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RSC - Lab Chip latest articles RSC - Lab Chip latest articles

  • Non-small cell lung carcinoma spheroid models in agarose microwells for drug response studies
    by Qiyue Luan on May 12, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00244B, PaperQiyue Luan, Jeffrey H. Becker, Celine Macaraniag, Malek G. Massad, Jian Zhou, Takeshi Shimamura, Ian PapautskyAn agarose microwell platform developed for in vitro lung carcinoma spheroid culture and drug response evaluation of targeted anti-cancer therapies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Tuning particle inertial separation in sinusoidal channels by embedding periodic obstacle microstructures
    by HAOTIAN CHA on May 12, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00197G, PaperHAOTIAN CHA, Hedieh Fallahi, Yuchen Dai, Sharda Yadav, Samith Hettiarachchi , Antony P. McNamee, Hongjie An, Nan Xiang, Nam-Trung Nguyen, Jun ZhangInertial microfluidics functions solely based on fluid dynamics at relatively high flow speed. Thus, channel geometry is the critical design parameter that contributes to the performance of the device. Four...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Engineering Cell-Substrate Interactions on Porous Membranes for Microphysiological Systems
    by Zahra Allahyari on May 12, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00114D, PerspectiveZahra Allahyari, Thomas R GaborskiMicrophysiological systems are now widely used to recapitulate physiological and pathological microenvironments in order to study and understand a variety of cellular processes as well as drug delivery and stem...The content of this RSS Feed (c) The Royal Society of Chemistry

  • High-throughput digital pathology via a handheld, multiplexed, and AI-powered ptychographic whole slide scanner
    by Guoan Zheng on May 11, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00084A, PaperGuoan Zheng, Shaowei Jiang, Chengfei Guo, Pengming Song, Tianbo Wang, Ruihai Wang, Terrance Zhang, Qian Wu, Rishikesh PandeyThe recent advent of whole slide imaging (WSI) systems has moved digital pathology closer to diagnostic applications and clinical practices. Furthermore, integrating WSI with machine learning promises the growth of...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Recent Advances in Microfluidic Production of Functional Microcapsules by Multiple-Emulsion Templating
    by Ji-Won Kim on May 10, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00196A, Critical ReviewJi-Won Kim, Sang Hoon Han, Ye Hun Choi, Wahyu Martumpal Hamonangan, Yoonjin Oh, Shin-Hyun KimMultiple-emulsion drops have served as versatile templates to design functional microcapsules due to their core-shell geometry and multiple compartments. Microfluidics has been used for the elaborate production of multiple-emulsion drops...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Fluid shear stress in a logarithmic microfluidic device enhances cancer cell stemness marker expression
    by Sanat Kumar Dash on May 10, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D1LC01139A, PaperSanat Kumar Dash, Bamadeb Patra, Vineeta Sharma, Sarit K. Das, Rama Shanker VermaOur logarithmic microfluidic device shows the dependence of cancer metastasis, recurrence and drug resistance on fluid shear stress mechanotransduction in cancer microenvironment and circulation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • One-step assembly of barcoded planar microparticles for efficient readout of multiplexed immunoassay
    by Sang Wook Bae on May 9, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00174H, CommunicationSang Wook Bae, Daewon Lee, Hunjong Na, Jisung Jang, Sunghoon KwonBarcoded planar microparticles are suitable for developing cost-efficient multiplexed assays. But robustness and efficiency of the readout process still needs improvement. Here, we designed a one-step microparticle assembling chip that...The content of this RSS Feed (c) The Royal Society of Chemistry

  • A graphene oxide scaffold-encapsulated microcapsule for polysulfide-immobilized long life lithium–sulfur batteries
    by Xirong Lin on May 9, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00161F, PaperXirong Lin, Chaoyu Yang, Tianli Han, Jinjin Li, Zhonghua Chen, Haikuo Zhang, Kai Mu, Ting Si, Jinyun LiuA three-dimensional graphene oxide scaffold/sulfur composite-encapsulated microcapsule for lithium–sulfur batteries is developed through a microfluidic approach, which displays high electrochemical performance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Systematic characterization of effect of flow rates and buffer compositions on double emulsion droplet volumes and stability
    by Suzanne G.K. Calhoun on May 8, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00229A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Suzanne G.K. Calhoun, Kara Brower, Vinny Chandran Suja, Gaeun Kim, Ningning Wang, Alexandra L. McCully, Halim Kusumaatmaja, Gerald G. Fuller, Polly M FordyceDouble emulsion droplets (DEs) are water/oil/water droplets that can be sorted via Fluorescence-Activated Cell Sorting (FACS), allowing for new opportunities in high-throughput cellular analysis, enzymatic screening, and synthetic biology. These...The […]

  • Shape-based separation of drug-treated Escherichia coli using viscoelastic microfluidics
    by TIANLONG ZHANG on May 8, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00339B, PaperTIANLONG ZHANG, Hangrui Liu, Kazunori Okano, Tao Tang, Kazuki Inoue, Yoichi Yamazaki, Hironari Kamikubo, Amy K Cain, Yo Tanaka, David Inglis, Yoichiroh Hosokawa, Yalikun Yaxiaer, Ming LiHere, we achieve shape-based separation of drug-treated Escherichia coli (E. coli) by viscoelastic microfluidics. Since shape is critical for modulating biological functions of E. coli, the ability to prepare homogeneous...The content of this RSS Feed (c) The Royal Society of Chemistry

  • From saliva to SNP: non-invasive, point-of-care genotyping for precision medicine applications using recombinase polymerase amplification and giant magnetoresistive nanosensors
    by Ana Sofia de Olazarra on May 6, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00233G, PaperAna Sofia de Olazarra, Dana Lee Cortade, Shan X. WangWe present a portable, highly integrated platform that employs isothermal recombinase polymerase amplification and giant magnetoresistive nanosensors to perform multiplex SNP genotyping at the point-of-care.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Cellular point-of-care diagnostics using an inexpensive layer-stack microfluidic device
    by Kilean Lucas on May 5, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00162D, PaperKilean Lucas, Juhyun Oh, Jan Hoelzl, Ralph WeisslederPassively pumped layer stack microfluidics allow for simple, inexpensive cyclic imaging with reduced reagent usage.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Semi-automated preparation of fine-needle aspiration samples for rapid on-site evaluation
    by Filipe Marques on May 5, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00241H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Filipe Marques, Janosch Hauser, Emre Iseri, Igor Schliemann, Wouter van der Wijngaart, Niclas RoxhedA portable microfluidic sample preparation device that allows inexperienced personnel to perform ROSE of FNA samples.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic harvesting of breast cancer tumor spheroid-derived extracellular vesicles from immobilized microgels for single-vesicle analysis
    by Xilal Y. Rima on May 4, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D1LC01053K, PaperXilal Y. Rima, Jingjing Zhang, Luong TH Nguyen, Aaron Rajasuriyar, Min Jin Yoon, Chi-Ling Chiang, Nicole Walters, Kwang Joo Kwak, L.James Lee, Eduardo ReáteguiInvestigating cellular and vesicular heterogeneity in breast cancer remains a challenge, which encourages the development of controllable in vitro systems that mimic the tumor microenvironment. Although three-dimensional cell culture better...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Micro-PCR chip-based multifunctional ultrafast SARS-CoV-2 detection platform
    by Hao Yin on May 3, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00101B, PaperHao Yin, Zhaoduo Tong, Chuanjie Shen, Xin Xu, Hui Ma, Zhenhua Wu, Yong Qi, Hongju MaoBy using different customized microfluidic chips, a multifunctional rapid PCR platform allows fast screening of suspected cases within 15 min, followed by rapidly providing precise quantification of the SARS-CoV-2 virus.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Fundamentals, biomedical applications and future potential of micro-scale cavitation-a review
    by Seyedali Seyedmirzaei Sarraf on May 1, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00169A, Critical ReviewSeyedali Seyedmirzaei Sarraf, Farzad Rokhsar Talabazar, Ilayda Namli, Mohammadamin Maleki, Araz Sheibani Aghdam, Ghazaleh Gharib, Dmitry Grishenkov, Morteza Ghorbani, Ali KoşarA fundamental literature review of micro-scale cavitation and its applications for bio-related practices.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Sustained delivery of focal ischemia coupled to real-time neurochemical sensing in brain slices
    by Michael T. Cryan on May 1, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D1LC00908G, PaperMichael T. Cryan, Yuxin Li, Ashley E. RossA device capable of sustained local stimulation in tissue coupled to real-time electrochemical sensing was developed to study the impact of focal ischemia on local neurotransmission in the brain.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A Plantar Wearable Pressure Sensor Based on Hybrid Lead Zirconate-Titanate/Microfibrillated Cellulose Piezoelectric Composite Films for Human Health Monitoring
    by Yanfang Guan on May 1, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00051B, PaperYanfang Guan, Mingyang Bai, Qiuliang Li, Wujie Li, Guangyu Liu, Chunbo Liu, Yu Chen, Yang Lin, Yanbo Hui, Ronghan WeiFlexible and wearable electronic sensors hold great promise for improving the quality of life especially in the field of healthcare monitoring thanks to their low cost, flexibility, high electromechanical coupling...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Electrically-driven handling of gametes and embryos: taking a step towards the future of ARTs
    by Adriana Karcz on May 1, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D1LC01160J, Tutorial Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adriana Karcz, Ann Van Soom, Katrien Smits, Rik Verplancke, Sandra Van Vlierberghe, Jan VanfleterenElectric fields in in vitro processing of gametes and embryos: dielectrophoresis (DEP) and electrowetting on dielectric (EWOD).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples
    by Keisuke Oshimi on April 30, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00112H, PaperKeisuke Oshimi, Yushi Nishimura, Tsutomu Matsubara, Masuaki Tanaka, Eiji Shikoh, Li Zhao, Yajuan Zou, Naoki Komatsu, Yuta Ikado, Yuka Takezawa, Eriko Kage-Nakadai, Yumi Izutsu, Katsutoshi Yoshizato, Saho Morita, Masato Tokunaga, Hiroshi Yukawa, Yoshinobu Baba, Yoshio Teki, Masazumi FujiwaraThis on-chip device realizes large-area and predictable spin detection of fluorescent nanodiamonds, providing a scalable platform for quantum-sensor-based bioassay.To cite this article before page numbers are assigned, use the DOI form of citation […]

  • Lab-on-a-chip technologies for minimally invasive molecular sensing of diabetic retinopathy
    by Maria Vieira on April 28, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D1LC01138C, Critical ReviewMaria Vieira, Rosa Fernandes, António F. Ambrósio, Vanessa Cardoso, Mariana Carvalho, Peng Weng Kung, Miguel António Dias Neves, Inês Mendes PintoDiabetic retinopathy (DR) is the most common diabetic eye disease and the worldwide leading cause of vision loss in working-age adults.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • On the acoustically induced fluid flow in particle separation systems employing standing surface acoustic waves – Part II
    by Sebastian Sachs on April 28, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00106C, PaperSebastian Sachs, Christian Cierpka, Jörg KönigExperimental analysis of the acoustically induced fluid flow in the outer regions of a standing surface acoustic wave (sSAW) for varying sSAW wavelength, channel height and electrical power.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • On the acoustically induced fluid flow in particle separation systems employing standing surface acoustic waves – Part I
    by Sebastian Sachs on April 27, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D1LC01113H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sebastian Sachs, Mostafa Baloochi, Christian Cierpka, Jörg KönigExperimental and numerical studies on the acoustically induced fluid flow at the center of pseudo-standing surface acoustic waves, as typically employed in Lab-on-a-Chip devices for particle separation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]

  • Quantitative isothermal amplification on paper membranes using amplification nucleation site analysis
    by Benjamin P. Sullivan on April 26, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00007E, PaperBenjamin P. Sullivan, Yu-Shan Chou, Andrew T. Bender, Coleman D. Martin, Zoe G. Kaputa, Hugh March, Minyung Song, Jonathan D. PosnerWe report a novel method for the quantification of isothermal amplification reactions on paper membranes using discrete fluorescent amplification nucleation sites.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A tripodal wheeled mobile robot driven by a liquid metal motor
    by Rui Xue on April 24, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00267A, PaperRui Xue, Wenshang Guo, Ye Tao, Yukun RenAn 8-shaped tripodal wheeled mobile robot utilizing liquid metal motors as the core driving part is proposed herein. This robot can achieve three types of driving functions on a two-dimensional plane via wireless control.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • MicroRNA-21 expression in single living cells revealed by fluorescence and SERS dual-response microfluidic droplet platform
    by Dan Sun on April 22, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00096B, PaperDan Sun, Fanghao Cao, Xuan Yi, Hongyan Zhu, Guohua Qi, Weiqing Xu, Shuping XuSchematic diagram of the fluorescence and SERS dual-response microfluidic droplet system for encapsulating single cells and detecting miR-21.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Micro/Nano-fluidic devices and in vivo fluorescence imaging based on quantum dots for cytologic diagnosis- to be confirmed by the authors
    by Luo Minchuan on April 21, 2022 at 11:00 pm

    Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00113F, Critical ReviewLuo Minchuan, Hiroshi Yukawa, Yoshinobu BabaSemiconductor quantum dots (QDs) possess attractive merits over traditional organic dyes such as tunable emission, narrow emission spectra and good resistance against optical bleaching, which plays a vital role in...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Real-time monitoring of epithelial barrier function by impedance spectroscopy in a microfluidic platform
    by João Fernandes on April 21, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D1LC01046H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.João Fernandes, Nikita Karra, Joel Bowring, Riccardo Reale, Jonathan James, Cornelia Blume, Theresa J. Pell, Wendy C. Rowan, Donna E. Davies, Emily J. Swindle, Hywel MorganReal-time monitoring of epithelial barrier function by electrical impedance spectroscopy using a scalable and easy to use microfluidic platform.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]

  • In-line measurement of liquid–liquid phase separation boundaries using a turbidity-sensor-integrated continuous-flow microfluidic device
    by Paria Coliaie on April 21, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D1LC01112J, PaperParia Coliaie, Aditya Prajapati, Rabia Ali, Moussa Boukerche, Akshay Korde, Manish S. Kelkar, Nandkishor K. Nere, Meenesh R. SinghA novel turbidity-sensor-integrated microfluidic device is developed to quickly measure the liquid–liquid phase separation boundaries.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Extraction of small extracellular vesicles by label-free and biocompatible on-chip magnetic separation
    by Lin Zeng on April 19, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00217E, PaperLin Zeng, Shi Hu, Xi Chen, Pengcheng Zhang, Guoqiang Gu, Yuye Wang, Hongpeng Zhang, Yi Zhang, Hui YangSmall vesicles (sEVs) are closely related to many diseases as they carry various bio-markers. A label-free and biocompatible on-chip separation method based on negative magnetophoresis is presented for the extraction of sEVs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Integrated platform for culture, observation, and parallelized electroporation of spheroids
    by Pauline Bregigeon on April 19, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00074A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Pauline Bregigeon, Charlotte Rivière, Laure Franqueville, Christian Vollaire, Julien Marchalot, Marie Frénéa-RobinWe present a new microsystem enabling in vitro culture of hundreds of spheroids in hydrogel support, their monitoring and parallel electroporation. We demonstrate its relevance for electro-chemotherapy assays of increased reproducibility.To cite this article before page numbers are assigned, use the […]

  • A microreactor sealing method using adhesive tape for digital bioassays
    by Hideyuki Yaginuma on April 18, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00065B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hideyuki Yaginuma, Kuniko Ohtake, Takako Akamatsu, Hiroyuki Noji, Kazuhito V. TabataMicrodroplet formation using adhesive tape allows for easier digital bioassays.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Reagent free detection of SARS-CoV-2 using an antibody-based microwave sensor in a microfluidic platform
    by Weijia Cui on April 18, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00145D, PaperWeijia Cui, Pei Zhao, Jin Wang, Ning Qin, Emmanuel A. Ho, Carolyn L. RenSchematic of the microfluidic microwave detection of the SARS-CoV-2 virus. The detection relies on the frequency shift caused by the binding between the antibody coated on the microwave sensor and the SARS-CoV-2 antigen or virus.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Radiotherapy on-chip: microfluidics for translational radiation oncology
    by Rodin Chermat on April 12, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00177B, PerspectiveRodin Chermat, Maryam Ziaee, David Y. Mak, Elena Refet-Mollof, Francis Rodier, Philip Wong, Jean-François Carrier, Yuji Kamio, Thomas GervaisCurrent applications of radiotherapy on-a-chip in radiation physics and radiobiology and perspectives in translational radiobiology for cancer treatment.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Mainstreaming microfluidic microbial fuel cells: a biocompatible membrane grown in situ improves performance and versatility
    by Lingling Gong on April 11, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00098A, PaperLingling Gong, Mehran Abbaszadeh Amirdehi, Jayesh M. Sonawane, Nan Jia, Leon Torres de Oliveira, Jesse GreenerBucking the trend toward membraneless microbial fuel cells (MFC), a new approach to grow biocompatible separation membranes between electrodes is demonstrated. The result is the best performing system for pure culture Geobacter sulfurreducens.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A modular microfluidic platform to enable complex and customisable in vitro models for neuroscience
    by D. Megarity on April 11, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00115B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.D. Megarity, R. Vroman, M. Kriek, P. Downey, T. J. Bushell, M. ZagnoniBy manually assembling microfluidic modules, a variety of bespoke, in vitro brain models can be built for novel neuroscience research.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Cilo-seq: highly sensitive cell-in-library-out single-cell transcriptome sequencing with digital microfluidics
    by Qianqian Zhang on April 10, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00167E, PaperQianqian Zhang, Xing Xu, Li Lin, Jian Yang, Xing Na, Xin Chen, Lingling Wu, Jia Song, Chaoyong YangWe described Cilo-seq for high-performance scRNA-seq library construction in a single device with programmed and addressable droplet handling based on digital microfluidics, which allowed simultaneously convenient single-cell isolation, efficient nucleic acid amplification, low-loss nucleic acid purification and high-quality library preparation.To cite this article before page numbers are assigned, use the DOI form of citation […]

  • Temperature dependence of diffusiophoresis via a novel microfluidic approach
    by Parth R. Shah on April 10, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D1LC00916H, PaperParth R. Shah, Huanshu Tan, David Taylor, Xiaoyu Tang, Nan Shi, Afnan Mashat, Amr Abdel-Fattah, Todd M. SquiresOur manuscript uses a novel microfluidic approach to measure diffusiophoretic mobilities as a function of temperature, which match with the theoretical predictions based on electrophoretically measured zeta potentials.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Exponential magnetophoretic gradient for the direct isolation of basophils from whole blood in a microfluidic system
    by Nicolas Castaño on April 7, 2022 at 11:00 pm

    Lab Chip, 2022, 22,1690-1701DOI: 10.1039/D2LC00154C, PaperNicolas Castaño, Sungu Kim, Adrian M. Martin, Stephen J. Galli, Kari C. Nadeau, Sindy K. Y. TangWe developed a microfluidic platform for rapid immunomagnetic isolation of basophils directly from whole blood. Our 3D printed magnetic separation device imparts an exponentially increasing magnetic force field to remove tagged non-basophils.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Actuated 3D microgels for single cell mechanobiology
    by Berna Özkale on April 7, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00203E, PaperBerna Özkale, Junzhe Lou, Ece Özelçi, Alberto Elosegui-Artola, Christina M. Tringides, Angelo S. Mao, Mahmut Selman Sakar, David J. MooneyA mechanically active microgel platform for single cell mechanobiology is presented. Optically triggered nanoactuators generate isotropic compression in 3D microgels, leading to reversible and mechanosensitive calcium signaling in encapsulated MSCs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]

  • High-throughput and label-free enrichment of malignant tumor cells and clusters from pleural and peritoneal effusions using inertial microfluidics
    by Zhixian Zhu on April 7, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00082B, PaperZhixian Zhu, Shuang Li, Dan Wu, Hui Ren, Chen Ni, Cailian Wang, Nan Xiang, Zhonghua NiWe developed a polymer microfluidic chip with slanted spiral channels for high-throughput and label-free enrichment of malignant tumor cells and clusters from clinical effusions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Lab on a chip devices for fertility: from proof-of-concept to clinical impact
    by Reza Nosrati on April 6, 2022 at 11:00 pm

    Lab Chip, 2022, 22,1680-1689DOI: 10.1039/D1LC01144H, PerspectiveReza NosratiThis perspective provides an overview of microfluidics for fertility efforts with a particular focus on clinical applications and commercialization.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A large-volume sputum dry storage and transportation device for molecular and culture-based diagnosis of tuberculosis
    by Andrea Dsouza on April 6, 2022 at 11:00 pm

    Lab Chip, 2022, 22,1736-1747DOI: 10.1039/D1LC00900A, PaperAndrea Dsouza, Saylee Jangam, Shruti Soni, Priyanka Agarwal, Vishwanath Naik, J. Manjula, Chandrasekhar B. Nair, Bhushan J. ToleyWe present SPECTRA-tube (specimen transportation tube), a device that enables the dry stabilization and transportation of large volumes (>1 mL) of liquid specimens. We demonstrate its application in molecular and culture testing of tuberculosis.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Live single cell imaging assays in glass microwells produced by laser-induced deep etching
    by Niklas Sandström on April 6, 2022 at 11:00 pm

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00090C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Niklas Sandström, Ludwig Brandt, Patrick A. Sandoz, Chiara Zambarda, Karolin Guldevall, Malte Schulz-Ruhtenberg, Bernd Rösener, Robin A. Krüger, Björn ÖnfeltIn this work, we have used laser-induced deep etching of glass to produce unique designs of high-aspect ratio microwells and evaluated them in several different live single cell imaging assays.To cite this article before page numbers are assigned, use the DOI form of […]

  • Microscopic artificial cilia – a review
    by Tanveer ul Islam on April 3, 2022 at 11:00 pm

    Lab Chip, 2022, 22,1650-1679DOI: 10.1039/D1LC01168E, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tanveer ul Islam, Ye Wang, Ishu Aggarwal, Zhiwei Cui, Hossein Eslami Amirabadi, Hemanshul Garg, Roel Kooi, Bhavana B. Venkataramanachar, Tongsheng Wang, Shuaizhong Zhang, Patrick R. Onck, Jaap M. J. den ToonderBioinspired artificial cilia can provide microfluidic functions like flow generation, particle transport and flow sensing. This critical review broadly describes the progress in artificial cilia […]

  • Portable sample processing for molecular assays: application to Zika virus diagnostics
    by Tanya Narahari on March 30, 2022 at 11:00 pm

    Lab Chip, 2022, 22,1748-1763DOI: 10.1039/D1LC01068A, PaperTanya Narahari, Joshua Dahmer, Alexandros Sklavounos, Taehyeong Kim, Monika Satkauskas, Ioana Clotea, Man Ho, Julian Lamanna, Christopher Dixon, Darius G. Rackus, Severino Jefferson Ribeiro da Silva, Lindomar Pena, Keith Pardee, Aaron R. WheelerA digital microfluidic system was developed for portable Zika virus diagnosis, featuring integrated, automated sample extraction and amplification.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A self-contained and integrated microfluidic nano-detection system for the biosensing and analysis of molecular interactions
    by Xinwu Xie on March 29, 2022 at 11:00 pm

    Lab Chip, 2022, 22,1702-1713DOI: 10.1039/D1LC01056E, PaperXinwu Xie, Jinbiao Ma, Hao Wang, Zhen Cheng, Tie Li, Shixing Chen, Yaohua Du, Jianguo Wu, Can Wang, Xinxi XuA self-contained and integrated microfluidic nano-detection system was developed, demonstrating excellent performance for biosensing and analysis of molecular interactions.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Deciphering impedance cytometry signals with neural networks
    by Federica Caselli on March 24, 2022 at 12:00 am

    Lab Chip, 2022, 22,1714-1722DOI: 10.1039/D2LC00028H, PaperFederica Caselli, Riccardo Reale, Adele De Ninno, Daniel Spencer, Hywel Morgan, Paolo BisegnaA successful outcome of the coupling between microfluidics and AI: neural networks tackle the signal processing challenges of single-cell microfluidic impedance cytometry.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Emulating the chondrocyte microenvironment using multi-directional mechanical stimulation in a cartilage-on-chip
    by Carlo Alberto Paggi on March 23, 2022 at 12:00 am

    Lab Chip, 2022, 22,1815-1828DOI: 10.1039/D1LC01069G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Carlo Alberto Paggi, Jan Hendriks, Marcel Karperien, Séverine Le GacThe multi-directional mechanical stimulation experienced by cartilage during motion is transferred to chondrocytes, which respond by releasing matrix proteins and/or matrix-degrading enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Adhesive lift method for patterning arbitrary-shaped thin ion-selective films in micro/nanofluidic device
    by Myungjin Seo on March 18, 2022 at 12:00 am

    Lab Chip, 2022, 22,1723-1735DOI: 10.1039/D2LC00185C, PaperMyungjin Seo, Sungmin Park, Junghwan Ryu, Sung Jae KimWe presented a soft-lithographical nanofabrication method for patterning arbitrary-shaped ion-selective films in micro/nanofluidic device which mostly resembles practical system.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An antibiotic concentration gradient microfluidic device integrating surface-enhanced Raman spectroscopy for multiplex antimicrobial susceptibility testing
    by Shang-Jyun Lin on March 18, 2022 at 12:00 am

    Lab Chip, 2022, 22,1805-1814DOI: 10.1039/D2LC00012A, PaperShang-Jyun Lin, Po-Hsuan Chao, Ho-Wen Cheng, Juen-Kai Wang, Yuh-Lin Wang, Yin-Yi Han, Nien-Tsu HuangWe developed a microfluidic device to generate the concentration gradient of antibiotics along a series of lateral microwells to encapsulate bacteria and perform in situ multiplex surface-enhanced Raman scattering (SERS)-AST.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A star shaped acoustofluidic mixer enhances rapid malaria diagnostics via cell lysis and whole blood homogenisation in 2 seconds
    by Amir Pourabed on March 17, 2022 at 12:00 am

    Lab Chip, 2022, 22,1829-1840DOI: 10.1039/D2LC00195K, PaperAmir Pourabed, Thulya Chakkumpulakkal Puthan Veettil, Citsabehsan Devendran, Prasanna Nair, Bayden R. Wood, Tuncay AlanShear stresses generated by a silicon resonator embedded inside a microfluidic channel can rapidly and effectively lyse cells and homogenise whole blood. This significantly improves sensitivity of ATR-FTIR spectroscopy based diagnostic tests.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An epidermal wearable microfluidic patch for simultaneous sampling, storage, and analysis of biofluids with counterion monitoring
    by Brince Paul Kunnel on March 7, 2022 at 12:00 am

    Lab Chip, 2022, 22,1793-1804DOI: 10.1039/D2LC00183G, PaperBrince Paul Kunnel, Silvia DemuruAn epidermal, wearable bio-fluidic patch is demonstrated that facilitates simultaneous on-demand extraction, sampling, and storage of sweat and interstitial fluid (ISF) together with monitoring of their corresponding counterions.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Low-cost and rapid prototyping of integrated electrochemical microfluidic platforms using consumer-grade off-the-shelf tools and materials
    by Mohd Afiq Mohd Asri on February 28, 2022 at 12:00 am

    Lab Chip, 2022, 22,1779-1792DOI: 10.1039/D1LC01100F, PaperMohd Afiq Mohd Asri, Wing Cheung Mak, Siti Azizah Norazman, Anis Nurashikin NordinFabrication of laminated microfluidic devices with integrated electrochemical sensors using off-the-shelf tools and materials.The content of this RSS Feed (c) The Royal Society of Chemistry

  • High performance inkjet printed embedded electrochemical sensors for monitoring hypoxia in a gut bilayer microfluidic chip
    by Muhammad Asad Ullah Khalid on February 19, 2022 at 12:00 am

    Lab Chip, 2022, 22,1764-1778DOI: 10.1039/D1LC01079D, PaperMuhammad Asad Ullah Khalid, Kyung Hwan Kim, Abdul Rahim Chethikkattuveli Salih, Kinam Hyun, Sung Hyuk Park, Bohye Kang, Afaque Manzoor Soomro, Muhsin Ali, Yesl Jun, Dongeun Huh, Heeyeong Cho, Kyung Hyun ChoiHigh performance embedded electrochemical sensors fabricated with an inkjet printing system in a gut bilayer microfluidic chip monitored developmental and induced hypoxia.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic device and instrument prototypes for the detection of Escherichia coli in water samples using a phage-based bioluminescence assay
    by Luis F. Alonzo on January 28, 2022 at 12:00 am

    Lab Chip, 2022, Advance ArticleDOI: 10.1039/D1LC00888A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Luis F. Alonzo, Troy C. Hinkley, Andrew Miller, Ryan Calderon, Spencer Garing, John Williford, Nick Clute-Reinig, Ethan Spencer, Michael Friend, Damian Madan, Van T. T. Dinh, David Bell, Bernhard H. Weigl, Sam R. Nugen, Kevin P. Nichols, Anne-Laure M. Le NyA phage-based microfluidic platform for highly sensitive and rapid detection of E. coli in low-resource settings.To cite this article before page numbers are […]

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