Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00276C, PaperCharuksha Walgama, Michael P. Nguyen, Lisa M. Boatner, Ian Richards, Richard M. CrooksA hybrid paper/plastic microfluidic device for detection of Ag nanoparticle labels at concentrations as low as 12 pM.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC00775J, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Masoud Madadelahi, Luis F. Acosta-Soto, Samira Hosseini, Sergio O. Martinez-Chapa, Marc J. MadouThis paper focuses on theory and computational modelling of lab-on-a-disc devices of relevance for novel applications discovery and optimal designs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00121J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nicola Di Trani, Antonia Silvestri, Antons Sizovs, Yu Wang, Donald R. Erm, Danilo Demarchi, Xuewu Liu, Alessandro GrattoniControl of molecular diffusion through nanofluidic channels using electrostatic gating.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/C9LC01021A, PaperZongdai Liu, Dan Luo, Kun-Lin YangMany volatile organic compounds (VOCs) are hazardous to human health and their concentrations need to be monitored over a large area. However, most chemical sensors can only be used for...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00197J, PaperDavid P. Taylor, Govind V. KaigalaVirtual microfluidic channels, formed through hydrodynamic focusing within a 2D flow cell, enable the dynamic implementation of key microfluidic functionalities, such as the precise guiding, splitting, merging and mixing of microscale flows.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00115E, PaperVeasna Soum, Sooyong Park, Albertus Ivan Brilian, Jae-Youl Choi, Yongwoo Lee, Wonjung Kim, Oh-Sun Kwon, Kwanwoo ShinA precise, simple, and inexpensive method for controlling fluid flow in a photo-paper-based microfluidic device was reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01047E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mark Schurdak, Lawrence Vernetti, Luke Bergenthal, Quinn K. Wolter, Tong Ying Shun, Sandra Karcher, D. Lansing Taylor, Albert GoughThe Microphysiology Systems Database (MPS) is a critical tool for the design, management, analysis, and sharing of MPS study data.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00045K, PaperNicolas Garcia-Seyda, Laurene Aoun, Victoria Tishkova, Valentine Seveau, Martine Biarnes-Pelicot, Marc Bajénoff, Marie-Pierre Valignat, Olivier TheodolyPermeable agarose barriers allow flow-free gradient generation, applicable to adherent and non-adherent (swimming) cells, as well as co-culture experiments.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01039D, PaperZachary Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, Aydogan OzcanA rapid and cost-effective method for monitoring proteins in tear-fluid is reported, which enables biomarker monitoring using contact lenses toward personalized mobile-health applications.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00103A, PaperJuan Hu, Xiangpeng Li, Robert L. Judd, Christopher J. EasleyHigh temporal resolution sampling and quantitative detection of glycerol secretion dynamics from adipose tissue using our automated, droplet-based microfluidic system.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01103J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kartik Totlani, Jan-Willem Hurkmans, Walter M. van Gulik, Michiel T. Kreutzer, Volkert van SteijnWe developed a microfluidic droplet on-demand (DoD) generator that enables the production of droplets with a volume solely governed by the geometry of the generator for a range of operating conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]

Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01097A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mario Rothbauer, Gregor Höll, Christoph Eilenberger, Sebastian R. A. Kratz, Bilal Farooq, Patrick Schuller, Isabel Olmos Calvo, Ruth A. Byrne, Brigitte Meyer, Birgit Niederreiter, Seta Küpcü, Florian Sevelda, Johannes Holinka, Oliver Hayden, Sandro F. Tedde, Hans P. Kiener, Peter ErtlWe demonstrate that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible […]

Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01261C, PaperYuan Yuan, Julie Brouchon, J. Mauricio Calvo-Calle, Jing Xia, Li Sun, Xu Zhang, Kiera L. Clayton, Fangfu Ye, David A. Weitz, John A. HeymanIn-droplet cytokine capture assays combined with FACS to accurately identify and isolate activated immune cells.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1298-1308DOI: 10.1039/D0LC00106F, PaperShuaiguo Zhao, Mengxi Wu, Shujie Yang, Yuqi Wu, Yuyang Gu, Chuyi Chen, Jennifer Ye, Zhemiao Xie, Zhenhua Tian, Hunter Bachman, Po-Hsun Huang, Jianping Xia, Peiran Zhang, Heying Zhang, Tony Jun HuangA disposable acoustofluidic platform was developed for nano/microparticle separation with high versatility, precision, and biocompatibility.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00021C, CommunicationBo Wang, Ximiao Wen, Yan Cao, Shan Huang, Hoa A. Lam, Tingyi “Leo” Liu, Pei-Shan Chung, Harold G. Monbouquette, Pei-Yu Chiou, Nigel T. MaidmentPDMS thin-film transfer and enzyme microstamping enabled 3-in-1 Si/PDMS hybrid chemtrode for multi-analyte sensing and chemical delivery in vivo.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01220F, PaperRonny Frank, Christoph Prönnecke, Ronny Azendorf, Heinz-Georg Jahnke, Annette G. Beck-Sickinger, Andrea A. RobitzkiWe developed a novel 96-well microtiter plate based bioelectrochemical platform with a vertical divided cell three-electrode architecture and a 96-multipotentiostat to perform fully parallelised bioelectrocatalytic screenings on redox enzymes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01256G, PaperRodi Abdalkader, Ken-ichiro KameiHuman corneal epithelium coexists with tear fluids and shows its barrier functionality under the dynamic conditions of eye blinking. We developed a microfluidic platform enabling the dynamic culture of the human corneal barrier with recapitulation of eye blinking.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1290-1297DOI: 10.1039/C9LC01163C, PaperA. Enel, A. Bourrelier, J. Vial, D. Thiébaut, B. BourlonThe first device for digital manipulation of gaseous samples; from elementary operations to demonstration of a more complex application.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1281-1289DOI: 10.1039/D0LC00072H, PaperHunter Bachman, Yuyang Gu, Joseph Rufo, Shujie Yang, Zhenhua Tian, Po-Hsun Huang, Lingyu Yu, Tony Jun HuangAn acoustofluidic particle manipulation platform that uses low frequency flexural waves produced by commercial transducers.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00149J, PaperChun-Miao Xu, Man Tang, Jiao Feng, Hou-Fu Xia, Ling-Ling Wu, Dai-Wen Pang, Gang Chen, Zhi-Ling ZhangA system integrating diagnostic and therapeutic functions for cancer is presented using magnetically controlled microfluidics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00028K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yoshiki Soda, Kye J. Robinson, Thomas J. Cherubini, Eric BakkerA pixel-level colorimetric absorbance analysis can measure the total quantity of dye on paper, irrespective of shape and size.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00024H, PaperJingjing Guo, Li Lin, Kaifeng Zhao, Yanling Song, Mengjiao Huang, Zhi Zhu, Leiji Zhou, Chaoyong YangAn automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method that reduces the bead loss.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01187K, PaperM. Shane Woolf, Leah M. Dignan, Hannah M. Lewis, Christopher J. Tomley, Aeren Q. Nauman, James P. LandersMicrovalving is a pivotal component in many microfluidic lab-on-a-chip platforms and micro-total analysis systems (μTAS).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1204-1211DOI: 10.1039/D0LC00140F, PaperKui Han, Long Mei, Ruoyu Zhong, Yuhong Pang, Eric Erquan Zhang, Yanyi HuangA proof-of-concept platform to reconstitute the intercellular coupling system of the central clock using uncoupled, single fibroblast cells in vitro, to mimic SCN slice cultures ex vivo and mouse behavior in vivo phenotypically.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1267-1280DOI: 10.1039/C9LC01182J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jonathan T. Butement, Paul M. Holloway, Joshua A. Welsh, Judith A. Holloway, Nicola A. Englyst, Peter Horak, Jonathan West, James S. WilkinsonOn chip MMI-lenses combined with multi-angle waveguide collection and 3d focussing fluidics allows high performance size measurement of submicron particles.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1212-1226DOI: 10.1039/D0LC00009D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Thomas E. Winkler, Michael Feil, Eva F. G. J. Stronkman, Isabelle Matthiesen, Anna HerlandHigh costs are a key challenge in “democratization” of organ-chip research. We present a low-resource barrier-on-chip based on tape, and use it to model small intestine and its response to chili peppers (capsaicinoids).The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1083-1091DOI: 10.1039/C9LC00853E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Takashi Anazawa, Hiroko Matsunaga, Shuhei Yamamoto, Ryoji InabaMutant (MT) in a large excess of wild type (WT) was quantified with high-sensitivity (LOD of 0.004% MT/WT) and four-orders-of-magnitude dynamic range (0.01–100% MT/WT) by a high-dynamic-range capillary-array electrophoresis (HiDy CE).The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1238-1248DOI: 10.1039/C9LC01171D, PaperHunter Bachman, Chuyi Chen, Joseph Rufo, Shuaiguo Zhao, Shujie Yang, Zhenhua Tian, Nitesh Nama, Po-Hsun Huang, Tony Jun HuangAn acoustofluidic mixer which can achieve thorough mixing across a wide range of flow rates.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01165J, PaperJose A. Wippold, Han Wang, Joseph Tingling, Julian L. Leibowitz, Paul de Figueiredo, Arum HanIdentifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1177-1190DOI: 10.1039/C9LC01107B, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Matthew F. Peters, Allison L. Choy, Carmen Pin, Derek J. Leishman, Annie Moisan, Lorna Ewart, Peggy J. Guzzie-Peck, Radhakrishna Sura, Douglas A. Keller, Clay W Scott, Kyle L. KolajaDrug-induced gastrointestinal toxicities (DI-GITs) are among the most common adverse events in clinical trials.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1249-1258DOI: 10.1039/D0LC00111B, PaperFangsheng Huang, Zhiqiang Zhu, Ye Niu, Yi Zhao, Ting Si, Ronald X. XuWe propose a coaxial oblique interface shearing (COIS) process to one-step generate and sort double emulsions for thermal- and chemical-responsive spatial gradient releases.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1191-1203DOI: 10.1039/D0LC00047G, Critical ReviewJuhwan Park, Dong Hyun Han, Je-Kyun ParkAn overview and future perspectives of user-friendly microfluidic devices have been reported in terms of practical sample preparation in point-of-care testing.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1153-1166DOI: 10.1039/C9LC01170F, PaperWilliam Y. Wang, Daphne Lin, Evan H. Jarman, William J. Polacheck, Brendon M. BakerThe formation of functional microvasculature results from physical and soluble microenvironmental cues that balance endothelial cell migration with proliferation during multicellular sprouting morphogenesis.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1259-1266DOI: 10.1039/D0LC00036A, PaperOmer Wagner, Eitan Edri, Pooria Hadikahani, Hagay Shpaisman, Zeev Zalevsky, Demetri PsaltisMicrofluidic channel flows and traps biological samples inside a water droplet along with suspended nanoparticles. Linear optics nanoscopy is then used to image the sample by decoding the scattered light from the nanoparticles in its vicinity.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1227-1237DOI: 10.1039/D0LC00040J, PaperChang Chen, Dong Xu, Siwei Bai, Zhihang Yu, Yonggang Zhu, Xiao Xing, Huaying ChenInoculation of single cells into separate chambers is one of the key requirements in single-cell analysis. Here we report a three-layer microfluidic platform integrated with dual-pneumatic valves for dynamic screening and printing of single cells.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1140-1152DOI: 10.1039/C9LC01179J, PaperJoseph A. Fantuzzo, Denise A. Robles, Vincent R. Mirabella, Ronald P. Hart, Zhiping P. Pang, Jeffrey D. ZahnDevelopment and functionality of a 96 well plate-based platform for high-throughput drug screening of compartmentalized neurocircuit models.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1066-1071DOI: 10.1039/D0LC00039F, CommunicationNan Jia, Erica Rosella, Estelle Juère, Roxane Pouliot, Freddy Kleitz, Jesse GreenerPhysically crosslinked layered microscale biomembranes from pure chitosan are demonstrated for pH-triggered release functionalized mesoporous silica nanoparticles. The work opens the door to synthesis of complex nano-enhanced micro membranes.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1124-1139DOI: 10.1039/C9LC00921C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Steven P. Maher, Amy J. Conway, Alison Roth, Swamy R. Adapa, Phillip Cualing, Chiara Andolina, James Hsiao, Jessica Turgeon, Victor Chaumeau, Myles Johnson, Chris Palmiotti, Naresh Singh, Samantha J. Barnes, Raahil Patel, Virginia Van Grod, Robert Carter, H.-C. Steve Sun, Jetsumon Sattabongkot, Brice Campo, François Nosten, Wajeeh M. Saadi, John H. Adams, Rays H. Y. Jiang, Dennis E. KyleAn intrahepatic Plasmodium vivax liver […]

Lab Chip, 2020, 20,1072-1082DOI: 10.1039/D0LC00078G, PaperJiyu Li, Ya Liu, Jifeng Ren, Benjamin Zikai Tay, Tao Luo, Lei Fan, Dong Sun, Guannan Luo, Denvid Lau, Marcos, Raymond H. W. LamSelective immune cell isolation from diluted blood achieved with antibody-coated micropillar and micro-sieve structures in a microfluidic system.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1058-1065DOI: 10.1039/C9LC01027K, CommunicationShaowei Jiang, Jiakai Zhu, Pengming Song, Chengfei Guo, Zichao Bian, Ruihai Wang, Yikun Huang, Shiyao Wang, He Zhang, Guoan ZhengWe report a novel lensless on-chip microscopy platform based on near-field blind ptychographic modulation.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1049-1057DOI: 10.1039/C9LC01168D, PerspectiveKristin Fabre, Brian Berridge, William R. Proctor, Sherry Ralston, Yvonne Will, Szczepan W. Baran, Gorm Yoder, Terry R. Van VleetOpportunities in the drug discovery/development process for potential MPS incorporation.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1092-1102DOI: 10.1039/C9LC01003C, PaperHong-Beom Kwon, Seong-Jae Yoo, Yong-Jun KimWe present a compact, cost-efficient, water-based nanoparticle counter that can accurately monitor the personal nanoparticle exposure in real-time.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1103-1109DOI: 10.1039/C9LC00979E, PaperSheng-Po Huang, Yuan-Jhe Chuang, Wen-Bin Lee, Yi-Cheng Tsai, Chang-Ni Lin, Keng-Fu Hsu, Gwo-Bin LeeAn integrated microfluidic platform capable of labeling ovarian cancer biomarkers within formalin-fixed, paraffin embedded tissues via aptamer probes was developed.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1110-1123DOI: 10.1039/C9LC01066A, PaperZhen Liu, Pengfei Zhang, Hao Ji, Yu Long, Boping Jing, Lu Wan, Daoming Xi, Rui An, Xiaoli LanPharmacokinetics of parallel or comparison samples can be imaged simultaneously with a mini PET scanner-based microfluidic radiobioassay system.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,1023-1048DOI: 10.1039/C9LC01022J, Critical ReviewSajad Razavi Bazaz, Ali Mashhadian, Abbas Ehsani, Suvash Chandra Saha, Timm Krüger, Majid Ebrahimi WarkianiSchematic illustration of various kinds of geometries used for inertial microfluidics.The content of this RSS Feed (c) The Royal Society of Chemistry