Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00216C, Paper Mohammad Osaid, Yi-Sin Chen, Chih-Hung Wang, Anirban Sinha, Wen-Bin Lee, Priya Gopinathan, Hung-Bin Wu, Gwo-Bin LeeAntimicrobial resistance stemming from indiscriminate usage of antibiotics has emerged as a global healthcare issue with substantial economic implications. The inefficacy of commonly used antibiotics combined with superfluous consumption has...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00182E, Paper Jaehyun Lee, Seong-Eun Kim, Dowon Moon, Junsang DohCancer immunotherapies based on the ability of T cells to recognize and kill tumor cells (TCs), including immune checkpoint blockades (ICBs) and chimeric antigen receptor (CAR) T cell therapy, have...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01250E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Charlotte Volpe, Olav Vadstein, Geir Andersen, Tom AndersenA versatile LED based miniature photobioreactor ideal for factorial experiments that allows simultaneous testing of a wide range of variables and experimental combinations needed for high-throughput screening analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00169H, Paper Lingjun Zhang, Jian feng Sun, Hong He, Yingzhou Huang, Haiyang Shi, Weigen ChenBecause of the complicated component and suppression in spectrum, the Raman detection of trace substances in complex oil is still the great challenge at present. In this work, a simple...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00047K, Paper Peer Erfle, Juliane Riewe, Heike Bunjes, Andreas DietzelPoorly soluble drugs can be incorporated in lipid carrier nanoparticles to achieve sufficient bioavailability and open up diverse routes of administration. Preparation by antisolvent precipitation in microfluidic systems enables excellent...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00038A, Critical Review Davood Khoeini, Timothy F Scott, Adrian NeildDynamic, kinetically-controlled, self-assembly processes are commonly observed in nature and are capable of creating intricate, functional architectures from simple precursors. However, notably, much of the research into molecular self-assembly has...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00067E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. H. Azizgolshani, J. R. Coppeta, E. M. Vedula, E. E. Marr, B. P. Cain, R. J. Luu, M. P. Lech, S. H. Kann, T. J. Mulhern, V. Tandon, K. Tan, N. J. Haroutunian, P. Keegan, M. Rogers, A. L. Gard, K. B. Baldwin, J. C. de Souza, B. C. Hoefler, S. S. Bale, L. B. Kratchman, A. Zorn, A. Patterson, E. S. Kim, T. A. Petrie, E. L. Wiellette, C. Williams, B. C. Isenberg, J. L. Charest96 microfluidic devices with […]

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00082A, Paper Hedieh Fallahi, Sharda Yadav, Hoang-Phuong Phan, Hang Ta, Jun Zhang, Nam-Trung NguyenWe present a stretchable inertial microfluidic device for tuneable separation of spiked cancer cells from blood sample.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00104C, Paper Yijun Cheng, Shuyan Zhu, Stella W PangTo realize highly directional guidance for cell migration, both micro− and nano−scale topographies were studied to better understand and mimic the complex extracellular matrix environment. Polydimethylsiloxane based platforms with micro−...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01271H, Comment Huimin Lv, Jun Dong, Yue Yang, Yonggang ZhuNon-uniform radial perturbations due to non-self-similar alveolar expansion drive the closed vortex into a spiral and the change of spiral rotation direction.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00884B, Comment Akira Tsuda, Frank S. HenryThis comment on an article that appeared in this journal (H. Lv, J. Dong, Y. Qiu, Y. Yang and Y. Zhu, Lab Chip, 2020, 20, 2394–2402) highlights some important inconsistencies between the authors' experimental results and their numerical simulations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00048A, Paper Kazuki Yamamoto, Nao Yamaoka, Yu Imaizumi, Takunori Nagashima, Taiki Furutani, Takuji Ito, Yohei Okada, Hiroyuki Honda, Kazunori ShimizuEngineered three-dimensional models of neuromuscular tissues are promising for use in mimicking their disorder states in vitro. Although several models have been developed, it is still challenging to mimic the...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00097G, Paper Roozbeh Abedini-Nassab, Sajjad BahramiSingle magnetic particles and magnetized cells are transported on-chip using a TI magnetic pattern. The tri-axial external magnetic field provides the driving force for manipulating all the particles simultaneously.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00135C, Paper Reha Abbasi, Thomas Brian LeFevre, Aaron David Benjamin, Isaak John Thornton, James Nolen WilkingHydrogels are soft, water-based polymer gels that are increasingly used to fabricate free-standing fluidic devices for tissue and biological engineering applications. In many of these applications, pressurized liquid must be...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01262A, Paper Shan He, Zefang Wang, Wei Pang, Chang Liu, Miaosen Zhang, Yang Yang, Xuexin Duan, Yanyan WangA gigahertz acoustic streaming effect stimulates PC12 cell structure change within 10 min, and produces a higher ratio of neurite-bearing cells compared to NGF stimulation. This method can be of single-cell modulation due to microminiaturization.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01235A, Critical Review Ran An, Yuning Huang, Yuncheng Man, Russell Valentine, Erdem Kucukal, Utku Goreke, Zoe Sekyonda, Connie Piccone, Amma Owusu-Ansah, Sanjay Ahuja, Jane A Little, Umut A. GurkanAnemia, characterized by low blood hemoglobin level, affects about 25% of the world's population with the heaviest burden borne by women and children. Anemia leads to impaired cognitive development in...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01222J, Paper Dan Liu, Haicong Shen, Yuqian Zhang, Danyu Shen, Mingyang Zhu, Yanling Song, Zhi Zhu, Chaoyong YangA simple microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay was developed for rapid COVID-19 detection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00079A, Paper Chung-An Chen, Hao Yuan, Chiao-Wen Chen, Yuh-Shiuan Chien, Wang-Huei Sheng, Chien-Fu ChenA three-dimensional origami-paper-based analytical device with electricity-free “timer” function for HIV type 1 p24 antigen detection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01323D, Paper Enkhtuya Radnaa, Lauren S. Richardson, Samantha Sheller-Miller, Tuvshintugs Baljinnyam, Mariana de Castro Silva, Ananth Kumar Kammala, Rheanna Urrabaz-Garza, Talar Kechichian, Sungjin Kim, Arum Han, Ramkumar MenonPreterm birth (PTB; <37 weeks of gestation) impacts ∼11% of all pregnancies and contributes to 1 million neonatal deaths worldwide annually.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01304H, Critical Review Wen-Chin Lee, Hwee-Yeong Ng, Chih-Yao Hou, Chien-Te Lee, Lung-Ming FuOverview of integrated lab-on-paper diagnostic devices.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00076D, Paper Ningquan Wang, Ruxiu Liu, Norh Asmare, Chia-Heng Chu, Ozgun Civelekoglu, A. Fatih SariogluAn adaptive microfluidic system changing its operational state in real-time based on cell measurements through an on-chip electrical sensor network.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1197-1198DOI: 10.1039/D1LC90030G, Editorial Andreas Manz, Abraham P. Lee, Aaron R. WheelerWe check in with past, present, and future Editors-in-Chief, including Andreas Manz (2001–2008), Abe Lee (2017–2020), and Aaron Wheeler (2021–), about the state of the field.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1318-1332DOI: 10.1039/D0LC00940G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Kyle T. Gustafson, Katherine T. Huynh, Daniel Heineck, Jesus Bueno, Augusta Modestino, Sejung Kim, Austin Gower, Randall Armstrong, Carolyn E. Schutt, Stuart D. IbsenDescribed is a fully automated algorithm and a particle-based internal standard to optically quantify immunostained particles collected using microfluidic chips.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01295E, Paper Daehan Kim, Kideok Kim, Joong Yull ParkOur unique microwell in the shape of the Greek letter sigma (σ) with a roof can culture floating spheroids.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01288B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Martin Andersson, Sofia Johansson, Henrik Bergman, Linhong Xiao, Lars Behrendt, Maria TenjeA heat-stage for spatiotemporal temperature control in microfluidic chips is developed. The technology is used for mapping thermoresponses of single cells of Symbiodinium in order to improve our understanding of temperature-induced coral bleaching.To cite this article before page numbers are assigned, use the DOI form […]

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01292K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Iiro Kiiski, Päivi Järvinen, Elisa Ollikainen, Ville Jokinen, Tiina SikanenThis work demonstrates the feasibility of material-enabled oxygen scavenging in thiol-ene microchannels for on-chip subcellular drug metabolism assays under hypoxia.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1241-1268DOI: 10.1039/D0LC01120G, Critical Review H. M. Xia, J. W. Wu, J. J. Zheng, J. Zhang, Z. P. WangNonlinear microfluidics, including the typical devices, their working mechanisms and applications are discussed.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00101A, Paper Yaru Xing, Yu Liu, Rifei Chen, Yuyan Li, Chengzhi Zhang, Youwei Jiang, Yao Lu, Bingcheng Lin, Peizhong Chen, Ruijun Tian, Xianming Liu, Xing ChengAn active-matrix digital microfluidic platform based on printed-circuit board technology is developed as a robust, highly scalable, low cost, easy to use, and contamination-insensitive device for automatic and parallel droplet handling.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01328E, Paper Haizhen Sun, Yukun Ren, Ye Tao, Tianyi Jiang, Hongyuan JiangThis work describes a universal, massive and versatile technique, namely, alternating current electrothermal-flow field-effect transistor, to accomplish online in-droplet cell/synthetic particle concentration on demand.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01148G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Yuewen Zhang, Maya Wright, Kadi-Liis Saar, Pavankumar challa, Alexey Morgunov, Quentin Peter, Sean Devenish, Christopher M Dobson, Tuomas KnowlesThe ability to determine the identity of specific proteins is a critical challenge in many areas of cellular and molecular biology, and in medical diagnostics. Here, we present a microfluidic...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1418-1418DOI: 10.1039/D1LC90031E, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Chin Hong Ooi, Raja Vadivelu, Jing Jin, Kamalalayam Rajan Sreejith, Pradip Singha, Nhat-Khuong Nguyen, Nam-Trung NguyenThe content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00747A, Paper Keondo Lee, Seong-Eun Kim, Junsang Doh, Keehoon Kim, Wan Kyun ChungThe image-activated cell sorter employs a significantly simplified operational procedure based on a syringe connected to a piezoelectric actuator and high-performance inference with TensorRT Integration.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01078B, Paper Rachael K. Jayne, M. Çağatay Karakan, Kehan Zhang, Noelle Pierce, Christos Michas, David J. Bishop, Christopher S. Chen, Kamil L. Ekinci, Alice E. WhiteWe developed an organ-on-a-chip platform with integrated stimulators and sensors. The platform is fabricated using direct laser writing (DLW) and allows for generation and study of functional 3D cardiac microtissues in controlled microenvironments.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]

Lab Chip, 2021, 21,1299-1306DOI: 10.1039/D0LC01293A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Takumi Inui, Jiyang Mei, Chikahiro Imashiro, Yuta Kurashina, James Friend, Kenjiro TakemuraAfter exposing a plated C2C12 cells culture to PBS, ultrasound from the SAW device transmitted into the cell culture via a coupling water droplet. We can remove cells from an area 6 × 10−3 mm2, equivalent to about 12 cells.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01204A, Paper Xinne Zhao, Rico Illing, Philip Ruelens, Michael Bachmann, Gianaurelio Cuniberti, J. Arjan G. M. de Visser, Larysa BarabanWe use a millifluidic system to study the multi-species bacterial growth to unveil the details of cooperation between two Escherichia coli strains inside droplet reactors. This system also has the potential for studies of drug resistance transfer.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01332C, Paper Xi Yang, Chaoyang Gong, Yanqiong Wang, Yanhua Luo, Yun-Jiang Rao, Gang-Ding Peng, Yuan GongWe demonstrate the sequential bioconjugation method in fiber optofluidic lasers for sensitive, wash-out-free and fast biodetection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01283A, Paper Brandon K. Walther, Navaneeth Krishna Rajeeva Pandian, Karli A. Gold, Ecem S. Kiliç, Vineeth Sama, Jianhua Gu, Akhilesh K. Gaharwar, Anthony Guiseppi-Elie, John P. Cooke, Abhishek JainWalther et al. employed vessel-chip technology to study how matrix stiffness and shear stress combine to influence endothelial cell YAP mechanobiology, discovering that stiff matrices impede the protective effects of physiologic shear stress.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00012H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Junxian Luo, Shen Liu, Peijing Chen, Shengzhen Lu, Qiang Zhang, Yanping Chen, Bin Du, Jian Tang, Jun He, Changrui Liao, Yiping WangA novel probe-type FPI-based fiber optic hydrogen sensor with a graphene–Au–Pd sandwich structure film and FBG is proposed and experimentally demonstrated in this study.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01135E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Alfred Nguyen, Matthias Brandt, Till M. Muenker, Timo BetzWe present a novel method for frequency-dependent microrheology on endothelial cell monolayer at high throughput and fluid flow.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01268H, Paper Fu-Min Wang, I-Pei Lu, Chih-Ting Lin, Shey-Shi Lu, Shih-Kang FanField-effect pumps (FEPs) driving liquids continuously from source, via gate, toward drain electric fields along a virtual microchannel between parallel plates in linear, transition and saturation regions analogous to field-effect transistors (FETs).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01303J, Paper Alinaghi Salari, Sila Appak-Baskoy, Imogen R. Coe, John Abousawan, Costin N. Antonescu, Scott S. H. Tsai, Michael C. KoliosMicrostreaming-based acoustofluidics facilitates the intracellular delivery of dextran with various molecular sizes into different adherent cell lines.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01264E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Stephan Freitag, Bettina Baumgartner, Stefan Radel, Andreas Schwaighofer, Antonio Varriale, Angela Pennacchio, Sabato D'Auria, Bernhard LendlA thermostabilized aluminium acoustic trap combined with attenuated total reflection infrared spectroscopy used to perform ultrasound-assisted E. coli detection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]

Lab Chip, 2021, 21,1185-1185DOI: 10.1039/D1LC90024B, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Martina Crippa, Simone Bersini, Mara Gilardi, Chiara Arrigoni, Sara Gamba, Anna Falanga, Christian Candrian, Gabriele Dubini, Marco Vanoni, Matteo MorettiThe content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,987-993DOI: 10.1039/D1LC90012A, Editorial Séverine Le Gac, Hang LuThe purpose of this article is to reflect on and share our on-line MicroTAS2020 adventure and our view on new opportunities and best practices, and hopefully prompt the community to contribute to the conversations about how we move forward in the post-pandemic world.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1287-1298DOI: 10.1039/D0LC01217C, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Soohong Kim, Gabriel Dorlhiac, Rodrigo Cotrim Chaves, Mansi Zalavadia, Aaron StreetsThe “thin-chip” provides the functionality of multilayer PDMS microfluidic devices with integrated valves, in a paper-thin form factor, enabling integration with advanced optical microscopy and magnetic trapping.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1307-1317DOI: 10.1039/D0LC01275K, Paper Riku Takahashi, Hiroki Miyazako, Aya Tanaka, Yuko Ueno, Masumi YamaguchiWe demonstrate pressure-driven microfluidic devices based on buckle-delaminated architectures of thin hydrogel films, which exhibit high durability, permeability, and biocompatibility with intricate 3D morphologies.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1217-1240DOI: 10.1039/D0LC01208D, Critical Review Ronghui Wu, Taesung KimIntelligent fiber devices with shape characteristics tailored by microfluidic approaches are reviewed, including sensors and actuators, luminous fibers, and devices for water collection, energy harvesting, and tissue engineering applications.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1036-1048DOI: 10.1039/D0LC01133A, Paper Yuncheng Man, Debnath Maji, Ran An, Sanjay P. Ahuja, Jane A. Little, Michael A. Suster, Pedram Mohseni, Umut A. GurkanMicrofluidic Impedance Red Cell Assay (MIRCA) is integrated with capillary network-inspired micropillar arrays and electrical impedance sensing electrodes to enable standardized assessment of red blood cell-mediated microvascular occlusion.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1269-1286DOI: 10.1039/D0LC01317J, Perspective Haein Shin, Hunkyu Seo, Won Gi Chung, Byung Jun Joo, Jiuk Jang, Jang-Ung ParkEyes have remarkable potential as biological sensing sites for various physical factors and biomarkers, which makes contact lens sensors a promising platform for a wearable point-of-care device for monitoring and diagnosis of diseases.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,994-1015DOI: 10.1039/D0LC01101K, Tutorial Review Yaoping Liu, Han Xu, Tingyu Li, Wei WangThis review summarizes the state-of-art microtechnology enabled filtration-based liquid biopsy, and addresses guidelines and perspectives for future filter designs and developments to promote application efficacy in clinical practices.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1333-1351DOI: 10.1039/D0LC01216E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Stephanie J. Hachey, Silva Movsesyan, Quy H. Nguyen, Giselle Burton-Sojo, Ani Tankazyan, Jie Wu, Tuyen Hoang, Da Zhao, Shuxiong Wang, Michaela M. Hatch, Elizabeth Celaya, Samantha Gomez, George T. Chen, Ryan T. Davis, Kevin Nee, Nicholas Pervolarakis, Devon A. Lawson, Kai Kessenbrock, Abraham P. Lee, John Lowengrub, Marian L. Waterman, Christopher C. W. HughesVMTs recapitulate in vivo drug responses and also […]

Lab Chip, 2021, 21,1199-1216DOI: 10.1039/D0LC01290D, Critical Review Chin Hong Ooi, Raja Vadivelu, Jing Jin, Kamalalayam Rajan Sreejith, Pradip Singha, Nhat-Khuong Nguyen, Nam-Trung NguyenLiquid marbles are microliter-sized non-wetting droplets. Their versatility makes them an attractive digital microfluidics platform. This paper provides state-of-the-art discoveries in the physics of liquid marbles and their applications.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1395-1408DOI: 10.1039/D0LC01034K, Paper Simone Perottoni, Nuno G. B. Neto, Cesare Di Nitto, Ruslan I. Dmitriev, Manuela Teresa Raimondi, Michael G. MonaghanThe stem cell niche at the perivascular space plays a role in dictating the fate of stem cells within it. This study predicts in silico and models the perivascular space, in a miniaturised bioreactor, with non-invasive assessment of cell metabolism.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1409-1417DOI: 10.1039/D0LC01223H, Paper Di Huang, Nan XiangA three-stage i-Mag device combines the passive inertial microfluidics and the active magnetophoresis method for rapid, precise, and tumor antigen-independent separation of rare tumor cells from blood.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1385-1394DOI: 10.1039/D0LC01113D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Wen Xiao, Lu Xin, Runyu Cao, Xintong Wu, Ran Tian, Leiping Che, Lianwen Sun, Pietro Ferraro, Feng PanWe propose a method to compensate the aberrations of digital holographic microscopy based on a multiple regression convolutional neural network. The experimental verification is carried out by measuring the morphological change of living cells under micro-Fluidic Shear Stress.The content of this RSS Feed (c) The […]

Lab Chip, 2021, 21,1352-1363DOI: 10.1039/D0LC01008A, Paper An Huang, William Connacher, Mark Stambaugh, Naiqing Zhang, Shuai Zhang, Jiyang Mei, Aditi Jain, Sravya Alluri, Vincent Leung, Anushi E Rajapaksa, James FriendPractical acoustofluidics for lab-on-a-chip applications is now enabled by battery-powered handheld circuits.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1016-1035DOI: 10.1039/D0LC01173H, Critical Review Yuyang Li, Xiaoming Liu, Qiang Huang, Aaron T. Ohta, Tatsuo AraiWe critically review the extensive applications and the frontline advances of bubbles in microfluidics for manipulation.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1364-1372DOI: 10.1039/D0LC01056A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Michaela Purtscher, Mario Rothbauer, Sebastian Rudi Adam Kratz, Andrew Bailey, Peter Lieberzeit, Peter ErtlWe have established a lab-on-a-chip for detection, quantification and monitoring of virus – host cell interactions that are of great importance when evaluating the safety of pharmaceutical products.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1061-1072DOI: 10.1039/D0LC01011A, Paper Martina Crippa, Simone Bersini, Mara Gilardi, Chiara Arrigoni, Sara Gamba, Anna Falanga, Christian Candrian, Gabriele Dubini, Marco Vanoni, Matteo MorettiOur microfluidic model of early metastatic niche reproduced the extravasation of breast cancer cells in presence of immune blood cells and allowed us to test the effect of an already approved inhibitor of integrin β3 on cancer cell extravasation.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1150-1163DOI: 10.1039/D0LC01092H, Paper Emily A. Margolis, David S. Cleveland, Yen P. Kong, Jeffrey A. Beamish, William Y. Wang, Brendon M. Baker, Andrew J. PutnamWe employed a multiplexed microvasculature-on-a-chip platform to investigate the impact of stromal cell identity on microvascular network formation and perfusion.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1373-1384DOI: 10.1039/D0LC01037E, Paper Weijian Liu, Xiao Luo, Changhao Chen, Guochen Jiang, Xinyu Hu, Hongjun Zhang, Minlin ZhongHigh-throughput experiments involving isolated droplets based on patterned superwettable surfaces are important for various applications related to biology, chemistry, and medicine, and they have attracted a large amount of interest.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1139-1149DOI: 10.1039/D0LC00988A, Paper Jose M. Ayuso, Shreyans Sadangi, Marcos Lares, Shujah Rehman, Mouhita Humayun, Kathryn M. Denecke, Melissa C. Skala, David J. Beebe, Vijayasaradhi SetaluriMelanoma evolution is a complex process.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1164-1174DOI: 10.1039/D0LC01205J, Paper Hammad Khan, Connor Beck, Anja KunzeSoft-embossed highly-parallelized multi-curvature micropatterns model the impact of different curvatures (k = 0.003–0.2 μm−1) inspired by the human cerebral tissue folds on changes in spontaneous neuronal calcium signals and mitochondrial transport.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1175-1184DOI: 10.1039/D0LC01146K, Paper Junxia Wang, Yuyu Tan, Jiajun Ling, Mingxia Zhang, Liang Li, Wenli Liu, Mengjiao Huang, Jia Song, Ao Li, Yanling Song, Chaoyong Yang, Zhi ZhuThe double monoclonal display (dm-Display) has realized highly efficient monoclonal ligand screening, which can accelerate the whole process from weeks to 24 h with clone characterization throughput 1000-time higher than that of traditional approach.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1118-1130DOI: 10.1039/D0LC01229G, Paper Mohamed El-Tholoth, Huiwen Bai, Michael G. Mauk, Linda Saif, Haim H. BauThe porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) are coronaviruses (CoVs) of neonatal pigs that cause great economic losses to pig farms and pork processors.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1073-1083DOI: 10.1039/D0LC00937G, Paper Brian Scherer, Christine Surrette, Hui Li, Peter Torab, Erik Kvam, Craig Galligan, Steven Go, Greg Grossmann, Tyler Hammond, Tammy Johnson, Richard St-Pierre, John R. Nelson, Radislav A. Potyrailo, Tejas Khire, Kuangwen Hsieh, Tza-Huei Wang, Pak Kin Wong, Chris M. PuleoWe report on a hand-held multiplexed impedance sensor system and show evidence for impedance-based monitoring of the growth of a single bacterium.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1131-1138DOI: 10.1039/D0LC01324B, Paper Wen-Qi Ye, Yun-Yun Wei, Dan-Ni Wang, Chun-Guang Yang, Zhang-Run XuDroplet manipulation on a near-infrared light-responsive shape-memory micropillar array.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1084-1095DOI: 10.1039/D0LC01048K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Tomas Rosén, Ruifu Wang, HongRui He, Chengbo Zhan, Shirish Chodankar, Benjamin S. HsiaoWe present a shear-free flow-focusing mixing experiment to study time-resolved reaction kinetics of nanoscale materials through scanning-SAXS.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1109-1117DOI: 10.1039/D0LC01057J, Paper Fang Wang, Jiaomeng Zhu, Xuejia Hu, Longfei Chen, Yunfeng Zuo, Yi Yang, Fenghua Jiang, Chengjun Sun, Weihong Zhao, Xiaotian HanThe portable lab-on-chip device based on microstructured assisted reactors enables rapid and smart nitrate determination.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1096-1108DOI: 10.1039/D0LC01123A, Paper Weiyang Yang, Yan Gong, Cheng-You Yao, Maheshwar Shrestha, Yaoyao Jia, Zhen Qiu, Qi Hua Fan, Arthur Weber, Wen LiUltra-flexible, highly-conductive and fully-transparent μECoG electrode arrays made of PEDOT:PSS–ITO–Ag–ITO on thin parylene C successfully achieved neurophysiology recording.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,1049-1060DOI: 10.1039/D0LC00853B, Paper Yu-Chun Kung, Kayvan R. Niazi, Pei-Yu ChiouIn this study, we present a microfluidic device that can achieve label-free and size-based cell separation with high size differential resolution for arbitrary cell size band filtering.The content of this RSS Feed (c) The Royal Society of Chemistry