Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00454E, PaperTobias Lange, Sophie Charton, Thomas Bizien, Fabienne Testard, Florent MalloggiIn recent years, microfluidic-based sample preparation techniques have emerged as a powerful tool for measurements at large scale X-ray facilities. Most often the microfluidic device was a form of hybrid...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00239A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mark A. Levenstein, Yi-Yeoun Kim, Liam Hunter, Clara Anduix-Canto, Carlos González, Sarah Day, Shunbo Li, William Marchant, Phillip Lee, Chiu C Tang, Manfred Burghammer, Fiona C Meldrum, Nikil KapurThe clean and reproducible conditions provided by microfluidic devices are ideal sample environments for in situ analyses of chemical and biochemical reactions and assembly processes. However, the small size of...The […]

Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00348D, PaperBaobao Lin, Zijian Guo, Zhi Geng, Siwat Jakaratanopas, Bingqian Han, Peng LiuSample compartmentalization is a pivotal technique in many bioanalytical applications, such as multiplex polymerase chain reaction (PCR) and digital PCR (dPCR). In this study, we successfully developed a novel self-...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00567C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chris J. W. Bolton, Olivia Howells, Gareth J. Blayney, Pey F. Eng, James C. Birchall, Benedetta Gualeni, Kerry Roberts, Huma Ashraf, Owen J. GuyA novel production process flow is presented for the manufacture of hollow silicon microneedles using deep reactive-ion etching (DRIE) technology.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society […]

Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00530D, PaperJan-Niklas Klatt, Maren Depke, Neha Goswami, Nils Paust, Roland Zengerle, Frank Schmidt, Tobias HutzenlaubMass spectrometry has become an important analytical tool for protein research studies to identify, characterise and quantify proteins with unmatched sensitivity in a highly parallel manner. When transferred into clinical...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00361A, PaperZhixing Ge, Junhua Zhao, Haibo Yu, Wenguang Yang, Peilin Zhou, Zhenning Wang, Lianqing LiuCurrently, the mechanisms underlying the peritoneal metastasis of gastric cancer cells and the function of mesothelial cells during this process are unclear, primarily due to the absence of an effective...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00595A, PaperZhichao Ma, Yinning Zhou, Feiyan Cai, Long Meng, Hairong Zheng, Ye AiPrecisely controllable transport and rotation of microparticles and cells has great potential to enable new capabilities for single-cell level analysis. In this work, we present a versatile ultrasonic microstreaming based...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00521E, Critical ReviewAkihiro Isozaki, Jeffrey Harmon, Yuqi Zhou, Shuai Li, Yuta Nakagawa, Mika Hayashi, Hideharu Mikami, Cheng Lei, Keisuke GodaArtificial intelligence (AI) has dramatically changed the landscape of science, industry, defense, and medicine in the last several years. Supported by considerably enhanced computational power and cloud storage, the field...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00397B, PaperCitsabehsan Devendran, Kyungyong Choi, Jongyoon Han, Ye Ai, Adrian Neild, David J. CollinsWe explore a unique diffractive acoustic phenomenon arising from a surface acoustic wave and channel elements, which we term diffractive acoustic surface acoustic waves (DASAW), which can be applied robustly for all channel orientations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00064G, PaperVittorio Viri, Matteo Cornaglia, Huseyin Baris Atakan, Thomas Lehnert, Martin A. M. GijsA microfluidic device for studying bacterial transit dynamics in the intestine of Caenorhabditis elegans.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00145G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mary Kathryn Sewell-Loftin, Joshua B. Katz, Steven C. George, Gregory D. LongmoreA microtissue platform with independent control over biomechanical parameters is described and used to demonstrate how cell-generated forces drive angiogenesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00034E, Critical ReviewRathina Kumar Shanmuga Kani, Balaji Srinivasan, Marshall J Glesby, Lars F Westblade, Washington B. Cárdenas, Tony Raj, David Erickson, Saurabh MehtaAntimicrobial resistance (AMR) is a fundamental global concern analogous to climate change threatening both public health and global development progress. Infections caused by antimicrobial-resistant pathogens pose serious threats to healthcare...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00309C, PaperDongwoo Lee, Yohan Choi, Wonhee LeeInertial microfluidic systems have been widely used for particle or cell separation applications, especially for rare-cell enrichment and separation from blood due to the high throughput and simplicity of the...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00451K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Juan Manuel Martinez Galvez, Maite Garcia-Hernando, Fernando Benito-Lopez, Lourdes Basabe-Desmonts, Anna V. ShnyrovaMicroarray surface chemistry and design set the geometry of lipid membrane nanotubes easily formed and observed in a microfluidic chamber.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00296H, PaperNgoc-Duy Dinh, Marek Kukumberg, Anh-Tuan Nguyen, Hamed Keramati, Song Guo, Dinh-Tuan Phan, Nurdiyana B. Ja'Afar, Erik Birgersson, Hwa Liang Leo, Ruby Yun-Ju Huang, Theodoros Kofidis, Abdul Jalil Rufaihah, Chia-Hung ChenThe reservoir microcapsules are fabricated through one-step microfluidic phase separation for long-term cardiovascular therapeutics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00219D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tom Scheidt, Tadas Kartanas, Quentin Peter, Matthias M. Schneider, Kadi L. Saar, Thomas Müller, Pavan Kumar Challa, Aviad Levin, Sean Devenish, Tuomas P. J. KnowlesDirect combination of liquid chromatography with multidimensional post-column analysis through microfluidics for individual quantification of biophysical parameters.To cite this article before page numbers are assigned, use the DOI form of citation […]

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00432D, PaperJuhwan Park, Dong Hyun Han, Sang-Hyun Hwang, Je-Kyun ParkA finger-actuated microfluidic reciprocator was developed and exploited to improve the recovery rate of nucleic acid purification in a finger-actuated microfluidic device.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00440E, PaperNamgyu Noh, Jungjae Park, Ji Su Park, Kunmo Koo, Jae Yeol Park, Jong Min YukThe micro-holey pattered graphene liquid cells provide micro-sized viewing areas and controllable liquid thickness, thus enable remarkable imaging performance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00545B, PaperOnur Ergen, Ecem Celik, Ahmet Hamdi Unal, Mert Yusuf Erdolu, Feriha Eylem Sarac, Ugur UnalWearable bioelectronic systems are one of the most important tools for human health and motion monitoring.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00325E, PaperYoon Ho Roh, Hyun Jee Lee, Ju Yeon Kim, Hyeon Ung Kim, Sun Min Kim, Ki Wan BongHigh-performance colorimetric immunoassay based on hydrogel particles was developed by precipitation and amplification of coloured products inside hydrogel networks.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00062K, PaperTing Yang, Shin-Chen Pan, Chao-Min ChengIn this study, we have developed a paper-based elastase detection device (PEDD) for clinical wound assessment that specifically examines human neutrophil elastase (HNE).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00165A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Carla Mulas, Andrew C. Hodgson, Timo N. Kohler, Chibeza C. Agley, Peter Humphreys, Hans Kleine-Brüggeney, Florian Hollfelder, Austin Smith, Kevin J. Chalut3D cell culture and microfluidic platform for monitoring biological process and single clone retrieval for downstream molecular or functional analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00333F, CommunicationLiviu Clime, Lidija Malic, Jamal Daoud, Luke Lukic, Matthias Geissler, Teodor VeresWe present here a new method for controlling the droplet size in step emulsification processes on a centrifugal microfluidic platform, which, in addition to the centrifugal force, uses pneumatic actuation for fluid displacement.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00294A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Martin Schulz, Silvia Calabrese, Florian Hausladen, Holger Wurm, Dominik Drossart, Karl Stock, Anna M. Sobieraj, Fritz Eichenseher, Martin J. Loessner, Mathias Schmelcher, Anja Gerhardts, Ulrike Goetz, Marina Handel, Annerose Serr, Georg Haecker, Jia Li, Mara Specht, Philip Koch, Martin Meyer, Philipp Tepper, Raimund Rother, Michael Jehle, Simon Wadle, Roland Zengerle, Felix von Stetten, Nils Paust, Nadine […]

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00203H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Byungjin Lee, Seong-Geun Jeong, Si Hyung Jin, Ranjan Mishra, Matthias Peter, Chang-Soo Lee, Sung Sik LeeEukaryotic cells developed complex signaling networks to sense their environment and respond to various stress conditions. We investigate yeast MAPK signaling pathways and their crosstalk by a microfluidic device coupled to quantitative microscopy.To cite this article before page numbers are assigned, use the DOI […]

Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/D0LC00283F, PaperAmir Saadat, Diego Antonio Huyke, Diego Ignacio Oyarzun, Paulina V. Escobar, Ingrid H. Øvreeide, Eric S. G. Shaqfeh, Juan Gabriel SantiagoReduced deformability of red blood cells (RBCs) can affect the hemodynamics of the microcirculation and reduce oxygen transport efficiency. It is also well known that reduced RBC deformability is a...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00439A, PaperYanfang Guan, Kun Zhang, Fengqian Xu, Ruiyang Guo, Anshu Fang, Baichuan Sun, Xiangxin Meng, Yansheng Liu, Mingyang BaiFibrinogen (FIB) plays a key role in blood coagulation and thrombosis and its concentration in blood can directly reflect health conditions, thus an efficient detection of FIB would benefit the treatments of certain diseases such as liver and heart diseases.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00387E, PaperMaryam Navi, Jennifer Kieda, Scott S. H. TsaiWe report an all-aqueous microfluidic platform based on integration of ferrofluid and water-in-water droplets for fabrication of magnetic polyelectrolyte microcapsules.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00131G, PaperKe-Chih Lin, Yusha Sun, Gonzalo Torga, Pema Sherpa, Yihua Zhao, Junle Qu, Sarah R. Amend, Kenneth J. Pienta, James C. Sturm, Robert H. AustinA microfluidic platform was developed that generates a gradient of chemotherapy via diffusion to study evolutionary dynamics of cancer.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00400F, PaperYingxue Zhang, Yao Chen, Jielong Huang, Yangchengyi Liu, Jinfeng Peng, Shangda Chen, Kui Song, Xiaoping Ouyang, Huanyu Cheng, Xiufeng WangSoft, skin-interfaced microfluidic platforms are capable of capturing, storing, and assessing sweat chemistry and total sweat loss, which provides essential insight into human physiological health.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00196A, PaperKyunghun Lee, Jongwan Lee, Dogyeong Ha, Minseok Kim, Taesung KimWe developed a novel multiphysics-based nanoparticle separation technique utilizing low-electric-potential-assisted diffusiophoresis (LEPDP).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00288G, PaperYu Hou, Xiaoni Ai, Lin Zhao, Zhao Gao, Yujiang Wang, Yingyuang Lu, Pengfei Tu, Yong JiangAn integrated biomimetic array chip (iBAC) enables co-culture of three-dimensional (3D) liver and tumor microtissues for anticancer bioactivity screening at throughputs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00166J, PaperMonica Piergiovanni, Valeria Galli, Gregor Holzner, Stavros Stavrakis, Andrew DeMello, Gabriele DubiniExperimental and computational methods: together to disentangle the role of extensional and shear fluid dynamics on single cell deformation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00242A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jehangir Cama, Margaritis Voliotis, Jeremy Metz, Ashley Smith, Jari Iannucci, Ulrich F. Keyser, Krasimira Tsaneva-Atanasova, Stefano PagliaraA novel, rapid single-cell assay for quantifying antibiotic accumulation in Gram-negative bacteria reveals important insights about bacterial drug accumulation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The […]

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00552E, PaperSoumen Mandal, Souvik Paul, Saswata Mukhopadhyay, Ravi Kumar Arun, Debeshi Dutta, Nripen ChandaFlow of water in a gold-nanoparticle-embedded microchannel power generator generated a power density of 4.3 μW cm−2, a value ∼256 times higher than that last reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00360C, PaperJenna Poonoosamy, Cyprien Soulaine, Alina Burmeister, Guido Deissmann, Dirk Bosbach, Sophie RomanMicrofluidics flow-through reactor combined with in-situ, non-destructive Raman measurement for a spatio-temporal visualisation of the mineralogical changes in porous media. Advance pore scale modelling diagnostics of the coupled hydro-geochemical processes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00178C, PaperZhang Zhang, Jing Pan, Yao Tang, Yue Xu, Lei Zhang, Yuan Gong, Limin TongA smart microfluidic chip enabled by optical micro/nanofibres embedded soft film can detect flow rate, count droplets, and predict the morphology of droplets.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00395F, PaperH. L. Liu, Y. F. Zuo, X. Q. Zhu, Y. YangOptofluidic gradient refractive index resonators based on liquid diffusion were demonstrated for tunable unidirectional emission.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00156B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xia Huang, Cvetelin Vasilev, C. Neil HunterRemarkably stable artificial light-harvesting arrays capable of harvesting and trapping solar energy were fabricated using purified bacterial pigment–protein complexes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00518E, PaperMinjie Shen, Nan Li, Ying Lu, Jing Cheng, Youchun XuAn enhanced centrifugation-assisted lateral flow immunoassay was proposed for automated protein biomarker detections using blood samples within 15 minutes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00287A, PaperXiangyu Hu, Yongjian Li, Jiang Li, Haosheng ChenA microfluidic venous valve model to illustrate how the altered blood flow induced by the muscle pump influences venous thrombosis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2394-2402DOI: 10.1039/C9LC01273G, PaperHuimin Lv, Jun Dong, Yan Qiu, Yue Yang, Yonggang ZhuFlow patterns in the alveoli are investigated using an alveolar microchip and stagnation saddle points are revealed experimentally.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00425A, PaperHsiu-Kang Huang, Ho-Wen Cheng, Cheng-Chieh Liao, Shang-Jyun Lin, Yi-Zih Chen, Juen-Kai Wang, Yuh-Lin Wang, Nien-Tsu HuangWe developed a microfluidic microwell device integrating SERS substrate for an efficient bacteria encapsulation and enrichment followed by in situ SERS-AST measurement, which can potentially apply for high throughput and multi-parallel AST.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00477D, PaperWenguang Yang, Lujing Sun, Shuxiang Cai, Yibao Chen, Wenfeng Liang, Peilin Zhou, Haibo Yu, Yuechao Wang, Lianqing LiuWe present a simple method to fabricate micro-hump patterned interfaces based on electrohydrodynamic jet (E-jet) printing to control and direct cell organization. Microstructures were rapidly fabricated and cell adhesion was significantly enhanced by the micro-hump structures.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]

Lab Chip, 2020, 20,2075-2085DOI: 10.1039/D0LC00373E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michael P. McRae, Glennon W. Simmons, Nicolaos J. Christodoulides, Zhibing Lu, Stella K. Kang, David Fenyo, Timothy Alcorn, Isaac P. Dapkins, Iman Sharif, Deniz Vurmaz, Sayli S. Modak, Kritika Srinivasan, Shruti Warhadpande, Ravi Shrivastav, John T. McDevittThe COVID-19 Severity Score combines multiplex biomarker measurements and risk factors in a statistical learning algorithm to predict mortality.The content of this RSS Feed (c) […]

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00320D, PaperSarah E. Mena, Martin P. de Beer, Joseph McCormick, Nahal Habibi, Joerg Lahann, Mark A. BurnsA unique glass etching process creates variable height channels capable of separating particles or cells by size or deformability.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00339E, PaperCyrille L. Delley, Adam R. AbateWe describe a microfluidic particle zipper which enables hydrogel bead pairing at high throughput for single-cell genomic applications.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2247-2262DOI: 10.1039/D0LC00347F, PerspectiveEmory M. Payne, Daniel A. Holland-Moritz, Shuwen Sun, Robert T. KennedyThis perspective outlines the major challenges and future prospects for the field of droplet microfluidics for high throughput screening applications.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2372-2382DOI: 10.1039/D0LC00114G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kati Piironen, Markus Haapala, Virpi Talman, Päivi Järvinen, Tiina SikanenThis work reveals the material impacts on long-term cell survival and adhesion on 3D printed surfaces manufactured by stereolithography.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2403-2411DOI: 10.1039/D0LC00227E, PaperAgnese Piovesan, Tim Van De Looverbosch, Pieter Verboven, Clement Achille, Cesar Parra Cabrera, Elodie Boller, Yin Cheng, Rob Ameloot, Bart NicolaiWe investigate fluid flow at the pore scale in novel 3D printed microfluidic channels through synchrotron microtomography and pore-network modelling.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2364-2371DOI: 10.1039/D0LC00367K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alexander Mendl, J. Michael Köhler, Dušan Bošković, Stefan LöbbeckeA new SERS method for segmented flow screening using parallelized silver/polyacrylamide composite spots and miniaturized equipment.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2354-2363DOI: 10.1039/D0LC00316F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tomoko Gowa Oyama, Kotaro Oyama, Mitsumasa TaguchiWe have developed a high-throughput method for obtaining hydrophilic, rigid, low-absorption/adsorption, and sterilized multi-layer 3D integrated PDMS microfluidic chips simply by applying electron beam or γ-ray irradiation to stacked PDMS layers.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2274-2283DOI: 10.1039/D0LC00243G, PaperThomas W. Cowell, Enrique Valera, Aaron Jankelow, Joonhyuck Park, Alex W. Schrader, Ruihua Ding, Jacob Berger, Rashid Bashir, Hee-Sun HanElectrically distinct microparticles enable rapid, versatile, and multiplexed electrical detection of biomolecules using Coulter counting-based detection.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2383-2393DOI: 10.1039/D0LC00279H, PaperHoang-Thanh Nguyen, Morgan Massino, Camille Keita, Jean-Baptiste SalmonPermeable hydrogel membranes in PDMS chips integrating Quake valves for dialysis applications in closed nanoliter chambers.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00431F, Critical ReviewGuan Huang, Gungun Lin, Ying Zhu, Wei Duan, Dayong JinApproaches, challenges and promising opportunities towards decoding the complexity of extracellular vesicle heterogeneity are discussed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2057-2061DOI: 10.1039/D0LC00351D, CommunicationKatia-Emiko Guima, Pedro-Henrique L. Coelho, Magno A. G. Trindade, Cauê Alves Martins3D-Printed microfluidic fuel cell.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2306-2316DOI: 10.1039/D0LC00258E, PaperKonstanze Aurich, Bob Fregin, Raghavendra Palankar, Jan Wesche, Oliver Hartwich, Doreen Biedenweg, Thi-Huong Nguyen, Andreas Greinacher, Oliver OttoReal-time deformability cytometry is a unique tool for quality assessment of therapeutic blood cells utilizing their mechanical properties.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2296-2305DOI: 10.1039/D0LC00290A, PaperSiyuan Wang, Ning Liu, Lingyan Zheng, Gaozhe Cai, Jianhan LinRapid screening of foodborne pathogens is key to prevent food poisoning.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2284-2295DOI: 10.1039/D0LC00253D, PaperHyojae Kim, Yeongseok Jang, Jinmu Jung, Jonghyun OhThe cardiostimulant-induced deconditioning of platelet physical activity can be overcome with the microporous structure of S-PPXC.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2043-2043DOI: 10.1039/D0LC90047H, EditorialWe would like to take this opportunity to highlight the Outstanding Reviewers for Lab on a Chip in 2019, as selected by the editorial team for their significant contribution to the journal.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2334-2342DOI: 10.1039/D0LC00235F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jiukai Tang, Guangyu Qiu, Xiaobao Cao, Yang Yue, Xiaole Zhang, Jean Schmitt, Jing Wang3D microlenses (in plane) via mold replication were incorporated in the microfluidic chip for improving the performance of absorbance measurements.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2263-2273DOI: 10.1039/D0LC00080A, PaperAkihiro Isozaki, Hideharu Mikami, Hiroshi Tezuka, Hiroki Matsumura, Kangrui Huang, Marino Akamine, Kotaro Hiramatsu, Takanori Iino, Takuro Ito, Hiroshi Karakawa, Yusuke Kasai, Yan Li, Yuta Nakagawa, Shinsuke Ohnuki, Tadataka Ota, Yong Qian, Shinya Sakuma, Takeichiro Sekiya, Yoshitaka Shirasaki, Nobutake Suzuki, Ehsen Tayyabi, Tsubasa Wakamiya, Muzhen Xu, Mai Yamagishi, Haochen Yan, Qiang Yu, Sheng Yan, Dan Yuan, Wei Zhang, Yaqi Zhao, Fumihito Arai, Robert E. Campbell, Christophe Danelon, Dino Di Carlo, Kei Hiraki, Yu Hoshino, Yoichiroh […]

Lab Chip, 2020, 20,2343-2353DOI: 10.1039/D0LC00092B, PaperZhenlin Chen, Yonggang Zhu, Dong Xu, Md. Mahbub Alam, Lingling Shui, Huaying ChenThe study of cell elasticity provides new insights into not only cell biology but also disease diagnosis based on cell mechanical state variation.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2044-2056DOI: 10.1039/C9LC01184F, Critical ReviewCynthia Richard, Adrian Neild, Victor J. CadarsoTo assist the transition of 3D bioprinting technology from simple lab-based tissue fabrication, to fully functional and implantable organs, the technology must not only provide shape control, but also functional control.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2188-2196DOI: 10.1039/D0LC00173B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shuyan Zhu, Mohammed A. Eldeeb, Stella W. PangFilopodia detection using nanoplasmonic biosensors, where microposts were used to separate the cell membrane from filopodia and 3D nanopillars were used to monitor nanometer-sized filopodia.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2062-2074DOI: 10.1039/D0LC00261E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kara K. Brower, Catherine Carswell-Crumpton, Sandy Klemm, Bianca Cruz, Gaeun Kim, Suzanne G. K. Calhoun, Lisa Nichols, Polly M. FordyceWe have developed a novel workflow (sdDE-FACS, ̲ingle ̲roplet ̲ouble ̲mulsion FACS) that allows robust production, screening, and sorting of single double emulsion droplets with complete nucleic acid recovery.The content of this RSS Feed (c) The Royal Society of […]

Lab Chip, 2020, 20,2328-2333DOI: 10.1039/D0LC00052C, PaperFangli Zhang, Peiyu Liao, Yue Sun, Zitian Chen, Yuhong Pang, Yanyi HuangA systematic survey of the oil and surfactant components of stable monodisperse w/o droplets suitable for various methods.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2228-2236DOI: 10.1039/D0LC00255K, PaperXuejia Hu, Shukun Zhao, Ziyi Luo, Yunfeng Zuo, Fang Wang, Jiaomeng Zhu, Longfei Chen, Dongyong Yang, Yajing Zheng, Yujia Zheng, Yanxiang Cheng, Fuling Zhou, Yi YangMulticellular aggregates in three-dimensional (3D) environments provide novel solid tumor models that can provide insight into in vivo drug resistance.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2209-2217DOI: 10.1039/D0LC00191K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Vasileios A. Papadimitriou, Stella A. Kruit, Loes I. Segerink, Jan C. T. EijkelNovel continuous or on-demand droplet generator for extraction of electrokinetically focused and separated analytes on chip. White scale bars – 100 μm.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2317-2327DOI: 10.1039/D0LC00158A, PaperSaheli Sarkar, Wenjing Kang, Songyao Jiang, Kunpeng Li, Somak Ray, Ed Luther, Alexander R. Ivanov, Yun Fu, Tania KonryComparative proteomic profiling and development of convolution neural network algorithm for quantifying discrete target interaction by engineered NK cells in microfluidic droplets.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2218-2227DOI: 10.1039/D0LC00317D, PaperGuanglei Fu, Wan Zhou, XiuJun LiA novel on-demand photothermal microfluidic pumping platform is developed using the nanomaterial-mediated photothermal effect as the tunable microfluidic driving force.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2136-2153DOI: 10.1039/C9LC01054H, PaperGlen Kelp, Joy Li, Junlan Lu, Nicholas DiNapoli, Robert Delgado, Chao Liu, Donglei Fan, Shourya Dutta-Gupta, Gennady ShvetsMicrofluidics, dielectrophoresis (DEP) and metasurface-enhanced infrared reflection spectroscopy (MEIRS) are combined for capturing and rapid spectroscopy of live cells.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2197-2208DOI: 10.1039/D0LC00257G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Calvin Lumban Gaol, Jonas Wegner, Leonhard GanzerIn this work, an attempt to close gaps between micromodels and reservoir rocks was performed by constructing chips based on the X-ray micro-computed tomography (μCT) images of a Bentheimer core plug.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2100-2112DOI: 10.1039/D0LC00214C, PaperDana Lorber, Ron Rotkopf, Talila VolkMuscle contractions produce reiterated cytoplasmic mechanical variations, which potentially influence nuclear mechanotransduction, however information regarding the dynamics of muscle nuclei in the course of muscle contraction is still missing.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2122-2135DOI: 10.1039/D0LC00267D, PaperCheuk W. Kan, Carmen I. Tobos, David M. Rissin, Alexander D. Wiener, Ray E. Meyer, Danielle M. Svancara, Anna Comperchio, Christopher Warwick, Roger Millington, Nicholas Collier, David C. DuffyWe report approaches to improve the sensitivity of digital ELISA up to 400-fold, enabling detection of proteins at subattomolar concentrations.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2175-2187DOI: 10.1039/D0LC00300J, PaperAsmaa Khater, Osama Abdelrehim, Mehdi Mohammadi, Milad Azarmanesh, Mohsen Janmaleki, Razieh Salahandish, Abdulmajeed Mohamad, Amir Sanati-NezhadDroplet microfluidics has provided lab-on-a-chip platforms with the capability of bacteria encapsulation in biomaterials, controlled culture environments, and live monitoring of growth and proliferation.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2166-2174DOI: 10.1039/D0LC00096E, PaperHanfei Shen, Tony Liu, Jesse Cui, Piyush Borole, Ari Benjamin, Konrad Kording, David IssadoreWe have developed a web-based, self-improving and overfitting-resistant automated machine learning tool tailored specifically for liquid biopsy data, where machine learning models can be built without the user's input.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2086-2099DOI: 10.1039/D0LC00112K, PaperYuncheng Man, Erdem Kucukal, Ran An, Quentin D. Watson, Jürgen Bosch, Peter A. Zimmerman, Jane A. Little, Umut A. GurkanA gradient of microcapillary networks and microfluidic anastomoses enable standardized quantitative assessment of red blood cell mediated microvascular occlusion.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2154-2165DOI: 10.1039/D0LC00250J, PaperYuexiao Song, Feng Xin, Yongsheng XuLiquid phase catalytic exchange of hydrogen isotopes is intensified by stratified flow in a microchannel reactor coated with hydrophobic Pt/AC/PDMS.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2020, 20,2113-2121DOI: 10.1039/D0LC00079E, PaperKenji Akama, Hiroyuki NojiHomogeneous digital immunoassay is a powerful analytical method for highly sensitive biomarker detection with a simple protocol. By using this method, we demonstrated the simultaneous multiple protein detection.The content of this RSS Feed (c) The Royal Society of Chemistry