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RSC - Lab Chip latest articles RSC - Lab Chip latest articles

  • Recapitulation of dynamic nanoparticle transport around tumor using a triangular multi-chamber tumor-on-a-chip
    by You Chen on September 21, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00631F, PaperYou Chen, Yifan Xue, Langtao Xu, Weilin Li, Yiling Chen, Shunan Zheng, Rui Dai, Jie Liu3D tumor models are emerging as valuable tools for drug screen and personalized nanoparticle based cancer treatments. The current main challenges of constructing 3D tumor model based on microfluidic chip...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Dissolution-After-Precipitation (DAP): A Simple Microfluidic Approach for Studying Carbonate Rock Dissolution and Multiphase Reactive Transport Mechanisms
    by Jianping Xu on September 21, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00426G, PaperJianping Xu, Matthew Thomas BalhoffWe propose a simple microfluidic approach: Dissolution-After-Precipitation (DAP), to investigate regimes of carbonate rock dissolution and multiphase reactive transport. In this method, a carbonate porous medium is created in a...The content of this RSS Feed (c) The Royal Society of Chemistry

  • LY6E protein facilitates adeno-associated virus crossing in a biomimetic chip model of the human blood-brain barrier
    by Dan Liu on September 21, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00698G, PaperDan Liu, Mingyang Zhu, Yi Lin, Mengmeng Li, Ruolan Huang, Liu Yang, Yanling Song, Yong Diao, Chaoyong James YangThe blood-brain barrier (BBB) controls chemical access to the brain and maintains fluid homeostasis, but in vitro models accurately simulating the physiological characteristics of the BBB are lacking. Here, we...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Induction of embryogenic development in haploid microspore stem cells in droplet-based microfluidics
    by Felix Richter on September 20, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00788F, PaperFelix Richter, minqian chen, Patrick Schaub, Steffen Schneider, Alexander Gross, Patrick Mäder, Di Zhang, Oleksandr Dovzhenko, Klaus Palme, Johann Michael Köhler, Jialan Cao, florian WüstThis work presents the application of droplet-based microfluidics for the cultivation of microspores from Brassica napus using the doubled haploid technology. Under stress conditions (e.g. heat shock) or by chemical...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic techniques for bridging spatiotemporal scales in biomolecular condensate research
    by Nadia A. Aicha Erkamp on September 20, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00622G, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nadia A. Aicha Erkamp, Timothy J Welsh, Runzhang Qi, Tuomas KnowlesMembraneless organelles formed through condensation of biomolecules in living cells have become the focus of sustained efforts to elucidate their mechanisms of formation and function. These condensates perform a range...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Intolerance of Profligacy: Aptamer Concentration Gradient-Tailored Unicellular Array for High-Throughput Biologics-Mediated Phenotyping
    by Xuan Zhang on September 18, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00729K, PaperXuan Zhang, Ya-Nan Zhao, Xing Wei, Xue Men, Cheng-Xin Wu, Jun-Jie Bai, Ting Yang, Ming-Li Chen, Jian-Hua WangIn aptamer based assay schemes, the aptamer probes unlabeled with bio-markers have to be eliminated before testing, which may be a tremendous squander for precious probes. We herein propose a...The content of this RSS Feed (c) The Royal Society of Chemistry

  • An integrated microfluidic device for multiplexed imaging on spatial gene expression patterns of Drosophila embryos
    by Hongcun Zhu on September 18, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00514J, PaperHongcun Zhu, Wenting Shen, Chunxiong Luo, Feng LiuTo reveal the underlying mechanism of the biological function of the multicellular systems, it is important to obtain comprehensive spatial gene expression profiles. Among the emerging single-cell spatial-omics techniques, immunofluorescence...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Optical 4D oxygen mapping of microperfused tissue models with tunable in vivo-like 3D oxygen microenvironments
    by Milan Finn Wesseler on September 18, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00063F, PaperMilan Finn Wesseler, Mathias Nørbæk Johansen, Aysel Kiziltay, Kim Mortensen, Niels B. LarsenSufficient and controllable oxygen supply is essential for in vitro 3D cell and tissue culture at high cell densities, which calls for volumetric in situ oxygen analysis methods to quantitatively...The content of this RSS Feed (c) The Royal Society of Chemistry

  • 3D printed field-deployable microfluidic systems for the separation and assay of Pu in nuclear forensics
    by Kevin J. Glennon on September 14, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00391K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kevin J. Glennon, Hector F. Valdovinos, Tashi Parsons-Davis, Jennifer A. Shusterman, Anna G. Servis, Kenton J. Moody, Narek GharibyanPu is separated from excess U and isotopically assayed using our novel microfluidic platform designed to miniaturize traditional laboratory techniques into a field-deployable system for rapid nuclear forensics in post-detonation nuclear scenarios.To cite this article before page […]

  • Computer vision enabled funnel adapted sensing tube (FAST) for power-free and pipette-free nucleic acid detection
    by Mengdi Bao on September 13, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00586G, PaperMengdi Bao, Shuhuan Zhang, Chad ten Pas, Stephen J. Dollery, Ruth V. Bushnell, F. N. U. Yuqing, Rui Liu, Guoyu Lu, Gregory J. Tobin, Ke DuA simple, portable, and low-cost microfluidic system-funnel adapted sensing tube (FAST) is developed as an integrated, power-free, and pipette-free biosensor for viral nucleic acids.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • On-demand liquid microlens arrays by non-contact relocation of inhomogeneous fluids in acoustic fields
    by Xiaoqi Gao on September 13, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00603K, PaperXiaoqi Gao, Xuejia Hu, Jingjing Zheng, Qinghao Hu, Shukun Zhao, Longfei Chen, Yi YangA tunable and on-demand liquid microlens array was created contactlessly by different distributions of miscible liquids in an acoustic standing wave field.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • MagPure chip: an immunomagnetic-based microfluidic device for high purification of circulating tumor cells from liquid biopsies
    by Lucie Descamps on September 13, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00443G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lucie Descamps, Jessica Garcia, David Barthelemy, Emmanuelle Laurenceau, Léa Payen, Damien Le Roy, Anne-Laure DemanThe isolation of circulating tumor cells (CTCs) directly from blood, as a liquid biopsy, could lead to a paradigm shift in cancer care. The MagPure chip provides a powerful tool for subsequent purification of CTCs and dissection of their clinical information.To cite this article before page numbers are assigned, […]

  • Non-adhesive contrast substrate for single-cell trapping and Raman spectroscopic analysis
    by Alina Peethan on September 12, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00665K, PaperAlina Peethan, Aravind M, Santhosh Chidangil, Sajan D. GeorgeDroplet splitting by exploiting tailored surface wettability is emerging as an important pathway to creating ultralow volumes of samples that can have applications in bioassays, tissue engineering, protein chips, and material synthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Influence of microchannel geometry on device performance and electrophysiological recording fidelity during long-term studies of connected neural populations
    by Noah Goshi on September 11, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00683A, PaperNoah Goshi, Gregory Girardi, Felipe da Costa Souza, Alexander Gardner, Pamela J. Lein, Erkin SekerThis study examines the role of microchannel geometry on the long-term performance of compartmentalized microfluidic neural cell culture platforms and provides general design rules for different experimental objectives.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Transcriptomic analysis of 3D vasculature-on-a-chip reveals paracrine factors affecting vasculature growth and maturation
    by Sin Yen Tan on September 11, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00570K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sin Yen Tan, Qiuyu Jing, Ziuwin Leung, Ying Xu, Lily Kwan Wai Cheng, Sindy Sing Ting Tam, Angela Ruohao WuTranscriptomic studies of spatially arranged 3D vasculatures and fibroblasts revealed paracrine cues for improved vasculature growth.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Bending stiffness of Candida albicans hyphae as a proxy of cell wall properties
    by Elodie Couttenier on September 11, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00219A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Elodie Couttenier, Sophie Bachellier-Bassi, Christophe d'Enfert, Catherine VillardHydrodynamic forces applied in a microfluidic device on hyphae of C. albicans allow to measure their bending stiffness in a control situation as well as under various pharmacological, mechanical and genetical perturbations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]

  • Design and fabrication of a novel on-chip pressure sensor for microchannels
    by Nishagar Raventhiran on September 8, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00648K, PaperNishagar Raventhiran, Razin Sazzad Molla, Kshithij Nandishwara, Erick Johnson, Yaofa LiThis paper presents a novel pressure sensor to be used with microfluidic channels. The sensor is based on optical particle tracking, which turns a regular fluorescence microscope into a pressure measurement device.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Capillary pressure-based measurement of dynamic interfacial tension in a spontaneous microfluidic sensor
    by Boxin Deng on September 7, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00545J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Boxin Deng, Karin Schroën, Maartje Steegmans, Jolet de RuiterThe EDGE tensiometer allows access to nearly the full range of dynamic interfacial tension at relevant time scales for both droplet and bubble interfaces.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidics for antibiotic susceptibility testing
    by Witold Postek on September 6, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00394E, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Witold Postek, Natalia Pacocha, Piotr GarsteckiThe rise of antibiotic resistance is a threat to global health.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Simultaneous quantification of blood rheology and oxygen saturation to evaluate affinity-modifying therapies in sickle cell disease
    by Scott Hansen on September 5, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00623E, PaperScott Hansen, David K. WoodSickle cell blood flow and hemoglobin oxygen saturation can be simultaneously measured using a microfluidic device. This combined measurement platform provides a tool to evaluate the potential clinical benefit of anti-sickling therapies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Ceiling culture chip reveals dynamic lipid droplet transport during adipocyte dedifferentiation via actin remodeling
    by Jiwon Kim on September 5, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00428C, PaperJiwon Kim, Kun-Young Park, Sungwoo Choi, Ung Hyun Ko, Dae-Sik Lim, Jae Myoung Suh, Jennifer H. ShinThe two-layered ceiling culture chip allows buoyant adipocytes to be maintained and observed, revealing mechanisms involved in adipocyte dedifferentiation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Surfactant-laden droplet size prediction in a flow-focusing microchannel: a data-driven approach
    by Loïc Chagot on September 5, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00416J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Loïc Chagot, César Quilodrán-Casas, Maria Kalli, Nina M. Kovalchuk, Mark J. H. Simmons, Omar K. Matar, Rossella Arcucci, Panagiota AngeliImproving surfactant-laden microdroplet size prediction using data-driven methods.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Combinatorial screening SlipChip for rapid phenotypic antimicrobial susceptibility testing
    by Xiang Li on September 5, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00661H, PaperXiang Li, Xu Liu, Ziqing Yu, Yang Luo, Qixin Hu, Zhenye Xu, Jia Dai, Nannan Wu, Feng ShenA combinatorial-screening SlipChip based on a self-partitioning mechanism performs high-throughput phenotypic AST with a panel of antibiotics and antibiotic combinations in three hours by monitoring the phenotypic profile of bacterial growth.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Cell marathon: long-distance cell migration and metastasis-associated gene analysis using a folding paper system
    by Chia-Hao Huang on September 4, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00663D, PaperChia-Hao Huang, Kin Fong LeiA folding paper system was developed to mimic a tumor–vascular interface for the study of long-distance cell migration.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Label-free OIRD microarray chips with a nanostructured sensing interface: enhanced sensitivity and mechanism
    by Xiaoyi Li on September 4, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00671E, PaperXiaoyi Li, Changxiang Fang, Zhihao Feng, Junying Li, Yan Li, Weihua HuA label-free OIRD microarray chip was specifically designed by using a nanostructured fluorine-doped tin oxide (FTO) slide as a substrate, showing improved sensitivity. The unique optical enhancement mechanism was revealed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Zigzag microchannel for rigid inertial separation and enrichment (Z-RISE) of cells and particles
    by Sajad Razavi Bazaz on September 2, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00290F, PaperSajad Razavi Bazaz, Asma Mihandust, Robert Salomon, Hossein Ahmadi Nejad Joushani, Wenyan Li, Hoseyn A. Amiri, Fateme Mirakhorli, Sareh Zhand, Jesus Shrestha, Morteza Miansari, Benjamin Thierry, Dayong Jin, Majid Ebrahimi WarkianiOverview of the zigzag microchannel for rigid inertial separation and enrichment (Z-RISE). The proposed device has superior performance for particle focusing and separation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]

  • A self-contained acoustofluidic platform for biomarker detection
    by Xian Chen on September 1, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00541G, PaperXian Chen, Chuanchao Zhang, Bohua Liu, Ye Chang, Wei Pang, Xuexin DuanWe proposed a handheld self-contained acoustofluidic system actuated by the Lamb wave resonator (LWR) array for POC chemiluminescent assay, in which the fluidic pumping, mixing, switching, and bioparticle trapping are all achieved on chip.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An automatic centrifugal system for rapid detection of bacteria based on immunomagnetic separation and recombinase aided amplification
    by Siyuan Wang on September 1, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00650B, PaperSiyuan Wang, Wuzhen Qi, Shangyi Wu, Jing Yuan, Hong Duan, Yanbin Li, Jianhan LinThis study reported an automatic centrifugal system for rapid detection of foodborne pathogenic bacteria based on immunomagnetic separation (IMS) for target bacteria enrichment and recombinase aided amplification (RAA) for nucleic acid detection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Similar color analysis based on deep learning (SCAD) for multiplex digital PCR via a single fluorescent channel
    by Chaoyu Cao on September 1, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00637E, PaperChaoyu Cao, Minli You, Haoyang Tong, Zhenrui Xue, Chang Liu, Wanghong He, Ping Peng, Chunyan Yao, Ang Li, Xiayu Xu, Feng XuWe proposed an explainable deep learning-based method to classify similar fluorescence colors for multiplex digital PCR in a single fluorescent channel.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Excitation modalities for enhanced micro and nanoparticle imaging in a smartphone coupled 3D printed fluorescent microscope
    by Muhammad A. Sami on August 31, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00589A, PaperMuhammad A. Sami, Muhammad Tayyab, Umer HassanRepresentative figures depicting the design of parallel, perpendicular, and oblique excitation modalities for smartphone fluorescent microscopes (SFM).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Development of an IoT-integrated multiplexed digital PCR system for quantitative detection of infectious diseases
    by Ji Wook Choi on August 31, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00726F, PaperJi Wook Choi, Won Ho Seo, Young Suh Lee, So Young Kim, Bong Suk Kim, Kyoung G. Lee, Seok Jae Lee, Bong Geun ChungIoT-integrated multiplexed digital PCR system for detection of infectious diseases.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A similarity scaling approach for organ-on-chip devices
    by James J. Feng on August 30, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00641C, CommunicationJames J. Feng, Sarah HedtrichWe propose similarity scaling as a novel and universally applicable scaling approach for organ-on-chip platforms. It will ensure high predictivity of on-chip models for human physiology and pathology, and improve their clinical translations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Electrokinetic deterministic lateral displacement for fractionation of vesicles and nano-particles
    by Richard J. Gillams on August 29, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00583B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Richard J. Gillams, Victor Calero, Raul Fernandez-Mateo, Hywel MorganWe demonstrate vesicle and nanoparticle fractionation in an optimised DLD array with micron-sized structures. When combined with an orthogonal AC electric field, these devices enable high-throughput fractionation in high-conductivity electrolytes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]

  • High sensitivity label-free detection of HER2 using an Al–GaN/GaN high electron mobility transistor-based biosensor
    by Shivanshu Mishra on August 28, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00349J, PaperShivanshu Mishra, Pharyanshu Kachhawa, Amber Kumar Jain, Rajiv Ranjan Thakur, Nidhi ChaturvediThis work reports rapid, label-free and specific detection of the HER2 antigen using a gallium nitride (GaN) high electron mobility transistor (HEMT).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • High density, addressable electrohydrodynamic printhead made of a silicon plate and polymer nozzle structure
    by Yongqing Duan on August 28, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00624C, PaperYongqing Duan, Weili Yang, Jingjing Xiao, Jixin Gao, Lai Wei, YongAn Huang, Zhouping YinElectrohydrodynamic nozzle array chips with stable and uniform printing performance were developed for applications in micro/nanoelectronics, biomedical devices, etc.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Nonequilibrium interfacial diffusion across microdroplet interface
    by Davood Khoeini on August 25, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00326K, PaperDavood Khoeini, Vincent He, Ben J. Boyd, Adrian Neild, Timothy F. ScottIncreases in complexity attainable in molecular self-assembly necessitates both advanced molecular design as well as microenvironmental control.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Integrated biosensors for monitoring microphysiological systems
    by Lei Mou on August 24, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00262K, Critical ReviewLei Mou, Kalpana Mandal, Marvin Magan Mecwan, Ana Lopez Hernandez, Surjendu Maity, Saurabh Sharma, Rondinelli Donizetti Herculano, Satoru Kawakita, Vadim Jucaud, Mehmet Remzi Dokmeci, Ali KhademhosseiniThis review discusses the state-of-the-art integrated biosensors by providing specific examples, detailing their main advantages in monitoring MPSs, and describing the remaining challenges and potential future developments.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]

  • Correction: On-chip miRNA extraction platforms: recent technological advances and implications for next generation point-of-care nucleic acid tests
    by Loukia Petrou on August 23, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3567-3567DOI: 10.1039/D2LC90079C, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Loukia Petrou, Sylvain LadameThe content of this RSS Feed (c) The Royal Society of Chemistry

  • Dual-function microneedle array for efficient photodynamic therapy with transdermal co-delivered light and photosensitizers
    by Huiting Zhao on August 23, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00505K, PaperHuiting Zhao, Xu Wang, Zhanhui Geng, Naixin Liang, Qin Li, Xiaoming Hu, Zewen WeiA dual-function microneedle array was developed to co-delivery photosensitizers and light for photodynamic therapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidics in vascular biology research: a critical review for engineers, biologists, and clinicians
    by Grigor Simitian on August 23, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00352J, Critical ReviewGrigor Simitian, María Virumbrales-Muñoz, Cristina Sánchez-de-Diego, David J. Beebe, David KosoffHere we provide a detailed review of the use of microfluidic technologies in vascular biology. This review focuses on how to recapitulate and investigate biological hallmarks and is written for a wide audience ranging from clinicians to engineers.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Point-of-care SARS-CoV-2 sensing using lens-free imaging and a deep learning-assisted quantitative agglutination assay
    by Colin J. Potter on August 23, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00289B, PaperColin J. Potter, Yanmei Hu, Zhen Xiong, Jun Wang, Euan McLeodTo address the persistence of the COVID-19 pandemic, we have developed a novel point-of-care SARS-CoV-2 biosensor. This sensor has a limit of detection within an order of magnitude of traditional PCR and can provide an accurate measure of viral load.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Femtosecond laser direct writing of a 3D microcantilever on the tip of an optical fiber sensor for on-chip optofluidic sensing
    by Changxu Li on August 22, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00625A, PaperChangxu Li, Yi Liu, Changpeng Lang, Yonglai Zhang, Shiliang QuA microcantilever is fabricated by femtosecond laser direct writing for on-chip optofluidic sensing.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Motor-like microlasers functioning in biological fluids
    by Ziyihui Wang on August 22, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00513A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ziyihui Wang, Linwei Shang, Zehang Gao, Kok Ken Chan, Chaoyang Gong, Chenlu Wang, Tianhua Xu, Tiegen Liu, Shilun Feng, Yu-Cheng ChenThe concept of a motor-like microlaser with a controllable direction, velocity, and spatial motions was introduced, providing a novel approach for laser writing, laser switching, and localized cell stimulation and imaging.To cite this article before page numbers are assigned, use the […]

  • Miniaturized sensor for electroanalytical and electrochemiluminescent detection of pathogens enabled through laser-induced graphene electrodes embedded in microfluidic channels
    by Florian Gerstl on August 21, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00593J, PaperFlorian Gerstl, Uma Pongkitdachoti, Fuangfa Unob, Antje J. BaeumnerMiniaturized electrochemical and electrochemiluminescent biosensor using laser-induced graphene electrodes for highly sensitive and selective detection of C. parvum DNA.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • CandyCollect: at-home saliva sampling for capture of respiratory pathogens
    by Ulri N. Lee on August 18, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3555-3564DOI: 10.1039/D1LC01132D, PaperUlri N. Lee, Xiaojing Su, Damielle L. Hieber, Wan-chen Tu, Anika M. McManamen, Meg G. Takezawa, Grant W. Hassan, Tung Ching Chan, Karen N. Adams, Ellen R. Wald, Gregory P. DeMuri, Erwin Berthier, Ashleigh B. Theberge, Sanitta ThongpangThis paper presents a new sample collection platform for a common bacterial infection, group A streptococcal (GAS) pharyngitis, also known as strep throat, caused by Streptococcus pyogenes.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Recent advances in microfluidics-based cell migration research
    by Jiaqi Ren on August 16, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3361-3376DOI: 10.1039/D2LC00397J, Critical ReviewJiaqi Ren, Ning Wang, Piao Guo, Yanping Fan, Francis Lin, Jiandong WuThis article reviews recent advances in microfluidics-based cell migration research, focusing on four aspects: host–pathogen interactions, cell migration in spatiotemporal chemical fields, cell transmigration, and deep learning analysis methods.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Correction: Actuated 3D microgels for single cell mechanobiology
    by Berna Özkale on August 16, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3565-3566DOI: 10.1039/D2LC90078E, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Berna Özkale, Junzhe Lou, Ece Özelçi, Alberto Elosegui-Artola, Christina M. Tringides, Angelo S. Mao, Mahmut Selman Sakar, David J. MooneyThe content of this RSS Feed (c) The Royal Society of Chemistry

  • Efficient bioparticle extraction using a miniaturized inertial microfluidic centrifuge
    by Yaohui Fang on August 14, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3545-3554DOI: 10.1039/D2LC00496H, PaperYaohui Fang, Shu Zhu, Weiqi Cheng, Zhonghua Ni, Nan XiangA miniaturized centrifuge with integrated inertial spiral and two-stage serpentine channels, allowing for the efficient washing and acquisition of concentrated bioparticles from background fluids.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Simplifying the complex: accessible microfluidic solutions for contemporary processes within in vitro diagnostics
    by Nathan K. Khosla on August 14, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3340-3360DOI: 10.1039/D2LC00609J, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nathan K. Khosla, Jake M. Lesinski, Monika Colombo, Léonard Bezinge, Andrew J. deMello, Daniel A. RichardsThis review details how microfluidic technologies are disrupting the status quo, and facilitating the development of simple, affordable, and accessible integrated IVDs.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Acoustofluidic cell micro-dispenser for single cell trajectory control
    by Cynthia Richard on August 14, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3533-3544DOI: 10.1039/D2LC00216G, PaperCynthia Richard, Citsabehsan Devendran, Dariush Ashtiani, Victor J. Cadarso, Adrian NeildA surface acoustic wave micro-dispenser for the on-demand trap and release of single cells with trajectory control.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Characterization of nanoparticle size distributions using a microfluidic device with integrated optical microcavities
    by Kiana Malmir on August 9, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3499-3507DOI: 10.1039/D2LC00180B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kiana Malmir, William Okell, Aurélien A. P. Trichet, Jason M. SmithOpen-access optical microcavities act as a combined optical trap and sensor. This work shows that the integration of optical microcavities into microfluidics with controlled flow speed can open up new avenues for nanoparticle characterization.The content of this RSS Feed (c) The Royal Society of Chemistry

  • On the robustness of machine learning algorithms toward microfluidic distortions for cell classification via on-chip fluorescence microscopy
    by Ali Ahmad on August 8, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3453-3463DOI: 10.1039/D2LC00482H, PaperAli Ahmad, Federico Sala, Petra Paiè, Alessia Candeo, Sarah D'Annunzio, Alessio Zippo, Carole Frindel, Roberto Osellame, Francesca Bragheri, Andrea Bassi, David RousseauMachine learning algorithms for cell classification via on-chip fluorescence microscopy are shown to be robust to microfluidic distortions due to cell displacement during acquisition.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Ultra-rapid real-time microfluidic RT-PCR instrument for nucleic acid analysis
    by Renna L. Nouwairi on August 8, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3424-3435DOI: 10.1039/D2LC00495J, PaperRenna L. Nouwairi, Larissa L. Cunha, Rachelle Turiello, Orion Scott, Jeff Hickey, Scott Thomson, Stuart Knowles, Jeff D. Chapman, James P. LandersThe described microfluidic instrument performs real-time PCR (40 cycles) with comparable sensitivity to commercial instrumentation in under 10 minutes.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Hydrodynamic dissection of Stentor coeruleus in a microfluidic cross junction
    by Rajorshi Paul on August 7, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3508-3520DOI: 10.1039/D2LC00527A, PaperRajorshi Paul, Kevin S. Zhang, Myra Kurosu Jalil, Nicolas Castaño, Sungu Kim, Sindy K. Y. TangThe hydrodynamic cell splitter splits single-cell ciliate Stentor coeruleus using a microfluidic cross junction at a high throughput of 500 cells min−1. Fragment viability decreases with increasing hydrodynamic stress and decreasing fragment size.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Acoustofluidics 24: theory and experimental measurements of acoustic interaction force
    by Shahrokh Sepehrirahnama on August 4, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3290-3313DOI: 10.1039/D2LC00447J, Tutorial ReviewShahrokh Sepehrirahnama, Abhishek Ray Mohapatra, Sebastian Oberst, Yan Kei Chiang, David A. Powell, Kian-Meng LimThis tutorial review covers theoretical and experimental aspects of acoustic interaction force, as one of the driving forces of acoustophoresis. The non-reciprocity, rotational coupling, viscosity effects, and particle agglomeration are discussed.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A sample-to-answer, quantitative real-time PCR system with low-cost, gravity-driven microfluidic cartridge for rapid detection of SARS-CoV-2, influenza A/B, and human papillomavirus 16/18
    by Yunfeng Zai on August 4, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3436-3452DOI: 10.1039/D2LC00434H, PaperYunfeng Zai, Chao Min, Zunliang Wang, Yongjun Ding, Huan Zhao, Enben Su, Nongyue HeWe present a low-cost microfluidic cartridge design scheme that combines gravity-driven passive microfluidic pumping with extraction-free amplification to achieve “sample-in, answer-out” point-of-care nucleic acid detection within 30 minutes.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Highly flexible and accurate serial picoinjection in droplets by combined pressure and flow rate control
    by Jolien Breukers on August 4, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3475-3488DOI: 10.1039/D2LC00368F, PaperJolien Breukers, Hannah Op de Beeck, Iene Rutten, Montserrat López Fernández, Sven Eyckerman, Jeroen LammertynThis novel methodology to control serial picoinjectors allows for accurate and flexible combinatorial reagent addition into droplets.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Quantitative brain-derived neurotrophic factor lateral flow assay for point-of-care detection of glaucoma
    by Yue Wu on August 1, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3521-3532DOI: 10.1039/D2LC00431C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yue Wu, Yubing Hu, Nan Jiang, Rajeevan Anantharanjit, Ali K. Yetisen, M. Francesca CordeiroWe develop a quantitative lateral flow assay (LFA) device that is able to measure the tear level of brain derived neurotrophic factor (BDNF). The device shows great potential to serve as an ideal platform for early detection of glaucoma.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Artificial intelligence-based classification of peripheral blood nucleated cells using label-free imaging flow cytometry
    by Amane Hirotsu on July 31, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3464-3474DOI: 10.1039/D2LC00166G, PaperAmane Hirotsu, Hirotoshi Kikuchi, Hidenao Yamada, Yusuke Ozaki, Ryoma Haneda, Sanshiro Kawata, Tomohiro Murakami, Tomohiro Matsumoto, Yoshihiro Hiramatsu, Kinji Kamiya, Daisuke Yamashita, Yuki Fujimori, Yukio Ueda, Shigetoshi Okazaki, Masatoshi Kitagawa, Hiroyuki Konno, Hiroya TakeuchiWe developed a method for label-free image identification and classification of peripheral blood nucleated cells flowing in a microfluidic channel, based on the subcellular structures of quantitative phase microscopy images.The content of this RSS Feed […]

  • A micro-scale rheometer to study foam texture and flow resistance in planar fractures
    by Negar Nazari on July 31, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3489-3498DOI: 10.1039/D2LC00595F, PaperNegar Nazari, Anthony R. KovscekWe developed a novel foam rheometer based on microfluidic principles to quantify foam texture and flow resistance. Our analysis showed that there is an optimal foam quality that maximizes apparent viscosity during flow in fractures that has a slight gas rate dependence.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Droplet transportation by adjusting the temporal phase shift of surface acoustic waves in the exciter–exciter mode
    by Mingyang Sui on July 20, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3402-3411DOI: 10.1039/D2LC00402J, PaperMingyang Sui, Huijuan Dong, Guanyu Mu, Jingze Xia, Jie Zhao, Zhen Yang, Tianlong Li, Tong Sun, Kenneth T. V. GrattanThe velocity and direction of actuated droplet can be adjusted by changing temporal phase shift of surface acoustic waves in an exciter–exciter mode only.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Emerging micro-nanotechnologies for extracellular vesicles in immuno-oncology: from target specific isolations to immunomodulation
    by Nna-Emeka Onukwugha on July 17, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3314-3339DOI: 10.1039/D2LC00232A, Critical ReviewNna-Emeka Onukwugha, Yoon-Tae Kang, Sunitha NagrathIn this paper, we summarized the recent advances in cell specific EV isolation, engineering and their potential applications in immune-oncology along with suggested areas of study necessary to bring EVs into clinical practice.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Interactive and synergistic behaviours of multiple heterogeneous microrobots
    by Shilu Zhu on July 17, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3412-3423DOI: 10.1039/D2LC00265E, PaperShilu Zhu, Weijie Zheng, Jian Wang, Xingmiao Fang, Lijiu Zhang, Fuzhou Niu, Ying Wang, Tingting Luo, Guangli Liu, Runhuai YangA robotic system whose interactive and synergistic behaviour can be successfully controlled by exploiting frequency-responsive programmable individual microrobots.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Rapid and inexpensive process to fabricate paper based microfluidic devices using a cut and heat plastic lamination process
    by Nityanand Kumawat on July 7, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3377-3389DOI: 10.1039/D2LC00452F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nityanand Kumawat, Soja Saghar Soman, Sanjairaj Vijayavenkataraman, Sunil KumarCut and heat microfluidic paper-based analytical devices (CH-microPADs) are simple-to-use, low-cost point-of-care testing platforms.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Label-free detection and enumeration of rare circulating tumor cells by bright-field image cytometry and multi-frame image correlation analysis
    by Ziqiang Du on May 30, 2022 at 11:00 pm

    Lab Chip, 2022, 22,3390-3401DOI: 10.1039/D2LC00190J, PaperZiqiang Du, Ya Li, Bing Chen, Lulu Wang, Yu Hu, Xu Wang, Wenchang Zhang, Xiaonan YangA bright-field image cytometry technique, assisted by a multi-frame image correlation algorithm, is introduced for label-free CTC detection.The content of this RSS Feed (c) The Royal Society of Chemistry

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