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RSC - Lab Chip latest articles RSC - Lab Chip latest articles

  • OSTE+ for in-situ SAXS Analysis with Droplet Microfluidic Devices
    by Tobias Lange on July 7, 2020 at 11:00 pm

    Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00454E, PaperTobias Lange, Sophie Charton, Thomas Bizien, Fabienne Testard, Florent MalloggiIn recent years, microfluidic-based sample preparation techniques have emerged as a powerful tool for measurements at large scale X-ray facilities. Most often the microfluidic device was a form of hybrid...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Evaluation of Microflow Configurations for Scale Inhibition and Serial X-ray Diffraction Analysis of Crystallization Processes
    by Mark A. Levenstein on July 6, 2020 at 11:00 pm

    Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00239A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mark A. Levenstein, Yi-Yeoun Kim, Liam Hunter, Clara Anduix-Canto, Carlos González, Sarah Day, Shunbo Li, William Marchant, Phillip Lee, Chiu C Tang, Manfred Burghammer, Fiona C Meldrum, Nikil KapurThe clean and reproducible conditions provided by microfluidic devices are ideal sample environments for in situ analyses of chemical and biochemical reactions and assembly processes. However, the small size of...The […]

  • A scalable microfluidic chamber array for sample-loss-free and bubble-proof sample compartmentalization with a simple pipetting
    by Baobao Lin on July 6, 2020 at 11:00 pm

    Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00348D, PaperBaobao Lin, Zijian Guo, Zhi Geng, Siwat Jakaratanopas, Bingqian Han, Peng LiuSample compartmentalization is a pivotal technique in many bioanalytical applications, such as multiplex polymerase chain reaction (PCR) and digital PCR (dPCR). In this study, we successfully developed a novel self-...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Hollow silicon microneedle fabrication using advanced plasma etch technologies for applications in transdermal drug delivery
    by Chris J. W. Bolton on July 6, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00567C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chris J. W. Bolton, Olivia Howells, Gareth J. Blayney, Pey F. Eng, James C. Birchall, Benedetta Gualeni, Kerry Roberts, Huma Ashraf, Owen J. GuyA novel production process flow is presented for the manufacture of hollow silicon microneedles using deep reactive-ion etching (DRIE) technology.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]

  • TRYPTIC DIGESTION OF HUMAN SERUM FOR PROTEOMIC MASS SPECTROMETRY AUTOMATED BY CENTRIFUGAL MICROFLUIDICS
    by Jan-Niklas Klatt on July 5, 2020 at 11:00 pm

    Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00530D, PaperJan-Niklas Klatt, Maren Depke, Neha Goswami, Nils Paust, Roland Zengerle, Frank Schmidt, Tobias HutzenlaubMass spectrometry has become an important analytical tool for protein research studies to identify, characterise and quantify proteins with unmatched sensitivity in a highly parallel manner. When transferred into clinical...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Biomimetic construction of peritoneum to imitate peritoneal metastasis using digital micromirror device-based optical projection lithography
    by Zhixing Ge on July 5, 2020 at 11:00 pm

    Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00361A, PaperZhixing Ge, Junhua Zhao, Haibo Yu, Wenguang Yang, Peilin Zhou, Zhenning Wang, Lianqing LiuCurrently, the mechanisms underlying the peritoneal metastasis of gastric cancer cells and the function of mesothelial cells during this process are unclear, primarily due to the absence of an effective...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Ultrasonic Microstreaming for Complex-trajectory Transport and Rotation of Single Particles and Cells
    by Zhichao Ma on July 2, 2020 at 11:00 pm

    Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00595A, PaperZhichao Ma, Yinning Zhou, Feiyan Cai, Long Meng, Hairong Zheng, Ye AiPrecisely controllable transport and rotation of microparticles and cells has great potential to enable new capabilities for single-cell level analysis. In this work, we present a versatile ultrasonic microstreaming based...The content of this RSS Feed (c) The Royal Society of Chemistry

  • AI on a chip
    by Akihiro Isozaki on July 2, 2020 at 11:00 pm

    Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00521E, Critical ReviewAkihiro Isozaki, Jeffrey Harmon, Yuqi Zhou, Shuai Li, Yuta Nakagawa, Mika Hayashi, Hideharu Mikami, Cheng Lei, Keisuke GodaArtificial intelligence (AI) has dramatically changed the landscape of science, industry, defense, and medicine in the last several years. Supported by considerably enhanced computational power and cloud storage, the field...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Diffraction-based acoustic manipulation in microchannels enables continuous particle and bacteria focusing
    by Citsabehsan Devendran on June 30, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00397B, PaperCitsabehsan Devendran, Kyungyong Choi, Jongyoon Han, Ye Ai, Adrian Neild, David J. CollinsWe explore a unique diffractive acoustic phenomenon arising from a surface acoustic wave and channel elements, which we term diffractive acoustic surface acoustic waves (DASAW), which can be applied robustly for all channel orientations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An in vivo microfluidic study of bacterial transit in C. elegans nematodes
    by Vittorio Viri on June 30, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00064G, PaperVittorio Viri, Matteo Cornaglia, Huseyin Baris Atakan, Thomas Lehnert, Martin A. M. GijsA microfluidic device for studying bacterial transit dynamics in the intestine of Caenorhabditis elegans.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Micro-strains in the extracellular matrix induce angiogenesis
    by Mary Kathryn Sewell-Loftin on June 29, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00145G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mary Kathryn Sewell-Loftin, Joshua B. Katz, Steven C. George, Gregory D. LongmoreA microtissue platform with independent control over biomechanical parameters is described and used to demonstrate how cell-generated forces drive angiogenesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Current state of the art in rapid diagnostics for antimicrobial resistance
    by Rathina Kumar Shanmuga Kani on June 29, 2020 at 11:00 pm

    Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00034E, Critical ReviewRathina Kumar Shanmuga Kani, Balaji Srinivasan, Marshall J Glesby, Lars F Westblade, Washington B. Cárdenas, Tony Raj, David Erickson, Saurabh MehtaAntimicrobial resistance (AMR) is a fundamental global concern analogous to climate change threatening both public health and global development progress. Infections caused by antimicrobial-resistant pathogens pose serious threats to healthcare...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Enhancement of inflection point focusing and rarecell separations from untreated whole blood
    by Dongwoo Lee on June 28, 2020 at 11:00 pm

    Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00309C, PaperDongwoo Lee, Yohan Choi, Wonhee LeeInertial microfluidic systems have been widely used for particle or cell separation applications, especially for rare-cell enrichment and separation from blood due to the high throughput and simplicity of the...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic chip with pillar arrays for controlled production and observation of lipid membrane nanotubes
    by Juan Manuel Martinez Galvez on June 28, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00451K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Juan Manuel Martinez Galvez, Maite Garcia-Hernando, Fernando Benito-Lopez, Lourdes Basabe-Desmonts, Anna V. ShnyrovaMicroarray surface chemistry and design set the geometry of lipid membrane nanotubes easily formed and observed in a microfluidic chamber.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Functional reservoir microcapsules generated via microfluidic fabrication for long-term cardiovascular therapeutics
    by Ngoc-Duy Dinh on June 25, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00296H, PaperNgoc-Duy Dinh, Marek Kukumberg, Anh-Tuan Nguyen, Hamed Keramati, Song Guo, Dinh-Tuan Phan, Nurdiyana B. Ja'Afar, Erik Birgersson, Hwa Liang Leo, Ruby Yun-Ju Huang, Theodoros Kofidis, Abdul Jalil Rufaihah, Chia-Hung ChenThe reservoir microcapsules are fabricated through one-step microfluidic phase separation for long-term cardiovascular therapeutics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Multidimensional protein characterisation using microfluidic post-column analysis
    by Tom Scheidt on June 25, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00219D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tom Scheidt, Tadas Kartanas, Quentin Peter, Matthias M. Schneider, Kadi L. Saar, Thomas Müller, Pavan Kumar Challa, Aviad Levin, Sean Devenish, Tuomas P. J. KnowlesDirect combination of liquid chromatography with multidimensional post-column analysis through microfluidics for individual quantification of biophysical parameters.To cite this article before page numbers are assigned, use the DOI form of citation […]

  • Reciprocating flow-assisted nucleic acid purification using a finger-actuated microfluidic device
    by Juhwan Park on June 24, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00432D, PaperJuhwan Park, Dong Hyun Han, Sang-Hyun Hwang, Je-Kyun ParkA finger-actuated microfluidic reciprocator was developed and exploited to improve the recovery rate of nucleic acid purification in a finger-actuated microfluidic device.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Lithographically patterned well-type graphene liquid cells with rational designs
    by Namgyu Noh on June 23, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00440E, PaperNamgyu Noh, Jungjae Park, Ji Su Park, Kunmo Koo, Jae Yeol Park, Jong Min YukThe micro-holey pattered graphene liquid cells provide micro-sized viewing areas and controllable liquid thickness, thus enable remarkable imaging performance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Real time chemical and mechanical human motion monitoring with aerogel-based wearable sensors
    by Onur Ergen on June 23, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00545B, PaperOnur Ergen, Ecem Celik, Ahmet Hamdi Unal, Mert Yusuf Erdolu, Feriha Eylem Sarac, Ugur UnalWearable bioelectronic systems are one of the most important tools for human health and motion monitoring.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Precipitation-based colorimetric multiplex immunoassay in hydrogel particles
    by Yoon Ho Roh on June 22, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00325E, PaperYoon Ho Roh, Hyun Jee Lee, Ju Yeon Kim, Hyeon Ung Kim, Sun Min Kim, Ki Wan BongHigh-performance colorimetric immunoassay based on hydrogel particles was developed by precipitation and amplification of coloured products inside hydrogel networks.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Paper-based human neutrophil elastase detection device for clinical wound monitoring
    by Ting Yang on June 22, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00062K, PaperTing Yang, Shin-Chen Pan, Chao-Min ChengIn this study, we have developed a paper-based elastase detection device (PEDD) for clinical wound assessment that specifically examines human neutrophil elastase (HNE).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic platform for 3D cell culture with live imaging and clone retrieval
    by Carla Mulas on June 22, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00165A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Carla Mulas, Andrew C. Hodgson, Timo N. Kohler, Chibeza C. Agley, Peter Humphreys, Hans Kleine-Brüggeney, Florian Hollfelder, Austin Smith, Kevin J. Chalut3D cell culture and microfluidic platform for monitoring biological process and single clone retrieval for downstream molecular or functional analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]

  • Buoyancy-driven step emulsification on pneumatic centrifugal microfluidic platforms
    by Liviu Clime on June 21, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00333F, CommunicationLiviu Clime, Lidija Malic, Jamal Daoud, Luke Lukic, Matthias Geissler, Teodor VeresWe present here a new method for controlling the droplet size in step emulsification processes on a centrifugal microfluidic platform, which, in addition to the centrifugal force, uses pneumatic actuation for fluid displacement.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Point-of-care testing system for digital single cell detection of MRSA directly from nasal swabs
    by Martin Schulz on June 21, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00294A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Martin Schulz, Silvia Calabrese, Florian Hausladen, Holger Wurm, Dominik Drossart, Karl Stock, Anna M. Sobieraj, Fritz Eichenseher, Martin J. Loessner, Mathias Schmelcher, Anja Gerhardts, Ulrike Goetz, Marina Handel, Annerose Serr, Georg Haecker, Jia Li, Mara Specht, Philip Koch, Martin Meyer, Philipp Tepper, Raimund Rother, Michael Jehle, Simon Wadle, Roland Zengerle, Felix von Stetten, Nils Paust, Nadine […]

  • Quantitative analysis of yeast MAPK signaling networks and crosstalk using a microfluidic device
    by Byungjin Lee on June 21, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00203H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Byungjin Lee, Seong-Geun Jeong, Si Hyung Jin, Ranjan Mishra, Matthias Peter, Chang-Soo Lee, Sung Sik LeeEukaryotic cells developed complex signaling networks to sense their environment and respond to various stress conditions. We investigate yeast MAPK signaling pathways and their crosstalk by a microfluidic device coupled to quantitative microscopy.To cite this article before page numbers are assigned, use the DOI […]

  • A system for the high-throughput measurement of the shear modulus distribution of human red blood cells
    by Amir Saadat on June 21, 2020 at 11:00 pm

    Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00283F, PaperAmir Saadat, Diego Antonio Huyke, Diego Ignacio Oyarzun, Paulina V. Escobar, Ingrid H. Øvreeide, Eric S. G. Shaqfeh, Juan Gabriel SantiagoReduced deformability of red blood cells (RBCs) can affect the hemodynamics of the microcirculation and reduce oxygen transport efficiency. It is also well known that reduced RBC deformability is a...The content of this RSS Feed (c) The Royal Society of Chemistry

  • An integrated platform for fibrinogen quantification on a microfluidic paper-based analytical device
    by Yanfang Guan on June 18, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00439A, PaperYanfang Guan, Kun Zhang, Fengqian Xu, Ruiyang Guo, Anshu Fang, Baichuan Sun, Xiangxin Meng, Yansheng Liu, Mingyang BaiFibrinogen (FIB) plays a key role in blood coagulation and thrombosis and its concentration in blood can directly reflect health conditions, thus an efficient detection of FIB would benefit the treatments of certain diseases such as liver and heart diseases.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Magnetic polyelectrolyte microcapsules via water-in-water droplet microfluidics
    by Maryam Navi on June 17, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00387E, PaperMaryam Navi, Jennifer Kieda, Scott S. H. TsaiWe report an all-aqueous microfluidic platform based on integration of ferrofluid and water-in-water droplets for fabrication of magnetic polyelectrolyte microcapsules.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An in vitro tumor swamp model of heterogeneous cellular and chemotherapeutic landscapes
    by Ke-Chih Lin on June 17, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00131G, PaperKe-Chih Lin, Yusha Sun, Gonzalo Torga, Pema Sherpa, Yihua Zhao, Junle Qu, Sarah R. Amend, Kenneth J. Pienta, James C. Sturm, Robert H. AustinA microfluidic platform was developed that generates a gradient of chemotherapy via diffusion to study evolutionary dynamics of cancer.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Skin-interfaced microfluidic devices with one-opening chambers and hydrophobic valves for sweat collection and analysis
    by Yingxue Zhang on June 17, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00400F, PaperYingxue Zhang, Yao Chen, Jielong Huang, Yangchengyi Liu, Jinfeng Peng, Shangda Chen, Kui Song, Xiaoping Ouyang, Huanyu Cheng, Xiufeng WangSoft, skin-interfaced microfluidic platforms are capable of capturing, storing, and assessing sweat chemistry and total sweat loss, which provides essential insight into human physiological health.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Low-electric-potential-assisted diffusiophoresis for continuous separation of nanoparticles on a chip
    by Kyunghun Lee on June 15, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00196A, PaperKyunghun Lee, Jongwan Lee, Dogyeong Ha, Minseok Kim, Taesung KimWe developed a novel multiphysics-based nanoparticle separation technique utilizing low-electric-potential-assisted diffusiophoresis (LEPDP).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An integrated biomimetic array chip for high-throughput co-culture of liver and tumor microtissues for advanced anticancer bioactivity screening
    by Yu Hou on June 15, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00288G, PaperYu Hou, Xiaoni Ai, Lin Zhao, Zhao Gao, Yujiang Wang, Yingyuang Lu, Pengfei Tu, Yong JiangAn integrated biomimetic array chip (iBAC) enables co-culture of three-dimensional (3D) liver and tumor microtissues for anticancer bioactivity screening at throughputs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Deformation of leukaemia cell lines in hyperbolic microchannels: investigating the role of shear and extensional components
    by Monica Piergiovanni on June 15, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00166J, PaperMonica Piergiovanni, Valeria Galli, Gregor Holzner, Stavros Stavrakis, Andrew DeMello, Gabriele DubiniExperimental and computational methods: together to disentangle the role of extensional and shear fluid dynamics on single cell deformation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Single-cell microfluidics facilitates the rapid quantification of antibiotic accumulation in Gram-negative bacteria
    by Jehangir Cama on June 15, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00242A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jehangir Cama, Margaritis Voliotis, Jeremy Metz, Ashley Smith, Jari Iannucci, Ulrich F. Keyser, Krasimira Tsaneva-Atanasova, Stefano PagliaraA novel, rapid single-cell assay for quantifying antibiotic accumulation in Gram-negative bacteria reveals important insights about bacterial drug accumulation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]

  • Gold-nanoparticle-embedded microchannel array for enhanced power generation
    by Soumen Mandal on June 14, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00552E, PaperSoumen Mandal, Souvik Paul, Saswata Mukhopadhyay, Ravi Kumar Arun, Debeshi Dutta, Nripen ChandaFlow of water in a gold-nanoparticle-embedded microchannel power generator generated a power density of 4.3 μW cm−2, a value ∼256 times higher than that last reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic flow-through reactor and 3D Raman imaging for in situ assessment of mineral reactivity in porous and fractured porous media
    by Jenna Poonoosamy on June 14, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00360C, PaperJenna Poonoosamy, Cyprien Soulaine, Alina Burmeister, Guido Deissmann, Dirk Bosbach, Sophie RomanMicrofluidics flow-through reactor combined with in-situ, non-destructive Raman measurement for a spatio-temporal visualisation of the mineralogical changes in porous media. Advance pore scale modelling diagnostics of the coupled hydro-geochemical processes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Optical micro/nanofibre embedded soft film enables multifunctional flow sensing in microfluidic chips
    by Zhang Zhang on June 12, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00178C, PaperZhang Zhang, Jing Pan, Yao Tang, Yue Xu, Lei Zhang, Yuan Gong, Limin TongA smart microfluidic chip enabled by optical micro/nanofibres embedded soft film can detect flow rate, count droplets, and predict the morphology of droplets.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Optofluidic gradient refractive index resonators using liquid diffusion for tunable unidirectional emission
    by H. L. Liu on June 11, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00395F, PaperH. L. Liu, Y. F. Zuo, X. Q. Zhu, Y. YangOptofluidic gradient refractive index resonators based on liquid diffusion were demonstrated for tunable unidirectional emission.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Excitation energy transfer between monomolecular layers of light harvesting LH2 and LH1-reaction centre complexes printed on a glass substrate
    by Xia Huang on June 10, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00156B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xia Huang, Cvetelin Vasilev, C. Neil HunterRemarkably stable artificial light-harvesting arrays capable of harvesting and trapping solar energy were fabricated using purified bacterial pigment–protein complexes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An enhanced centrifugation-assisted lateral flow immunoassay for the point-of-care detection of protein biomarkers
    by Minjie Shen on June 8, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00518E, PaperMinjie Shen, Nan Li, Ying Lu, Jing Cheng, Youchun XuAn enhanced centrifugation-assisted lateral flow immunoassay was proposed for automated protein biomarker detections using blood samples within 15 minutes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Effects of altered blood flow induced by the muscle pump on thrombosis in a microfluidic venous valve model
    by Xiangyu Hu on June 8, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00287A, PaperXiangyu Hu, Yongjian Li, Jiang Li, Haosheng ChenA microfluidic venous valve model to illustrate how the altered blood flow induced by the muscle pump influences venous thrombosis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microflow in a rhythmically expanding alveolar chip with dynamic similarity
    by Huimin Lv on June 7, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2394-2402DOI: 10.1039/C9LC01273G, PaperHuimin Lv, Jun Dong, Yan Qiu, Yue Yang, Yonggang ZhuFlow patterns in the alveoli are investigated using an alveolar microchip and stagnation saddle points are revealed experimentally.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Bacteria encapsulation and rapid antibiotic susceptibility test using a microfluidic microwell device integrating surface-enhanced Raman scattering
    by Hsiu-Kang Huang on June 5, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00425A, PaperHsiu-Kang Huang, Ho-Wen Cheng, Cheng-Chieh Liao, Shang-Jyun Lin, Yi-Zih Chen, Juen-Kai Wang, Yuh-Lin Wang, Nien-Tsu HuangWe developed a microfluidic microwell device integrating SERS substrate for an efficient bacteria encapsulation and enrichment followed by in situ SERS-AST measurement, which can potentially apply for high throughput and multi-parallel AST.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces
    by Wenguang Yang on June 3, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00477D, PaperWenguang Yang, Lujing Sun, Shuxiang Cai, Yibao Chen, Wenfeng Liang, Peilin Zhou, Haibo Yu, Yuechao Wang, Lianqing LiuWe present a simple method to fabricate micro-hump patterned interfaces based on electrohydrodynamic jet (E-jet) printing to control and direct cell organization. Microstructures were rapidly fabricated and cell adhesion was significantly enhanced by the micro-hump structures.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]

  • Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
    by Michael P. McRae on June 2, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2075-2085DOI: 10.1039/D0LC00373E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michael P. McRae, Glennon W. Simmons, Nicolaos J. Christodoulides, Zhibing Lu, Stella K. Kang, David Fenyo, Timothy Alcorn, Isaac P. Dapkins, Iman Sharif, Deniz Vurmaz, Sayli S. Modak, Kritika Srinivasan, Shruti Warhadpande, Ravi Shrivastav, John T. McDevittThe COVID-19 Severity Score combines multiplex biomarker measurements and risk factors in a statistical learning algorithm to predict mortality.The content of this RSS Feed (c) […]

  • Variable-height channels for microparticle characterization and display
    by Sarah E. Mena on June 2, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00320D, PaperSarah E. Mena, Martin P. de Beer, Joseph McCormick, Nahal Habibi, Joerg Lahann, Mark A. BurnsA unique glass etching process creates variable height channels capable of separating particles or cells by size or deformability.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic particle zipper enables controlled loading of droplets with distinct particle types
    by Cyrille L. Delley on May 31, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00339E, PaperCyrille L. Delley, Adam R. AbateWe describe a microfluidic particle zipper which enables hydrogel bead pairing at high throughput for single-cell genomic applications.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • High-throughput screening by droplet microfluidics: perspective into key challenges and future prospects
    by Emory M. Payne on May 31, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2247-2262DOI: 10.1039/D0LC00347F, PerspectiveEmory M. Payne, Daniel A. Holland-Moritz, Shuwen Sun, Robert T. KennedyThis perspective outlines the major challenges and future prospects for the field of droplet microfluidics for high throughput screening applications.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Cell adhesion and proliferation on common 3D printing materials used in stereolithography of microfluidic devices
    by Kati Piironen on May 31, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2372-2382DOI: 10.1039/D0LC00114G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kati Piironen, Markus Haapala, Virpi Talman, Päivi Järvinen, Tiina SikanenThis work reveals the material impacts on long-term cell survival and adhesion on 3D printed surfaces manufactured by stereolithography.The content of this RSS Feed (c) The Royal Society of Chemistry

  • 4D synchrotron microtomography and pore-network modelling for direct in situ capillary flow visualization in 3D printed microfluidic channels
    by Agnese Piovesan on May 31, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2403-2411DOI: 10.1039/D0LC00227E, PaperAgnese Piovesan, Tim Van De Looverbosch, Pieter Verboven, Clement Achille, Cesar Parra Cabrera, Elodie Boller, Yin Cheng, Rob Ameloot, Bart NicolaiWe investigate fluid flow at the pore scale in novel 3D printed microfluidic channels through synchrotron microtomography and pore-network modelling.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Novel SERS-based process analysis for label-free segmented flow screenings
    by Alexander Mendl on May 28, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2364-2371DOI: 10.1039/D0LC00367K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alexander Mendl, J. Michael Köhler, Dušan Bošković, Stefan LöbbeckeA new SERS method for segmented flow screening using parallelized silver/polyacrylamide composite spots and miniaturized equipment.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A simple method for production of hydrophilic, rigid, and sterilized multi-layer 3D integrated polydimethylsiloxane microfluidic chips
    by Tomoko Gowa Oyama on May 27, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2354-2363DOI: 10.1039/D0LC00316F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tomoko Gowa Oyama, Kotaro Oyama, Mitsumasa TaguchiWe have developed a high-throughput method for obtaining hydrophilic, rigid, low-absorption/adsorption, and sterilized multi-layer 3D integrated PDMS microfluidic chips simply by applying electron beam or γ-ray irradiation to stacked PDMS layers.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Rapid, multiplexed detection of biomolecules using electrically distinct hydrogel beads
    by Thomas W. Cowell on May 27, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2274-2283DOI: 10.1039/D0LC00243G, PaperThomas W. Cowell, Enrique Valera, Aaron Jankelow, Joonhyuck Park, Alex W. Schrader, Ruihua Ding, Jacob Berger, Rashid Bashir, Hee-Sun HanElectrically distinct microparticles enable rapid, versatile, and multiplexed electrical detection of biomolecules using Coulter counting-based detection.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic dialysis using photo-patterned hydrogel membranes in PDMS chips
    by Hoang-Thanh Nguyen on May 26, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2383-2393DOI: 10.1039/D0LC00279H, PaperHoang-Thanh Nguyen, Morgan Massino, Camille Keita, Jean-Baptiste SalmonPermeable hydrogel membranes in PDMS chips integrating Quake valves for dialysis applications in closed nanoliter chambers.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Emerging technologies for profiling extracellular vesicle heterogeneity
    by Guan Huang on May 26, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00431F, Critical ReviewGuan Huang, Gungun Lin, Ying Zhu, Wei Duan, Dayong JinApproaches, challenges and promising opportunities towards decoding the complexity of extracellular vesicle heterogeneity are discussed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • 3D-Printed glycerol microfluidic fuel cell
    by Katia-Emiko Guima on May 26, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2057-2061DOI: 10.1039/D0LC00351D, CommunicationKatia-Emiko Guima, Pedro-Henrique L. Coelho, Magno A. G. Trindade, Cauê Alves Martins3D-Printed microfluidic fuel cell.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Label-free on chip quality assessment of cellular blood products using real-time deformability cytometry
    by Konstanze Aurich on May 19, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2306-2316DOI: 10.1039/D0LC00258E, PaperKonstanze Aurich, Bob Fregin, Raghavendra Palankar, Jan Wesche, Oliver Hartwich, Doreen Biedenweg, Thi-Huong Nguyen, Andreas Greinacher, Oliver OttoReal-time deformability cytometry is a unique tool for quality assessment of therapeutic blood cells utilizing their mechanical properties.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A lab-on-chip device for the sample-in-result-out detection of viable Salmonella using loop-mediated isothermal amplification and real-time turbidity monitoring
    by Siyuan Wang on May 18, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2296-2305DOI: 10.1039/D0LC00290A, PaperSiyuan Wang, Ning Liu, Lingyan Zheng, Gaozhe Cai, Jianhan LinRapid screening of foodborne pathogens is key to prevent food poisoning.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Parylene-C coated microporous PDMS structure protecting from functional deconditioning of platelets exposed to cardiostimulants
    by Hyojae Kim on May 18, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2284-2295DOI: 10.1039/D0LC00253D, PaperHyojae Kim, Yeongseok Jang, Jinmu Jung, Jonghyun OhThe cardiostimulant-induced deconditioning of platelet physical activity can be overcome with the microporous structure of S-PPXC.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Outstanding Reviewers for Lab on a Chip in 2019
    on May 18, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2043-2043DOI: 10.1039/D0LC90047H, EditorialWe would like to take this opportunity to highlight the Outstanding Reviewers for Lab on a Chip in 2019, as selected by the editorial team for their significant contribution to the journal.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Self-aligned 3D microlenses in a chip fabricated with two-photon stereolithography for highly sensitive absorbance measurement
    by Jiukai Tang on May 17, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2334-2342DOI: 10.1039/D0LC00235F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jiukai Tang, Guangyu Qiu, Xiaobao Cao, Yang Yue, Xiaole Zhang, Jean Schmitt, Jing Wang3D microlenses (in plane) via mold replication were incorporated in the microfluidic chip for improving the performance of absorbance measurements.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Intelligent image-activated cell sorting 2.0
    by Akihiro Isozaki on May 17, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2263-2273DOI: 10.1039/D0LC00080A, PaperAkihiro Isozaki, Hideharu Mikami, Hiroshi Tezuka, Hiroki Matsumura, Kangrui Huang, Marino Akamine, Kotaro Hiramatsu, Takanori Iino, Takuro Ito, Hiroshi Karakawa, Yusuke Kasai, Yan Li, Yuta Nakagawa, Shinsuke Ohnuki, Tadataka Ota, Yong Qian, Shinya Sakuma, Takeichiro Sekiya, Yoshitaka Shirasaki, Nobutake Suzuki, Ehsen Tayyabi, Tsubasa Wakamiya, Muzhen Xu, Mai Yamagishi, Haochen Yan, Qiang Yu, Sheng Yan, Dan Yuan, Wei Zhang, Yaqi Zhao, Fumihito Arai, Robert E. Campbell, Christophe Danelon, Dino Di Carlo, Kei Hiraki, Yu Hoshino, Yoichiroh […]

  • Cell elasticity measurement using a microfluidic device with real-time pressure feedback
    by Zhenlin Chen on May 17, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2343-2353DOI: 10.1039/D0LC00092B, PaperZhenlin Chen, Yonggang Zhu, Dong Xu, Md. Mahbub Alam, Lingling Shui, Huaying ChenThe study of cell elasticity provides new insights into not only cell biology but also disease diagnosis based on cell mechanical state variation.The content of this RSS Feed (c) The Royal Society of Chemistry

  • The emerging role of microfluidics in multi-material 3D bioprinting
    by Cynthia Richard on May 17, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2044-2056DOI: 10.1039/C9LC01184F, Critical ReviewCynthia Richard, Adrian Neild, Victor J. CadarsoTo assist the transition of 3D bioprinting technology from simple lab-based tissue fabrication, to fully functional and implantable organs, the technology must not only provide shape control, but also functional control.The content of this RSS Feed (c) The Royal Society of Chemistry

  • 3D nanoplasmonic biosensor for detection of filopodia in cells
    by Shuyan Zhu on May 17, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2188-2196DOI: 10.1039/D0LC00173B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shuyan Zhu, Mohammed A. Eldeeb, Stella W. PangFilopodia detection using nanoplasmonic biosensors, where microposts were used to separate the cell membrane from filopodia and 3D nanopillars were used to monitor nanometer-sized filopodia.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Double emulsion flow cytometry with high-throughput single droplet isolation and nucleic acid recovery
    by Kara K. Brower on May 16, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2062-2074DOI: 10.1039/D0LC00261E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kara K. Brower, Catherine Carswell-Crumpton, Sandy Klemm, Bianca Cruz, Gaeun Kim, Suzanne G. K. Calhoun, Lisa Nichols, Polly M. FordyceWe have developed a novel workflow (sdDE-FACS, ̲ingle ̲roplet ̲ouble ̲mulsion FACS) that allows robust production, screening, and sorting of single double emulsion droplets with complete nucleic acid recovery.The content of this RSS Feed (c) The Royal Society of […]

  • Surfactant and oil formulations for monodisperse droplet emulsion PCR
    by Fangli Zhang on May 14, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2328-2333DOI: 10.1039/D0LC00052C, PaperFangli Zhang, Peiyu Liao, Yue Sun, Zitian Chen, Yuhong Pang, Yanyi HuangA systematic survey of the oil and surfactant components of stable monodisperse w/o droplets suitable for various methods.The content of this RSS Feed (c) The Royal Society of Chemistry

  • On-chip hydrogel arrays individually encapsulating acoustic formed multicellular aggregates for high throughput drug testing
    by Xuejia Hu on May 14, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2228-2236DOI: 10.1039/D0LC00255K, PaperXuejia Hu, Shukun Zhao, Ziyi Luo, Yunfeng Zuo, Fang Wang, Jiaomeng Zhu, Longfei Chen, Dongyong Yang, Yajing Zheng, Yujia Zheng, Yanxiang Cheng, Fuling Zhou, Yi YangMulticellular aggregates in three-dimensional (3D) environments provide novel solid tumor models that can provide insight into in vivo drug resistance.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Droplet encapsulation of electrokinetically-focused analytes without loss of resolution
    by Vasileios A. Papadimitriou on May 14, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2209-2217DOI: 10.1039/D0LC00191K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Vasileios A. Papadimitriou, Stella A. Kruit, Loes I. Segerink, Jan C. T. EijkelNovel continuous or on-demand droplet generator for extraction of electrokinetically focused and separated analytes on chip. White scale bars – 100 μm.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Machine learning-aided quantification of antibody-based cancer immunotherapy by natural killer cells in microfluidic droplets
    by Saheli Sarkar on May 13, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2317-2327DOI: 10.1039/D0LC00158A, PaperSaheli Sarkar, Wenjing Kang, Songyao Jiang, Kunpeng Li, Somak Ray, Ed Luther, Alexander R. Ivanov, Yun Fu, Tania KonryComparative proteomic profiling and development of convolution neural network algorithm for quantifying discrete target interaction by engineered NK cells in microfluidic droplets.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Remotely tunable microfluidic platform driven by nanomaterial-mediated on-demand photothermal pumping
    by Guanglei Fu on May 13, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2218-2227DOI: 10.1039/D0LC00317D, PaperGuanglei Fu, Wan Zhou, XiuJun LiA novel on-demand photothermal microfluidic pumping platform is developed using the nanomaterial-mediated photothermal effect as the tunable microfluidic driving force.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Infrared spectroscopy of live cells from a flowing solution using electrically-biased plasmonic metasurfaces
    by Glen Kelp on May 13, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2136-2153DOI: 10.1039/C9LC01054H, PaperGlen Kelp, Joy Li, Junlan Lu, Nicholas DiNapoli, Robert Delgado, Chao Liu, Donglei Fan, Shourya Dutta-Gupta, Gennady ShvetsMicrofluidics, dielectrophoresis (DEP) and metasurface-enhanced infrared reflection spectroscopy (MEIRS) are combined for capturing and rapid spectroscopy of live cells.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Real structure micromodels based on reservoir rocks for enhanced oil recovery (EOR) applications
    by Calvin Lumban Gaol on May 10, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2197-2208DOI: 10.1039/D0LC00257G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Calvin Lumban Gaol, Jonas Wegner, Leonhard GanzerIn this work, an attempt to close gaps between micromodels and reservoir rocks was performed by constructing chips based on the X-ray micro-computed tomography (μCT) images of a Bentheimer core plug.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A minimal constraint device for imaging nuclei in live Drosophila contractile larval muscles reveals novel nuclear mechanical dynamics
    by Dana Lorber on May 10, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2100-2112DOI: 10.1039/D0LC00214C, PaperDana Lorber, Ron Rotkopf, Talila VolkMuscle contractions produce reiterated cytoplasmic mechanical variations, which potentially influence nuclear mechanotransduction, however information regarding the dynamics of muscle nuclei in the course of muscle contraction is still missing.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Digital enzyme-linked immunosorbent assays with sub-attomolar detection limits based on low numbers of capture beads combined with high efficiency bead analysis
    by Cheuk W. Kan on May 10, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2122-2135DOI: 10.1039/D0LC00267D, PaperCheuk W. Kan, Carmen I. Tobos, David M. Rissin, Alexander D. Wiener, Ray E. Meyer, Danielle M. Svancara, Anna Comperchio, Christopher Warwick, Roger Millington, Nicholas Collier, David C. DuffyWe report approaches to improve the sensitivity of digital ELISA up to 400-fold, enabling detection of proteins at subattomolar concentrations.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Picoliter agar droplet breakup in microfluidics meets microbiology application: numerical and experimental approaches
    by Asmaa Khater on May 7, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2175-2187DOI: 10.1039/D0LC00300J, PaperAsmaa Khater, Osama Abdelrehim, Mehdi Mohammadi, Milad Azarmanesh, Mohsen Janmaleki, Razieh Salahandish, Abdulmajeed Mohamad, Amir Sanati-NezhadDroplet microfluidics has provided lab-on-a-chip platforms with the capability of bacteria encapsulation in biomaterials, controlled culture environments, and live monitoring of growth and proliferation.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A web-based automated machine learning platform to analyze liquid biopsy data
    by Hanfei Shen on May 6, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2166-2174DOI: 10.1039/D0LC00096E, PaperHanfei Shen, Tony Liu, Jesse Cui, Piyush Borole, Ari Benjamin, Konrad Kording, David IssadoreWe have developed a web-based, self-improving and overfitting-resistant automated machine learning tool tailored specifically for liquid biopsy data, where machine learning models can be built without the user's input.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic assessment of red blood cell mediated microvascular occlusion
    by Yuncheng Man on May 4, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2086-2099DOI: 10.1039/D0LC00112K, PaperYuncheng Man, Erdem Kucukal, Ran An, Quentin D. Watson, Jürgen Bosch, Peter A. Zimmerman, Jane A. Little, Umut A. GurkanA gradient of microcapillary networks and microfluidic anastomoses enable standardized quantitative assessment of red blood cell mediated microvascular occlusion.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Catalytic exchange of hydrogen isotopes intensified by two-phase stratified flow in wettability designable microchannels
    by Yuexiao Song on May 3, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2154-2165DOI: 10.1039/D0LC00250J, PaperYuexiao Song, Feng Xin, Yongsheng XuLiquid phase catalytic exchange of hydrogen isotopes is intensified by stratified flow in a microchannel reactor coated with hydrophobic Pt/AC/PDMS.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Multiplexed homogeneous digital immunoassay based on single-particle motion analysis
    by Kenji Akama on April 21, 2020 at 11:00 pm

    Lab Chip, 2020, 20,2113-2121DOI: 10.1039/D0LC00079E, PaperKenji Akama, Hiroyuki NojiHomogeneous digital immunoassay is a powerful analytical method for highly sensitive biomarker detection with a simple protocol. By using this method, we demonstrated the simultaneous multiple protein detection.The content of this RSS Feed (c) The Royal Society of Chemistry

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  • Single-vesicle imaging quantifies calcium’s regulation of nanoscale vesicle clustering mediated by α-synuclein
    by Bin Cai on June 29, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 29 June 2020; doi:10.1038/s41378-020-0147-1Calcium plays a critical role in the clustering of synaptic vesicles (which in a neuron store various neurotransmitters released at the synapse) induced by the protein alpha-synuclein, and different calcium concentrations exert different effects on such clustering. Alpha-synuclein is a key element in the development of Parkinson’s disease and other neurodegenerative conditions: it has been shown to interact with synaptic vesicles under the influence of calcium, but its physiological […]

  • Generation of tumor spheroids using a droplet-based microfluidic device for photothermal therapy
    by Jong Min Lee on June 29, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 29 June 2020; doi:10.1038/s41378-020-0167-xA microfluidic device for the efficient production of three-dimensional ‘spheroid’ cell cultures could accelerate the discovery and testing of therapeutic agents. These small clumps of cells can better recapitulate the physiology of the tissue environment than two-dimensional cultures, but are challenging to produce in a high-throughput fashion. Researchers led by Prof. Bong Geun Chung of Sogang University, Seoul, Korea have now developed a system that can generate 42,000 spheroids/h […]

  • A versatile microfluidic device for multiple ex vivo/in vitro tissue assays unrestrained from tissue topography
    by Jose M. de Hoyos-Vega on June 29, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 29 June 2020; doi:10.1038/s41378-020-0156-0A microfluidic device enables eight independent assays to be performed simultaneously on the surface of topologically irregular tissue sections. Current limitations for assays of tissue slices include, typically, a limited amount of tissue sample—limiting the range of assays that can be performed for a uniform sample—and sensitivity to the surface of the tissue, which might be inconsistent due to the spatially irregular composition of tissue. Here, a team from the Center for Research […]

  • Bubble entrapment during the recoil of an impacting droplet
    by Thanh-Vinh Nguyen on June 29, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 29 June 2020; doi:10.1038/s41378-020-0158-yResearchers in Japan have characterized bubbles of air that form within water droplets when they hit a hydrophobic surface. During impact, an air cavity can form through the center of a droplet, and this can become trapped as bubble when the droplet merges together again. Thanh-Vinh Nguyen and Masaaki Ichiki of the National Institute of Advanced Industrial Science and Technology used a MEMS-based sensor to measure acoustic vibrations during the impact. They found that the frequency of the […]

  • A 3D-printed modular magnetic digital microfluidic architecture for on-demand bioanalysis
    by Pojchanun Kanitthamniyom on June 29, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 29 June 2020; doi:10.1038/s41378-020-0152-4A Lego-inspired, modular magnetic digital microfluidic architecture enables customizable bioanalysis. Magnetic digital microfluidics controls droplets on a surface via magnetic particles, with the liquid droplets themselves acting as mini bioreactors for analysis. Such devices often include surface energy traps to aide droplet manipulation. However, because they are fabricated as monolithic systems, they cannot be altered for different bioanalysis post-fabrication. Here, a team led by Yi Zhang […]

  • Knudsen pumps: a review
    by Xiaowei Wang on June 15, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 15 June 2020; doi:10.1038/s41378-020-0135-5Knudsen pumps are micro-sized, non-mechanical gas pumps that can be useful in a range of biomedical and mechanical fields. Zhang and his team from China’s North-eastern University analyzed Knudsen pumps’ configurations, performance, applications, and current problems. In Knudsen pumps, gas flow is induced by temperature gradients along the walls of the device. They benefit from low energy consumption and ease of manufacture. Different configurations, realized through the placement of […]