Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00631F, PaperYou Chen, Yifan Xue, Langtao Xu, Weilin Li, Yiling Chen, Shunan Zheng, Rui Dai, Jie Liu3D tumor models are emerging as valuable tools for drug screen and personalized nanoparticle based cancer treatments. The current main challenges of constructing 3D tumor model based on microfluidic chip...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00426G, PaperJianping Xu, Matthew Thomas BalhoffWe propose a simple microfluidic approach: Dissolution-After-Precipitation (DAP), to investigate regimes of carbonate rock dissolution and multiphase reactive transport. In this method, a carbonate porous medium is created in a...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00698G, PaperDan Liu, Mingyang Zhu, Yi Lin, Mengmeng Li, Ruolan Huang, Liu Yang, Yanling Song, Yong Diao, Chaoyong James YangThe blood-brain barrier (BBB) controls chemical access to the brain and maintains fluid homeostasis, but in vitro models accurately simulating the physiological characteristics of the BBB are lacking. Here, we...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00788F, PaperFelix Richter, minqian chen, Patrick Schaub, Steffen Schneider, Alexander Gross, Patrick Mäder, Di Zhang, Oleksandr Dovzhenko, Klaus Palme, Johann Michael Köhler, Jialan Cao, florian WüstThis work presents the application of droplet-based microfluidics for the cultivation of microspores from Brassica napus using the doubled haploid technology. Under stress conditions (e.g. heat shock) or by chemical...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00622G, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nadia A. Aicha Erkamp, Timothy J Welsh, Runzhang Qi, Tuomas KnowlesMembraneless organelles formed through condensation of biomolecules in living cells have become the focus of sustained efforts to elucidate their mechanisms of formation and function. These condensates perform a range...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00729K, PaperXuan Zhang, Ya-Nan Zhao, Xing Wei, Xue Men, Cheng-Xin Wu, Jun-Jie Bai, Ting Yang, Ming-Li Chen, Jian-Hua WangIn aptamer based assay schemes, the aptamer probes unlabeled with bio-markers have to be eliminated before testing, which may be a tremendous squander for precious probes. We herein propose a...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00514J, PaperHongcun Zhu, Wenting Shen, Chunxiong Luo, Feng LiuTo reveal the underlying mechanism of the biological function of the multicellular systems, it is important to obtain comprehensive spatial gene expression profiles. Among the emerging single-cell spatial-omics techniques, immunofluorescence...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Accepted ManuscriptDOI: 10.1039/D2LC00063F, PaperMilan Finn Wesseler, Mathias Nørbæk Johansen, Aysel Kiziltay, Kim Mortensen, Niels B. LarsenSufficient and controllable oxygen supply is essential for in vitro 3D cell and tissue culture at high cell densities, which calls for volumetric in situ oxygen analysis methods to quantitatively...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00391K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kevin J. Glennon, Hector F. Valdovinos, Tashi Parsons-Davis, Jennifer A. Shusterman, Anna G. Servis, Kenton J. Moody, Narek GharibyanPu is separated from excess U and isotopically assayed using our novel microfluidic platform designed to miniaturize traditional laboratory techniques into a field-deployable system for rapid nuclear forensics in post-detonation nuclear scenarios.To cite this article before page […]

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00586G, PaperMengdi Bao, Shuhuan Zhang, Chad ten Pas, Stephen J. Dollery, Ruth V. Bushnell, F. N. U. Yuqing, Rui Liu, Guoyu Lu, Gregory J. Tobin, Ke DuA simple, portable, and low-cost microfluidic system-funnel adapted sensing tube (FAST) is developed as an integrated, power-free, and pipette-free biosensor for viral nucleic acids.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00603K, PaperXiaoqi Gao, Xuejia Hu, Jingjing Zheng, Qinghao Hu, Shukun Zhao, Longfei Chen, Yi YangA tunable and on-demand liquid microlens array was created contactlessly by different distributions of miscible liquids in an acoustic standing wave field.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00443G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lucie Descamps, Jessica Garcia, David Barthelemy, Emmanuelle Laurenceau, Léa Payen, Damien Le Roy, Anne-Laure DemanThe isolation of circulating tumor cells (CTCs) directly from blood, as a liquid biopsy, could lead to a paradigm shift in cancer care. The MagPure chip provides a powerful tool for subsequent purification of CTCs and dissection of their clinical information.To cite this article before page numbers are assigned, […]

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00665K, PaperAlina Peethan, Aravind M, Santhosh Chidangil, Sajan D. GeorgeDroplet splitting by exploiting tailored surface wettability is emerging as an important pathway to creating ultralow volumes of samples that can have applications in bioassays, tissue engineering, protein chips, and material synthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00683A, PaperNoah Goshi, Gregory Girardi, Felipe da Costa Souza, Alexander Gardner, Pamela J. Lein, Erkin SekerThis study examines the role of microchannel geometry on the long-term performance of compartmentalized microfluidic neural cell culture platforms and provides general design rules for different experimental objectives.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00570K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sin Yen Tan, Qiuyu Jing, Ziuwin Leung, Ying Xu, Lily Kwan Wai Cheng, Sindy Sing Ting Tam, Angela Ruohao WuTranscriptomic studies of spatially arranged 3D vasculatures and fibroblasts revealed paracrine cues for improved vasculature growth.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00219A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Elodie Couttenier, Sophie Bachellier-Bassi, Christophe d'Enfert, Catherine VillardHydrodynamic forces applied in a microfluidic device on hyphae of C. albicans allow to measure their bending stiffness in a control situation as well as under various pharmacological, mechanical and genetical perturbations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00648K, PaperNishagar Raventhiran, Razin Sazzad Molla, Kshithij Nandishwara, Erick Johnson, Yaofa LiThis paper presents a novel pressure sensor to be used with microfluidic channels. The sensor is based on optical particle tracking, which turns a regular fluorescence microscope into a pressure measurement device.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00545J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Boxin Deng, Karin Schroën, Maartje Steegmans, Jolet de RuiterThe EDGE tensiometer allows access to nearly the full range of dynamic interfacial tension at relevant time scales for both droplet and bubble interfaces.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00394E, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Witold Postek, Natalia Pacocha, Piotr GarsteckiThe rise of antibiotic resistance is a threat to global health.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00623E, PaperScott Hansen, David K. WoodSickle cell blood flow and hemoglobin oxygen saturation can be simultaneously measured using a microfluidic device. This combined measurement platform provides a tool to evaluate the potential clinical benefit of anti-sickling therapies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00428C, PaperJiwon Kim, Kun-Young Park, Sungwoo Choi, Ung Hyun Ko, Dae-Sik Lim, Jae Myoung Suh, Jennifer H. ShinThe two-layered ceiling culture chip allows buoyant adipocytes to be maintained and observed, revealing mechanisms involved in adipocyte dedifferentiation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00416J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Loïc Chagot, César Quilodrán-Casas, Maria Kalli, Nina M. Kovalchuk, Mark J. H. Simmons, Omar K. Matar, Rossella Arcucci, Panagiota AngeliImproving surfactant-laden microdroplet size prediction using data-driven methods.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00661H, PaperXiang Li, Xu Liu, Ziqing Yu, Yang Luo, Qixin Hu, Zhenye Xu, Jia Dai, Nannan Wu, Feng ShenA combinatorial-screening SlipChip based on a self-partitioning mechanism performs high-throughput phenotypic AST with a panel of antibiotics and antibiotic combinations in three hours by monitoring the phenotypic profile of bacterial growth.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00663D, PaperChia-Hao Huang, Kin Fong LeiA folding paper system was developed to mimic a tumor–vascular interface for the study of long-distance cell migration.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00671E, PaperXiaoyi Li, Changxiang Fang, Zhihao Feng, Junying Li, Yan Li, Weihua HuA label-free OIRD microarray chip was specifically designed by using a nanostructured fluorine-doped tin oxide (FTO) slide as a substrate, showing improved sensitivity. The unique optical enhancement mechanism was revealed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00290F, PaperSajad Razavi Bazaz, Asma Mihandust, Robert Salomon, Hossein Ahmadi Nejad Joushani, Wenyan Li, Hoseyn A. Amiri, Fateme Mirakhorli, Sareh Zhand, Jesus Shrestha, Morteza Miansari, Benjamin Thierry, Dayong Jin, Majid Ebrahimi WarkianiOverview of the zigzag microchannel for rigid inertial separation and enrichment (Z-RISE). The proposed device has superior performance for particle focusing and separation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00541G, PaperXian Chen, Chuanchao Zhang, Bohua Liu, Ye Chang, Wei Pang, Xuexin DuanWe proposed a handheld self-contained acoustofluidic system actuated by the Lamb wave resonator (LWR) array for POC chemiluminescent assay, in which the fluidic pumping, mixing, switching, and bioparticle trapping are all achieved on chip.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00650B, PaperSiyuan Wang, Wuzhen Qi, Shangyi Wu, Jing Yuan, Hong Duan, Yanbin Li, Jianhan LinThis study reported an automatic centrifugal system for rapid detection of foodborne pathogenic bacteria based on immunomagnetic separation (IMS) for target bacteria enrichment and recombinase aided amplification (RAA) for nucleic acid detection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00637E, PaperChaoyu Cao, Minli You, Haoyang Tong, Zhenrui Xue, Chang Liu, Wanghong He, Ping Peng, Chunyan Yao, Ang Li, Xiayu Xu, Feng XuWe proposed an explainable deep learning-based method to classify similar fluorescence colors for multiplex digital PCR in a single fluorescent channel.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00589A, PaperMuhammad A. Sami, Muhammad Tayyab, Umer HassanRepresentative figures depicting the design of parallel, perpendicular, and oblique excitation modalities for smartphone fluorescent microscopes (SFM).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00726F, PaperJi Wook Choi, Won Ho Seo, Young Suh Lee, So Young Kim, Bong Suk Kim, Kyoung G. Lee, Seok Jae Lee, Bong Geun ChungIoT-integrated multiplexed digital PCR system for detection of infectious diseases.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00641C, CommunicationJames J. Feng, Sarah HedtrichWe propose similarity scaling as a novel and universally applicable scaling approach for organ-on-chip platforms. It will ensure high predictivity of on-chip models for human physiology and pathology, and improve their clinical translations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00583B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Richard J. Gillams, Victor Calero, Raul Fernandez-Mateo, Hywel MorganWe demonstrate vesicle and nanoparticle fractionation in an optimised DLD array with micron-sized structures. When combined with an orthogonal AC electric field, these devices enable high-throughput fractionation in high-conductivity electrolytes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS […]

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00349J, PaperShivanshu Mishra, Pharyanshu Kachhawa, Amber Kumar Jain, Rajiv Ranjan Thakur, Nidhi ChaturvediThis work reports rapid, label-free and specific detection of the HER2 antigen using a gallium nitride (GaN) high electron mobility transistor (HEMT).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00624C, PaperYongqing Duan, Weili Yang, Jingjing Xiao, Jixin Gao, Lai Wei, YongAn Huang, Zhouping YinElectrohydrodynamic nozzle array chips with stable and uniform printing performance were developed for applications in micro/nanoelectronics, biomedical devices, etc.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00326K, PaperDavood Khoeini, Vincent He, Ben J. Boyd, Adrian Neild, Timothy F. ScottIncreases in complexity attainable in molecular self-assembly necessitates both advanced molecular design as well as microenvironmental control.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00262K, Critical ReviewLei Mou, Kalpana Mandal, Marvin Magan Mecwan, Ana Lopez Hernandez, Surjendu Maity, Saurabh Sharma, Rondinelli Donizetti Herculano, Satoru Kawakita, Vadim Jucaud, Mehmet Remzi Dokmeci, Ali KhademhosseiniThis review discusses the state-of-the-art integrated biosensors by providing specific examples, detailing their main advantages in monitoring MPSs, and describing the remaining challenges and potential future developments.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]

Lab Chip, 2022, 22,3567-3567DOI: 10.1039/D2LC90079C, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Loukia Petrou, Sylvain LadameThe content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00505K, PaperHuiting Zhao, Xu Wang, Zhanhui Geng, Naixin Liang, Qin Li, Xiaoming Hu, Zewen WeiA dual-function microneedle array was developed to co-delivery photosensitizers and light for photodynamic therapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00352J, Critical ReviewGrigor Simitian, María Virumbrales-Muñoz, Cristina Sánchez-de-Diego, David J. Beebe, David KosoffHere we provide a detailed review of the use of microfluidic technologies in vascular biology. This review focuses on how to recapitulate and investigate biological hallmarks and is written for a wide audience ranging from clinicians to engineers.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00289B, PaperColin J. Potter, Yanmei Hu, Zhen Xiong, Jun Wang, Euan McLeodTo address the persistence of the COVID-19 pandemic, we have developed a novel point-of-care SARS-CoV-2 biosensor. This sensor has a limit of detection within an order of magnitude of traditional PCR and can provide an accurate measure of viral load.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00625A, PaperChangxu Li, Yi Liu, Changpeng Lang, Yonglai Zhang, Shiliang QuA microcantilever is fabricated by femtosecond laser direct writing for on-chip optofluidic sensing.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00513A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ziyihui Wang, Linwei Shang, Zehang Gao, Kok Ken Chan, Chaoyang Gong, Chenlu Wang, Tianhua Xu, Tiegen Liu, Shilun Feng, Yu-Cheng ChenThe concept of a motor-like microlaser with a controllable direction, velocity, and spatial motions was introduced, providing a novel approach for laser writing, laser switching, and localized cell stimulation and imaging.To cite this article before page numbers are assigned, use the […]

Lab Chip, 2022, Advance ArticleDOI: 10.1039/D2LC00593J, PaperFlorian Gerstl, Uma Pongkitdachoti, Fuangfa Unob, Antje J. BaeumnerMiniaturized electrochemical and electrochemiluminescent biosensor using laser-induced graphene electrodes for highly sensitive and selective detection of C. parvum DNA.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3555-3564DOI: 10.1039/D1LC01132D, PaperUlri N. Lee, Xiaojing Su, Damielle L. Hieber, Wan-chen Tu, Anika M. McManamen, Meg G. Takezawa, Grant W. Hassan, Tung Ching Chan, Karen N. Adams, Ellen R. Wald, Gregory P. DeMuri, Erwin Berthier, Ashleigh B. Theberge, Sanitta ThongpangThis paper presents a new sample collection platform for a common bacterial infection, group A streptococcal (GAS) pharyngitis, also known as strep throat, caused by Streptococcus pyogenes.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3361-3376DOI: 10.1039/D2LC00397J, Critical ReviewJiaqi Ren, Ning Wang, Piao Guo, Yanping Fan, Francis Lin, Jiandong WuThis article reviews recent advances in microfluidics-based cell migration research, focusing on four aspects: host–pathogen interactions, cell migration in spatiotemporal chemical fields, cell transmigration, and deep learning analysis methods.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3565-3566DOI: 10.1039/D2LC90078E, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Berna Özkale, Junzhe Lou, Ece Özelçi, Alberto Elosegui-Artola, Christina M. Tringides, Angelo S. Mao, Mahmut Selman Sakar, David J. MooneyThe content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3545-3554DOI: 10.1039/D2LC00496H, PaperYaohui Fang, Shu Zhu, Weiqi Cheng, Zhonghua Ni, Nan XiangA miniaturized centrifuge with integrated inertial spiral and two-stage serpentine channels, allowing for the efficient washing and acquisition of concentrated bioparticles from background fluids.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3340-3360DOI: 10.1039/D2LC00609J, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nathan K. Khosla, Jake M. Lesinski, Monika Colombo, Léonard Bezinge, Andrew J. deMello, Daniel A. RichardsThis review details how microfluidic technologies are disrupting the status quo, and facilitating the development of simple, affordable, and accessible integrated IVDs.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3533-3544DOI: 10.1039/D2LC00216G, PaperCynthia Richard, Citsabehsan Devendran, Dariush Ashtiani, Victor J. Cadarso, Adrian NeildA surface acoustic wave micro-dispenser for the on-demand trap and release of single cells with trajectory control.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3499-3507DOI: 10.1039/D2LC00180B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kiana Malmir, William Okell, Aurélien A. P. Trichet, Jason M. SmithOpen-access optical microcavities act as a combined optical trap and sensor. This work shows that the integration of optical microcavities into microfluidics with controlled flow speed can open up new avenues for nanoparticle characterization.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3453-3463DOI: 10.1039/D2LC00482H, PaperAli Ahmad, Federico Sala, Petra Paiè, Alessia Candeo, Sarah D'Annunzio, Alessio Zippo, Carole Frindel, Roberto Osellame, Francesca Bragheri, Andrea Bassi, David RousseauMachine learning algorithms for cell classification via on-chip fluorescence microscopy are shown to be robust to microfluidic distortions due to cell displacement during acquisition.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3424-3435DOI: 10.1039/D2LC00495J, PaperRenna L. Nouwairi, Larissa L. Cunha, Rachelle Turiello, Orion Scott, Jeff Hickey, Scott Thomson, Stuart Knowles, Jeff D. Chapman, James P. LandersThe described microfluidic instrument performs real-time PCR (40 cycles) with comparable sensitivity to commercial instrumentation in under 10 minutes.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3508-3520DOI: 10.1039/D2LC00527A, PaperRajorshi Paul, Kevin S. Zhang, Myra Kurosu Jalil, Nicolas Castaño, Sungu Kim, Sindy K. Y. TangThe hydrodynamic cell splitter splits single-cell ciliate Stentor coeruleus using a microfluidic cross junction at a high throughput of 500 cells min−1. Fragment viability decreases with increasing hydrodynamic stress and decreasing fragment size.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3290-3313DOI: 10.1039/D2LC00447J, Tutorial ReviewShahrokh Sepehrirahnama, Abhishek Ray Mohapatra, Sebastian Oberst, Yan Kei Chiang, David A. Powell, Kian-Meng LimThis tutorial review covers theoretical and experimental aspects of acoustic interaction force, as one of the driving forces of acoustophoresis. The non-reciprocity, rotational coupling, viscosity effects, and particle agglomeration are discussed.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3436-3452DOI: 10.1039/D2LC00434H, PaperYunfeng Zai, Chao Min, Zunliang Wang, Yongjun Ding, Huan Zhao, Enben Su, Nongyue HeWe present a low-cost microfluidic cartridge design scheme that combines gravity-driven passive microfluidic pumping with extraction-free amplification to achieve “sample-in, answer-out” point-of-care nucleic acid detection within 30 minutes.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3475-3488DOI: 10.1039/D2LC00368F, PaperJolien Breukers, Hannah Op de Beeck, Iene Rutten, Montserrat López Fernández, Sven Eyckerman, Jeroen LammertynThis novel methodology to control serial picoinjectors allows for accurate and flexible combinatorial reagent addition into droplets.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3521-3532DOI: 10.1039/D2LC00431C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yue Wu, Yubing Hu, Nan Jiang, Rajeevan Anantharanjit, Ali K. Yetisen, M. Francesca CordeiroWe develop a quantitative lateral flow assay (LFA) device that is able to measure the tear level of brain derived neurotrophic factor (BDNF). The device shows great potential to serve as an ideal platform for early detection of glaucoma.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3464-3474DOI: 10.1039/D2LC00166G, PaperAmane Hirotsu, Hirotoshi Kikuchi, Hidenao Yamada, Yusuke Ozaki, Ryoma Haneda, Sanshiro Kawata, Tomohiro Murakami, Tomohiro Matsumoto, Yoshihiro Hiramatsu, Kinji Kamiya, Daisuke Yamashita, Yuki Fujimori, Yukio Ueda, Shigetoshi Okazaki, Masatoshi Kitagawa, Hiroyuki Konno, Hiroya TakeuchiWe developed a method for label-free image identification and classification of peripheral blood nucleated cells flowing in a microfluidic channel, based on the subcellular structures of quantitative phase microscopy images.The content of this RSS Feed […]

Lab Chip, 2022, 22,3489-3498DOI: 10.1039/D2LC00595F, PaperNegar Nazari, Anthony R. KovscekWe developed a novel foam rheometer based on microfluidic principles to quantify foam texture and flow resistance. Our analysis showed that there is an optimal foam quality that maximizes apparent viscosity during flow in fractures that has a slight gas rate dependence.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3402-3411DOI: 10.1039/D2LC00402J, PaperMingyang Sui, Huijuan Dong, Guanyu Mu, Jingze Xia, Jie Zhao, Zhen Yang, Tianlong Li, Tong Sun, Kenneth T. V. GrattanThe velocity and direction of actuated droplet can be adjusted by changing temporal phase shift of surface acoustic waves in an exciter–exciter mode only.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3314-3339DOI: 10.1039/D2LC00232A, Critical ReviewNna-Emeka Onukwugha, Yoon-Tae Kang, Sunitha NagrathIn this paper, we summarized the recent advances in cell specific EV isolation, engineering and their potential applications in immune-oncology along with suggested areas of study necessary to bring EVs into clinical practice.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3412-3423DOI: 10.1039/D2LC00265E, PaperShilu Zhu, Weijie Zheng, Jian Wang, Xingmiao Fang, Lijiu Zhang, Fuzhou Niu, Ying Wang, Tingting Luo, Guangli Liu, Runhuai YangA robotic system whose interactive and synergistic behaviour can be successfully controlled by exploiting frequency-responsive programmable individual microrobots.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3377-3389DOI: 10.1039/D2LC00452F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nityanand Kumawat, Soja Saghar Soman, Sanjairaj Vijayavenkataraman, Sunil KumarCut and heat microfluidic paper-based analytical devices (CH-microPADs) are simple-to-use, low-cost point-of-care testing platforms.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2022, 22,3390-3401DOI: 10.1039/D2LC00190J, PaperZiqiang Du, Ya Li, Bing Chen, Lulu Wang, Yu Hu, Xu Wang, Wenchang Zhang, Xiaonan YangA bright-field image cytometry technique, assisted by a multi-frame image correlation algorithm, is introduced for label-free CTC detection.The content of this RSS Feed (c) The Royal Society of Chemistry