Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01294G, Paper Ming Wang, Mui Hoon Nai, Ruby Yun-Ju Huang, Hwa Liang Leo, Chwee Teck Lim, Chia Hung ChenSingle-adherent-cell phenotyping on extracellular matrix (ECM) is essential to determine cellular biological functions, such as morphological adaptations and biomolecule secretions, correlated to medical treatments and metastasis, yet there is no...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01103G, Paper Menglin Shang, Su Bin Lim, Kuan Jiang, Yoon-Sim Yap, Bee Luan Khoo, Jongyoon Han, Chwee Teck LimAcquired multidrug resistance in tumors is a big challenge in cancer therapy. As an important physical stimulus in the tumor microenvironment, elevated interstitial fluid pressure has been reported to inhibit...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC00985G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Eleonora Perego, Sarah KösterDespite the importance for cellular processes, the dynamics of molecular assembly, especially on fast time scales, is not yet fully understood. To this end, we present a multi-layer microfluidic device...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC00464B, Critical Review Vahid Hosseini, Anna Mallone, Fatemeh Nasrollahi, Serge Ostrovidov, Rohollah Nasiri, Mahboobeh Mahmoodi, Reyhaneh Haghniaz, Avijit Baidya, Mehdi Salek, Mohammad Ali Darabi, Amir Shamloo, Mehmet Remzi Dokmeci, Samad Ahadian, Ali Khademhosseini, Gorka OriveIrregular hemodynamics affects the progression of various vascular diseases, such atherosclerosis or aneurysms. Despite the extensive hemodynamics studies on animal models, the inter-species differences between humans and animals hamper the...The content of this RSS […]

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01032D, Paper Junwoo Lee, Yong Kyoung Yoo, Dohwan Lee, Cheonjung Kim, Kang Hyeon Kim , Seungmin Lee, Seungmin Kwak, Ji Yoon Kang, Hyungseok Kim, Dae Sung Yoon, Don Hur, Jeonghoon LeeIon concentration polarization (ICP) is one of the preconcentration technique which can acquire high preconcentration factor. Still, the main hurdles of ICP are its instability and low efficiency in physiological...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01333A, Paper Cheng-Sheng Lin, Yi-Cheng Tsai, Keng-Fu Hsu, Gwo-Bin LeeCancer is among the world’s most deadly inflictions, and early diagnosis is critical. Aptamers have shown utility as cancer probes since they can be screened rapidly in vitro against cancer...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01186J, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Shun Zhang, Zhengpeng Wan, Roger D. KammHuman organoids, self-organized and differentiated from homogenous pluripotent stem cells (PSC), replicate the key structural and functional characteristics of their in vivo counterparts. Despite the rapid advancement of organoid technology...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01040E, Tutorial Review Amy Pointon, Jonathan Maher, Myrtle Davis, Thomas Baker, Joseph Cichocki, Diane Ramsden, Christopher Hale, Kyle L. Kolaja, Paul Levesque, Radhakrishna Sura, David M. Stresser, Gary GintantThe integrative responses of the cardiovascular (CV) system are essential for maintaining blood flow to provide oxygenation, nutrients, and waste removal for the entire body.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00845A, Paper Yimo Yan, Boxuan Zhang, Qiqi Fu, Jian Wu, Ran LiuWe developed a fully integrated biomimetic microfluidic system for screening sperm for their characteristics when exposed to temperature and chemical gradients.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01025A, Paper Minji Kim, Philip V Bayly, J. Mark MeachamAcoustic microfluidics has emerged as a versatile solution for particle manipulation in medicine and biology. However, current technologies are largely confined to specialized research laboratories. The translation of acoustofluidics from...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01106A, Paper Myung Uk Park, Yonghee Bae, Kyo-Seok Lee, Jun Ho Song, Sun-Mi Lee, Kyung-Hwa YooModularity is a key feature of structural and functional brain networks. However, the association between the structure and function of modular brain networks has not been revealed. We constructed three...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00962H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Roberto Pioli, Miguel Angel Fernandez-Rodriguez, Fabio Grillo, Laura Alvarez, Roman Stocker, Lucio Isa, Eleonora SecchiExploiting capillarity, a new microfluidic platform enables the placement of multiple colloidal particles into complex patterns within a microchannel, as required in a variety of applications, including electronics, sensing, and plasmonics.To cite this article before page numbers are […]

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00960A, Paper Xiongfeng Zhu, Tianxing Man, Xing Haw Marvin Tan, Pei-Shan Chung, Michael A. Teitell, Pei-Yu ChiouA distributed color interferometry-based pressure-sensing platform with more than 10 000 pressure sensing spots spanning a 1 cm2 cross-sectional area.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00948B, Paper Joycelyn K. Yip, Debarghya Sarkar, Andrew P. Petersen, Jennifer N. Gipson, Jun Tao, Salil Kale, Megan L. Rexius-Hall, Nathan Cho, Natalie N. Khalil, Rehan Kapadia, Megan L. McCainITO integrated into PDMS-based heart-on-a-chip devices using laser-cut masks enable parallel, point, and multiplexed stimulation for calcium and contractility assays.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01012J, Paper Naiqing Zhang, Juan P. Zuniga-Hertz, Elizabeth Yan Zhang, Tilvawala Gopesh, Mckenzie J. Fannon, Jiaying Wang, Yue Wen, Hemal H. Patel, James FriendAcoustically centrifuge and extract cells from blood samples using 152-Y-rotated lithium niobate and spiral electrodes with an extraction syringe.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01198C, Paper Kai Sun, Han Wang, Lei Wang, Ying Lu, Ran Liu, Peng Liu, Jing ChengA portable sperm cell purification instrument based on continuous flow acoustophoretic separation of sperm cells without cell lysis is presented.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01155J, Critical Review Misagh Rezapour Sarabi, Nan Jiang, Ece Ozturk, Ali K. Yetisen, Savas TasogluTasoglu, Yetisen and co-workers review the emerging medical and health-related applications of optical fibers, illustrating the new wave for the fabrication of implantable devices, wearable sensors, and photodetection and therapy setups.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01061H, Communication Chungha Lee, Seunggyu Kim, Herve Hugonnet, Moosung Lee, Weisun Park, Jessie Sungyun Jeon, YongKeun ParkLabel-free, three-dimensional (3D) quantitative observations of on-chip vasculogenesis were achieved using optical diffraction tomography. Exploiting 3D refractive index maps as an intrinsic imaging contrast, the vascular structures, multicellular activities, and...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00411A, Paper Yuanyuan Chen, Yunfan Pan, Yuzhen Feng, Donghai Li, Jia Man, Lin Feng, Deyuan Zhang, Huawei Chen, Haosheng ChenGlucose helps erythrocytes maintain their biconcave morphology and deformability as they pass through small capillaries with a repetitive high squeeze effect.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01147A, Paper Yansheng Li, Xiujin Men, Guowei Gao, Ye Tian, Yongqiang Wen, Xueji ZhangDistance-based detection methods with quantitative readout are of great significance to point-of-care testing (POCT), which are low-cost, user-friendly and can be integrated into portable analytical devices. Here, we submit a...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01230K, Paper Jisu Hong, Yoonkyung Shin, Jiseok Lee, Chaenyung ChaProgrammable multilayer printing is utilized to develop a 3D hydrogel co-culture system, consisting of a microgel array and hydrogel overlay with independently controlled mechanical properties and concurrent generation of mechanical gradients.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D0LC01143F, Paper Sally Anderson, Ben Hadwen, Chris BrownThe latest developments in Thin-Film-Transistor Digital-microfluidics (TFT-DMF, also known by the commercial name aQdropTM) are reported, and proof of concept application to molecular diagnostics (e.g. for coronavirus disease, COVID-19) at...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01075H, Paper Zhiqi Zhao, Qiujin Li, Linna Chen, Yu Zhao, Jixian Gong, Zheng Li, Jianfei ZhangThread/fabric-based microfluidic device for sweat sensing and monitoring.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00899K, Paper Thanawat Suwatthanarak, Ivan Adiyasa Thiodorus, Masayoshi Tanaka, Taisuke Shimada, Daiki Takeshita, Takao Yasui, Yoshinobu Baba, Mina OkochiA peptide–nanowire interface that can effectively capture cancer-derived exosomes and release captured intact exosomes was constructed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00994F, Paper Junjie Yu, Xiaoxiang Wei, Yuanchao Guo, Ziwei Zhang, Pinshu Rui, Yan Zhao, Wen Zhang, Shiwei Shi, Peihong WangA self-powered microfluidic system based on a rotary triboelectric nanogenerator can realize moving, splitting, merging, mixing and chemical transporting of droplets.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00702A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Augusto Márquez, Moliria V. Santos, Gonzalo Guirado, Alex Moreno, Salvador D. Aznar-Cervantes, Jose Luis Cenis, Silvia H. Santagneli, Carlos Domínguez, Fiorenzo G. Omenetto, Xavier Muñoz-BerbelNanoporous silk-fibroin films in test strips present capillary action and size-exclusion filtering capacity enabling quick optical biosensing in whole blood samples.To cite this article before page numbers are […]

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00986E, Communication Lei Zhao, Pengfei Niu, Eudald Casals, Muling Zeng, Chen Wu, Yang Yang, Sheng Sun, Zongwei Zheng, Zhaoxun Wang, Yuan Ning, Xuexin Duan, Wei PangAcoustic induced nanoparticle patterning and location migration in inhomogeneous media formed in situ.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,55-74DOI: 10.1039/D0LC00871K, Critical Review Tatsuhiro Fukuba, Teruo FujiiThis article overviews the contributions of LoC technologies for in situ measurements to elucidate the biogeochemical processes in the ocean, which is the largest fluidic system on the Earth.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,83-92DOI: 10.1039/D0LC01046D, Communication Yongxiao Zhou, Erik M. Werner, Eugene Lee, Michael Chu, Thao Nguyen, Kevin D. Costa, Elliot E. Hui, Michelle KhineWe have developed a soft piezoresistive sensor to measure micron-level strains that can be easily integrated into devices via soft lithography. We apply this sensor to achieve fast and localized monitoring of pressure, flow, and valve actuation.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00838A, Paper Alexandra Perebikovsky, Yujia Liu, Alexander Hwu, Horacio Kido, Ehsan Shamloo, Dian Song, Gabriel Monti, Oren Shoval, Daniel Gussin, Marc MadouWe demonstrated a novel instrument and a centrifugal microfluidics disc design that is capable of remarkably accomplishing the sample treatment steps, which pave the way to realize the antibody susceptibility test in point-of-care situation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,184-195DOI: 10.1039/D0LC00783H, Paper Chang-Ho Han, Jaesung JangA microfluidic carbon-nanotube-based field-effect transistor immunosensor equipped with electrohydrodynamic focusing for continuous and label-free detection of flowing Staphylococcus aureus particles.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,205-214DOI: 10.1039/D0LC00811G, Paper Julian Menges, Claude Meffan, Fabian Dolamore, Conan Fee, Renwick Dobson, Volker NockOff-valves, fabricated by a simple milling process and engaged by trigger channels, enable autonomous flow and sequencing control in capillary circuits for point-of-care applications.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,154-162DOI: 10.1039/D0LC00855A, Paper Xiaoxia Mao, Dongsheng Mao, Juanjuan Jiang, Benyue Su, Guifang Chen, Xiaoli ZhuA semi-dry chemistry-based biosensing platform was developed for detection of metal ions by intelligent stimulus-responsive DNA hydrogel. The platform combines the advantages of liquid (wet) chemistry and solid (dry) chemistry, providing a promising approach for on-site testing.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,105-112DOI: 10.1039/D0LC00805B, Paper Renchang Zhang, Chang Gao, Lu Tian, Ronghang Wang, Jie Hong, Meng Gao, Lin GuiThis study presented a convenient method of gathering, splitting, merging, and sorting microdroplets by dynamic pneumatic rails in double-layered microfluidic devices.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,9-21DOI: 10.1039/D0LC00963F, Perspective Darwin R. Reyes, Henne van Heeren, Suvajyoti Guha, Luke Herbertson, Alexios P. Tzannis, Jens Ducrée, Hugo Bissig, Holger BeckerWorldwide, the microfluidics industry has grown steadily over the last 5 years, with the market for microfluidic medical devices experiencing a compound growth rate of 22%.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,196-204DOI: 10.1039/D0LC01006E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Yifei Wang, Qinming Zhang, Wang Yuan, Yixuan Wang, Hannah J. Loghry, Zijian Zhao, Michael J. Kimber, Liang Dong, Meng LuA high-throughput hyperspectral image-based exosome (EV) microarray technology to differentiate EVs released by similar cell types or phenotypes.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,22-54DOI: 10.1039/D0LC00840K, Tutorial Review Carlos Honrado, Paolo Bisegna, Nathan S. Swami, Federica CaselliReview of chip designs and data analytics to stratify heterogeneity in cellular systems via microfluidic impedance cytometry.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,75-82DOI: 10.1039/D0LC00917B, Communication Yingdong Luo, Jinwu Yang, Xinqi Zheng, Jianjun Wang, Xin Tu, Zhizhao Che, Jiakun Fang, Lei Xi, Nam-Trung Nguyen, Chaolong SongWe present real-time quantitative phase microscopy (RT-QPM) that can be used for on-chip three-dimensional visualization of droplets and high-throughput quantitative molecular measurement via real-time extraction of sample-induced phase variation.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,93-104DOI: 10.1039/D0LC01068E, Paper Roberto Rodriguez-Moncayo, Diana F. Cedillo-Alcantar, Pablo E. Guevara-Pantoja, Oriana G. Chavez-Pineda, Jose A. Hernandez-Ortiz, Josue U. Amador-Hernandez, Gustavo Rojas-Velasco, Fausto Sanchez-Muñoz, Daniel Manzur-Sandoval, Luis D. Patino-Lopez, Daniel A. May-Arrioja, Rosalinda Posadas-Sanchez, Gilberto Vargas-Alarcon, Jose L. Garcia-CorderoA microfluidic device to quantitate antibody reactivities to SARS-CoV-2 antigens: spike protein, RDB, S1 subunit, and nucleocapsid, from 50 serum samples.The content of this RSS Feed (c) The Royal […]

Lab Chip, 2021, 21,215-222DOI: 10.1039/D0LC00892C, Paper Koohee Han, Alexey SnezhkoThe collective chiral state of flocking magnetic rollers can be programmed via phase shifts of the energizing magnetic field.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,113-121DOI: 10.1039/D0LC00966K, Paper Yen-Ling Fang, Chih-Hung Wang, Yi-Sin Chen, Chun-Chih Chien, Feng-Chih Kuo, Huey-Ling You, Mel S. Lee, Gwo-Bin LeeIsolation and identification of bacteria from human blood were automated on an integrated microfluidic system for sepsis-inducing bacteria.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,174-183DOI: 10.1039/D0LC00756K, Paper Shekh Mojibur Rahman, Vladimir HladyWe have developed a microfluidic system to perfuse whole blood through a flow channel with an upstream stenotic region and a downstream protein capture region.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,163-173DOI: 10.1039/D0LC00830C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Paul Jannis Zurek, Raphaëlle Hours, Ursula Schell, Ahir Pushpanath, Florian HollfelderSuccessful screening of enzyme libraries in functional metagenomics and directed evolution becomes more likely after uniform cell growth in droplets amplifies genotype and phenotype.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,122-142DOI: 10.1039/D0LC00801J, Paper Lisa F. Horowitz, Adan D. Rodriguez, Allan Au-Yeung, Kevin W. Bishop, Lindsey A. Barner, Gargi Mishra, Aashik Raman, Priscilla Delgado, Jonathan T. C. Liu, Taranjit S. Gujral, Mehdi Mehrabi, Mengsu Yang, Robert H. Pierce, Albert FolchA microfluidic platform permits multiple drug testing of uniformly-sized microscale “cuboids” of live tissue with well-preserved microenvironments.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2021, 21,143-153DOI: 10.1039/D0LC00944J, Paper Bo Dai, Cheng Yin, Jiandong Wu, Wei Li, Lulu Zheng, Francis Lin, Xiaodian Han, Yongfeng Fu, Dawei Zhang, Songlin ZhuangA flux-adaptable, self-contained and pump-free microfluidic platform is presented for the chemiluminescence immunoassay of multiple colorectal cancer biomarkers.The content of this RSS Feed (c) The Royal Society of Chemistry