kinetics and response to antibiotics
    by B. Ibarlucea on October 18, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4283-4293DOI: 10.1039/C7LC00807D, PaperB. Ibarlucea, T. Rim, C. K. Baek, J. A. G. M. de Visser, L. Baraban, G. CunibertiWe monitor bacterial growth kinetics and response to bactericidal and bacteriostatic antibiotics using silicon nanowire transistors.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Integrated microHall magnetometer to measure the magnetic properties of nanoparticles
    by Changwook Min on October 18, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4000-4007DOI: 10.1039/C7LC00934H, CommunicationChangwook Min, Jongmin Park, Jae Kyoung Mun, Yongjun Lim, Jouha Min, Jong-Won Lim, Dong-Min Kang, Ho-Kyun Ahn, Tae-Hyun Shin, Jinwoo Cheon, Hae-Seung Lee, Ralph Weissleder, Cesar M. Castro, Hakho LeeWe developed an integrated Hall magnetometer to measure magnetic properties in small sample volumes.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Automated microfluidic platform for systematic studies of colloidal perovskite nanocrystals: towards continuous nano-manufacturing
    by Robert W. Epps on October 17, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4040-4047DOI: 10.1039/C7LC00884H, PaperRobert W. Epps, Kobi C. Felton, Connor W. Coley, Milad AbolhasaniAn automated microfluidic platform enables systematic high-throughput studies of mixing enhancement on the emission band-gap of in-flow synthesized perovskite quantum dots, resulting in kinetically tunable nanocrystals.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • A highly-occupied, single-cell trapping microarray for determination of cell membrane permeability
    by Lindong Weng on October 17, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4077-4088DOI: 10.1039/C7LC00883J, PaperLindong Weng, Felix Ellett, Jon Edd, Keith H. K. Wong, Korkut Uygun, Daniel Irimia, Shannon L. Stott, Mehmet TonerA passive pumping, single-cell trapping microarray was developed to monitor volumetric change of multiple, single cells following hypertonic exposure.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Enrichment of magnetic particles using temperature and magnetic field gradients induced by benchtop fabricated micro-electromagnets
    by A. Hosseini on October 16, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4097-4104DOI: 10.1039/C7LC00825B, PaperA. Hosseini, D. N. Philpott, L. SoleymaniCooperation of thermal and magnetic forces used to drive and capture magnetic particles inside microsystems.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Determination of pore-scale hydrate phase equilibria in sediments using lab-on-a-chip technology
    by Stian Almenningen on October 15, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4070-4076DOI: 10.1039/C7LC00719A, PaperStian Almenningen, Josef Flatlandsmo, Anthony R. Kovscek, Geir Ersland, Martin A. FernoWe present an experimental protocol for fast determination of hydrate stability in porous media for a range of pressure and temperature conditions.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • A microfluidic device for partial immobilization, chemical exposure and behavioural screening of zebrafish larvae
    by Asal Nady on October 11, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4048-4058DOI: 10.1039/C7LC00786H, PaperAsal Nady, Amir Reza Peimani, Georg Zoidl, Pouya RezaiMovement response of zebrafish to chemicals is of interest in screening studies. We introduce a microfluidic device for partial immobilization, head L-arginine exposure and movement screening of zebrafish larvae under controlled conditions.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Enhanced surface acoustic wave cell sorting by 3D microfluidic-chip design
    by W. L. Ung on October 2, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4059-4069DOI: 10.1039/C7LC00715A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.W. L. Ung, K. Mutafopulos, P. Spink, R. W. Rambach, T. Franke, D. A. WeitzWe demonstrate an acoustic wave driven microfluidic cell sorter that combines advantages of multilayer device fabrication with planar surface acoustic wave excitation.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Cell migration in microengineered tumor environments
    by Eujin Um on September 20, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4171-4185DOI: 10.1039/C7LC00555E, Tutorial ReviewEujin Um, Jung Min Oh, Steve Granick, Yoon-Kyoung ChoRecent advances in microengineered cell migration platforms are discussed critically with focus on how cell migration is influenced by engineered tumor microenvironments, the medical relevance being to understand how tumor microenvironments may promote or suppress the progression of cancer.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Modeling angiogenesis with micro- and nanotechnology
    by Li-Jiun Chen on September 14, 2017 at 11:00 pm

    Lab Chip, 2017, 17,4186-4219DOI: 10.1039/C7LC00774D, Critical ReviewLi-Jiun Chen, Hirokazu KajiApplication of micro- and nano-technology in pathological angiogenesis and revascularization strategies towards better clinical outcomes.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Why microfluidics? Merits and trends in chemical synthesis
    by Yong Liu on September 14, 2017 at 11:00 pm

    Lab Chip, 2017, 17,3960-3978DOI: 10.1039/C7LC00627F, Critical ReviewYong Liu, Xingyu JiangMicrofluidic platforms provide endless possibilities for synthetic chemistry.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • The power of solid supports in multiphase and droplet-based microfluidics: towards clinical applications
    by M. Serra on September 12, 2017 at 11:00 pm

    Lab Chip, 2017, 17,3979-3999DOI: 10.1039/C7LC00582B, Critical ReviewM. Serra, D. Ferraro, I. Pereiro, J.-L. Viovy, S. DescroixThis review focuses on devices developed for the manipulation of functionalized particles as solid-support in multiphase and droplet microfluidic systems, and on their clinical applications.The content of this RSS Feed (c) The Royal Society of Chemistry […]

  • Non-planar PDMS microfluidic channels and actuators: a review
    by Yongha Hwang on August 17, 2017 at 11:00 pm

    Lab Chip, 2017, 17,3948-3959DOI: 10.1039/C7LC00523G, Critical ReviewYongha Hwang, Rob N. CandlerReview of recent advances in fabrication of geometrically complex channels and actuators in PDMS, with a focus on 3D printing.The content of this RSS Feed (c) The Royal Society of Chemistry […]

Analytical Chemistry: Latest Articles (ACS Publications) latest articles published in Analytical Chemistry

    • H2S sensing mechanism of SnO2-CuWO4 operated under pulsed temperature modulation
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Cristian Eugen Simion, Simona Somacescu, Valentin Serban Teodorescu, Petre Osiceanu, Adelina StanoiuThis paper reports the sensing mechanism of SnO2-CuWO4 mixed oxides towards H2S detection revealed through Pulsed Temperature Mode (PTM). After thick film deposition onto commercial substrates, the final annealing temperature enhances the material reliability through the changes occurred during the experimental conditions. PTM approach represents a tradeoff in terms of sensing mechanism […]

    • A ratiometric fluorescent probe for Zn2+ based on pyrene-appended naphthalimide-dipicolylamine
      on December 18, 2017 at 7:28 am

      Publication date: 1 April 2018Source:Sensors and Actuators B: Chemical, Volume 258 Author(s): Shin A Yoon, Jinju Lee, Min Hee LeeA pyrene-appended naphthalimide-dipicolylamine was developed as a ratiometric fluorescent probe for Zn2+ ions. This probe displayed a ratiometric change in the fluorescent intensities at 385 and 530nm corresponding to the emissions of pyrene and naphthalimide units for Zn2+ over other metal ions, allowing for a precise quantitative analysis of the Zn2+ ion. The fluorescent color change was also visualized from blue to green. We demonstrated that probe […]

    • Optimizing the sensitivity of palladium based hydrogen sensors
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Maximilian Fisser, Rodney A. Badcock, Paul D. Teal, Arvid HunzeThis paper reports on the sensitivity optimization of palladium based hydrogen sensors. The transduction mechanism is the volumetric expansion of palladium, leading to induced strain in a strain sensing element. Absorption of hydrogen in the palladium lattice causes expansion, which can be measured using strain sensors attached to the palladium. The strain transduced from the expanding palladium is dependent not only on the […]

    • A chemosensor to recognize N-acyl homoserine lactone in bacterial biofilm
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Sujoy Das, Himadri Sekhar Sarkar, Md Raihan Uddin, Sukhendu Mandal, Prithidipa SahooA simple, sensitive, and rapid assay has been developed for detection of N-acyl homoserine lactone (HSL) autoinducers involved in bacterial quorum sensing (QS) by a new coumarin appended rhodamine derivative (RNC) ensembled with Cu2+. RNC-Cu2+ conjugate shows “turn on” fluorescence while binding with HSLs. The interaction of ensemble with HSL is found to be 1:1 stoichiometry on the basis of […]

    • A new silver (I) ions optical sensor based on nanoporous thin films of sol–gel by rose bengal dye
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Seyed Alireza Shahamirifard, Mehrorang Ghaedi, Shaaker HajatiIn this work, a new optical sensor was fabricated based on the incorporation of rose bengal (RB) dye as ionophore into the nanopores of thin film prepared through the sol-gel technique which was suitable for the determination of silver (I) ions in aqueous solutions. The prepared thin films were composed of Tetraethoxysilane (TEOS), RB dye, methanol (MeOH), hydrochloric acid and Triton X-100. They were characterized by field […]

    • A novel “turn-on” fluorescent probe with a large stokes shift for homocysteine and cysteine: Performance in living cells and zebrafish
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Haohan Song, Junli Zhang, Xiao Wang, Yanmei Zhou, Chenggong Xu, Xiaobin Pang, Xiaojun PengCarbazole-based fluorescent probes have a significant edge on structure and optical properties, but stokes shift of them were mostly less than 100 nm. In this work, a novel carbazole-based fluorescent probe, which featured with a large stokes shift (128 nm), was used to effectively detect homocysteine (Hcy) and cysteine (Cys). This probe revealed obvious color variation and a […]

    • Selective NO2 detection using YSZ-based amperometric sensor attached with NiFe2O4(+ Fe2O3) sensing electrode
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Sri Ayu Anggraini, Soichiro Yoshida, Hiroshi Ikeda, Norio MiuraA YSZ-based amperometric sensor using spinel oxide as a sensing electrode (SE) has been proposed here for detecting NO2 sensitively and selectively. Among the examined spinel-oxide SEs, NiFe2O4-SE was found to give relatively sensitive and selective response to NO2. Addition of 30 wt.% Fe2O3 into NiFe2O4-SE increased the NO2 response, while the responses to other interfering gases were maintained small. The sensor using […]

    • Biocompatible silica nanoparticles conjugated with azidocoumarin for trace level detection and visualization of endogenous H2S in PC3 cells
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Kanagaraj Rajalakshmi, Yun-Sik Nam, Sumin Youg, Muthusamy Selvaraj, Kang-Bong LeeThe silica nanoparticles (SiO2NPs) conjugated with azidocoumarin (Cy-N3) was applied for the selective and sensitive H2S detection, even when H2S was present in 1000-fold excess of other bio thiols and ions. In the silica nanoprobes, azide in the Cy-N3 group acted as the recognition element, and the probe was biocompatible. The nanoprobe displayed blue emission at 456 nm and excitation at […]

    • Performance optimization of single-layer and double-layer high-k gate nanoscale ion-sensitive field-effect transistors
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Tarek M. Abdolkader, Abdurrahman G. AlahdalThe use of high-k dielectric materials for the gate insulator of nanoscale Ion-Sensitive Field-Effect Transistor (ISFET) has been demonstrated to generally improve the ISFET performance. High-k gate insulator reduces the gate leakage current and increases the gate capacitance, which lead to higher trans-conductance and higher current sensitivity. The best high-k material for ISFET sensors is not simply the material of highest dielectric constant […]

    • Combination of periodic hybrid nanopillar arrays and gold nanorods for improving detection performance of surface-enhanced Raman spectroscopy
      on December 18, 2017 at 7:28 am

      Publication date: 1 April 2018Source:Sensors and Actuators B: Chemical, Volume 258 Author(s): Nak-hyeon Kim, Soogeun Kim, Munsik Choi, Hyeong-Ho Park, Nam Hoon Kim, Sang Yoon Park, Kyung Min Byun, Soo Yeol LeeSurface-enhanced Raman spectroscopy (SERS) based on metallic nanoparticles has suffered from poor reproducibility and line broadening of SERS signals. To overcome these problems, we newly propose the SERS substrate incorporating periodic hybrid nanopillar arrays combined with gold nanorods on a flat gold surface. Low reproducibility caused by inhomogeneously […]

    • An NIR-emitting ESIPT dye with large stokes shift for plasma membrane of prokaryotic (E. coli) cells
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Dipendra Dahal, Krishna Raj Ojha, Nicolas Alexander, Michael Konopka, Yi PangA near infrared-emitting cyanine with a very large Stokes shift (Δλ ≈ 230 nm) was synthesized by coupling with excited state intramolecular proton transfer (ESIPT). Fluorescence response of the probe was examined at different pH and at different temperatures, which revealed the important role of ESIPT in the fluorescence. In comparison with commercial FM1-43 […]

    • Selective and sensitive glycoprotein detection via a biomimetic electrochemical sensor based on surface molecular imprinting and boronate-modified reduced graphene oxide
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Jing Huang, Yunan Wu, Jiaojiao Cong, Jing Luo, Xiaoya LiuGlycoproteins are closely associated with the occurrence of diverse diseases, and they have been used as biomarkers and therapeutic targets in clinical diagnostics. The selective and sensitive sensing of glycoproteins still remains a challenge. Herein, we describe a biomimetic electrochemical sensor based on a novel boronate-modified graphene-molecular imprinted polymers composite ([email protected]) as recognition element that is well […]

    • Novel two-step activation of biomass-derived carbon for highly sensitive electrochemical determination of acetaminophen
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Dongwon Kim, Jong Min Kim, Youngmoo Jeon, Jeongyeon Lee, Jiseop Oh, Wytse Hooch Antink, Daekyu Kim, Yuanzhe PiaoThe determination of the concentration of acetaminophen (AC) in the human body is of significant importance to carefully monitor and regular drug safety and public health. However, most conventional methods are insufficient due to their time-consuming, expensive and complicated nature. In this study, we report a novel two-step activation of biomass-derived carbon for […]

    • An investigation on NO2 sensing mechanism and shielding behavior of WO3 nanosheets
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Zhongqiu Hua, Chen Tian, Zhilei Qiu, Yan Li, Xuemin Tian, Mengjun Wang, Erping LiNO2 sensor based on WO3 nanosheets was fabricated and its basic sensing mechanism was investigated. It is found that sensor response of WO3 nanosheets is linearly proportional with concentrations of NO2. It is revealed that the linear response could be theoretically derived from assumption of the grain controlled conductivity, which is caused by the tiny thickness of nanosheet. With the same […]

    • Molybdenum oxide nanosheets meet ascorbic acid: Tunable surface plasmon resonance and visual colorimetric detection at room temperature
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Rui Li, Hongjie An, Wei Huang, Yi HeHere we report a simple, rapid, and environmentally friendly method for the preparation of non-stoichiometric MoO3 (MoO3-x) nanosheets using ascorbic acid (AA) as a reducing agent under an acidic environment at room temperature. The resultant MoO3-x nanosheets show an intense blue color and strong localized surface plasmon resonance (LSPR) in the visible and near-infrared region, which can be tuned by changing the pH values of the preparation solution. […]

    • Highly sensitive and selective RNase A recognition systems based on “OFF – ON – OFF” fluorescence probes
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Jinya Du, Huiran Yang, Na Huang, Yuzhi Dong, Qingyun Gao, Wei Yang, Biao Liu, Changying YangThe “Switching – On” complexes, indolium derivatives bound with nuclear acids, were used as fluorescence probes to recognize the endonuclease and monitor the enzyme activities. Three probes, H1, L1 and N1, weakly emitted in aqueous buffer, exhibited strong red emissions when they bound into DNA or RNA. For H1-RNA or L1-RNA, the fluorescence was sensitively quenched by […]

    • Transparent polymer-based SERS substrates templated by a soda can
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Niamh C. Creedon, Pierre Lovera, Ambrose Furey, Alan O’RiordanThis paper demonstrates the reproducible fabrication of transparent Surface Enhanced Raman Scattering (SERS) substrates, fabricated by employing an aluminium soda can to template nanostructures on a flexible thermoplastic polymer surface, followed by deposition of a silver over layer. Electron microscopy and finite element modelling simulations strongly suggested the SERS response arose at regions of high electromagnetic […]

    • An intriguing signal-off responsive photoelectrochemical aptasensor for ultrasensitive detection of microcystin-LR and its mechanism study
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Xiaojiao Du, Ding Jiang, Henan Li, Nan Hao, Tianyan You, Kun WangA direct formatted photoelectrochemical (PEC) aptasensing platform was constructed for ultrasensitive microcystin-LR (MC-LR) detection with AgI-nitrogen-doped graphene (AgI-NG) composites as photocathode and aptamer as recognition element. The photocurrent of the AgI-NG composites was about 10.9 times higher than that of AgI. Furthermore, to investigate the sensing mechanism, the experiments with photoluminescence (PL) […]

    • Quantitative butyrylcholinesterase activity detection by surface-enhanced Raman spectroscopy
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Natalia Nechaeva, Taisiya Prokopkina, Galina Makhaeva, Elena Rudakova, Natalia Boltneva, Christophor Dishovsky, Arkadiy Eremenko, Ilya KurochkinThe butyrylcholinesterase activity in human blood is an important marker of healthiness. Either level of this enzyme – increased or otherwise – can indicate disease or intoxication. The most popular technique to assess the cholinesterase activity is the detection of thiocholine, a product of enzymatic hydrolysis of […]

    • An ESIPT based fluorescence probe for ratiometric monitoring of nitric oxide
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Liyan Chen, Di Wu, Juyoung YoonDevelopment of simple and selective fluorescence probes for the detection of nitric oxide (NO) is of great important because of the key roles this gasotransmitter plays in various physiological and pathological processes. Although a large number of fluorescence probes for NO have been developed thus far, only a few display ratiometric fluorescence changes. In this study, an excited-state intramolecular proton transfer (ESIPT) fluorophore based, ratiometric […]

    • Protein stabilized fluorescent gold nanocubes as selective probe for alkaline phosphatase via inner filter effect
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Amit Kumar Sharma, Sunil Pandey, M. Shahnawaz Khan, Hui-Fen WuWe present a novel approach for the synthesis of unique template free protein stabilized gold nanocubes (PSGNCs) for sensing and quantification of alkaline phosphatase (ALP) in biological fluids. The unique wavelength independent excitation of PSGNCs and absorption of the final product of ALP catalysis, i.e., p-Nitrophenol (p-NP) at 405 nm was exploited for the inner filter effect (IFE) as a sensitive and efficient […]

    • Novel urchin-like Co9S8 nanomaterials with efficient intrinsic peroxidase-like activity for colorimetric sensing of copper (II) ion
      on December 18, 2017 at 7:28 am

      Publication date: 1 April 2018Source:Sensors and Actuators B: Chemical, Volume 258 Author(s): Jianshuai Mu, Jie Li, Xin Zhao, En-Cui Yang, Xiao-Jun ZhaoNovel and uniform urchin-like Co9S8 nanomaterials assembled with needle-like nanorods were synthesized by a facile two-step hydrothermal process, and were found to exhibit intrinsic peroxidase-like activity. As a new peroxidase mimic, their catalytic properties, kinetics and mechanism were studied in depth by several techniques. The results showed that the catalytic activity of urchin-like Co9S8 nanomaterials was highly […]

    • Metal free bioimaging reagent for intracellular citrate in prostate cancer cells using aryl boronate derivative
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Kanagaraj Rajalakshmi, Yun-Sik Nam, Muthusamy Selvaraj, Yeonhee Lee, Kang-Bong LeeA boronate group integrated on a triphenylimidazoleoxadiazolephenyl (TPIOP) moiety exhibited unusual sensing and detection abilities towards citrate. TPIOP boronate exhibited a bathochromic shift in its fluorescence emission upon interaction with citrate. Quantification of trace levels of citrate ions in the human body may aid in the diagnosis of prostate cancer and kidney malfunctions. Herein, a novel, […]

    • A novel oligothiophene-based colorimetric and fluorescent “turn on” sensor for highly selective and sensitive detection of cyanide in aqueous media and its practical applications in water and food samples
      on December 18, 2017 at 7:28 am

      Publication date: 1 April 2018Source:Sensors and Actuators B: Chemical, Volume 258 Author(s): Tao Sun, Qingfen Niu, Yang Li, Tianduo Li, Tingting Hu, Enhua Wang, Haixia LiuA novel oligothiophene-based naked-eye colorimetric and fluorescent turn-on sensor 3TT with a typical donor-π-acceptor structure has been successfully developed, which displayed excellent selectivity and sensitivity for the dual-channel detection of toxic cyanide (CN−) in 70% aqueous THF media due to the nucleophilic addition of CN− to the β-conjugated position of the barbituric acid […]

    • Hydrodynamic rotating motion of micromotors from femtosecond laser microfabrication
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Wei Guan, Chao Lv, Yi-Shi Xu, Yan-Hao Yu, Hong Xia, Li-Gang Niu, Sen Liu, Gong Wang, Ying-Shuai Wang, Hong-Bo SunThe micro-motion of the machine is essential and valuable in environment, biology and medicine research. Environment-propelled micromotion can exhibit driven non-equilibrium behaviors. The energy conversation of micromotors from fluid environment would be an important power supply method for the distributed sensor network. Here, we report a kind of rotating motion […]

    • UV-light-induced synthesis of PEI-CuNCs based on Cu2+-quenched fluorescence turn-on assay for sensitive detection of biothiols, acetylcholinesterase activity and inhibitor
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Jinlan Yang, Naizhong Song, Xueju Lv, Qiong JiaPolyethyleneimine-protected copper nanoclusters (PEI-CuNCs) were synthesized and applied to detect Cu2+, biothiols, and acetylcholinesterase (AChE). A facile UV-light-induced method was used in the synthesize process to obtain PEI-CuNCs with high stability and strong fluorescence intensity. Based on the quenching mechanism, a label-free assay for sensing Cu2+ by PEI-CuNCs was developed with the limit of detection (LOD) of 0.12 μM. […]

    • Ultrasensitive in-vitro monitoring of monoamine neurotransmitters from dopaminergic cells
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Mohammed Y. Emran, Mohamed A. Shenashen, Moataz Mekawy, Ahmed M. Azzam, Naeem Akhtar, Hassenien Gomaa, Mahmoud M. Selim, Ahmed Faheem, Sherif A. El-SaftyThe design of biosensing assay of monoamine neurotransmitters (MANTs) such as epinephrine (Ep), norepinephrine (NE), and dopamine (DA), as well as the monitoring of these MANTs released from dopaminergic cells, are of particular interest. Electrochemical sensors based on the novel construction of nickel oxides (NiO) were […]

    • 3D-printed capillary circuits for rapid, low-cost, portable analysis of blood viscosity
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Sein Oh, Byeongyeon Kim, Jeong K. Lee, Sungyoung ChoiBlood viscosity is an important rheological property that have a potential for the diagnosis and prognosis of hemorheological alterations; however, conventional viscometers typically rely on costly and sophisticated equipment for device operation and viscosity measurement that limits their use in resource-limited settings. We present a 3D-printed capillary circuit (3D-CC) technology that enables facile analysis of blood viscosity by […]

    • A facile indicator box based on Eu3+ functionalized MOF hybrid for the determination of 1-naphthol, a biomarker for carbaryl in urine
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Si-Jia Qin, Bing YanCarbaryl is the most frequently used carbamate pesticide in the agriculture field, which is associated with a series of potential adverse health impacts including neurological disorder and cancer. 1-naphthol (1-N), a metabolite of the insecticide carbaryl, is an established human biomarker used for assessing food intake and environmental exposure. The present study, amied to investigate the potential application of Eu3+ functionalized metal-organic frameworks for the […]

    • Enhancing electronic nose performance based on a novel QPSO-RBM technique
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Hanxiao Luo, Pengfei Jia, Siqi Qiao, Shukai DuanA novel classification technique for bacteria detection termed quantum-behaved particle swarm optimization-based restricted Boltzmann machine (QPSO-RBM) based on electronic nose technology is proposed in this paper. In order to improve the performance of the QPSO-RBM technique, three training objective functions have been adopted in the training process of RBM respectively. A new synchronous optimization method is adopted in QPSO-RBM to […]

    • Fabrication of a new electrochemical imprinted sensor for determination of ketamine based on modified polytyramine/sol-gel/[email protected] nanocomposite/pencil graphite electrode
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Behjat Deiminiat, Gholam Hossein RounaghiThis paper proposes a new strategy for measurement of ketamine through one-step electropolymerization of the molecularly imprinted polymer (MIP) composed of polytyramine (pty), sol-gel, functionalized multiwall carbon [email protected] nanoparticles ([email protected]) nanocomposite and ketamine on a pencil graphite electrode (PGE) by cyclic voltammetric (CV) technique. [email protected] nanocomposite was entrapped within the polymer network to enhance the […]

    • Visible light-assisted room temperature gas sensing with ZnO-Ag heterostructure nanoparticles
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Qiuping Zhang, Guangzhong Xie, Ming Xu, Yuanjie Su, Huiling Tai, Hongfei Du, Yadong JiangNoble metal-metal oxide nanohybrids play an ever-increasing role in photocatalytic applications. Here, a ZnO-Ag nanoparticle prepared by a modified polymer-network gel method was utilized for room temperature light-assisted NO2 gas detection. Since a heterojunction forms between the two materials and surface oxygen vacancies increase, the sensitivities of the sensors to NO2 gas […]

    • Simultaneous determination of codeine and its co-formulated drugs acetaminophen and caffeine by utilising cerium oxide nanoparticles modified screen-printed electrodes
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Mohamed Khairy, Bahaa G. Mahmoud, Craig E. BanksWe report a facile and low-cost methodology for the simultaneous determination of codeine (COD) and its common co-formulated drugs acetaminophen (APAP) and caffeine (CAF) utilising cerium oxide nanoparticles modified screen-printed electrodes (CeO2-SPEs) for the first time. Interestingly, CeO2-SPEs offer a promising, sensitive, robust and chemically stable non-enzymatic electrochemical sensor for the simultaneous determination of APAP, COD […]

    • Chemically functionalized 3D reticular graphene oxide frameworks decorated with MOF-derived Co3O4: Towards highly sensitive and selective detection to acetone
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Degong Ding, Qingzhong Xue, Wenbo Lu, Ya Xiong, Jianqiang Zhang, Xinglong Pan, Baoshou TaoHere, we have newly developed chemically functionalized three-dimension (3D) graphene oxide hydrogels (FGH) decorated with metal-organic frameworks (MOFs)-derived Co3O4 nanostructures, in which the Co3O4 nanostructures are uniformly distributed in 3D FGH frameworks. It is found that the Co3O4/FGH composites exhibits excellent acetone sensing properties, for instance, it shows an ultra-high […]

    • Highly sensitive naked eye detection of Iron (III) and H2O2 using poly-(tannic acid) (PTA) coated Au nanocomposite
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Yan Fang, Jiajun Tan, Hyunjun Choi, Sierin Lim, Dong-Hwan KimIn the present study, we present a room temperature-, one-pot method for the synthesis of functional poly (tannic acid) (PTA)-based [email protected] nanocomposites ([email protected]). The addition of tannic acid (TA) to gold (Au) salt solutions at mildly alkaline pH induced reduction of the metal salts to Au nanoparticles (NPs) while TA was oxidized and self-polymerized before encapsulating the AuNPs to form [email protected] Through the use of […]

    • The application of mitochondrial targetable pyronine-pyridinium skeleton in the detection of nitroreductase
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Ling Yang, Jin-Yun Niu, Ru Sun, Yu-Jie Xu, Jian-Feng GeIn this paper, a new compound (3) with pyronine-pyridine skeleton had a strong fluorescence at pH 5.0−9.0, while the emission turned off at pH = 1.0–2.0. It was a mitochondrial biomarker in cancer cells (KB, 4T1, HeLa) and normal cells (Ges-1, L929, WS1). Based on these above results, probe 1 with pyronine-pyridinium skeleton was further designed and prepared to detect nitroreductase (NTR). The nitrofuran […]

    • Plasmonic ELISA for naked-eye detection of ochratoxin A based on the tyramine-H2O2 amplification system
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Yi Liang, Xiaolin Huang, Xirui Chen, Wenjing Zhang, Guo Ping, Yonghua XiongA novel direct competitive plasmonic enzyme-linked immunosorbent assay (dc-pELISA) was applied to detect ochratoxin A (OTA) with naked eyes. In this assay, horseradish peroxidase (HRP) + hydrogen peroxide (H2O2) + tyramine (TYR)-induced gold nanoparticle (AuNP) aggregation was considered as a signal output; AuNP aggregation could be triggered through the phenol polymerization of TYR, […]

    • Mechanically programmed valving technology and the active flow switching application in centrifugal microfluidics
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Jiwen Xiang, Ziliang Cai, Yong Zhang, Wanjun WangCentrifugal microfluidic system (Lab-on-CD) is attractive for realizing the conventional laboratory processes on a single microfluidic platform. Efficient valving technology for centrifugal microfluidics is highly desired for fluidic sample regulation. This paper reports a new valving technology based on the intrinsic centrifugal force. The valving system is mechanically programed to achieve sequential control of fluidic samples. The […]

    • Colorimetric sensor based on a poly(ortho-phenylenediamine-co-aniline) copolymer for the monitoring of tilapia (Orechromis niloticus) freshness
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Angélica Domínguez-Aragón, Jorge A. Olmedo-Martínez, E. Armando Zaragoza-ContrerasFor monitoring tilapia (Orechromis niloticus) freshness degree, a colorimetric method based on a copolymer of ortho-phenylenediamine and aniline, in a molar ratio of 1 to 1, was developed. The optical sensor changes color as a function of pH, therefore, it is sensitive to the presence of alkaline vapors such as the volatile amines (TVB-N) produced during fish spoilage. A kinetic […]

    • Highly sensitive fluorogenic sensing of L-Cysteine in live cells using gelatin-stabilized gold nanoparticles decorated graphene nanosheets
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Balamurugan Thirumalraj, Namasivayam Dhenadhayalan, Shen-Ming Chen, Yan-Jin Liu, Tse-Wei Chen, Po-Huang Liang, King-Chuen LinA highly sensitive and selective fluorogenic sensing of L-Cysteine (L-Cys) was implemented based on gelatin stabilized gold nanoparticles decorated reduced graphene oxide (rGO/Au) nanohybrid. The rGO/Au nanohybrid was prepared by the one-pot hydrothermal method and well characterized by different physiochemical techniques. The nanohybrid exhibits a weak […]

    • Supramolecular recognition of A-tracts DNA by calix[4]carbazole
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Gang Li, Xiaoyu Song, Hui Yu, Chun Hu, Mingzhe Liu, Jie Cai, Liang Zhao, Yan Chen, Peng YangNaturally occurring biomolecules such as transcription factors recognize specific sequences of DNA by binding to its major groove whereas the synthetic sequence-specific major-groove binders are rare. We herein report that a synthetic calix[4]carbazole could serve as the optical ligand of A-tracts (B*-form DNA) by binding to its major-groove, elucidated by UV-vis, fluorescence, CD and […]

    • Ultrasensitive photoelectrochemical immunosensor for insulin detection based on dual inhibition effect of CuS-SiO2 composite on CdS sensitized C-TiO2
      on December 18, 2017 at 7:28 am

      Publication date: 1 April 2018Source:Sensors and Actuators B: Chemical, Volume 258 Author(s): Xueping Wang, Picheng Gao, Tao Yan, Rongxia Li, Rui Xu, Yong Zhang, Bin Du, Qin WeiHigh sensitivity of biosensor is one of the most important factor to realize the accurate detection of biomarkers. To achieve this purpose, enhancing initial signal and amplifying the value of signal change are two main approaches. In this study, a novel signal-off photoelectrochemical (PEC) immunosensor for highly sensitive determination of insulin was developed upon dual inhibition effect of […]

    • A cluster analysis approach based on exploiting density peaks for gas discrimination with electronic noses in open environments
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Han Fan, Victor Hernandez Bennetts, Erik Schaffernicht, Achim J. LilienthalGas discrimination in open and uncontrolled environments based on smart low-cost electro-chemical sensor arrays (e-noses) is of great interest in several applications, such as exploration of hazardous areas, environmental monitoring, and industrial surveillance. Gas discrimination for e-noses is usually based on supervised pattern recognition techniques. However, the difficulty and high cost of obtaining extensive […]

    • A sensitive polymer dots-manganese dioxide fluorescent nanosensor for “turn-on” detection of glutathione in human serum
      on December 18, 2017 at 7:28 am

      Publication date: 1 April 2018Source:Sensors and Actuators B: Chemical, Volume 258 Author(s): Lei Han, Shi Gang Liu, Xiao Fang Zhang, Bai Xiang Tao, Nian Bing Li, Hong Qun LuoGlutathione (GSH), as a crucial endogenous thiol and antioxidant, plays an essential role in the biological system, and its abnormal levels are closely related to various diseases. Therefore, it continues to be of enormous significance to develop a sensitive and efficient method for the assay of GSH. Herein, we report a facile and sensitive polymer dots (PDs)-manganese dioxide (MnO2) nanosensor for […]

    • DNA-templated Au nanoclusters and MnO2 sheets: a label-free and universal fluorescence biosensing platform
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Hai-Bo Wang, Yang Li, Hong-Yu Bai, Yan-Ming LiuA label-free and universal fluorescence biosensing paltform has been constructed for probing and recognizing biomolecular interactions based on the excellent fluorescent properties of poly(adenine) (poly A) DNA templated-Au nanoclusters (DNA-AuNCs) and the good quenching ability of MnO2 sheets. Due to the high quenching efficiency of MnO2 sheets, the luminescence of DNA-AuNCs was decreased. Because single-stranded DNA-AuNCs was adsorbed onto […]

    • A simple two-output near-infrared fluorescent probe for hydrazine detection in living cells and mice
      on December 18, 2017 at 7:28 am

      Publication date: 1 April 2018Source:Sensors and Actuators B: Chemical, Volume 258 Author(s): Zhengliang Lu, Xiaomin Shi, Yufan Ma, Wenlong Fan, Yanan Lu, Zhuo Wang, Chunhua FanHydrazine is an important reactive base in chemistry, pharmacy and agriculture and an effective propellant in aeronautics and astronautics. However, tiny leakage might induce serious environmental contamination and fatal biological damage. Thus, how to rapidly detect hydrazine with high selectivity and sensitivity is of significance and challenge. In this report, we demonstrate a hydrazine-specific […]

    • Enhancing the quantum yield and Cu2+ sensing sensitivity of carbon dots based on the nano-space confinement effect of silica matrix
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Yali Qiao, Chunyan Liu, Xingwang ZhengAlthough the analytical applications of the fluorescent carbon dots (CDs) were widely explored, the development of effective fluorescence signal amplification scheme based on the CDs was challengeable. In this work, we firstly found that, after CDs and polyethyleneimine (PEI) were together doped into silica nanoparticles via a reverse microemulsion route, the CDs inside as-prepared CDs/PEI/silica nanoparticles (CDs/PEI/SiO2 NPs) presented the higher […]

    • A silver-grafted sponge as an effective surface-enhanced Raman scattering substrate
      on December 18, 2017 at 7:28 am

      Publication date: 1 April 2018Source:Sensors and Actuators B: Chemical, Volume 258 Author(s): Ningning Zhou, Guowen Meng, Chuhong Zhu, Bin Chen, Qitao Zhou, Yan Ke, Dexian HuoA silver film is in situ grafted on a melamine sponge via the silver mirror reaction. The porous structure of the sponge possesses an enlarged total SERS-active surface area without increasing the overall footprint of the SERS substrate. The Ag-grafted sponge exhibits high SERS activity toward Rhodamine 6G with a concentration down to 0.1 pM. Moreover, the sponge-based substrate also offers a good […]

    • Construction of a fluorine substituted chromenylium-cyanine near-infrared fluorophore for ratiometric sensing
      on December 18, 2017 at 7:28 am

      Publication date: 15 April 2018Source:Sensors and Actuators B: Chemical, Volume 259 Author(s): Xiaoyan Zhu, Lin Yuan, Xiaoxiao Hu, Lili Zhang, Yuxin Liang, Shengyuan He, Xiao-Bing Zhang, Weihong TanNear-infrared (NIR) fluorescent probes have been considered as powerful tools for exploring bioactive species and biological processes in living systems by virtue of the substantial merits of the NIR window (such as minimal photo-toxicity, deep tissue penetration, and low background interference). However, the development of effective NIR fluorescent probes for biological […]

    • Two-stage ratiometric fluorescent responsive probe for rapid glutathione detection based on BODIPY thiol-halogen nucleophilic mono- or disubstitution
      on December 18, 2017 at 7:28 am

      Publication date: 1 April 2018Source:Sensors and Actuators B: Chemical, Volume 258 Author(s): Deyan Gong, Jiaxi Ru, Ting Cao, Jing Qian, Wei Liu, Anam Iqbal, Weisheng Liu, Wenwu Qin, Huichen Guo3,5-dichloro-8-phenyl-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BOD-2Cl) (1) as a classical fluorescent dye was synthesized for the purpose of functionalization of BODIPY dye. Herein, it was applied for the purpose of achieving two-stage ratiometric fluorescent detection of glutathione based on the two-step thiol-halogen substitution reaction with the sulfhydryl group of […]

    Microsystems & Nanoengineering - nature.com technology Microsystems & Nanoengineering is an international open access journal, publishing original articles and reviews covering all aspects of microsystems and nanoengineering from fundamental to applied research.

    • Chopper-modulated gas chromatography electroantennography enabled using high-temperature MEMS flow control device
      by Ming-Da Zhou on December 18, 2017 at 12:00 am

      Chopper-modulated gas chromatography electroantennography enabled using high-temperature MEMS flow control deviceChopper-modulated gas chromatography electroantennography enabled using high-temperature MEMS flow control device, Published online: 18 December 2017; doi:10.1038/micronano.2017.62A compact and ultrasensitive MEMS device could lead to the identification of biologically active compounds at previously undetectable levels. Gas chromatography electroantennography (GC–EAG) can be used to detect and identify volatile organic compounds, known as odorants, from the electrical […]

    • A microscale optical implant for continuous <i>in vivo</i> monitoring of intraocular pressure
      by Jeong Oen Lee on December 18, 2017 at 12:00 am

      A microscale optical implant for continuous in vivo monitoring of intraocular pressureA microscale optical implant for continuous <i>in vivo</i> monitoring of intraocular pressure, Published online: 18 December 2017; doi:10.1038/micronano.2017.57The treatment and management of glaucoma could be become easier and more effective thanks to a tiny and flexible implantable sensor. Current therapies aim to lower elevated pressure inside the eye (intraocular pressure, IOP), the only known modifiable risk factor for glaucoma, and an important parameter for monitoring the condition. But […]

    • Soft electrostatic trapping in nanofluidics
      by Michael A. Gerspach on December 4, 2017 at 12:00 am

      Soft electrostatic trapping in nanofluidicsSoft electrostatic trapping in nanofluidics, Published online: 04 December 2017; doi:10.1038/micronano.2017.51A method for the bulk manufacture of precision nanofluidic trapping devices could lead to applications in biophysics and medical diagnostics. Trapping and manipulating nanoscale objects in solutions has a range of applications such as disease diagnostics, drug discovery, cell biology and photonics. But fabricating stable devices for contact-free trapping of nano-objects in polydimethylsiloxane (PDMS), which has unique and advantageous […]

    • Photomechanical meta-molecule array for real-time terahertz imaging
      by Yongzheng Wen on December 4, 2017 at 12:00 am

      Photomechanical meta-molecule array for real-time terahertz imagingPhotomechanical meta-molecule array for real-time terahertz imaging, Published online: 04 December 2017; doi:10.1038/micronano.2017.71Real-time terahertz imaging has been realized by coupling an array of terahertz-absorbing meta-molecules to heat-sensitive cantilevers. Imaging using terahertz waves, which lie between microwaves and infrared waves in the electromagnetic spectrum, is promising for many applications, including airport security and medical diagnosis. But most terahertz detectors have to be scanned, making it […]

    • Monolithic ultrasound fingerprint sensor
      by Xiaoyue Jiang on November 20, 2017 at 12:00 am

      Monolithic ultrasound fingerprint sensorMonolithic ultrasound fingerprint sensor, Published online: 20 November 2017; doi:10.1038/micronano.2017.59Sensors capable of capturing both epidermal and subsurface fingerprints can be micromachined into consumer-grade electronics. Capacitive sensors are found in most modern fingertip-imaging devices, but emerging ultrasonic technology offers important advantages. For example, sound waves are unaffected by moisture and other contaminants, and can detect features below the skin. David Horsley from the University of California, Davis, and colleagues […]

    • Using airbrushes to pattern reagents for microarrays and paper-fluidic devices
      by Christopher L. Cassano on November 20, 2017 at 12:00 am

      Using airbrushes to pattern reagents for microarrays and paper-fluidic devicesUsing airbrushes to pattern reagents for microarrays and paper-fluidic devices, Published online: 20 November 2017; doi:10.1038/micronano.2017.55An innovative technique that uses airbrushes to pattern reagents onto substrates offers a simple and cheap solution for medical diagnostics. DNA and protein microarrays have become powerful tools in the cost-effective and timely diagnosis of infectious diseases. They are also increasingly important for point-of-care testing. However these techniques require tiny amounts of […]