Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00683D, Papermeng shao, Qin Yu, Nan Jing, Yu Cheng, Dong Wang, Yundong Wang, Jianhong XuCarbon dots with different emission fluorescence have greatly potential applications for various areas from in vitro imaging and biotherapy due to good biosafety of red fluorescent CDs to efficient ion...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00973F, PaperKa Ram Kim, Hyeong Jin Chun, Kyung Won Lee, Kwan Young Jeong, Jae-Ho Kim, Hyun Chul YoonHere, we proposed a retroreflective optical immunoassay platform by introducing the intrinsic sedimentation characteristics of a micro-retroreflector, namely retroreflective Janus particles (RJPs), wherein the sediment-based passive movement of RJPs minimised...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00842J, PaperIsmail Emre Araci, Sevda Agaoglu, Ju Young Lee, Laura Rivas Yepes, Priscilla Diep, Matthew Martini, Andrew SchmidtDilatometric strain sensors (DSS) that work based on detection of volume change in microfluidic channels; i) are highly sensitive to biaxial strain, ii) can be fabricated using only soft and...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00779B, PaperYufeng Zhao, Wei Zhang, Yongxin Zhao, Robert E. Campbell, D. Jed HarrisonWe introduce a single-phase flow microfluidic cell sorter with a two-point detection system capable of a two-parameter screen, to assist with directed evolution of a fluorescent protein based Ca2+ sensor...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00631A, PaperYuye Wang, Shiyue Liu, Tiankai Zhang, Hengji CONG, Yuanyuan Wei, Jianbin Xu, Yi-Ping Ho, Siu-Kai Kong, Ho Pui HODroplet microfluidics is an emerging tool in many biological and chemical application areas such as digital polymerase chain reaction (PCR) and in vitro diagnosis because of its extremely small sample...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00633H, PaperYing-Ting Lin, Sung-Tzu Chen, Jui-Chih Chang, Ren-Jie Toeh, Chin-San Liu, Gou-Jen WangIn this research, we propose a novel centrifugal device for the massive extraction of healthy mitochondria with a centrifuge used in general laboratories within 30 minutes. The device mainly consists...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00818G, PaperChenguang Zhang, Gongchen Sun, Satyajyoti Senapati, Hsueh-Chia ChangWe report a bifurcated continuous field-flow fractionation (BCFFF) chip for high-yield and high-throughput (20 min) extraction of nucleic acids from physiological samples. The design uses a membrane ionic transistor to...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00412B, CommunicationYiting Zheng, Qingxuan Li, Weike Hu, Jun Liao, Guoan Zheng, Ming SuLiquid biopsy with circulating tumor cells (CTCs) can aid in cancer detection at early stage and determine whether a certain treatment is effective or not. However, existing CTC techniques focus...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00519F, Tutorial ReviewRhiannon N. Hardwick, Catherine J. Betts, Jessica Whritenour, Radhakrishna Sura, Maike Thamsen, Elad H. Kaufman, Kristin FabreSelected skin MPS features desired to advance further adoption within the pharmaceutical industry.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00797K, PaperYu-Dong Ma, Kuang-Hsien Li, Yi-Hong Chen, Yung-Mao Lee, Shang-Ta Chou, Yue-Yuan Lai, Po-Chiun Huang, Hsi-Pin Ma, Gwo-Bin LeeEmerging and re-emerging infectious diseases pose global threats to human health. Although several conventional diagnostic methods have been widely adopted in the clinic, the long turn-around times of “gold standard”...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00903E, Critical ReviewEka Noviana, Cynthia McCord, Kaylee Clark, Ilhoon Jang, Charles HenryPaper-based sensors offer an affordable yet powerful platform for field and point-of-care (POC) testing due to their self-pumping ability and utility for many different analytical measurements. When combined with electrochemical...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00822E, CommunicationMohamad S. Sotoudegan, Omar Mohd, Frances S. Ligler, Glenn M. WalkerGrooved paper pumps provide controllable flow of complex biofluids within microfluidic devices.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00695H, PaperDomenico Rossi, David Dannhauser, Mariarosaria Telesco, Paolo Antonio Netti, Filippo CausaT-Lymphocytes are a group of cells representing the main effectors of the human adaptive immunity. Characterization of the most representative T-lymphocytes subclasses - CD4+ and CD8+ - is challenging, but...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Accepted ManuscriptDOI: 10.1039/C9LC00641A, PaperAbtin Saateh, Ali Kalantarifard, Oguz Tolga Celik, Mohammad Asghari, Murat Serhatlioglu, Caglar ElbukenDroplet-based microfluidic systems require a precise control on droplet physical properties, hence measuring the morphological properties of droplets is critical to obtain high sensitivity analysis. The ability to perform such...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00716D, PaperAnchi Scott, Daniel Mills, Christopher Birch, Satvinder Panesar, Jingyi Li, Daniel Nelson, Margarita Starteva, Albert Khim, Brian Root, James P. LandersAn automated alignment method was optimized for maximizing laser-induced fluorescence detection in a total DNA analysis system, using innate opto-signatures from microchannel features.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC90109D, EditorialPratip K. Chattopadhyay, Daniel T. ChiuThought leaders Pratip Chattopadhyay and Daniel Chiu introduce the Lab on a Chip single cell analysis thematic collection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00774A, CommunicationSimon I. R. Lane, Jonathan Butement, Jack Harrington, Tim Underwood, John Shrimpton, Jonathan WestParticles in a rotating fluid experience gravity-directed orbits to remain in suspension.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00612E, PaperKuan-Wen Tung, Pei-Shan Chung, Cong Wu, Tianxing Man, Sidhant Tiwari, Ben Wu, Yuan-Fang Chou, Fu-ling Yang, Pei-Yu ChiouThis manuscript demonstrates a near-field acoustic platform to synthesize high resolution, complex and non-periodic energy potential wells for patterning micro-objects.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00902G, PaperLeilei Shi, Damaris Kuhnell, Vishnupriya J. Borra, Scott M. Langevin, Takahisa Nakamura, Leyla EsfandiariRapid and low voltage iDEP device for purification of exosomes from biofluids with high yield and small initial sample volumes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00793H, PaperYutaka Kazoe, Takuya Ugajin, Ryoichi Ohta, Kazuma Mawatari, Takehiko KitamoriAqueous/organic parallel two-phase flow in a nanochannel was realized by a nanoscale partial hydrophobic surface modification method, and applied to solvent extraction of lipid to achievefemtoliter sample volume and millisecond processing time.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3366-3367DOI: 10.1039/C9LC90103E, EditorialJames R. HeathThought leader Jim Heath introduces the Lab on a Chip Immunotherapy thematic collection.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00441F, Tutorial ReviewJ. F. Hess, S. Zehnle, P. Juelg, T. Hutzenlaub, R. Zengerle, N. PaustThe combination of pneumatic and centrifugal forces enables robust automation of multistep biochemical workflows. We review technical implementations on microfluidic cartridges and discuss the design of pneumatic unit operations within two tutorials.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3438-3447DOI: 10.1039/C9LC00574A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Liu-Liu Shen, Gui-Rong Zhang, Markus Biesalski, Bastian J. M. EtzoldAluminum–air batteries with a unique paper-based microfluidic configuration are fabricated, and their superior discharging performance along with miniaturized size makes them feasible as next-generation power supplies for small electronic devices.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00907H, CommunicationBingbing Gao, Yaqiong Yang, Junlong Liao, Bingfang He, Hong LiuMultistructured papers (MSPs) with ordered micropillars and colloidal crystal structures were used for fabricating pumpless liquid transport and fluorescence and chemiluminescence (CL) enhancement microfluidic chips for POCT.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3375-3386DOI: 10.1039/C9LC00506D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Elizabeth A. Phillips, Taylor J. Moehling, Karin F. K. Ejendal, Orlando S. Hoilett, Kristin M. Byers, Laud Anthony Basing, Lauren A. Jankowski, Jackson B. Bennett, Li-Kai Lin, Lia A. Stanciu, Jacqueline C. LinnesThis handheld sample-to-answer platform combines blood cell separation, viral lysis, and isothermal nucleic acid amplification with capillary fluidics and heating controls to automatically detect HIV from blood samples […]

Lab Chip, 2019, 19,3552-3562DOI: 10.1039/C9LC00653B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Barkan Sidar, Brittany R. Jenkins, Sha Huang, Jason R. Spence, Seth T. Walk, James N. WilkingHuman intestinal organoids (HIOs) have many research applications but are structurally limited with closed epithelial surfaces that limit material transport. Here, we present a fluidic device designed to establish long-term flow through HIOs.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3427-3437DOI: 10.1039/C9LC00575G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Chia-Heng Chu, Ruxiu Liu, Tevhide Ozkaya-Ahmadov, Mert Boya, Brandi E. Swain, Jacob M. Owens, Enerelt Burentugs, Mehmet Asim Bilen, John F. McDonald, A. Fatih SariogluA monolithic 3D-printed microfluidic device integrated with stacked layers of functionalized leukodepletion channels and microfiltration for the negative enrichment of circulating tumor cells directly from clinically relevant volumes of whole blood.The […]

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00338J, PaperThao Nguyen, Su Hyun Jung, Min Seok Lee, Tae-Eun Park, Suk-kyun Ahn, Joo H. KangA GLYMO-based method enables robust fabrication of PMMA–PETE cell-culturing microfluidic devices, which permits more precise cytotoxicity response to lipophilic drugs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00562E, PaperPatrick H. McMinn, Laurel E. Hind, Anna Huttenlocher, David J. BeebeHer we report a new microfluidic technology designed to facilitate the study of neutrophil trafficking and priming using primary human cells with a high degree of spatiotemporal control.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00660E, PaperSamuel Sofela, Sarah Sahloul, Christopher Stubbs, Ajymurat Orozaliev, Fathima Shaffra Refai, Abdelhady Mostafa Esmaeel, Hala Fahs, Mohamed Omar Abdelgawad, Kristin C. Gunsalus, Yong-Ak SongA microfluidic force assay chip was used to quantify the relative changes in the thrashing force of C. elegans upon exposure to various external stimuli.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00546C, PaperJunchao Wang, Naiyin Zhang, Jin Chen, Victor G. J. Rodgers, Philip Brisk, William H. GroverFind an optimal design and establish the design criteria of a passive microfluidic mixer using a multi-objective genetic algorithm.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00636B, CommunicationLeonardo D. Garma, Laura M. Ferrari, Paola Scognamiglio, Francesco Greco, Francesca SantoroWe present an innovative fabrication process for the production of low cost fully-plastic flexible MEAs and prove that they are a valid proof-of-concept for a platform for the electrophysiological analysis of cardiac cell cultures.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3481-3489DOI: 10.1039/C9LC00275H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kristina Reinmets, Amin Dehkharghani, Jeffrey S. Guasto, Stephen M. FuchsFungal adhesion is fundamental to processes ranging from infections to food production. We developed a microfluidic assay for rapid screening and fractionation of genetically-related yeast based on adhesive properties.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3543-3551DOI: 10.1039/C9LC00672A, PaperErel Lasnoy, Omer Wagner, Eitan Edri, Hagay ShpaismanAn optically based assembly line approach that allows continuous and automated formation of colloids with on-demand dimensions inside microfluidic channels is presented.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00686A, PaperLeonel M. Meireles, Ingrid D. Barcelos, Gustavo A. Ferrari, Paulo Alexandre A. de A. Neves, Raul O. Freitas, Rodrigo G. LacerdaHere we present a graphene chip designed to nanoscale infrared analysis of materials in liquid environments. We measured the local chemistry of protein clusters in water and a variety of biocompatible liquids.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00318E, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.M. Solsona, J. C. Vollenbroek, C. B. M. Tregouet, A.-E. Nieuwelink, W. Olthuis, A. van den Berg, B. M. Weckhuysen, M. OdijkIn this review article, we discuss the latest advances and future perspectives of microfluidics for micro/nanoscale catalyst particle synthesis and analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]

Lab Chip, 2019, 19,3397-3404DOI: 10.1039/C9LC00465C, PaperPeiran Zhang, Chuyi Chen, Feng Guo, Julien Philippe, Yuyang Gu, Zhenhua Tian, Hunter Bachman, Liqiang Ren, Shujie Yang, Zhanwei Zhong, Po-Hsun Huang, Nicholas Katsanis, Krishnendu Chakrabarty, Tony Jun HuangImmersed interdigital transducer array enables contactless, programmable manipulation floating objects on water via acoustofluidics.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00352E, PaperYujin Shin, Seongjin Lim, Jinwon Kim, Jessie S. Jeon, Hongki Yoo, Bomi GweonThe pathophysiological phenotype and function of endothelial cells (ECs) in atherosclerotic lesions are replicated within a micro-channel by mimicking the microenvironment of the lesions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3405-3415DOI: 10.1039/C9LC00622B, PaperJingjing Wang, Ka Deng, Chuqing Zhou, Zecong Fang, Conary Meyer, Kaustubh Umesh-Anjali Deshpande, Zhihao Li, Xianqiang Mi, Qian Luo, Bruce D. Hammock, Cheemeng Tan, Yan Chen, Tingrui PanA novel microfluidic–robotic interface that is able to achieve automatic on-demand volume distribution ranging from nanoliter to microliter is introduced.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3535-3542DOI: 10.1039/C9LC00764D, PaperGwang-Noh Ahn, Taejong Yu, Hyune-Jea Lee, Ki-Won Gyak, Ji-Ho Kang, Donghyun You, Dong-Pyo KimIn this study, we present a new numbering-up metal microreactor by integrating a flow distributor and a copper catalytic module for high productivity of a commercial synthetic drug.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3512-3525DOI: 10.1039/C9LC00649D, PaperGenaro Vázquez-Victorio, Cindy Peto-Gutiérrez, Beatriz Díaz-Bello, Mariel Cano-Jorge, Daniel Pérez-Calixto, Alejandra Jiménez-Escobar, Silvia Espinosa-Matías, Reyna Lara Martínez, Rémi Courson, Laurent Malaquin, Diego Zamarrón-Hernández, Mathieu HautefeuilleThe study of cell response to mechanotransduction signals requires designing culture substrates offering biocompatibility and adhesion, stiffness control and dynamics, patternability at microscale and integration […]

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00444K, PaperPatricia M. Davidson, Gregory R. Fedorchak, Solenne Mondésert-Deveraux, Emily S. Bell, Philipp Isermann, Denis Aubry, Rachele Allena, Jan LammerdingWe report the development, validation, and application of an easy-to-use microfluidic micropipette aspiration device and automated image analysis platform that enables high-throughput measurements of the viscoelastic properties of cell nuclei.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]

Lab Chip, 2019, 19,3416-3426DOI: 10.1039/C9LC00786E, PaperJian Zhou, Ian PapautskyThis work demonstrates size-dependent lateral migration of cells in untreated whole blood flow under the effect of shear-induced diffusion. In-depth investigation with high-speed imaging offers insights on cell migration in whole blood.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3499-3511DOI: 10.1039/C9LC00569B, PaperJitender Bisht, Paige LeValley, Benjamin Noren, Ralph McBride, Prathamesh Kharkar, April Kloxin, Jesse Gatlin, John OakeyProtein release from microfluidically-confined photodegradable hydrogels allows dynamic cycling of cell-free Xenopus egg extracts, a widely used and biochemically tractable model system.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3472-3480DOI: 10.1039/C9LC00788A, PaperKan Shoji, Ryuji KawanoA new liposome migration mechanism in a microfluidic channel based on an osmotic engine model.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3268-3276DOI: 10.1039/C9LC00415G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Carolin Drieschner, Sarah Könemann, Philippe Renaud, Kristin SchirmerCombining fish intestinal cells and organ-on-chip technology will offer new insights into fish physiology and evaluation of chemical uptake mechanisms.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3526-3534DOI: 10.1039/C9LC00722A, PaperYage Zhang, Xiangyu Fu, Wei Guo, Yi Deng, Bernard P. Binks, Ho Cheung ShumWe present coalescence of liquid marbles in a non-contact approach by applying electrostatics to embedded electrodes.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3368-3374DOI: 10.1039/C9LC00730J, CommunicationNianzuo Yu, Yongshun Liu, Shuli Wang, Xiaoduo Tang, Peng Ge, Jingjie Nan, Junhu Zhang, Bai YangUltramicro-volume syringes are fabricated in microchannels. The minimum of available droplet volume is in increments as low as 0.5 pL with 96% accuracy. Specifically, controllable synthesis of nanocrystals could be produced in a lab-on-chip platform.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3461-3471DOI: 10.1039/C9LC00270G, PaperJose M. Ayuso, Maria Virumbrales-Munoz, Patrick H. McMinn, Shujah Rehman, Ismael Gomez, Mohammad R. Karim, Regan Trusttchel, Kari B. Wisinski, David J. Beebe, Melissa C. SkalaLimited blood supply and rapid tumor metabolism within solid tumors leads to nutrient starvation, waste product accumulation and the generation of pH gradients across the tumor mass.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3490-3498DOI: 10.1039/C9LC00715F, PaperJan Leipert, Andreas TholeyThe combination of digital microfluidics and magnetic beads for removal of polymer surfactants enables sensitive LC-MS-based microproteomics analyses down to 100 mammalian cells.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3249-3260DOI: 10.1039/C9LC00690G, PaperShadi Karimi, Pouya Mehrdel, Josep Farré-Lladós, Jasmina Casals-TerréA passive portable microfluidic blood–plasma separator for simultaneous determination of direct and indirect ABO/Rh blood typing.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3238-3248DOI: 10.1039/C9LC00434C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Vasileios A. Papadimitriou, Loes I. Segerink, Jan C. T. EijkelSelective extraction of concentrated anionic analytes focused via ion concentration polarization focusing.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3344-3353DOI: 10.1039/C9LC00552H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Suzanne Smith, Adelaide Oberholzer, Jan G. Korvink, Dario Mager, Kevin LandA low-cost, automated wireless result readout device for point-of-care diagnostics in resource-limited clinics in Southern Africa.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, Advance ArticleDOI: 10.1039/C9LC00602H, PaperCarmen M. Morrow, Apratim Mukherjee, Mahama A. Traore, Eric J. Leaman, AhRam Kim, Evan M. Smith, Amrinder S. Nain, Bahareh BehkamIntegrating ECM-mimicking nanofibers with biochemical gradients reveals that fiber spacing-driven cell shape broadens chemotaxis sensitivity in fibroblasts compared to 2D flat substrata.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3152-3161DOI: 10.1039/C9LC00492K, Tutorial ReviewGarrett R. Ainslie, Myrtle Davis, Lorna Ewart, Linda A. Lieberman, David J. Rowlands, Andrew J. Thorley, Gorm Yoder, Anne M. RyanDrug developers seek specific advancements in the development and qualification of microphysiological lung models for the evaluation of drug safety; here these essential elements are discussed from the perspective of the biopharmaceutical industry.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3448-3460DOI: 10.1039/C9LC00734B, PaperZhong Zhang, Morteza Azizi, Michelle Lee, Philip Davidowsky, Peter Lawrence, Alireza AbbaspourradPoint-of-care (POC) diagnostics have shown excellent potential in rapid biological analysis and health/disease monitoring.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3316-3325DOI: 10.1039/C9LC00637K, PaperM. Reza Rasouli, Maryam TabrizianThis paper reports an ultra-rapid acoustic mixer by the integration of oscillatory bubbles and sharp edges as a versatile platform for nanoparticle synthesis.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3277-3291DOI: 10.1039/C9LC00658C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Daniel Stoecklein, Michael Davies, Joseph Michael de Rutte, Chueh-Yu Wu, Dino Di Carlo, Baskar GanapathysubramanianMicrofluidic devices for asymmetric and multi-material inertial flow sculpting are rapidly designed using FlowSculpt: an efficient, cross-platform, and free application.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3305-3315DOI: 10.1039/C9LC00624A, PaperYi-Sin Chen, Yu-Dong Ma, Chihchen Chen, Shu-Chu Shiesh, Gwo-Bin LeeAn integrated microfluidic system was developed for extracellular vesicle (EV) enrichment and quantification by using anti-CD63-coated magnetic beads and an on-chip enzyme-linked immunosorbent assay in human whole blood.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3337-3343DOI: 10.1039/C9LC00746F, PaperN. Raj, V. Breedveld, D. W. HessA fully enclosed paper microfluidic device has been fabricated using pentafluoroethane (PFE) plasma deposition followed by O2 plasma etching.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3387-3396DOI: 10.1039/C9LC00344D, PaperWei Zhou, Mian Chen, Xiufang Liu, Wenjun Zhang, Feiyan Cai, Fei Li, Junru Wu, Jinping Wang, Yang Wang, Xiaowei Huang, Zhengrong Lin, Hui Zhou, Long Meng, Lili Niu, Hairong ZhengAn integrated microfluidic system, involving nanocage manipulation by SAW and patterned nanocage-induced temperature elevation by laser irradiation, was established for selectively destroying cancer cells.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3326-3336DOI: 10.1039/C9LC00526A, PaperHwapyeong Jeong, Hyunwoo Shin, Johan Yi, Yonghyun Park, Jiyoul Lee, Yogesh Gianchandani, Jaesung ParkWe report spatial separation of extracellular vesicle (EVs) populations based on size by using Marangoni flow and the coffee-ring effect in microdroplets.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3200-3211DOI: 10.1039/C9LC00541B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dmitriy V. Zhukov, Eugenia M. Khorosheva, Tahmineh Khazaei, Wenbin Du, David A. Selck, Alexander A. Shishkin, Rustem F. IsmagilovUsing interfacial energy between carrier and sample phases, this manually operated device accurately meters and merges nanoliter scale reagent droplets repeatedly.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3162-3167DOI: 10.1039/C9LC00736A, CommunicationWenming Liu, Kai Han, Meilin Sun, Jinyi WangWe present a straightforward strategy to promote and engineer neuron adhesion on a polydimethylsiloxane substrate by a one-step modification using a functionalized triblock polymer.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3292-3304DOI: 10.1039/C9LC00597H, PaperNingquan Wang, Ruxiu Liu, Norh Asmare, Chia-Heng Chu, A. Fatih SariogluDeep learning-enhanced Coulter counter networks for electronic tracking of particles in microfluidic devices.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3228-3237DOI: 10.1039/C9LC00608G, PaperSara M. Imani, Maryam Badv, Amid Shakeri, Hanie Yousefi, Darren Yip, Claire Fine, Tohid F. DidarMicropatterned lubricant-infused biofunctional surfaces exhibit biofunctionality and omniphobicity simultaneously which leads to targeted cell attachment and alignment, both in surfaces and in microfluidic devices.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3220-3227DOI: 10.1039/C9LC00676A, PaperKamalalayam Rajan Sreejith, Lena Gorgannezhad, Jing Jin, Chin Hong Ooi, Helen Stratton, Dzung Viet Dao, Nam-Trung NguyenLiquid marbles can serve as a biochemical reactor for the polymerase chain reaction, eliminating the conventional single use plastic reaction vial.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3261-3267DOI: 10.1039/C9LC00503J, PaperJinwon Jeong, Jeong-Bong Lee, Sang Kug Chung, Daeyoung KimIn this paper, we report three-dimensional (3-D) liquid metal manipulation using electromagnets, which can be applied to electrical switching applications.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3179-3189DOI: 10.1039/C9LC00598F, PaperZhen Yuan, Lei Hou, Mallika Bariya, Hnin Yin Yin Nyein, Li-Chia Tai, Wenbo Ji, Lu Li, Ali JaveyA wearable, multi-modal sensing patch for sweat rate and electrolyte analysis with inbuilt cross-verification schemes to ensure data integrity.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3168-3178DOI: 10.1039/C9LC00473D, PaperRen Li, Fei Jia, Weikai Zhang, Fanghao Shi, Zhiguo Fang, Hong Zhao, Zhiyuan Hu, Zewen WeiTo sequence single circulating tumor cells (CTCs) from whole blood, a microfluidic chip was developed to perform blood filtering/CTC enrichment/CTC sorting and in situ MDA for whole genome sequencing.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3190-3199DOI: 10.1039/C9LC00508K, PaperSeongho Baek, Jihye Choi, Seok Young Son, Junsuk Kim, Seongjun Hong, Hee Chan Kim, Jong-Hee Chae, Hyomin Lee, Sung Jae KimA nanoelectrokinetic study reveals that the Peclet number determines the shape of preconcentrated analytes, as either plug or dumbbell shaped.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2019, 19,3212-3219DOI: 10.1039/C9LC00446G, PaperYang Yang, Parinaz Fathi, Glenn Holland, Dipanjan Pan, Nam Sun Wang, Mandy B. EschWe have developed a pumpless cell culture chip that can recirculate small amounts of cell culture medium (400 μL) in a unidirectional or bidirectional flow pattern, producing physiologic levels of shear suitable for culturing endothelial cells.The content of this RSS Feed (c) The Royal Society of Chemistry

Analytical ChemistryDOI: 10.1021/acs.analchem.9b00081

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02666

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03212

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03999

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02620

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02840

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02555

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03602

Analytical ChemistryDOI: 10.1021/acs.analchem.9b01914

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03047

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03064

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02754

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03494

Analytical ChemistryDOI: 10.1021/acs.analchem.9b01844

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02558

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03385

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02584

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03239

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03279

Analytical ChemistryDOI: 10.1021/acs.analchem.9b04035

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03379

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03521

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02845

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03717

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03134

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02786

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03779

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03942

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03311

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03953

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03749

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03119

Analytical ChemistryDOI: 10.1021/acs.analchem.9b01895

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03107

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02610

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02690

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03463

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02822

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03589

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02483

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03599

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02893

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03315

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02622

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02461

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02716

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02579

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03408

Analytical ChemistryDOI: 10.1021/acs.analchem.9b02410

Analytical ChemistryDOI: 10.1021/acs.analchem.9b03322

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Yuanyuan Dong, Jinming Li, Lei ZhangAbstractEpinephrine (EP) is a catecholamine neurotransmitter produced from l-tyrosine (L-TY), which usually coexists with each other in biological fluids. Moreover, their abnormal concentrations are related to multiple diseases, so sensitive simultaneous determination of EP and l-TY is important. Herein, we delicately designed 3D SnS@Co,N-C hierarchical hollow microrod assembled from 2D SnS nanoplates vertically anchored on the MOF derived cobalt, nitrogen […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Asya Kalinichenko, Larysa ArseniyevaAbstractThis paper is devoted to the multiclass classification of quartz crystal microbalance sensor-array data based on two chemometric approaches, and aimed at the development of rapid analytical technique (both at the chemical and data levels) for detection and quantitative assessment of soy protein at the levels 0, 10, 20, 30% w/w in sausages for avoiding different type of frauds and thus providing the effective meat products quality control issue. The first […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Jing Cong, Pei Duan, Fulan Zhong, Yu Luo, Yong Zheng, Guohui Cai, Yihong Xiao, Lilong JiangAbstractThe work showed a novel amperometric NH3 sensor based on SrM2O4 (M = Sm, La, Gd, Y) with CaFe2O4 type structural sensing electrode. A distinct B-site strategy was developed to prepare a series of semiconductor oxides SrM2O4 (M = Sm, La, Gd, Y) to establish the relationships between the band structure and sensing properties of the optimized sensing electrode. The structural […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): A.A. Alharbi, A. Sackmann, U. Weimar, N. BârsanAbstractGas sensing using metal oxides can be a highly cost effective and reliable technology in a variety of medical and industrial applications. However, selectively sensing a specific gas in a complex gas mixture continues to be a significant challenge. Here, we focus on acetylene and ethylene sensing with LaFeO3 (LFO) based sensors with novel applications, such as online monitoring and maintenance of electrical power transformers, in mind. […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Haiwei Fu, Qiqi Wang, Jijun Ding, Yi Zhu, Min Zhang, Chong Yang, Shuai WangAbstractThis paper presents a convenient and effective method for the determination of ammonia concentration. The structure is manufactured of Fe2O3 coated tapered microfiber interferometer (MFI). The Fe2O3 nanotube coated on the MFI acts as sensing layer, which enhance the gas selectivity, adsorptivity for ammonia molecule and also enhances the evanescent field strength distribution of the sensor and changes the mode […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Wenhui Lu, Jiaxin Zhang, Nianlu Li, Zhi You, Zhenyu Feng, Vinothkumar Natarajan, Jing Chen, Jinhua ZhanAbstractTransition metal oxides nanoparticles have shown enzyme-mimetic performance. It was demonstrated that the Co3O4@β-cyclodextrin nanoparticles (Co3O4@β-CD NPs) showed a higher peroxidase-mimicking catalytic activity than pure Co3O4 NPs. β-CD molecules were coated onto the surface of Co3O4 NPs via a one-pot synthesis method. Co3O4@β-CD NPs displayed higher affinity to […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Shuwen Wu, Danzhao Guo, Xuechao Xu, Jianming Pan, Xiangheng NiuAbstractGiven the great harm of toxic phenolic pollutants toward the environment and human health, exploring efficient and low-cost methods for their monitoring becomes strongly necessary. Herein, we propose a facile and high-performance sensor array for colorimetric quantification and discrimination of phenolic pollutants by employing Fe3O4 nanoparticles (Fe3O4 NPs) as a peroxidase mimic. The small-size Fe3O4 NPs exhibit favorable […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Jian Hua Wang, Yao Ming Liu, Jian Bin Chao, Hui Wang, Yu Wang, ShaoMin ShuangAbstractA very simple schiff base fluorescent probe (NIS) was facilely prepared via a one-step, one-pot condensation reaction between 2, 3-naphthalenediamine and imidazole-2-carboxaldehyde. Among common biologically relevant metal ions, NIS can selectively recognize Cd2+ via ratiometric fluorescence signal. The chelation of NIS with the Cd2+ ions resulted in a fluorescence enhancement together with a blue shift […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Yue Cai, Jingkun Fang, Hongshuai Zhu, Weiwei Qin, Yiran Cao, Huijuan Yu, Guang Shao, Yingju Liu, Weipeng LiuAbstractAs a sulfur-containing amino acid, cysteine (Cys) plays a crucial role in life process. Abnormal Cys content can trigger a series of diseases, such as developmental delay, hair discoloration, neurological diseases and cardiovascular diseases. In this work, 4-(10-{4-[Bis-(4-hexyloxy-phenyl)-amino]-phenyl}-anthracen-9-ylethynyl)-benzoic acid (FSD-103) was found to exhibit the […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Wenjing Du, Wenxu Si, Fenglong Wang, Longfei Lv, Lili Wu, Zhou Wang, Jiurong Liu, Wei LiuAbstractInvestigating the correlation between the electronic structure of indium oxide materials with oxygen vacancy defects and their sensing property to nitrogen dioxide is important for future development of high-efficient sensing materials. For the first time, the defective structure of porous In2O3 nanospheres was introduced in a two-zone tube furnace using metallic Al as reducing agent. Texture […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Matthew Donora, Andrés Vásquez Quintero, Herbert De Smet, Ian UnderwoodAbstractAn electrochemical smart contact lens (ESCL) capable of real-speed spatiotemporal electrochemical sensing across the surface of the eye is demonstrated. Four microelectrode arrays, each comprising 33 gold microdiscs of 30 μm diameter, and a distributed common gold counter electrode, are integrated into a soft smart contact lens platform based on polyimide and thermoplastic polyurethane. Using a […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Shabnam Allahverdiyeva, Pınar Talay Pınar, Ertuğrul Keskin, Oruç Yunusoğlu, Yavuz Yardım, Zühre ŞentürkAbstractThe present work describes the first electroanalytical investigation and a new voltammetric method for a cheap, rapid and simple determination of higenamine at a surface of mildly-oxidized boron-doped diamond electrode (at +1.6 V during 180 s). The oxidation of compound was strongly dependent on pH. The sensitivity of method was […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Shira Roth, Itzhak Zander, Yehudit Michelson, Yossi Ben-David, Ehud Banin, Amos DanielliAbstractInvestigating protein-protein interactions (PPIs) is essential in basic and clinical research, but current techniques for detecting PPI are hampered by lengthy protocols, reduced sensitivity, and a high rate of false positive results. To overcome these challenges, we use a magnetic modulation biosensing (MMB) system, in which one protein of interest is attached to a magnetic bead and another protein is […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Yang Li, Yanxin Chu, Yuanfang Li, Cheng Ma, Lingling LiAbstractThe detection of specific DNA sequences provides a powerful tool for early diagnosis and prevention of disease. Herein, an enzyme-free electrochemiluminescence (ECL) DNA biosensor was developed by coupling inorganic-organic nanocomposite as the luminophore and ZnCo2O4 as the efficient accelerator. ZnCo2O4 nanoparticles (ZCO NPs), derived from Co and Zn based bimetallic zeolite imidazole framework, was used as the ECL substrate due to […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Ritu Joshi, Santosh Lohumi, Rahul Joshi, Moon S. Kim, Jianwei Qin, Insuck Baek, Byoung-Kwan ChoAbstractCases of imitation or fake food materials are sometimes produced and sold for purposes of economic fraud. However, while some imitation or fake food materials merely incorporate lower quality or cheaper alternative ingredients that are safe to eat, others fakes are produced using non-edible or hazardous ingredients that are unsafe for consumption. The latter group includes fake eggs which are […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): I. Hajji, M. Serra, L. Geremie, I. Ferrante, R. Renault, J.-L. Viovy, S. Descroix, D. FerraroAbstractRT-qPCR represents a key method in cancer diagnostic, however the constant increase in patients and cancer biomarker panels to screen requires the implementation of faster approaches allowing smaller reagents and samples volumes consumption. To fulfil these needs, we present here a fully automated droplet microfluidics platform that couples a specifically designed thermal system with a fluorescence […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Homan Kang, Yul Koh, Sinyoung Jeong, Chulhwan Jeong, Myeong Geun Cha, Min-Hye Oh, Jin-Kyoung Yang, Hyunmi Lee, Dae Hong Jeong, Bong-Hyun Jun, Hyejin Chang, Yong-Kweon Kim, Yoon-Sik LeeAbstract‘Split-and-mix’ synthetic methods are widely utilized to prepare extensively large numbers of combinatorial libraries. For this, a simple and reliable encoding/decoding method is required to identify a lead compound, especially when it comes to combinatorial peptide/peptoid libraries. Here, we […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): Nicholas Colby Speller, Giorgio Gianini Morbioli, Michael E. Cato, Julianna L. McNeice, Amanda M. StocktonAbstractElastomeric membrane-based microvalves, especially pneumatically-actuated valves, are a core technology responsible for the proliferation of micro total analysis systems (μTAS) due to enabling the precise metering and mixing required by lab-on-a-chip applications. Hydraulic actuation is a promising actuation strategy, analogous to pneumatic actuation, useful in environments where […]

Publication date: 15 January 2020Source: Sensors and Actuators B: Chemical, Volume 303Author(s): M. Eltermann, V. Kiisk, A. Kikas, S. Lange, R. JaanisoAbstractWe studied sol-gel-prepared crystalline (anatase) TiO2 nanopowder coatings, exhibiting simultaneously three different oxygen-sensitive signals under ultraviolet illumination: photoconductivity, photoluminescence of intrinsic defects, and photoluminescence of Sm3+ impurity ions. The material was subjected to a flow of O2/N2 gas mixture at normal pressure, where the volume fraction of oxygen was precisely controlled. All three signals […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Fangmeng Liu, Jing Wang, Rui You, Zijie Yang, Junming He, Caileng Wang, Ao Liu, Qingji Wang, Xu Yan, Peng Sun, Geyu LuAbstractThe planar and compact type all-solid state electrochemical gas sensing device based on yttria-stabilized zirconia (YSZ) and Zinc molybdate (ZnMoO4) composite sensing electrode (SE) was proposed and fabricated to effectively detect ppb-level H2S at high temperature. The gas sensing property of different SEs (ZnMoO4, CoMoO4 and NiMoO4) is compared and explored. The sensor […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Kee-Ryung Park, Hong-Baek Cho, Jimin Lee, Yoseb Song, Woo-Byoung Kim, Yong-Ho ChoaAbstractHighly porous SnO2-CuO hollow nanofiber mats were synthesized by electrospinning combined with thermal processing for high performance H2S gas sensing applications. The porous morphology generated in the one-dimensional (1-D) nanocomposite led to an improvement in surface-to-adsorbate molecule interactions. Our novel concept lies in fabrication of SnO2-CuO with a 1-D highly porous structure by electrospinning […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Jae-Hyoung Lee, Ali Mirzaei, Jin-Young Kim, Jae-Hun Kim, Hyoun Woo Kim, Sang Sub KimAbstractThe functionalization of noble metal nanoparticles (NPs) is a highly efficient method for increasing the sensing performance of metal oxide nanowire (NWs) gas sensors. Despite the well-established strategy, the level of the optimal functionalization for obtaining the maximum sensing response has rarely been reported. Herein, the surfaces of SnO2 NWs were functionalized with Pt and Pd NPs, and the gas sensing […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Bettina Baumgartner, Jakob Hayden, Bernhard LendlAbstractSensitivity of evanescent wave sensing of gaseous species can be vastly increased by enrichment materials that locally concentrate the analyte on the sensor. Here, we investigate functionalized mesoporous silica films as versatile enrichment layer for sensing volatile organic compounds (VOCs) from gas-phase. Attenuated total reflection (ATR) crystals were coated with silica films of different pore sizes and their capability to enrich three […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Xidong Hao, Tong Liu, Weijia Li, Yuxi Zhang, Jinhua Ouyang, Xishuang Liang, Fangmeng Liu, Xu Yan, Chuan Zhang, Yuan Gao, Lang Wang, Geyu LuAbstractA series of planar mixed-potential type sensors based on AMn2O4(A = Co, Zn and Cd) sensing electrodes, yttria-stabilized zirconia solid electrolyte, and Pt reference electrode were fabricated for acetone detection. All of the sensing materials AMn2O4(A = Co, Zn and Cd) with a spinel structure were synthesized by a simple sol-gel […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Jae-Hun Kim, Ali Mirzaei, Hyoun Woo Kim, Sang Sub KimAbstractZnO-SnO2 core-shell nanowires (C-S NWs) with different shell thicknesses (0–120 nm) were prepared and their sensing behavior was systematically studied. ZnO-SnO2 C-S NWs were prepared using a two-step synthesis procedure, where core ZnO NWs were synthesized by a vapor-liquid-solid growth technique, and subsequently these cores were coated with SnO2 shell layers by using an advanced atomic layer deposition technique. The […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Dan Zhang, Yu Fan, Gaojie Li, Wei Du, Runlong Li, Yiming Liu, Zhixuan Cheng, Jiaqiang XuAbstractA series of zeolitic imidazolate frameworks (ZIFs) were synthesized by a facile and environmental friendly biomimetic method. The textural properties of the ZIFs were characterized by PXRD, FESEM, TEM and FT-IR spectra. These results showed ZIF 90 having typical rhombic dodecahedron crystals with a diameter of 800–1200 nm. Furthermore, the presence of rich aldehyde groups is confirmed through […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Xiaodong Zhai, Xiaobo Zou, Jiyong Shi, Xiaowei Huang, Zongbao Sun, Zhihua Li, Yue Sun, Yanxiao Li, Xin Wang, Melvin Holmes, Yunyun Gong, Megan Povey, Jianbo XiaoAbstractAmine-responsive bilayer films were developed by using agar (AG), anthocyanins (AN), gellan gum (GG) and TiO2 nanoparticles for visual monitoring of meat spoilage. The AG-AN layer worked as the sensing layer to volatile amines, while GG-TiO2 layer served as the light barrier layer and simultaneously the conducting layer to improve […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Xiao Wang, Tongkai Wang, Guangkuo Si, Yang Li, Shouwei Zhang, Xiaolong Deng, Xijin XuAbstractSurface oxygen vacancy defects (OV) are regarded to be beneficial to the gas sensing behavior by significantly improving the carrier density and providing more oxygen adsorption sites. In this work, Ce-doped α-Fe2O3 composites with abundant OV defects were synthesized using an oil bath method assisted with annealing treatment. Morphological characterization results indicate that the lamellar […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Keng Xu, Qian Tang, Wei Zhao, Xing Yu, Yong Yang, Ting Yu, Cailei YuanAbstractArray-based sensors are considered as potential candidates for gas detection due to their low cost and great miniaturization potential. However, the fabrication process of array-based sensors is complex and time-consuming since it usually contains the formation and growth processes of seed layers on the surface of alumina substrates. In addition, the gas-sensing materials for the fabrication of array-based sensors are […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Yoonki Hong, Meile Wu, Jong-Ho Bae, Seongbin Hong, Yujeong Jeong, Dongkyu Jang, Jun Shik Kim, Cheol Seong Hwang, Byung-Gook Park, Jong-Ho LeeAbstractA new capacitive-type FET (CFET) gas sensor is proposed in this work and fabricated by using Si FET technology. Only five photomasks are used to prepare the CFET sensor and a ZnO thin film prepared by atomic layer deposition (ALD) is adopted as a sensing material. A diluted nitrogen dioxide (NO2) is used as a test gas and the sensing properties of the […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Li Liu, Qingwen Huang, Zafar Iqbal Tanveer, Keqiu Jiang, Jinghui Zhang, Hongye Pan, Lianjun Luan, Xuesong Liu, Zheng Han, Yongjiang WuAbstractWe report herein a “turn off-on” fluorescent sensor based on ZnCdSe quantum dots (ZnCdSe QDs) and self-assembled zinc porphyrin for sensitive and rapid detection of ochratoxin A (OTA). Using environmentally friendly dodecyl dimethyl betaine as “soft template”, zinc 5, 10, 15, 20-tetra(4-pyridyl)-21H-23H-porphine (ZnTPyP) was […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Cihang Yan, Wei Qin, Zihua Li, Yusheng Zhou, Yuhan Cui, Guodong LiangAbstractThe development of fluorescent sensors for explosive detection with high sensitivity is of great importance for antiterrorism and environmental protection. A new efficient AIE luminogen, abbreviated as TPE-SFX, is designed and synthesized. It enjoys typical AIE features and high solid-state fluorescence quantum yield. It can be fabricated into fluorescent dots for explosive detection with good selectivity and rapid […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Ying Wu, Yuhuan Zhang, Lan Wang, Yuchen Huyan, Hongjuan Li, Zhichao Pei, Yanfeng Tang, Shiguo Sun, Yongqian XuAbstractSimultaneous detection of biothiols would be helpful for understanding their biological functions and pathological study of related diseases. The structural similarities of biothiols present a great challenge to achieve their selective detection. Herein, we report a simple acrylate-substituted fluorescent sensor BTHA with one recognition site and an assisted neighboring hydroxy […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Qian Yang, Xiaoyan Wang, Hailong Peng, Maryam Arabi, Jinhua Li, Hua Xiong, Jaebum Choo, Lingxin ChenAbstractAlkaline phosphatase (ALP) activity plays a crucial role in foods and varies greatly in livestock and dairy products; it is quite difficult to compatibly monitor the different activities in various complicated foods. Herein, we proposed a ratiometric fluorescence and colorimetry dual-mode assay based on manganese dioxide (MnO2) nanosheets for the visualization of ALP activity in livestock […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Pengjuan Ni, Chuanxia Chen, Yuanyuan Jiang, Chenghui Zhang, Bo Wang, Yizhong Lu, Hua WangAbstractA simple and sensitive fluorescent assay for determination of alkaline phosphatase (ALP) activity has been developed based on the inner filter effect (IFE) of p-nitrophenol (PNP) through the in-situ formation of azamonardine. Herein, p-nitrophenylphosphate (PNPP) was used as ALP substrate, which could be hydrolyzed to PNP with an absorption band centered at 405 nm. Under the alkaline condition, the […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Sen Yan, Ran An, Yongjin Zou, Nan Yang, Ying ZhangAbstractTwo-dimensional (2D) nanostructured arrays are regarded as attractive materials for surface-enhanced Raman scattering (SERS)-active substrates because of their excellent stability and signal reproducibility. We present a novel approach for fabricating stable and reusable 2D polymer colloidal monolayer on a SERS-active nanostructured Au substrate with high-density hotspots. Poly(styrene-co-N-isopropylacrylamide)@polyacrylic acid (PSN@PAA) […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Hongji Li, Junqing Qin, Mingji Li, Cuiping Li, Sheng Xu, Lirong Qian, Baohe YangAbstractA boron-doped graphene (BG)/boron-doped diamond (BDD) composite film was obtained by continuously growing BDD and BG by chemical vapor deposition. In this process, the sp3 CC bonds in the diamond phase structure are directly converted into sp2 CC bonds in graphene to combine the two carbon materials, while BG nanosheets are vertically grown on the exposed planes of BDD crystals. These process features impart the […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Nilem Khaliq, Muhammad Asim Rasheed, Gihoon Cha, Maaz Khan, Shafqat Karim, Patrik Schmuki, Ghafar AliAbstractA novel amperometric non-enzymatic cholesterol biosensor based on Cu2O-TiO2 hybrid nanostructure has been studied. TiO2 nanotubes (TNTs) were synthesized via anodization of titanium (Ti) foils and subsequently decorated with Cu2O nanoparticles (NPs) using chemical bath deposition (CBD) method. Incorporation of Cu2O NPs on TNTs have resulted in the high electroactive surface area which […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Qian Han, Fangjing Mo, Jingling Wu, Cun Wang, Min Chen, Yingzi FuAbstractA novel label-free dual-signal amplifying “on-off-on” electrochemical biosensor has been designed for specific recognition of histidine (His) enantiomers. The remarkable dual-signal is provided by engineering His-dependent DNAzyme and the Fe3O4 nanoparticles attached reduced graphene oxide nanocomposite (Fe3O4@rGO) as enzymatically magnified chiral selector and electroactive indicator, respectively. In this […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Pavel Podesva, Xiaocheng Liu, Martin Pumera, Pavel NeuzilAbstractThe mercury electrode is an attractive material for a working electrode due to its atomically smooth, self-healing surface and large potential window. Amalgams are attractive substitutes for toxic Hg in various electrochemical applications. They are typically prepared by mixing different metals with Hg, or by electrodeposition of Hg on the metals’ surfaces. These methods offer little to no control of the amalgam compositions and […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Dengbin Yu, Hui Zhang, Lu Bai, Youxing Fang, Changyu Liu, He Zhang, Ting Li, Lei Han, You Yu, Hongwen Yu, Shaojun DongAbstractA self-powered microbial fuel cell (MFC) biosensor containing a bioanode and Prussian blue (PB) cathode was successfully developed to assay the toxicity of wastewater. Factors such as the oxidation of Prussian white (PW), external resistor and reduction time were studied and optimized. The electrochromic PB cathode facilitated the process of monitoring the electrocatalytic […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): A.M. Fekry, M. Shehata, S.M. Azab, A. WalcariusAbstractCaffeine (Caf) is one of the most widespread compounds in food components, beverages and medicines, which drives us to find a simple, fast and convenient method for its determination. The promising Nano-Cobalt (II, III) oxide modified carbon paste (NCOMCP) sensor was fabricated and applied to the sensitive determination of Caf in both aqueous (0.01 mol L−1 H2SO4) and micellar media (0.5 mmol L−1 sodium dodecylsulfate, […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Jin Jiao, Chao Li, Limin Ning, Liu Shi, Lin Wang, Yang Xiang, Genxi LiAbstractCovalently closed circular RNA (circRNA) has potential implications for disease diagnosis and therapy. However, current methods for circRNA detection are infrequent, and require RNase R pretreatment in general, which is deviation-oriented and labor-intensive. Herein, we have developed a simple electrochemical method for direct detection of circRNA. Firstly, the hairpin probes are designed to identify circRNA based on […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Chen Li, Wei Meng, Xiaodi Xu, Xiaoli Zhuang, Yuanyuan Wen, Ling Wang, Zhangxing He, Lei DaiAbstractIn this paper, a well-performing solid electrolyte-based NO2 sensor was initially assembled by using Co3V2O8 derived from Co-V-MOF as sensitive electrode material and La10Si5.5Al0.5O26.75 as solid electrolyte. The sensor displayed excellent sensing behaviors towards NO2 by comparison with the sensor using Co3V2O8 fabricated from classical solid state method as electrode material at 575 °C. […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Sathish Panneer Selvam, Kyusik YunAbstractHerein, we have developed a sensitive and selective electrochemical sensor for the detection of serotonin (ST) by using self-assembled silver selenide on reduced graphene oxide (rGO-Ag2Se). The size of the Ag2Se nanoparticles was found to be approximately 60–70 nm by high-resolution transmission electron microscopy (HR-TEM). The absorption spectra of rGO-Ag2Se were observed at 258 nm using Ultraviolet-visible (UV–vis) spectroscopy. […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Katarzyna Jedlińska, Radosław Porada, Justyna Lipińska, Bogusław BaśAbstractIn this work a new type of working electrode for voltammetry – the bi-band silver microelectrode (b-BAgmE) – is presented for the first time. The sensor consists of two Ag bands 25 μm thick and 4.5 mm long. The bands are arranged symmetrically and contrariwise, along the lateral, cylindrical surface of the Ag guide, coated with a thin layer of epoxy resin. Simple and […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Pinak Chakraborty, Saurab Dhar, Nitumoni Deka, Kamalesh Debnath, Suvra Prakash MondalAbstractPorous CuO electrodes have been fabricated using a low cost hydrothermal synthesis. Enzyme-less glucose detection ability of such porous electrodes has been optimized for different growth conditions. The maximum sensitivity of the electrode has been found to be ∼3072 μAmM−1 cm-2, in the linear detection range of 5μM to 0.225 mM and detection limit of ∼0.41 μM. Such CuO […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Guihua Zhang, Ying Yu, Li Zhang, Bixia Lin, Yumin Wang, Manli Guo, Yujuan CaoAbstractProstate specific antigen (PSA) is of great significance for clinical detection. Herein, a surface molecular imprinted sensor based on a novel cooperated signal amplification strategy was constructed for the precise detection of PSA. MoS2 and gold nanoparticles were modified on the electrode surface as the sensing substrate, PSA template and 4-mercaptophenylboronic acid were employed to form the surface imprinted […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Faqi Yu, Xinying Jing, Weiying LinAbstractLipid droplets (LDs) play key roles in various physiological processes and the abnormalities of them are related to many diseases. Discrimination of living and dead cells is an important task in the field of pharmacology, pathology and biology. However, the physiological roles of LDs in cell apoptosis has not revealed due to the lack of tools that can visualize LDs as well as discriminate living and dead cells simultaneously. To address this great […]

Publication date: 1 January 2020Source: Sensors and Actuators B: Chemical, Volume 302Author(s): Mingjian Chen, Zhenwei Tang, Changbei Ma, Ying YanAbstractProstate specific antigen (PSA) is considered to be a well-established biomarker for prostate cancer, and the importance of PSA assay is increasing in order to improve the diagnosis and prognosis of prostate cancer. However, there are still some weaknesses with current methods of PSA detection including high-cost, heavy analyzer and complexed procedure, restricting the application of PSA assay in prevention of diseases. In this paper, we […]

Microsystems & Nanoengineering, Published online: 07 October 2019; doi:10.1038/s41378-019-0095-9A new concept for an all-silicon CMOS compatible microspeaker uses the volume of the chip to generate sound. Microspeakers are used in a range of smart devices, and must provide both high sound pressure levels and low harmonic distortion. The majority of existing devices achieve this by out-of-plane deflection of surfaces, such as membranes or plates. Now, a project run by Bert Kaiser from Fraunhofer-Institute for Photonic Microsystems demonstrates micro speakers that comprise of in-plane […]

Microsystems & Nanoengineering, Published online: 07 October 2019; doi:10.1038/s41378-019-0089-7Researchers in China have developed a small, portable gravimeter based on micro-electromechanical-system (MEMS) technology with a sensitivity and dynamic range comparable with larger, commercially available gravimeters. The new device was created by a team led by Liangcheng Tu at Huazhong University of Science and Technology. The MEMS mechanism consists of a spring-mass system designed around a combination of curved and folded beams. Together, these ensure that the system is stiff under low […]

Microsystems & Nanoengineering, Published online: 23 September 2019; doi:10.1038/s41378-019-0091-0Researchers in Canada have improved the design of paper-based analytical devices by developing paper valves which make it possible to carry out fully-automated multi-step analyses. Previous efforts to incorporate valves have been based on electromagnets or compressed sponges, making them too cumbersome or complicated for reliable use in paper-based analytical devices. To overcome this, a team led by Xinyu Liu of the University of Toronto turned to polymers that reversibly change shape in […]

Microsystems & Nanoengineering, Published online: 23 September 2019; doi:10.1038/s41378-019-0092-zA novel technique can fabricate multiple ‘soft microrobots’ from a single design process that may prove useful in biomedical applications. With a continuous drive for robots to get smaller and more efficient, researchers are looking for alternatives to complex, traditional machinery. Edwin Jager and his team from Linköping University in Sweden now report a technique that combines elastomeric silicone and electroactive polymer into an artificial muscle: a soft microrobot […]

Microsystems & Nanoengineering, Published online: 23 September 2019; doi:10.1038/s41378-019-0081-2A two-step process enables the fabrication of miniaturized enzymatic biofuel cells composed of nanomaterials for possible use as power sources in implantable devices. There is growing need for self-powered implanted medical devices. Enzymatic biofuel cells are attractive for this since they rely on bio-compatible and non-toxic materials. However, improvements in power cell density are needed, and agglomeration of nanomaterials on existing devices limits performance. Now, Yin Song and Chunlei […]

Microsystems & Nanoengineering, Published online: 23 September 2019; doi:10.1038/s41378-019-0090-1A simple, flexible femtosecond laser process yields substrates that enable the detection of miniscule traces of target molecules with surface-enhanced Raman scattering (SERS). SERS is a powerful tool for performing analysis of samples such as food and biological specimens, but detecting ultra-scarce molecules has proven to be a challenge. Lan Jiang of the Beijing Institute of Technology and his colleagues have now developed a strategy for concentrating samples to such an extent that even […]