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RSC - Lab Chip latest articles RSC - Lab Chip latest articles

  • A simple and reversible glass–glass bonding method to construct a microfluidic device and its application for cell recovery
    by Shun-ichi Funano on April 26, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00058F, PaperShun-ichi Funano, Nobutoshi Ota, Yo TanakaA simple method, using only neutral detergent for surface cleaning, produces reversible glass–glass bonding to enable use of a glass microfluidic device repeatedly and enable switching a microchannel from closed for cell cultivation to open for cell recovery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A minimally invasive flexible electrode array for simultaneous recording of ECoG signal from multiple brain regions
    by Ui-Jin Jeong on April 26, 2021 at 11:00 pm

    Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00117E, PaperUi-Jin Jeong, Jungpyo Lee, Namsun Chou, Kanghwan Kim, Hyogeun Shin, Uikyu Chae, Hyun-Yong Yu, Il-Joo ChoThe minimal invasiveness of electrocorticography (ECoG) enabled its widespread use in clinical areas as well as in neuroscience research. However, most existing ECoG arrays require that the entire surface area...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Membrane Integration into PDMS-free Microfluidic Platforms for Organ-on-Chip and Analytical Chemistry Applications
    by Stefan Schneider on April 25, 2021 at 11:00 pm

    Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00188D, Critical ReviewStefan Schneider, Denise Gruner, Andreas Richter, Peter LoskillMembranes play a crucial role in many microfluidic systems, enabling versatile applications in highly diverse research fields. However, the tight and robust integration of membranes into microfluidic systems requires complex...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Implementation of iMiDEV, a new fully automated microfluidic platform for radiopharmaceutical production
    by Olga Ovdiichuk on April 25, 2021 at 11:00 pm

    Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00148E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Olga Ovdiichuk, Hemantha Mallapura, Florian Pineda, Virginie Hourtané, Bengt Långström, Christer Halldin, Sangram Nag, Fatiha Maskali, Gilles Karcher, Charlotte ColletiMiDEV® microfluidic system is a new automated tool for a “dose-on-demand” production of radiopharmaceuticals. This new radiochemistry module utilizes microfluidic cassettes capable of producing diversified radiopharmaceuticals in both gas […]

  • Microfluidic valvular chips and numerical lymphatic vessel model for study of lymph transport characteristics
    by Jaemin In on April 21, 2021 at 11:00 pm

    Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00022E, PaperJaemin In, Jihye Ryu, Hyeonji Yu, Dongwon Kang, Taeyoung Kim, Jungwook KimLymph transport inside lymphatic vessels is highly complex and not yet fully understood. So far, a consensus has not been reached among existing analytical models on how spatiotemporal coordination of...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Rotational scan digital LAMP for accurate quantitation of nucleic acids
    by Mengcheng Jiang on April 19, 2021 at 11:00 pm

    Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00114K, PaperMengcheng Jiang, Peiyu Liao, Yue Sun, Xinyang Shao, Zitian Chen, Peng Fei, Jianbin Wang, Yanyi HuangDigital quantitation of nucleic acids is precise and sensitive because of its molecular-level resolution. However, only several quantitation formats are common, especially pertaining to how one obtains digital signals from...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Automation of peptide desalting for proteomic liquid chromatography – tandem mass spectrometry by centrifugal microfluidics
    by Jan-Niklas Klatt on April 18, 2021 at 11:00 pm

    Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00137J, PaperJan-Niklas Klatt, Thien-Ly Julia Dinh, Oliver Schilling, Roland Zengerle, Frank Schmidt, Tobias Hutzenlaub, Nils PaustFor large-scale analysis of complex protein mixtures, liquid chromatography – tandem mass spectrometry (LC-MS/MS) has been proven to be one of the most versatile tools due to its high sensitivity...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Fabrication of monodisperse alginate microgel beads by microfluidic picoinjection: a chelate free approach
    by Husnain Ahmed on April 18, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00111F, PaperHusnain Ahmed, Bjørn Torger StokkeMonodisperse microgel beads are fabricated by injecting chelate free aqueous Ca2+ in aqueous Na-alginate emulsion and vice versa. This method of producing alginate microbeads without reducing activity of Ca2+ is significant for biological assays.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Sheathless and high-throughput elasto-inertial bacterial sorting for enhancing molecular diagnosis of bloodstream infection
    by Xiaoguang Lu on April 15, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00085C, PaperXiaoguang Lu, Joycelyn Jia Ming Chow, Seok Hwee Koo, Boran Jiang, Thean Yen Tan, Dahou Yang, Ye AiWe present a microfluidic device for high-throughput, size-based bacterial sorting from whole blood in non-Newtonian fluids, enabling rapid and simple purification of bacteria for more accurate molecular diagnosis of bloodstream bacterial infection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Pulsed Electric Field-Assisted Overlimiting Current Enhancement through a Perm-selective Membrane
    by Soonhyun Kwon on April 15, 2021 at 11:00 pm

    Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00064K, PaperSoonhyun Kwon, Hyomin Lee, Sung Jae KimOverlimiting current through a perm-selective membrane has been actively researched not only for the fundamental advancement of electrokinetics but also for energy-/environmental- applications such as electrodialysis and fuel cell, etc....The content of this RSS Feed (c) The Royal Society of Chemistry

  • High throughput transepithelial electrical resistance (TEER) measurements on perfused membrane-free epithelia
    by A. Nicolas on April 14, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC00770F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.A. Nicolas, F. Schavemaker, K. Kosim, D. Kurek, M. Haarmans, M. Bulst, K. Lee, S. Wegner, T. Hankemeier, J. Joore, K. Domansky, H. L. Lanz, P. Vulto, S. J. TrietschWe present an instrument for simultaneously measuring TEER in up to 80 perfused epithelial tubules on an OrganoPlate. The sensitivity, speed and ease of use enables screening of tubules during formation, drug exposure and inflammatory processes.To cite this article […]

  • Measuring barrier function in organ-on-chips with cleanroom-free integration of multiplexable electrodes
    by Elsbeth G. B. M. Bossink on April 14, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01289K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Elsbeth G. B. M. Bossink, Mariia Zakharova, Douwe S. de Bruijn, Mathieu Odijk, Loes I. SegerinkA cleanroom-free method to integrate electrodes for transepithelial/transendothelial electrical resistance (TEER) measurements in Organ-on-Chips (OoCs) is presented and validated for a gut and a blood-brain barrier model.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]

  • A multiplexed nanoliter array-based microfluidic platform for quick, automatic antimicrobial susceptibility testing
    by Mohammad Osaid on April 13, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00216C, PaperMohammad Osaid, Yi-Sin Chen, Chih-Hung Wang, Anirban Sinha, Wen-Bin Lee, Priya Gopinathan, Hung-Bin Wu, Gwo-Bin LeeA nanoliter array-based automatic microfluidic platform for performing rapid antimicrobial susceptibility testing using only ∼2000 bacterial cells was reported, and required 8–9 hours to determine the minimum inhibitory concentration value.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A multilayered blood vessel/tumor tissue chip to investigate T cell infiltration into solid tumor tissues
    by Jaehyun Lee on April 13, 2021 at 11:00 pm

    Lab Chip, 2021, Accepted ManuscriptDOI: 10.1039/D1LC00182E, PaperJaehyun Lee, Seong-Eun Kim, Dowon Moon, Junsang DohCancer immunotherapies based on the ability of T cells to recognize and kill tumor cells (TCs), including immune checkpoint blockades (ICBs) and chimeric antigen receptor (CAR) T cell therapy, have...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Nanocosm: a well plate photobioreactor for environmental and biotechnological studies
    by Charlotte Volpe on April 12, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01250E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Charlotte Volpe, Olav Vadstein, Geir Andersen, Tom AndersenA versatile LED based miniature photobioreactor ideal for factorial experiments that allows simultaneous testing of a wide range of variables and experimental combinations needed for high-throughput screening analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]

  • Goodbye fouling: a unique coaxial lamination mixer (CLM) enabled by two-photon polymerization for the stable production of monodisperse drug carrier nanoparticles
    by Peer Erfle on April 11, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00047K, PaperPeer Erfle, Juliane Riewe, Heike Bunjes, Andreas DietzelCoaxial flow injection and mixing of solvent and antisolvent flows prevent contact of the lipid solution with microchannel walls and enable stable continuous precipitation of monodisperse nanoparticles in the order of 150 nm and below.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic enhancement of self-assembly systems
    by Davood Khoeini on April 11, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00038A, Critical ReviewDavood Khoeini, Timothy F. Scott, Adrian NeildA review of the advances in supramolecular chemistry achieved by the application of continuous and dispersed microfluidic approaches.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microdroplet extraction assisted ultrasensitive Raman detection in complex oil
    by Lingjun Zhang on April 11, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00169H, PaperLingjun Zhang, Jianfeng Sun, Hong He, Yingzhou Huang, Haiyang Shi, Weigen ChenThe Raman detection of trace substances (∼26 ppb) in complex mineral oils based on microdroplet extraction was demonstrated.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Size-tuneable isolation of cancer cells using stretchable inertial microfluidics
    by Hedieh Fallahi on April 7, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00082A, PaperHedieh Fallahi, Sharda Yadav, Hoang-Phuong Phan, Hang Ta, Jun Zhang, Nam-Trung NguyenWe present a stretchable inertial microfluidic device for tuneable separation of spiked cancer cells from blood sample.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows
    by H. Azizgolshani on April 7, 2021 at 11:00 pm

    Lab Chip, 2021, 21,1454-1474DOI: 10.1039/D1LC00067E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.H. Azizgolshani, J. R. Coppeta, E. M. Vedula, E. E. Marr, B. P. Cain, R. J. Luu, M. P. Lech, S. H. Kann, T. J. Mulhern, V. Tandon, K. Tan, N. J. Haroutunian, P. Keegan, M. Rogers, A. L. Gard, K. B. Baldwin, J. C. de Souza, B. C. Hoefler, S. S. Bale, L. B. Kratchman, A. Zorn, A. Patterson, E. S. Kim, T. A. Petrie, E. L. Wiellette, C. Williams, B. C. Isenberg, J. L. Charest96 microfluidic devices with independent […]

  • Reply to the ‘Comment on “Microflow in a rhythmically expanding alveolar chip with dynamic similarity”’ by A. Tsuda and F. S. Henry, Lab Chip, 2021, 21, DOI: 10.1039/D0LC00884B
    by Huimin Lv on April 6, 2021 at 11:00 pm

    Lab Chip, 2021, 21,1431-1432DOI: 10.1039/D0LC01271H, CommentHuimin Lv, Jun Dong, Yue Yang, Yonggang ZhuNon-uniform radial perturbations due to non-self-similar alveolar expansion drive the closed vortex into a spiral and the change of spiral rotation direction.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Development of a human neuromuscular tissue-on-a-chip model on a 24-well-plate-format compartmentalized microfluidic device
    by Kazuki Yamamoto on April 6, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00048A, PaperKazuki Yamamoto, Nao Yamaoka, Yu Imaizumi, Takunori Nagashima, Taiki Furutani, Takuji Ito, Yohei Okada, Hiroyuki Honda, Kazunori ShimizuA three-dimensional human neuromuscular tissue model that mimics the physically separated structures of motor neurons and skeletal muscle fibers is presented.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Directing osteoblastic cell migration on arrays of nanopillars and nanoholes with different aspect ratios
    by Yijun Cheng on April 6, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00104C, PaperYijun Cheng, Shuyan Zhu, Stella W. PangPlatforms with nanopillars in grating arrangements and larger height could promote more cell elongation, more directional migration, and higher migration speed, which could potentially lead to cell screening.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Comment on “Microflow in a rhythmically expanding alveolar chip with dynamic similarity” by H. Lv, J. Dong, Y. Qiu, Y. Yang and Y. Zhu, Lab Chip, 2020, 20, 2394
    by Akira Tsuda on April 6, 2021 at 11:00 pm

    Lab Chip, 2021, 21,1429-1430DOI: 10.1039/D0LC00884B, CommentAkira Tsuda, Frank S. HenryThis comment on an article that appeared in this journal (H. Lv, J. Dong, Y. Qiu, Y. Yang and Y. Zhu, Lab Chip, 2020, 20, 2394–2402) highlights some important inconsistencies between the authors' experimental results and their numerical simulations.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Synchronous control of magnetic particles and magnetized cells in a tri-axial magnetic field
    by Roozbeh Abedini-Nassab on April 2, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00097G, PaperRoozbeh Abedini-Nassab, Sajjad BahramiSingle magnetic particles and magnetized cells are transported on-chip using a TI magnetic pattern. The tri-axial external magnetic field provides the driving force for manipulating all the particles simultaneously.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Coupling fluid flow to hydrogel fluidic devices with reversible “pop-it” connections
    by Reha Abbasi on March 31, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00135C, PaperReha Abbasi, Thomas B. LeFevre, Aaron D. Benjamin, Isaak J. Thornton, James N. WilkingHere, we describe a simple, reversible, plug-based connector designed to couple microfluidic tubing to a hydrogel-based fluidic device, to allow for pressurized liquid flow through the system.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Ultra-rapid modulation of neurite outgrowth in a gigahertz acoustic streaming system
    by Shan He on March 30, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01262A, PaperShan He, Zefang Wang, Wei Pang, Chang Liu, Miaosen Zhang, Yang Yang, Xuexin Duan, Yanyan WangA gigahertz acoustic streaming effect stimulates PC12 cell structure change within 10 min, and produces a higher ratio of neurite-bearing cells compared to NGF stimulation. This method can be of single-cell modulation due to microminiaturization.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Emerging point-of-care technologies for anemia detection
    by Ran An on March 30, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01235A, Critical ReviewRan An, Yuning Huang, Yuncheng Man, Russell W. Valentine, Erdem Kucukal, Utku Goreke, Zoe Sekyonda, Connie Piccone, Amma Owusu-Ansah, Sanjay Ahuja, Jane A. Little, Umut A. GurkanIn this critical review, emerging non-invasive and minimally invasive point-of-care anemia detection technologies are discussed, highlighting future directions and the need for multiplexed approaches and integrated disease etiology identification.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]

  • A microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay for rapid COVID-19 detection
    by Dan Liu on March 29, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01222J, PaperDan Liu, Haicong Shen, Yuqian Zhang, Danyu Shen, Mingyang Zhu, Yanling Song, Zhi Zhu, Chaoyong YangA simple microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay was developed for rapid COVID-19 detection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An electricity- and instrument-free infectious disease sensor based on a 3D origami paper-based analytical device
    by Chung-An Chen on March 29, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00079A, PaperChung-An Chen, Hao Yuan, Chiao-Wen Chen, Yuh-Shiuan Chien, Wang-Huei Sheng, Chien-Fu ChenA three-dimensional origami-paper-based analytical device with electricity-free “timer” function for HIV type 1 p24 antigen detection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Closed-loop feedback control of microfluidic cell manipulation via deep-learning integrated sensor networks
    by Ningquan Wang on March 28, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00076D, PaperNingquan Wang, Ruxiu Liu, Norh Asmare, Chia-Heng Chu, Ozgun Civelekoglu, A. Fatih SariogluAn adaptive microfluidic system changing its operational state in real-time based on cell measurements through an on-chip electrical sensor network.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth
    by Enkhtuya Radnaa on March 28, 2021 at 11:00 pm

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01323D, PaperEnkhtuya Radnaa, Lauren S. Richardson, Samantha Sheller-Miller, Tuvshintugs Baljinnyam, Mariana de Castro Silva, Ananth Kumar Kammala, Rheanna Urrabaz-Garza, Talar Kechichian, Sungjin Kim, Arum Han, Ramkumar MenonPreterm birth (PTB; <37 weeks of gestation) impacts ∼11% of all pregnancies and contributes to 1 million neonatal deaths worldwide annually.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Recent advances in lab-on-paper diagnostic devices using blood samples
    by Wen-Chin Lee on March 28, 2021 at 11:00 pm

    Lab Chip, 2021, 21,1433-1453DOI: 10.1039/D0LC01304H, Critical ReviewWen-Chin Lee, Hwee-Yeong Ng, Chih-Yao Hou, Chien-Te Lee, Lung-Ming FuOverview of integrated lab-on-paper diagnostic devices.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Lab on a Chip – past, present, and future
    by Andreas Manz on March 25, 2021 at 12:00 am

    Lab Chip, 2021, 21,1197-1198DOI: 10.1039/D1LC90030G, EditorialAndreas Manz, Abraham P. Lee, Aaron R. WheelerWe check in with past, present, and future Editors-in-Chief, including Andreas Manz (2001–2008), Abe Lee (2017–2020), and Aaron Wheeler (2021–), about the state of the field.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Automated fluorescence quantification of extracellular vesicles collected from blood plasma using dielectrophoresis
    by Kyle T. Gustafson on March 24, 2021 at 12:00 am

    Lab Chip, 2021, 21,1318-1332DOI: 10.1039/D0LC00940G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kyle T. Gustafson, Katherine T. Huynh, Daniel Heineck, Jesus Bueno, Augusta Modestino, Sejung Kim, Austin Gower, Randall Armstrong, Carolyn E. Schutt, Stuart D. IbsenDescribed is a fully automated algorithm and a particle-based internal standard to optically quantify immunostained particles collected using microfluidic chips.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Novel microwell with a roof capable of buoyant spheroid culture
    by Daehan Kim on March 24, 2021 at 12:00 am

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01295E, PaperDaehan Kim, Kideok Kim, Joong Yull ParkOur unique microwell in the shape of the Greek letter sigma (σ) with a roof can culture floating spheroids.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microscopy-compatible temperature regulation system for single-cell phenotype analysis – demonstrated by thermoresponse mapping of microalgae
    by Martin Andersson on March 23, 2021 at 12:00 am

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01288B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Martin Andersson, Sofia Johansson, Henrik Bergman, Linhong Xiao, Lars Behrendt, Maria TenjeA heat-stage for spatiotemporal temperature control in microfluidic chips is developed. The technology is used for mapping thermoresponses of single cells of Symbiodinium in order to improve our understanding of temperature-induced coral bleaching.To cite this article before page numbers are assigned, use the DOI form of […]

  • Nonlinear microfluidics: device physics, functions, and applications
    by H. M. Xia on March 22, 2021 at 12:00 am

    Lab Chip, 2021, 21,1241-1268DOI: 10.1039/D0LC01120G, Critical ReviewH. M. Xia, J. W. Wu, J. J. Zheng, J. Zhang, Z. P. WangNonlinear microfluidics, including the typical devices, their working mechanisms and applications are discussed.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology
    by Yaru Xing on March 22, 2021 at 12:00 am

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D1LC00101A, PaperYaru Xing, Yu Liu, Rifei Chen, Yuyan Li, Chengzhi Zhang, Youwei Jiang, Yao Lu, Bingcheng Lin, Peizhong Chen, Ruijun Tian, Xianming Liu, Xing ChengAn active-matrix digital microfluidic platform based on printed-circuit board technology is developed as a robust, highly scalable, low cost, easy to use, and contamination-insensitive device for automatic and parallel droplet handling.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Flexible online in-droplet cell/synthetic particle concentration utilizing alternating current electrothermal-flow field-effect transistor
    by Haizhen Sun on March 22, 2021 at 12:00 am

    Lab Chip, 2021, Advance ArticleDOI: 10.1039/D0LC01328E, PaperHaizhen Sun, Yukun Ren, Ye Tao, Tianyi Jiang, Hongyuan JiangThis work describes a universal, massive and versatile technique, namely, alternating current electrothermal-flow field-effect transistor, to accomplish online in-droplet cell/synthetic particle concentration on demand.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Correction: Liquid marble-based digital microfluidics – fundamentals and applications
    by Chin Hong Ooi on March 19, 2021 at 12:00 am

    Lab Chip, 2021, 21,1418-1418DOI: 10.1039/D1LC90031E, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chin Hong Ooi, Raja Vadivelu, Jing Jin, Kamalalayam Rajan Sreejith, Pradip Singha, Nhat-Khuong Nguyen, Nam-Trung NguyenThe content of this RSS Feed (c) The Royal Society of Chemistry

  • Focused surface acoustic wave locally removes cells from culture surface
    by Takumi Inui on March 18, 2021 at 12:00 am

    Lab Chip, 2021, 21,1299-1306DOI: 10.1039/D0LC01293A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Takumi Inui, Jiyang Mei, Chikahiro Imashiro, Yuta Kurashina, James Friend, Kenjiro TakemuraAfter exposing a plated C2C12 cells culture to PBS, ultrasound from the SAW device transmitted into the cell culture via a coupling water droplet. We can remove cells from an area 6 × 10−3 mm2, equivalent to about 12 cells.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Coexistence of fluorescent Escherichia coli strains in millifluidic droplet reactors
    by Xinne Zhao on March 17, 2021 at 12:00 am

    Lab Chip, 2021, 21,1492-1502DOI: 10.1039/D0LC01204A, PaperXinne Zhao, Rico Illing, Philip Ruelens, Michael Bachmann, Gianaurelio Cuniberti, J. Arjan G. M. de Visser, Larysa BarabanWe use a millifluidic system to study the multi-species bacterial growth to unveil the details of cooperation between two Escherichia coli strains inside droplet reactors. This system also has the potential for studies of drug resistance transfer.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Isolation and recovery of extracellular vesicles using optically-induced dielectrophoresis on an integrated microfluidic platform
    by Yi-Sin Chen on March 15, 2021 at 12:00 am

    Lab Chip, 2021, 21,1475-1483DOI: 10.1039/D1LC00093D, PaperYi-Sin Chen, Charles Pin-Kuang Lai, Chihchen Chen, Gwo-Bin LeeA novel method for automating label-free, contact-free isolation and recovery of EVs by using ODEP on a microfluidic platform was developed and achieved effective EV enrichment (272-fold locally increase), releasing (99.8%) and recovery (52.2%).The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic platform for serial mixing experiments with in operando nuclear magnetic resonance spectroscopy
    by Marek Plata on March 4, 2021 at 12:00 am

    Lab Chip, 2021, 21,1598-1603DOI: 10.1039/D0LC01100B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Marek Plata, William Hale, Manvendra Sharma, Jörn M. Werner, Marcel UtzCoupling of pressure-driven microfuidics and NMR spectroscopy allows in operando observation of serial mixing experiments.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Paper-thin multilayer microfluidic devices with integrated valves
    by Soohong Kim on March 3, 2021 at 12:00 am

    Lab Chip, 2021, 21,1287-1298DOI: 10.1039/D0LC01217C, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Soohong Kim, Gabriel Dorlhiac, Rodrigo Cotrim Chaves, Mansi Zalavadia, Aaron StreetsThe “thin-chip” provides the functionality of multilayer PDMS microfluidic devices with integrated valves, in a paper-thin form factor, enabling integration with advanced optical microscopy and magnetic trapping.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Tough, permeable and biocompatible microfluidic devices formed through the buckling delamination of soft hydrogel films
    by Riku Takahashi on March 2, 2021 at 12:00 am

    Lab Chip, 2021, 21,1307-1317DOI: 10.1039/D0LC01275K, PaperRiku Takahashi, Hiroki Miyazako, Aya Tanaka, Yuko Ueno, Masumi YamaguchiWe demonstrate pressure-driven microfluidic devices based on buckle-delaminated architectures of thin hydrogel films, which exhibit high durability, permeability, and biocompatibility with intricate 3D morphologies.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Precision ejection of microfluidic droplets into air with a superhydrophobic outlet
    by Pengfei Zhang on March 1, 2021 at 12:00 am

    Lab Chip, 2021, 21,1484-1491DOI: 10.1039/D0LC01327G, PaperPengfei Zhang, Kai-Chun Chang, Adam R. AbateWe describe a general approach to controllably and precisely eject droplets of tunable composition from microfluidic devices using superhydrophobic patterning.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Controlled orientation and sustained rotation of biological samples in a sono-optical microfluidic device
    by Mia Kvåle Løvmo on February 26, 2021 at 12:00 am

    Lab Chip, 2021, 21,1563-1578DOI: 10.1039/D0LC01261K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mia Kvåle Løvmo, Benedikt Pressl, Gregor Thalhammer, Monika Ritsch-MarteOptical and 3D acoustic trapping are combined in a microfluidic ‘sono-optical’ device to control the orientation or to induce sustained rotation of sub-millimeter-sized biological samples, such as micro-organisms, pollen grains or cell-clusters.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Review of microfluidic approaches for fabricating intelligent fiber devices: importance of shape characteristics
    by Ronghui Wu on February 25, 2021 at 12:00 am

    Lab Chip, 2021, 21,1217-1240DOI: 10.1039/D0LC01208D, Critical ReviewRonghui Wu, Taesung KimIntelligent fiber devices with shape characteristics tailored by microfluidic approaches are reviewed, including sensors and actuators, luminous fibers, and devices for water collection, energy harvesting, and tissue engineering applications.The content of this RSS Feed (c) The Royal Society of Chemistry

  • The acoustic droplet printing of functional tumor microenvironments
    by Keke Chen on February 24, 2021 at 12:00 am

    Lab Chip, 2021, 21,1604-1612DOI: 10.1039/D1LC00003A, PaperKeke Chen, Erhui Jiang, Xiaoyun Wei, Yu Xia, Zezheng Wu, Zhiyi Gong, Zhengjun Shang, Shishang GuoAn acoustic droplet printing method is reported that enables high-concentration cells or spheroids to be printed with superior cell viability, allowing the creation of functional tumor microenvironments.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A polymer index-matched to water enables diverse applications in fluorescence microscopy
    by Xiaofei Han on February 22, 2021 at 12:00 am

    Lab Chip, 2021, 21,1549-1562DOI: 10.1039/D0LC01233E, PaperXiaofei Han, Yijun Su, Hamilton White, Kate M. O'Neill, Nicole Y. Morgan, Ryan Christensen, Deepika Potarazu, Harshad D. Vishwasrao, Stephen Xu, Yilun Sun, Shar-yin Huang, Mark W. Moyle, Qionghai Dai, Yves Pommier, Edward Giniger, Dirk R. Albrecht, Roland Probst, Hari ShroffDiffraction-limited and super-resolution imaging of biological samples using refractive-index matched polymers in microdevices.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Thermoplastic nanofluidic devices for identifying abasic sites in single DNA molecules
    by Swarnagowri Vaidyanathan on February 22, 2021 at 12:00 am

    Lab Chip, 2021, 21,1579-1589DOI: 10.1039/D0LC01038C, PaperSwarnagowri Vaidyanathan, Kumuditha M. Weerakoon-Ratnayake, Franklin I. Uba, Bo Hu, David Kaufman, Junseo Choi, Sunggook Park, Steven A. SoperNanofluidic circuit for detecting damage (abasic sites) in single DNA molecules.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Investigations on T cell transmigration in a human skin-on-chip (SoC) model
    by Xiaoou Ren on February 22, 2021 at 12:00 am

    Lab Chip, 2021, 21,1527-1539DOI: 10.1039/D0LC01194K, PaperXiaoou Ren, Anthony E. Getschman, Samuel Hwang, Brian F. Volkman, Thomas Klonisch, David Levin, Min Zhao, Susy Santos, Song Liu, Jasmine Cheng, Francis LinOur skin-on-chip (SoC) model uniquely enabled quantitative studies of transendothelial and transepithelial migration of human T lymphocytes under mimicked inflammatory skin conditions and was used to test new drug candidates.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A reusable single-cell patterning strategy based on an ultrathin metal microstencil
    by Yuhan Song on February 22, 2021 at 12:00 am

    Lab Chip, 2021, 21,1590-1597DOI: 10.1039/D0LC01175D, PaperYuhan Song, Qingqing Tian, Jianhong Liu, Wenting Guo, Yingnan Sun, Shusheng ZhangWe presented a reusable and simple method for the rapid preparation of high-throughput single-cell patterns using an ultrathin stainless steel microstencil with 5 μm thickness and common tools available in most laboratories.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Recent progress on wearable point-of-care devices for ocular systems
    by Haein Shin on February 22, 2021 at 12:00 am

    Lab Chip, 2021, 21,1269-1286DOI: 10.1039/D0LC01317J, PerspectiveHaein Shin, Hunkyu Seo, Won Gi Chung, Byung Jun Joo, Jiuk Jang, Jang-Ung ParkEyes have remarkable potential as biological sensing sites for various physical factors and biomarkers, which makes contact lens sensors a promising platform for a wearable point-of-care device for monitoring and diagnosis of diseases.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy
    by Stephanie J. Hachey on February 19, 2021 at 12:00 am

    Lab Chip, 2021, 21,1333-1351DOI: 10.1039/D0LC01216E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Stephanie J. Hachey, Silva Movsesyan, Quy H. Nguyen, Giselle Burton-Sojo, Ani Tankazyan, Jie Wu, Tuyen Hoang, Da Zhao, Shuxiong Wang, Michaela M. Hatch, Elizabeth Celaya, Samantha Gomez, George T. Chen, Ryan T. Davis, Kevin Nee, Nicholas Pervolarakis, Devon A. Lawson, Kai Kessenbrock, Abraham P. Lee, John Lowengrub, Marian L. Waterman, Christopher C. W. HughesVMTs recapitulate in vivo drug responses and also […]

  • Liquid marble-based digital microfluidics – fundamentals and applications
    by Chin Hong Ooi on February 17, 2021 at 12:00 am

    Lab Chip, 2021, 21,1199-1216DOI: 10.1039/D0LC01290D, Critical ReviewChin Hong Ooi, Raja Vadivelu, Jing Jin, Kamalalayam Rajan Sreejith, Pradip Singha, Nhat-Khuong Nguyen, Nam-Trung NguyenLiquid marbles are microliter-sized non-wetting droplets. Their versatility makes them an attractive digital microfluidics platform. This paper provides state-of-the-art discoveries in the physics of liquid marbles and their applications.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic ultrafine particle dosimeter using an electrical detection method with a machine-learning-aided algorithm for real-time monitoring of particle density and size distribution
    by Tae-Hoon Lee on February 17, 2021 at 12:00 am

    Lab Chip, 2021, 21,1503-1516DOI: 10.1039/D0LC01240H, PaperTae-Hoon Lee, Hong-Beom Kwon, Woo-Young Song, Seung-Soo Lee, Yong-Jun KimA compact, cost-efficient airborne ultrafine particle (UFP) dosimeter that can monitor essential parameters required for accurate UFP dosimetry.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Double emulsions with ultrathin shell by microfluidic step-emulsification
    by Xinjin Ge on February 15, 2021 at 12:00 am

    Lab Chip, 2021, 21,1613-1622DOI: 10.1039/D0LC01044H, PaperXinjin Ge, Boris Y. Rubinstein, Yifeng He, Frederick N. O. Bruce, Liaonan Li, Alexander M. Leshansky, Zhenzhen LiWe present a simple microfluidic device based on tri-phasic co-flow step-emulsification, for high throughput production of double emulsions with an ultrathin shell in a single step.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip
    by Simone Perottoni on February 15, 2021 at 12:00 am

    Lab Chip, 2021, 21,1395-1408DOI: 10.1039/D0LC01034K, PaperSimone Perottoni, Nuno G. B. Neto, Cesare Di Nitto, Ruslan I. Dmitriev, Manuela Teresa Raimondi, Michael G. MonaghanThe stem cell niche at the perivascular space plays a role in dictating the fate of stem cells within it. This study predicts in silico and models the perivascular space, in a miniaturised bioreactor, with non-invasive assessment of cell metabolism.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Continuous microfluidic fabrication of anisotropic microparticles for enhanced wastewater purification
    by Xiaokang Deng on February 15, 2021 at 12:00 am

    Lab Chip, 2021, 21,1517-1526DOI: 10.1039/D0LC01298J, PaperXiaokang Deng, Yukun Ren, Likai Hou, Tianyi Jiang, Hongyuan JiangAnisotropic microparticles with spherical, pear-like, maraca-like and rod-like shapes are continuously fabricated via a facile microfluidic strategy. Porous rod-like microparticles show enhanced performance in removal of organic contaminants.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic cartridge for fast and accurate diagnosis of Mycobacterium tuberculosis infections on standard laboratory equipment
    by Ana R. Homann on February 12, 2021 at 12:00 am

    Lab Chip, 2021, 21,1540-1548DOI: 10.1039/D1LC00035G, PaperAna R. Homann, Laura Niebling, Steffen Zehnle, Markus Beutler, Lubov Delamotte, Marie-Christine Rothmund, Daniel Czurratis, Klaus-Dieter Beller, Roland Zengerle, Harald Hoffmann, Nils PaustWe present a novel centrifugal microfluidic approach for fast and accurate Tuberculosis (TB) diagnosis based on the use of standard laboratory equipment.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Rapid and precise tumor cell separation using the combination of size-dependent inertial and size-independent magnetic methods
    by Di Huang on February 12, 2021 at 12:00 am

    Lab Chip, 2021, 21,1409-1417DOI: 10.1039/D0LC01223H, PaperDi Huang, Nan XiangA three-stage i-Mag device combines the passive inertial microfluidics and the active magnetophoresis method for rapid, precise, and tumor antigen-independent separation of rare tumor cells from blood.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Sensing morphogenesis of bone cells under microfluidic shear stress by holographic microscopy and automatic aberration compensation with deep learning
    by Wen Xiao on February 8, 2021 at 12:00 am

    Lab Chip, 2021, 21,1385-1394DOI: 10.1039/D0LC01113D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wen Xiao, Lu Xin, Runyu Cao, Xintong Wu, Ran Tian, Leiping Che, Lianwen Sun, Pietro Ferraro, Feng PanWe propose a method to compensate the aberrations of digital holographic microscopy based on a multiple regression convolutional neural network. The experimental verification is carried out by measuring the morphological change of living cells under micro-Fluidic Shear Stress.The content of this RSS Feed (c) The Royal […]

  • Practical microcircuits for handheld acoustofluidics
    by An Huang on February 3, 2021 at 12:00 am

    Lab Chip, 2021, 21,1352-1363DOI: 10.1039/D0LC01008A, PaperAn Huang, William Connacher, Mark Stambaugh, Naiqing Zhang, Shuai Zhang, Jiyang Mei, Aditi Jain, Sravya Alluri, Vincent Leung, Anushi E Rajapaksa, James FriendPractical acoustofluidics for lab-on-a-chip applications is now enabled by battery-powered handheld circuits.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic impedance-based extended infectivity assay: combining retroviral amplification and cytopathic effect monitoring on a single lab-on-a-chip platform
    by Michaela Purtscher on February 1, 2021 at 12:00 am

    Lab Chip, 2021, 21,1364-1372DOI: 10.1039/D0LC01056A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michaela Purtscher, Mario Rothbauer, Sebastian Rudi Adam Kratz, Andrew Bailey, Peter Lieberzeit, Peter ErtlWe have established a lab-on-a-chip for detection, quantification and monitoring of virus – host cell interactions that are of great importance when evaluating the safety of pharmaceutical products.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Directional anchoring patterned liquid-infused superamphiphobic surfaces for high-throughput droplet manipulation
    by Weijian Liu on January 29, 2021 at 12:00 am

    Lab Chip, 2021, 21,1373-1384DOI: 10.1039/D0LC01037E, PaperWeijian Liu, Xiao Luo, Changhao Chen, Guochen Jiang, Xinyu Hu, Hongjun Zhang, Minlin ZhongHigh-throughput experiments involving isolated droplets based on patterned superwettable surfaces are important for various applications related to biology, chemistry, and medicine, and they have attracted a large amount of interest.The content of this RSS Feed (c) The Royal Society of Chemistry

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