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Microfluidics-based cell culture

Organ-on-a-chip: a New Model of Microfluidic Chip

April 22, 2018

Cells in a microwell and their growth after two days of perfusion An organ-on-a-chip is a microfluidic device with continuously perfused chambers in which cells are cultured to obtain functional units that mimic organ functions. The [more...]

New Research Investigates Whether Microfluidic-based Cell Culture is Fit for Purpose

April 29, 2017

Bio-scientist attitudes towards the future of microfluidics-based 3D culture technology and the search for their ‘ideal’ model have been revealed in a new research survey conducted by the Department of Engineering. Organ-on-a-chip and [more...]

Magnet Inserts Help to Close a Modular Chip for Cell Culture

March 21, 2017

Figure 1. A cartoon of the modular microfluidic system (Image credit: Pitingolo etc, Journal of Micromechanics and Microengineering) Exploiting a magnetic process, IIT (Istituto Italiano di tecnologia) researchers have developed a modular [more...]

Capturing Cell Growth in 3D with Microfluidic Device

August 15, 2015

AIM Biotech’s microfluidics device (shown here) has an array of culturing sections, each with three chambers: a middle chamber for hydrogel and any cell type, and two side channels for culturing additional cell types. Replicating how [more...]

Is Now the Time to Move Your Research to 3D Cell Culture?

July 28, 2015

Cancer Spheroids, Image Courtesy of Molecular Devices Introduction Mammalian cell culture has been used in research and drug discovery for many years. The use of this technology has resulted in many key discoveries in developmental [more...]

3-D Organoids Grown from Patient Tumors Could Personalize Drug Screening

July 4, 2015

Cancer in 3-D (Image Credit: Wellcome Trust Sanger Institute) Three-dimensional cultures (or “organoids”) derived from the tumors of cancer patients closely replicate key properties of the original tumors, reveals a study [more...]

Microfluidics’ Watershed Moment

June 28, 2015

The HµRELflow™ cell-based assay system has three microfluidic devices on a biochip. Each device incorporates two cell culture compartments interconnected by microscale channels. Integrated micropumps recirculate culture media within the [more...]

New Microfluidic Device Could Be a Safer Alternative to Lung Ventilators

June 4, 2015

Dark red blood flows into the device, where it exchanges carbon dioxide for oxygen and emerges on the other side much brighter. A new technology that re-creates important characteristics of structures in the lung could eventually be a [more...]

Microfluidics for Accelerated Drug Assays

April 12, 2015

Multiple microwells on Yevgeny Berdichevsky’s assay chips make it possible to test up to 18 drug candidates at a time. (Image Credit: Linda Nye) Approximately 125,000 Americans each year develop epilepsy, a brain disease marked by [more...]

Lab Rats? No, Lab Chips

February 4, 2015

Using the compact multi-organ chip (comparable in size to a one-euro piece), and those of three separate microcircuits, researchers can study the regeneration of certain kidney cells. (Credit: Fraunhofer IWS) One small chip may put an end [more...]

iChip: The Future of Antibiotic Discovery

January 29, 2015

Two weeks ago, a team led by scientists from Northeastern University published a study describing a new class of antibiotics called teixobactin, which they found in the soil of a field in Maine. The Internet subsequently lit up with both [more...]

Novel Microfluidic Device Allows Electroporation of Stem Cells During Differentiation

January 20, 2015

Photo credit: Prof. Horacio D. Espinosa and Prof. John A. Kessler at Northwestern University, USA. Electroporation is a powerful technique in molecular biology. By using an electrical pulse to create a temporary nanopore in a cell [more...]

Microfluidic Method for Primary Neuron Culture and Analysis

January 15, 2015

Figure 1: Rat primary cortical neurons were seeded and cultured on the microfluidic plate for 21 days, and the medium was replenished every day until Day 5. After Day 5, the medium was replenished every two days. The phase contrast images [more...]

Organs-on-Chips

October 14, 2014

The Wyss Institute for Biologically Inspired Engineering at Harvard University today announced that its human ‘Organs-on-Chips’ technology will be commercialized by a newly formed private company to accelerate development of [more...]