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RSC - Lab Chip latest articles RSC - Lab Chip latest articles

  • Acoustic quasi-periodic bioassembly based diverse stem cell arrangements for differentiation guidance
    by Xiaoqi Gao on September 28, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00448A, PaperXiaoqi Gao, Xuejia Hu, Dongyong Yang, Qinghao Hu, Jingjing Zheng, Shukun Zhao, Chengliang Zhu, Xuan Xiao, Yi YangCellular arrangements with diverse patterns and positional relationships are obtained simultaneously and contactlessly by quasi-periodic acoustic tweezers for differentiation guidance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Portable rotary PCR system for real-time detection of Pseudomonas aeruginosa in milk
    by Weidu Song on September 28, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00401E, PaperWeidu Song, Chuanhao Zhang, Huichao Lin, Taiyi Zhang, Haixia Liu, Xiaowen HuangA PCR solution is heated by hot air between two heating blocks.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Real-time continuous monitoring of dynamic concentration profiles studied with biosensing by particle motion
    by Max H. Bergkamp on September 28, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00410D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Max H. Bergkamp, Sebastian Cajigas, Leo J. van IJzendoorn, Menno W. J. PrinsReal-time monitoring-and-control of biological systems requires lab-on-a-chip sensors that are able to accurately measure concentration–time profiles with a well-defined time delay and accuracy using only small amounts of sampled fluid.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]

  • A Biomimetic Renal Fibrosis Progression Model On-chip Evaluates Anti-Fibrotic Effects Longitudinally in a Dynamic Fibrogenic Niche
    by Di Wu on September 27, 2023 at 11:00 pm

    Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D3LC00393K, PaperDi Wu, Jianguo Wu, Hui Liu, Shengyu Shi, Liangwen Wang, Yixiao Huang, Xiaorui Yu, Zhuoyue Lei, Tanliang Ouyang, Jia Shen, Guohua Wu, Shuqi WangAlthough renal fibrosis can advance chronic kidney disease and progressively lead to end-stage renal failure, no effective anti-fibrotic drugs have been clinically approved. To aid drug development, we developed a...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Retraction: A new polymer lab-on-a-chip (LOC) based on a microfluidic capillary flow assay (MCFA) for detecting unbound cortisol in saliva
    by Vinitha T. U. on September 27, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC90089D, Retraction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Vinitha T. U., Sthitodhi Ghosh, Alexander Milleman, Thinh Nguyen, Chong H. AhnTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system
    by Vinny Negi on September 26, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00285C, PaperVinny Negi, Dillon Gavlock, Mark T. Miedel, Jeong Kyung Lee, Tongying Shun, Albert Gough, Lawrence Vernetti, Andrew M. Stern, D. Lansing Taylor, Vijay K. YechoorHuman Liver-on-a-chip microphysiological system was developed to model and COVID-19 infection in T2D patients and to screen drugs to mitigate cytokine storm syndrome and expedite drug development.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Millifluidic valves and pumps made of tape and plastic
    by Josue U. Amador-Hernandez on September 24, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00559C, PaperJosue U. Amador-Hernandez, Pablo E. Guevara-Pantoja, Diana F. Cedillo-Alcantar, Gabriel A. Caballero-Robledo, Jose L. Garcia-CorderoWe report millimeter-scale valves and pumps made of plastic and bonded with double-sided tape. Our manufacturing approach opens a path to mass-manufacture these fluidic elements in integrated milli-and micro-fluidic devices.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A monolithic microfluidic probe for ambient mass spectrometry imaging of biological tissues
    by Lixue Jiang on September 24, 2023 at 11:00 pm

    Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D3LC00637A, PaperLixue Jiang, Matthias Polack, Xiangtang Li, Manxi Yang, Detlev Belder, Julia LaskinAmbient mass spectrometry imaging (MSI) is a powerful technique that allows for the simultaneous mapping of hundreds of molecules in biological samples under atmospheric conditions, requiring minimal sample preparation. We...The content of this RSS Feed (c) The Royal Society of Chemistry

  • An all-in-one platform to deplete pathogenic bacteria for rapid and safe enrichment of plant-derived extracellular vesicles
    by Zhihao Wen on September 19, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00585B, PaperZhihao Wen, Jianning Yu, Hyorim Jeong, Dong-Uk Kim, Ji Yeong Yang, Kyung-A Hyun, Seoyeon Choi, Sunyoung Park, Hyo-Il JungAn all-in-one platform efficiently removed impurities, including pathogenic bacteria, from extracellular vesicles derived from liquorice (LdEVs). The resulting purified LdEVs hold promise for applications in cosmetics and therapeutics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • High-throughput adjustable deformability cytometry utilizing elasto-inertial focusing and virtual fluidic channel
    by Zheng Zhou on September 19, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00591G, PaperZheng Zhou, Chen Ni, Zhixian Zhu, Yao Chen, Zhonghua Ni, Nan XiangWe propose a high-throughput adjustable deformability cytometry system with three-dimensional elasto-inertial focusing and a virtual fluidic channel, enabling the fast mechanical phenotyping of various biological cells.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Islet-on-chip: promotion of islet health and function via encapsulation within a polymerizable fibrillar collagen scaffold
    by Emma L. Vanderlaan on September 18, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00371J, PaperEmma L. Vanderlaan, Joshua Sexton, Carmella Evans-Molina, Adrian Buganza Tepole, Sherry L. Voytik-HarbinWe present a novel, 3D-printed microphysiological system for performing multiparametric studies of islet health. Recreating components of the in vivo microenvironment via a fibrillar collagen scaffold supports long-term survival and function ex vivo.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Ultra-thin and ultra-porous nanofiber networks as a basement-membrane mimic
    by Philip M. Graybill on September 18, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00304C, PaperPhilip M. Graybill, Edward J. Jacobs, Aniket Jana, Atharva Agashe, Amrinder S. Nain, Rafael V. DavalosA high porosity (88%) and ultrathin (<3 μm) fibrous basement membrane mimic using (A) suspended nanofiber networks for a (B) brain endothelial–pericyte co-culture model. (C) Our approach achieved low cell membrane and nuclei separations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Development of a perfusable, hierarchical microvasculature-on-a-chip model
    by Sophia W. Chen on September 18, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00512G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sophia W. Chen, Adriana Blazeski, Shun Zhang, Sarah E. Shelton, Giovanni S. Offeddu, Roger D. KammIn this study, we have created a multi-compartmental model replicating a hierarchical vascular bed by combining two methods for vessel-on-chip preparation: viscous finger patterning and self-assembled vascular networks.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]

  • Mechanism and kinetics of enzymatic degradation of polyester microparticles using a shrinking particle–shrinking core model
    by Hooman Torabi on September 17, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00581J, PaperHooman Torabi, Farhad Javi, Ted W. Deisenroth, Toan V. Pho, Victoria Barbright, Alireza AbbaspourradGeneralized shrinking particle (SPM) and shrinking core (SCM) models were developed to describe the kinetics of heterogenous enzymatic degradation of polymer microparticles in a continuous microflow system.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic single-cell migration chip reveals insights into the impact of extracellular matrices on cell movement
    by Mengli Zhou on September 17, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00651D, PaperMengli Zhou, Yushu Ma, Edwin C. Rock, Chun-Cheng Chiang, Kathryn E. Luker, Gary D. Luker, Yu-Chih ChenCell migration in a microfluidic channel coated with various ECMs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Enhanced cardiomyocyte structural and functional anisotropy through synergetic combination of topographical, conductive, and mechanical stimulation
    by Jongyun Kim on September 17, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00451A, PaperJongyun Kim, Arunkumar Shanmugasundaram, Cheong Bin Lee, Jae Rim Kim, Jeong Jae Park, Eung-Sam Kim, Bong-Kee Lee, Dong-Weon LeeDrug-induced cardiotoxicity, a significant concern in the pharmaceutical industry, often results in the withdrawal of drugs from the market.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • In situ synthesis of [Cu(BODN)·5H2O]n@nano-Al composite energetic films with tunable properties in pyro-MEMS
    by Wei Liu on September 14, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00282A, PaperWei Liu, Yongan Feng, Yapeng Yao, Zihang Liang, Fei Xiao, Zhongliang Ma[Cu(BODN)·5H2O]n@nano-Al energetic films were successfully fabricated by the in situ reaction method and drop-coating method, which may break through the bottleneck of incompatibility between traditional ignition agents and MEMS processes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic double emulsion platform for spatiotemporal control of pH and particle synthesis
    by Maheen Rana on September 14, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00711A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maheen Rana, Raheel Ahmad, Annette F. TaylorThe temporal control of pH in microreactors such as emulsion droplets plays a vital role in applications including biomineralisation and microparticle synthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Efficient filter-in-centrifuge separation of low-concentration bacteria from blood
    by Kaiyang Zeng on September 14, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4334-4342DOI: 10.1039/D3LC00594A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kaiyang Zeng, Mohammad Osaid, Wouter van der WijngaartSeptic blood centrifugation over an inclined filter efficiently separates bacteria from blood cells at clinically relevant concentrations.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Bubble-particle dynamics in multiphase flow of capillary foams in a porous micromodel
    by Omotola Okesanjo on September 13, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00419H, PaperOmotola Okesanjo, Guillaume Aubry, Sven Behrens, Hang Lu, J. Carson MeredithSurfactant-free capillary foams (CFs) are known to be remarkably tolerant to oil, and possess unique stability and flow properties, studied here for the first time in poros media.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic mechano-chemostat for tissues and organisms reveals that confined growth is accompanied with increased macromolecular crowding
    by Zacchari Ben Meriem on September 13, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00313B, PaperZacchari Ben Meriem, Tiphaine Mateo, Julien Faccini, Céline Denais, Romane Dusfour-Castan, Catherine Guynet, Tatiana Merle, Magali Suzanne, Mickaël Di-Luoffo, Julie Guillermet-Guibert, Baptiste Alric, Sylvain Landiech, Laurent Malaquin, Fabien Mesnilgrente, Adrian Laborde, Laurent Mazenq, Rémi Courson, Morgan DelarueStructure sliding-elements allow for 3D culture of tissues, organisms or 3D multicellular organisms in microfluidic systems.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]

  • Acoustofluidics for simultaneous droplet transport and centrifugation facilitating ultrasensitive biomarker detection
    by Jingui Qian on September 12, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4343-4351DOI: 10.1039/D3LC00626C, PaperJingui Qian, Huaize Lan, Liang Huang, Shaohui Zheng, Xuefeng Hu, Minghui Chen, Joshua E.-Y. Lee, Wei ZhangAn orthogonal tunable acoustic tweezer enables simultaneous droplet transport and centrifugation facilitating ultrasensitive miRNA biomarker detection.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Magnetofluid-integrated biosensors based on DNase-dead Cas12a for visual point-of-care testing of HIV-1 by an up and down chip
    by Di Huang on September 10, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4265-4275DOI: 10.1039/D3LC00558E, PaperDi Huang, Yekai Zhao, Mengjun Fang, Peijie Shen, Hu Xu, Yichen He, Shengfu Chen, Zhenjun Si, Zhinan XuMagnetofluid-integrated biosensors based on DNase-dead Cas12a termed “up and down chip” was established for visual point-of-care testing of HIV-1.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A low-temperature digital microfluidic system used for protein–protein interaction detection
    by Jienan Shen on September 10, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00386H, PaperJienan Shen, Jiaqi Liao, Huiying Liu, Chunyan Liu, Chonghao Li, Hao Cheng, Hui Yang, Hong ChenA low-temperature digital microfluidic (LTDMF) system-based PPI detection box.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A New Tissue-Agnostic Microfluidic Device to model physiology and disease: The Lattice Platform
    by Hannes Campo on September 10, 2023 at 11:00 pm

    Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D3LC00378G, PaperHannes Campo, Didi Zha, Pawat Pattarawat, Jose Colina, Delong Zhang, Alina Murphy, Julia Yoon, Angela Russo, Hunter B. Rogers, Hoi Chang Lee, Jiyang Zhang, Katy Trotter, Sarah Wagner, Asia Ingram, Mary Ellen Pavone, Sara Fernandez Dunne, Christina E. Boots, Margrit Urbanek, Shuo Xiao, Joanna E Burdette, Teresa K. Woodruff, J. Julie KimTo accurately phenocopy human biology in vitro, researchers have been reducing their dependence on standard, static two-dimensional (2D) cultures and instead are moving towards […]

  • A magnetically controlled microfluidic device for concentration dependent in vitro testing of anticancer drug
    by Vinit Kumar Yadav on September 7, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4352-4365DOI: 10.1039/D3LC00495C, PaperVinit Kumar Yadav, Preetha Ganguly, Prashant Mishra, Samaresh Das, Dhiman MallickA magnetic–microfluidic device integrated with multi-wells capable of culturing mammalian cells is developed for concentration-dependent compartmentalization of anticancer-drugs and testing their efficacy.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Celebrating the 30th anniversary of a pioneering microfluidics paper
    by Z. Hugh Fan on September 6, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4157-4159DOI: 10.1039/D3LC90076B, EditorialZ. Hugh Fan, D. Jed HarrisonWe mark the 30th anniversary of the Science paper by Harrison et al. that is often credited for helping establish microfluidics as a research field.The content of this RSS Feed (c) The Royal Society of Chemistry

  • LoCKAmp: lab-on-PCB technology for <3 minute virus genetic detection
    by Sotirios Papamatthaiou on September 6, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00441D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sotirios Papamatthaiou, James Boxall-Clasby, Edward J. A. Douglas, Pawel Jajesniak, Hadrien Peyret, June Mercer-Chalmers, Varun K. S. Kumar, George P. Lomonossoff, Julien Reboud, Maisem Laabei, Jonathan M. Cooper, Barbara Kasprzyk-Hordern, Despina MoschouLoCKAmp: integrated LAMP genetic amplification device demonstrating reliable detection and ultrafast sample-to-answer time.To cite this article before page numbers are assigned, […]

  • Reverse flow enhanced inertia pinched flow fractionation
    by Saijie Wang on September 5, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4324-4333DOI: 10.1039/D3LC00473B, PaperSaijie Wang, Quanchen Xu, Zhihan Zhang, Shengbo Chen, Yizhou Jiang, Zhuowei Feng, Dou Wang, Xingyu JiangBy setting the reverse flow channel at the end of the abruptly broadened segment, the flow field can be fundamentally changed, and the separation performance can be improved comprehensively compared with the traditional iPFF device.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Correction: Design and validation of a flowless gradient generating microfluidic device for high-throughput drug testing
    by Ketaki Bachal on September 5, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4366-4366DOI: 10.1039/D3LC90080K, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ketaki Bachal, Shital Yadav, Prasanna Gandhi, Abhijit MajumderThe content of this RSS Feed (c) The Royal Society of Chemistry

  • Scalable mesenchymal stem cell enrichment from bone marrow aspirate using deterministic lateral displacement (DLD) microfluidic sorting
    by Nicholas Tan Kwan Zen on September 5, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4313-4323DOI: 10.1039/D3LC00379E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nicholas Tan Kwan Zen, Kerwin Kwek Zeming, Kim Leng Teo, Mavis Loberas, Jialing Lee, Chin Ren Goh, Da Hou Yang, Steve Oh, James Hui Hoi Po, Simon M. Cool, Han Wei Hou, Jongyoon HanMSCs are enriched twice more efficiently with 10-fold shorten processing time from undiluted human bone marrow aspirate.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Design of a multilayer lung chip with multigenerational alveolar ducts to investigate the inhaled particle deposition
    by Yan Qiu on September 5, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4302-4312DOI: 10.1039/D3LC00253E, PaperYan Qiu, Chao Lu, Fubing Bao, Guoqing HuWe present a multilayer lung chip to mimic passive breathing and highlight its potential as an innovative, cost-effective, and ethical approach to study aerosol deposition for health assessment and drug delivery in the lung.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Distal renal tubular system-on-a-chip for studying the pathogenesis of influenza A virus-induced kidney injury
    by Yueyue Huangfu on September 3, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4255-4264DOI: 10.1039/D3LC00616F, PaperYueyue Huangfu, Ji Wang, Jiao Feng, Zhi-Ling ZhangThe intelligence of viruses is unveiled in this study utilizing a distal renal tubular system-on-a-chip, demonstrating their ability to rapidly spread through tissues.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Ultrathin SU-8 membrane for highly efficient tunable cell patterning and massively parallel large biomolecular delivery
    by Pallavi Shinde on August 31, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00244F, PaperPallavi Shinde, Ashwini Shinde, Srabani Kar, Kavitha Illath, Moeto Nagai, Fan-Gang Tseng, Tuhin Subhra SantraMassively parallel high throughput single-cell intracellular delivery using infrared light pulses activated titanium micro-ring (TMR) device.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Reflow-molded deep concave microwell arrays for robust and large-scale production of embryoid bodies
    by Xue Han on August 31, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00504F, PaperXue Han, Qi Zhang, Hui He, Qiang Zhao, Gang LiAn extremely simple, feasible, and economical method for preparing high-quality and deep concave microwell arrays is presented for robustly producing homogeneous EBs on a large scale.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Micro- and nanosystems for the detection of hemorrhagic fever viruses
    by Mengdi Bao on August 28, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4173-4200DOI: 10.1039/D3LC00482A, Critical ReviewMengdi Bao, Jacob Waitkus, Li Liu, Yu Chang, Zhiheng Xu, Peiwu Qin, Juhong Chen, Ke DuHemorrhagic fever viruses (HFVs) are virulent pathogens that can cause severe and often fatal illnesses in humans.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Advances in miniaturized nanosensing platforms for analysis of pathogenic bacteria and viruses
    by Abdallah M. Zeid on August 28, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4160-4172DOI: 10.1039/D3LC00674C, Critical ReviewAbdallah M. Zeid, Islam M. Mostafa, Baohua Lou, Guobao XuIntegration of smart miniaturized nanosensors with artificial intelligence results in precise detection of pathogenic bacteria or viruses in biological samples.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Full-electric microfluidic platform to capture, analyze and selectively release single cells
    by Ruben Van den Eeckhoudt on August 28, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4276-4286DOI: 10.1039/D3LC00645J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ruben Van den Eeckhoudt, An-Sofie Christiaens, Frederik Ceyssens, Vasileios Vangalis, Kevin J. Verstrepen, Nico Boon, Filip Tavernier, Michael Kraft, Irene TaurinoSingle-cell capture and analysis with full-electric microfluidic device.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Acoustofluidic lysis of cancer cells and Raman spectrum profiling
    by Hyeono Nam on August 27, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4117-4125DOI: 10.1039/D3LC00550J, PaperHyeono Nam, Jong-Eun Park, Waqas Waheed, Anas Alazzam, Hyung Jin Sung, Jessie S. JeonAcoustofluidic cancer cell lysis and particle mixing facilitate Raman spectrum profiling.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Light-manipulated binary droplet transport on a high-energy surface
    by Wei Li on August 27, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4287-4301DOI: 10.1039/D3LC00582H, PaperWei Li, Dongliang Li, Xun Zhu, Dingding Ye, Yang Yang, Hong Wang, Rong Chen, Qiang LiaoA light strategy for flexible and precise manipulation of binary droplet transport on high-energy surface by localized photothermal effect.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A single-molecule study on polymer fluid dynamics in porous media
    by Antonia Sugar on August 22, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4104-4116DOI: 10.1039/D3LC00467H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Antonia Sugar, Maged Serag, Ulrich Buttner, Satoshi Habuchi, Hussein HoteitUnderstanding the dynamic behavior of polymeric fluids in porous media is essential for vast geoscience applications, particularly enhanced oil recovery and polymer-enhanced soil washing, to clean up soil contamination.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic organotypic device to test intestinal mucosal barrier permeability ex vivo
    by Amanda E. Cherwin on August 21, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4126-4133DOI: 10.1039/D3LC00615H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Amanda E. Cherwin, Hayley N. Templeton, Alexis T. Ehrlich, Brielle H. Patlin, Charles S. Henry, Stuart A. TobetThis study expands the utilization of an ex vivo dual flow microfluidic device to create a model of leaky gut using bacterial collagenase.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Is AI essential? Examining the need for deep learning in image-activated sorting of Saccharomyces cerevisiae
    by Mika Hayashi on August 21, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4232-4244DOI: 10.1039/D3LC00556A, PaperMika Hayashi, Shinsuke Ohnuki, Yating Tsai, Naoko Kondo, Yuqi Zhou, Hongqian Zhang, Natsumi Tiffany Ishii, Tianben Ding, Maik Herbig, Akihiro Isozaki, Yoshikazu Ohya, Keisuke GodaWe experimentally justify the advantages of jumping on the deep learning trend for image-activated budding yeast sorting and validate its applicability towards morphology-based yeast mutant screening.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Continuous-flow macromolecular sieving in slanted nanofilter array: stochastic model and coupling effect of electrostatic and steric hindrance
    by Sung Hee Ko on August 21, 2023 at 11:00 pm

    Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00405H, PaperSung Hee Ko, Pyeong Jun Park, Jongyoon HanThis paper elucidates the characteristics of macromolecule dynamics in a two-dimensional slanted nanofilter array (SNA) using DNA as a model molecule, a closed-form analytical solution and systematical experiments.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Capacitive platform for real-time wireless monitoring of liquid wicking in a paper strip
    by Isidoro Ruiz-García on August 20, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4092-4103DOI: 10.1039/D3LC00368J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Isidoro Ruiz-García, Pablo Escobedo, Celia E. Ramos-Lorente, Miguel M. Erenas, Luis F. Capitán-Vallvey, Miguel A. Carvajal, Alberto J. Palma, Nuria López-RuizWireless electronic platform for real-time flow monitoring in paper strips. Experimental/numerical study for physical-based modelling of capillary-driven flow dynamics.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Additive manufacturing leveraged microfluidic setup for sample to answer colorimetric detection of pathogens
    by Sripadh Guptha Yedire on August 20, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4134-4145DOI: 10.1039/D3LC00429E, PaperSripadh Guptha Yedire, Imman Isaac Hosseini, Hamed Shieh, Arash Khorrami Jahromi, Tamer AbdelFatah, Mahsa Jalali, Sara MahshidAdditive manufacturing leveraged automated sample-answer microfluidic setup for colorimetric detection of pathogen.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Design and build a green tent environment for growing and charactering mycelium growth in lab
    by Libin Yang on August 17, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4044-4051DOI: 10.1039/D3LC00336A, PaperLibin Yang, Ruohan Xu, Anushka Joardar, Michael Amponsah, Nina Sharifi, Bing Dong, Zhao QinA customized green tent with thermal/humidity control and data logger. We grow mycelium from spores to fibrous networks within the tent. Mycelium fibers grown on the hardwood and the hydrogel are found to have no difference in diameter.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies
    by Charlotte Bouquerel on August 17, 2023 at 11:00 pm

    Lab Chip, 2023, 23,3906-3935DOI: 10.1039/D3LC00531C, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Charlotte Bouquerel, Anastasiia Dubrova, Isabella Hofer, Duc T. T. Phan, Moencopi Bernheim, Ségolène Ladaigue, Charles Cavaniol, Danilo Maddalo, Luc Cabel, Fatima Mechta-Grigoriou, Claire Wilhelm, Gérard Zalcman, Maria Carla Parrini, Stéphanie DescroixWe present a multidisciplinary perspective by bringing together physicists, biologists, clinicians, and experts from pharmaceutical companies. We conducted an extensive […]

  • Sample preconcentration through airjet-induced liquid phase enrichment
    by Edward Wang on August 16, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4033-4043DOI: 10.1039/D3LC00481C, PaperEdward Wang, Louise C. Laurent, Drew A. Hall, Yu-Hwa LoAn evaporative, airjet-based method which reverses the coffee-ring and enables enrichment of diverse molecules and particles in liquids. The method is used as sample preconcentration step for improved detection performance in nucleic acids assays.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Tunable resins with PDMS-like elastic modulus for stereolithographic 3D-printing of multimaterial microfluidic actuators
    by Alireza Ahmadianyazdi on August 15, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4019-4032DOI: 10.1039/D3LC00529A, PaperAlireza Ahmadianyazdi, Isaac J. Miller, Albert FolchWe introduce high-elasticity photopolymers based on a low-viscosity tunable blend of the monomers poly(ethylene glycol) diacrylate (PEGDA, Mw ∼ 258) and the monoacrylate poly(ethylene glycol methyl ether) methacrylate (PEGMEMA, Mw ∼ 300) for SLA printing of multimaterial microfluidic actuators.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic membraneless microbial fuel cells: new protocols for record power densities
    by Nastaran Khodaparastasgarabad on August 14, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4201-4212DOI: 10.1039/D3LC00387F, PaperNastaran Khodaparastasgarabad, Jayesh M. Sonawane, Haleh Baghernavehsi, Lingling Gong, Linlin Liu, Jesse GreenerThe most advanced microfluidic microbial fuel cell to date incorporates new design parameters to control practical challenges associated with membaneless format, while new normalization protocols enable comparisons with systems at any scale.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Fabrication of a self-assembled and vascularized tumor array via bioprinting on a microfluidic chip
    by Gihyun Lee on August 13, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4079-4091DOI: 10.1039/D3LC00275F, PaperGihyun Lee, Soo Jee Kim, Je-Kyun ParkThis paper describes a novel integrative technology to fabricate a self-assembled and vascularized tumor array via bioprinting on a microfluidic chip for the recreation of a tumor microenvironment.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microscale system for in situ investigation of immobilized microalgal cell resistance against liquid flow in the early inoculation stage
    by C. Y. Tong on August 13, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4052-4066DOI: 10.1039/D3LC00415E, PaperC. Y. Tong, Huai Z. Li, C. J. C. DerekA 3D-coordinate system accurately predicted microalgal cell detachment and cohesion under the combined effect of reactor geometry and hydrodynamic conditions.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Label-free virtual staining of neutrophil extracellular traps (NETs) in microfluidics
    by Chayakorn Petchakup on August 13, 2023 at 11:00 pm

    Lab Chip, 2023, 23,3936-3944DOI: 10.1039/D3LC00398A, CommunicationChayakorn Petchakup, Siong Onn Wong, Rinkoo Dalan, Han Wei HouA virtual staining using convolutional neural networks was used to facilitate label-free quantification of NETs trapped in a microfluidic device based on morphological features in phase-contrast images.The content of this RSS Feed (c) The Royal Society of Chemistry

  • In situ measurement of viscoelastic properties of cellular monolayers via graphene strain sensing of elastohydrodynamic phenomena
    by Tianzheng Guo on August 13, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4067-4078DOI: 10.1039/D3LC00457K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tianzheng Guo, Xiaoyu Zou, Shalini Sundar, Xinqiao Jia, Charles DhongWe developed a new technique to measure the viscoelasticity of cellular monolayers in situ. To demonstrate, we tracked mechanical changes during trypsinization which occurs over minutes, and phenotypic changes from HGF which occurs over days.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Material-level countermeasures for securing microfluidic biochips
    by Navajit Singh Baban on August 13, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4213-4231DOI: 10.1039/D3LC00335C, PaperNavajit Singh Baban, Sohini Saha, Sofija Jancheska, Inderjeet Singh, Sachin Khapli, Maksat Khobdabayev, Jongmin Kim, Sukanta Bhattacharjee, Yong-Ak Song, Krishnendu Chakrabarty, Ramesh KarriWe present novel material-level countermeasures in the form of watermarking and machine learning-based solutions that biochip companies can effectively utilize to secure their products against malicious and intellectual property (IP) theft attacks.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Artificial intelligence-accelerated high-throughput screening of antibiotic combinations on a microfluidic combinatorial droplet system
    by Deyu Yang on August 13, 2023 at 11:00 pm

    Lab Chip, 2023, 23,3961-3977DOI: 10.1039/D3LC00647F, PaperDeyu Yang, Ziming Yu, Mengxin Zheng, Wei Yang, Zhangcai Liu, Jianhua Zhou, Lu HuangAn artificial intelligence-accelerated high-throughput combinatorial drug evaluation system was developed for rapid screening of antibiotic combinations and their dosage regimens.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Chitosan: a green adhesive for surface functionalization and fabrication of thermoplastic biomedical microdevices
    by Kieu The Loan Trinh on August 10, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4245-4254DOI: 10.1039/D3LC00500C, PaperKieu The Loan Trinh, Duc Anh Thai, Da Hyun Yang, Nae Yoon LeeA green chitosan adhesive was introduced for the robust bonding of thermoplastic microfluidic devices for biomedical applications. The biocompatible chitosan supported stable cell culture and promoted DNA purification for point-of-care testing.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Micro X-ray fluorescence reveals pore space details and spatially-resolved porosity of rock-based microfluidic devices
    by Laura Frouté on August 9, 2023 at 11:00 pm

    Lab Chip, 2023, 23,3978-3988DOI: 10.1039/D3LC00394A, PaperLaura Frouté, Kelly M. Guan, Wenbing Yun, Sylvia J. Y. Lewis, Benjamin D. Stripe, Xiaolin Yang, Alexandre Lapene, Anthony R. Kovscek, Patrice CreuxMicro X-ray fluorescence produces elemental images at μm resolution and offers insight into rock properties such as mineral composition and structure. This study presents a porosity mapping method using microfluidic devices and real-rock models.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Generating signals at converging liquid fronts to create line-format readouts of soluble assay products in three-dimensional paper-based devices
    by Ibrahim H. Abdullah on August 8, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4010-4018DOI: 10.1039/D3LC00511A, PaperIbrahim H. Abdullah, Daniel J. Wilson, Andrea C. Mora, Rayleigh W. Parker, Charles R. MaceA new class of paper-based microfluidic devices capable of detecting single or multiple analytes by forming colorimetric signals at the interface of converging liquid fronts.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Probing membrane hydration in microfluidic polymer electrolyte membrane electrolyzers via operando synchrotron Fourier-transform infrared spectroscopy
    by Kevin Krause on August 6, 2023 at 11:00 pm

    Lab Chip, 2023, 23,4002-4009DOI: 10.1039/D3LC00380A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kevin Krause, Marine Garcia, Dominique Michau, Gérald Clisson, Brant Billinghurst, Jean-Luc Battaglia, Stéphane ChevalierThe hydration of the proton exchange membrane (PEM) in water-splitting electrolyzers has been directly linked to improved performance. We present a novel platform for characterizing the PEM hydration in operando via synchrotron infrared spectroscopy.The content of this RSS Feed (c) The Royal […]

  • Contactless acoustic tweezer for droplet manipulation on superhydrophobic surfaces
    by Tao Luo on July 24, 2023 at 11:00 pm

    Lab Chip, 2023, 23,3989-4001DOI: 10.1039/D3LC00365E, PaperTao Luo, Sirui Liu, Rui Zhou, Chen Zhang, Dongyang Chen, Yi Zhan, Qilin Hu, Xi He, Yu Xie, Zhijie Huan, Wendi Gao, Ruirui Li, Gongfa Yuan, Yancheng Wang, Wei ZhouA contact acoustic tweezer uses a single ultrasound transducer to move droplets on superhydrophobic surfaces with great simplicity, versatility, and controllability.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic device with reconfigurable spatial temporal gradients reveals plastic astrocyte response to stroke and reperfusion
    by Catherine A. Reed-McBain on July 6, 2023 at 11:00 pm

    Lab Chip, 2023, 23,3945-3960DOI: 10.1039/D3LC00276D, PaperCatherine A. Reed-McBain, Rithvik V. Turaga, Seth R. T. Zima, Sara Abizanda Campo, Jeremiah Riendeau, Emmanuel Contreras Guzman, Terry D. Juang, Duane S. Juang, David W. Hampton, Melissa C. Skala, Jose M. AyusoNovel microphysiological platform permitting spatial temporal gradients reveals astrocyte placticity.The content of this RSS Feed (c) The Royal Society of Chemistry

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