Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00351F, PaperGuangzhu Shang, Shan Wei, Liqun He, Lei Gong, Gang ZhaoA vision-guided OET platform enables robust parallel manipulation of living cells with real-time detection, multi-target tracking, and collision-free control in complex microfluidic environments.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00184J, Tutorial Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zongjie WangRare cells, such as circulating tumour cells, minimal residual disease-associated populations, and antigen-specific immune cells, carry disproportionate diagnostic and therapeutic value. Yet rarity makes measurements fragile: sampling statistics, background interference,...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00454G, PaperXiaoshan Jin, Xun Cai, Meirong Yi, Xiaoxiao Chen, Yichuan Dai, Fangsheng Huang, Zhiqiang Zhu, Ke Li, Zhichao Guan, Mouqun Wan, Na Yang, Ziqun Xu, Jianfeng ChenA flexible patch of microfluidic-engineered monodisperse microcapsules achieves quasi-synchronous micro-explosions for rapid and adaptive fire suppression.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC90063A, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yulia Tobolovskaya, Bexi M. Bustillo-Perez, Yingshan Ma, Nadine Löw, Ophélie Zeyons, Daniel A. Richards, Eugenia KumachevaTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01114K, PaperEnhao Liu, Wei Tan, Xiaoliang Liang, Fengchang Yang, Gaofeng Wang, Shichang Kang, Jianxi Zhu, Hongping He, Bowen LingThe newly developed soil-embedded microfluidic platform makes real-soil microscale dynamic experiments feasible by visualizing solute transport.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00331A, PaperPing Dong, Yanfeng Gao, Wenjian Zhao, Lingtao Fan, Yuzhen WangWater pollution, particularly from heavy metals, poses a critical threat to ecosystems and human health. This study integrates the CRISPR-Cas12a system with MOF-based biobarcode technology to create a platform for...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00406G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chen Tang, Loïc Chagot, Panagiota AngeliDouble emulsions of water-in-oil-in-water (w1/o/w2) are critical for encapsulation and controlled release in microfluidic applications. In this work, double emulsion droplets were produced via a two-step flow-focusing process in a...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00290K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Gesine Hentschel, Steffen Michael Recktenwald, Katharina Doll-Nikutta, Jan F Drexler, Maren Prediger, Marc Mueller, Marc Wurz, Amy Q. Shen, Birgit GlasmacherBlood exhibits complex flow behavior governed by red blood cell (RBC) deformation, aggregation, and confinement effects, which are difficult to reproduce in-vitro at single-cell level under confinement. Existing blood mimicking...The content of this RSS Feed (c) The […]

Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00292G, PaperYuan Gao, Zhenwei Liang, Zeyu Wang, Xiaolei Guo, Qing Zhang, Bingbing Yang, Chuan Du, Hua Qin, Yuan MaHigh-throughput phenotypic cell sorting is essential for studying disease mechanisms and identifying therapeutic targets.Conventional magnetic sorting methods largely cannot isolate multiple cell subpopulations by membrane protein expression levels.They also rely...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00283H, PaperXinyi Li, Shijian Huang, Shuting Xie, Huan Liu, Lang Chen, Minmin Zhang, Zhenpin Liu, Mengjun Liu, Mingliang Jin, Xuming Zhang, Lingling ShuiThermochromic materials with temperature-dependent color changes and color memory are widely used in functional coatings, anti-counterfeiting, and smart architectures. Cholesteric liquid crystals (CLC) molecules undergo periodic helical twisting of their...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00339G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Torsten Wieduwilt, Matthias Zeisberger, Walter Hauswald, Adrian Lorenz, Shayan Vazirieh Lenjani, Christian Rossner, Markus A. SchmidtA fiber-integrated platform for nanoparticle tracking analysis based on fiber-like capillary structures that achieves high performance comparable to more complex microstructured fibers is presented.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00211K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michelle Hinrichs, Johanna Wallner, Johanna Thiery, Carolin Kleber, Manuel Metzger, Stephan A. Sieber, Tobias Hutzenlaub, Oliver Schilling, Nils Paust, Hannes Hahne, Jan Muntel, Jan-Niklas KlattThe AutoPAC-disk is a centrifugal microfluidic disk for protein aggregation capture-based sample preparation in bottom-up proteomics, enabling automated on-bead proteolysis with pre-stored buffers.To cite this article before page numbers […]

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00329J, PerspectiveDongwoo Seo, Taesung KimPhysicochemical fields and interfacial effects govern nanofluidic transport. This review summarizes their mechanisms, coupled interactions, emerging applications, challenges, and design principles for next-generation nanofluidic systems.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00452K, PaperK. S. Deepak, Arshad Javed, Sanket Goel, Satish Kumar DubeyWearable lab-on-glove systems offer the possibility of in situ electrochemical analysis for non-destructive detection by enabling direct human–surface interaction.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D5LC00219B, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Emily Ferrarese, Emily Swanekamp, Thuy-Vi Bui, Matthew J. Lazzara, Christopher B. HighleyMicrofluidic systems incorporating or contained within hydrogels are important in creating microphysiological systems (MPSs). Often naturally derived hydrogels are used, as their inherent bioactivity supports dynamic cellular behaviors. Hydrogel biomaterials...The content of this RSS Feed (c) The Royal Society of […]

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00360E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Anthony Mercader, Sang-Ho Ye, William R. Wagner, Sung Kwon ChoThis article presents a gas-exchange device featuring active mixing in blood via acoustic microstreaming driven by an oscillating membrane, enhancing oxygenation performance and hemocompatibility towards microfluidic artificial lung technology.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this […]

Lab Chip, 2026, Accepted ManuscriptDOI: 10.1039/D6LC00261G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Oliver Walker, Robin R Benedix, Julian Fischer, Kai Hirzel, Cosima Stubenrauch, Michael HeymannAdditive manufacturing has been invaluable for 3D microfluidic integration. We combine high-resolution two-photon printed microfluidic features with fast one-photon printing to reduce overall fabrication time by about 20fold without compromising...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00244G, PaperQihui Wu, Yulin Zhang, Yibo Yang, Jun Yao, Yongfei Yang, Hai Sun, Lei Zhang, Junjie Zhong“Rock-on-a-chip” technology enables direct observation of CO2 dispersion dynamics in multi-scale porous media.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00061D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Soongwon Cho, Michael Brothers, Ziyu Chen, Samet Şahin, Yirui Xiong, Nicole Schaeublin, Doug Adkins, Charles Call, Anthony Banks, Steve S. Kim, John A. RogersThe PDMS-based lab-on-a-CD ELISA platform enables rapid on-site detection of airborne bioaerosols with minimal sample volume.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC01173F, Critical ReviewLinwei Sang, Ajing Liu, Haochen Wang, Wanyi Li, Qin Tu, Jinyi WangThis review discusses skin-on-a-chip advances through the lens of dynamic biomimicry. It focuses on engineering dynamic skin microenvironments in vitro and their applications in disease modelling, drug screening, and cosmetic evaluation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00047A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ruben J. Trujillo, Phung H. Bui, Andrew P. Shreve, Matthew J. Campen, Menake E. Piyasena, Steven W. GravesAcoustofluidic trapping in cylindrical microcapillaries concentrates microparticles onto an axially centered micro-wire, demonstrating particle trapping to a suspended microstructure in flowing microfluidic systems.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D5LC00827A, PaperDoh-Won Yi, Jeongmok Kim, Joong Yull ParkA microfluidic plant-on-a-chip platform reveals a hydrodynamic threshold governing Medicago sativa root and root hair growth, as quantified by CFD simulations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3662-3669DOI: 10.1039/D5LC00959F, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Daniel A. Mokhtari, Ali Lashkaripour, Polly M. FordyceAn automated transfluorescence tandem-macro-lens optomechanical system (macroscope) capable of sensitive, multi-channel fluorescence imaging over a very large field of view (34 mm diameter, 740 square mm) and with low-micron resolution.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3905-3905DOI: 10.1039/D6LC90051H, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tejal Dube, Puja Prasad, Pragya Swami, Ankita Singh, Meenakshi Verma, Parul Tanwar, Shantanu Chowdhury, Shalini GuptaThe content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00382F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Matthias Geissler, Lidija Malic, Liviu Clime, Dillon Da Fonte, Christina Nassif, Mojra Janta-Polczynski, Caroline Miville-Godin, Daniel Brassard, Nasha Nassoury, Richard Gingras, Nazila Nazemi-Moghaddam, Parminder Singh Chahal, Rénald Gilbert, Teodor VeresAAV vectors are purified using a polymer-based microfluidic cartridge that features an embedded solid-phase extraction matrix and a layout that is compatible with workflow […]

Lab Chip, 2026, 26,3891-3904DOI: 10.1039/D6LC00133E, PaperAyoub Glia, Muhammedin Deliorman, Mohammad A. QasaimehPlug-and-play IPOF microfluidics converts open-space flows into addressable chemical nodes for programmable reagent delivery, gradient discretization, and multiplexed surface patterning.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00265J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shu-Yun Sheu, Ching-Fen Shen, Chao-Min ChengRapid urine screening requires simultaneous pathogen identification and clinically relevant bacteria burden assessment, yet most paper-based assays provide only one of these outputs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, Advance ArticleDOI: 10.1039/D6LC00058D, PaperMauricio Araiza Canizales, Alexander McGhee, Yang Wan, Jing Zhang, Emily Blick, Rafael D. González-Cruz, Diane Hoffman-Kim, Haneesh Kesari, Christian FranckA three-layer microfluidic platform for in situ compression, staining and monitoring of cortical spheroids to study mild traumatic brain injury.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3838-3850DOI: 10.1039/D6LC00100A, PaperDallin S. Miner, Timothy B. Skaggs, Barrett W. Schafer, Heidi E. Hunter, Troy Munro, Adam T. Woolley, Gregory P. NordinVacuum-enhanced high-resolution 3D printing enables scalable, high-density microfluidic fabrication, as demonstrated by the reliable production of 11 200 membrane valves and 198 uniform 7 μm isoporous membranes across the full print area.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3781-3795DOI: 10.1039/D6LC00206D, PaperYuyi Liu, Diansen YangUnderground hydrogen storage, involving periodic injection and extraction of hydrogen gas, serves as a crucial approach for achieving energy peak shaving and accommodating large-scale renewable energy.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3381-3391DOI: 10.1039/D6LC00107F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Roxanne Kate Balanay, Justin W. Yip, Justin Do, Omair Adil, Keith Johnson, Tyler R. RayAcoustic forces offer a powerful, contact-free modality for manipulating particles and fluids within microfluidic lab-on-a-chip systems.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3762-3769DOI: 10.1039/D6LC00145A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.J. Prat-Trunas, A. Code, Y. Avalos-Padilla, X. Fernández-Busquets, C. R. Mace, E. BaldrichThree-dimensional paper-based lysis device fabricated by laser cutting or by wax printing that achieves 100% cellular lysis independent of sample composition, facilitating detection of a malaria biomarker and sample storage for 1 week at RT.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3825-3837DOI: 10.1039/D6LC00143B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Avi Gupta, Jacqueline Van Zyl, Collin Bushey, Peter Shankles, Hoseyn A. Amiri, Guillem Pratx, Alexander Alexeev, Todd SulchekNarrow, parallelized channels reveal a dynamic loading regime that, when integrated with geometry, flow, single-cell kinematics, and delivery outcomes, defines a mechanistic framework for microfluidic mechanoporation.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3743-3761DOI: 10.1039/D6LC00301J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rana S. Ozcan, Fatemeh Vahedi, Shina Namakian, Ali A. Ashkar, Tohid F. DidarA droplet microfluidic workflow combines ML-based K562 death analysis with manual NK annotation to quantify attachment, killing, serial killing, and killing-time differences across primary, expanded, and tumor-conditioned NK cells.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3617-3661DOI: 10.1039/D5LC00957J, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ty Naquin, Chloe Naquin, Qian Wu, Ying Chen, Aidan Canning, Kaichun Yang, Yuna Li, Shuaiguo Zhao, Yun Ling, Zhiteng Ma, Ke Jin, Ye He, Shujie Yang, Luke P. Lee, Tony Jun HuangIntegrated microfluidic biosensors have rapidly evolved into powerful platforms to meet the increasing demand for ultrasensitive and high-throughput quantitative analysis.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3686-3702DOI: 10.1039/D6LC00096G, PaperChenyang Zhou, Feifan Wang, Jiaqi Xu, Aochen Wang, Hanping Song, Luyao Wei, Guoxiang Fu, Xiaolin WangA open-top microfluidic organ-on-a-chip that integrates stamp-based patterning with sequential cellular assembly to achieve simultaneous construction of organ-specific topological architectures and perfusable vascular networks.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3865-3876DOI: 10.1039/D5LC01048A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adam Gargasson, Julien Bouvard, Carine Douarche, Peter Mergaert, Harold AuradouBacteria can adjust their swimming behaviour in response to chemical variations, a phenomenon known as chemotaxis. Their chemotactic sensibility is logarithmic, and greatly reduced on surfaces.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3796-3809DOI: 10.1039/D5LC01140J, PaperDaidi Zhou, Xinghua Gao, Zhiyu Mao, Xiaoling Yang, Jingyun Ma, Ekaterina Andreevna Vorotelyak, Guohui Hu, Fengping Zhu, Jinbo WuThis study investigated the rapid drug delivery capabilities of neutrophil-like cells using a microfluidic chip-based mechanical deformation approach, with an emphasis on glioblastoma treatment at the cellular level.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3282-3319DOI: 10.1039/D6LC00202A, Critical ReviewBiqing Chen, Xiaohong Qiu, Yang LiMicrofluidic SERS platforms enable ultrasensitive, high-throughput bioanalysis via Raman enhancement and microfluidic control. Plasmonic integration supports multiplexed biomarker detection for biomedical research and clinical translation.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3508-3527DOI: 10.1039/D6LC00164E, PaperDonia Dominic, Srabani Kar, Rajdeep Ojha, Moeto Nagai, Tuhin Subhra SantraSchematic illustration of high-throughput biomolecular delivery in single-cell patterns. Pulsed laser scanning-activated photoporation mediated through a micropatterned rGO device facilitates intracellular delivery in cell micropatterns.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3546-3554DOI: 10.1039/D6LC00054A, PaperXiaoping Miao, Tianao Chen, Jijie Fu, Shilu Zhu, Mei Lan, Huayi Fu, Zhiqiang Zhu, Mingzhai Sun, Ronald X. XuA modular acoustic streaming vortex (MASV) platform has been developed for off-chip production of monodisperse microdroplets with broad size tunability and versatile viscoelastic properties.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3555-3581DOI: 10.1039/D5LC01079A, PaperJiayu Liu, Yuxin Wang, Shichao Su, Meng Su, Wenying Lv, Zhao Gao, Congwei Liu, Yanteng Li, Junzhao Sun, Peng Wang, Baorui Guo, Fan Yang, Renke He, Yanlin Song, Zeying Zhang, Jianning Zhang, Gang ChengThis integrated nanophotonic biosensor platform enables multiplex detection of TBI biomarkers through an end-to-end process, offering a rapid, ultrasensitive, and field-deployable solution for acute brain injury diagnostics.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3810-3824DOI: 10.1039/D5LC01050K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alexander Bevacqua, Do Hyun Park, Sheryar Khan, Qingxuan Li, Mahsa Hadidi, Jianzhu Chen, Jongyoon HanA 25-layer spiral microfluidic device significantly reduces cell biomass from high-turbidity feedstock using inertial focusing to perform primary clarification and harvest adeno-associated virus (AAV) vectors at 20 mL min−1 with 85% vector recovery.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3602-3616DOI: 10.1039/D6LC00116E, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Liyuan Gong, Erfan Eskandari, Md Iftakhar Khan, Yang LinIntegrated lab-on-a-chip systems enable streamlined sampling, detection, characterization, and bioassessment of micro- and nanoplastics, bridging environmental monitoring with human health risk assessment.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3473-3484DOI: 10.1039/D5LC00968E, PaperNaveen Kumar K. R., Saima Hamid, A. K. Niketa, Ekta Prajapati, Shishir KumarOstemer-based valved microfluidics with NOA 84 as a membrane replace PDMS using a three-layer design enables 200 ms switching time with strong chemical resistance, enabling robust and flexible microfluidic systems.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3877-3890DOI: 10.1039/D6LC00175K, PaperPreeda Larpthavee, Thitikorn Chomthong, Pareesa Pormrungruang, Suvimol Surassmo, Sakon RahongImmune-responsive microfluidics integrates dermal fibroblast–macrophage co-culture in 3D collagen to model inflammation. LPS induces NO/TNF-α responses, while nanocarriers suppress inflammation and restore ECM, enabling fast, animal-free drug screening.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3582-3590DOI: 10.1039/D5LC01090J, PaperEunyoung Park, Seungjin Kang, Jieung Oh, Sangwoo Kim, Ung Hyun KoHigh-throughput quantification of cell–metal adhesion using single-cell transit velocity measurements in a microfluidic channel.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3851-3864DOI: 10.1039/D6LC00197A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yulia Tobolovskaya, Bexi M. Bustillo-Perez, Yingshan Ma, Nadine Löw, Ophélie Zeyons, Daniel A. Richards, Eugenia KumachevaA fluorescence assay-based microfluidic approach for real-time studies of the surface adsorption of antibodies and high-throughput screening of anti-biofouling compounds.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3366-3380DOI: 10.1039/D6LC00108D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nikhil Kadivar, Guansheng Li, Jianlu Zheng, Ming Dao, George Em Karniadakis, Mengjia XuAI-assisted masks train nnU-Net to predict cell masks, followed by optional watershed refinement, labeling, counting, and sickling analysis.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3770-3780DOI: 10.1039/D5LC01020A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mansoureh Rashidi, Matina Nooryani, Giovanniantonio Natale, Anne M. BennekerThe movement of colloids in a solute concentration gradient plays a crucial role in applications, including separations, sorting and reactant transport. We show that porous particles respond different to solute gradients than solid particles.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3447-3458DOI: 10.1039/D6LC00071A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zachary Morris, Juliana Chawich, Owen Perreault, Simon Chewchuk, Kate Gragg, Vincent Tabard-Cossa, James L. McGrath, Michel GodinA microfluidic device with an integrated PDMS pressure transducer and a nanoporous membrane to capture nanoparticles. A predictive algorithm then infers particle concentration in solution from the dynamics of pressure change within the microchannels.The content of this RSS Feed (c) The Royal […]

Lab Chip, 2026, 26,3413-3424DOI: 10.1039/D6LC00035E, PaperRatul Paul, Declan Coster, Yuwen Zhao, Yi Liu, Yaling LiuCloud microfluidic platform for remote design, fabrication, and testing via maskless lithography. Integrates microscopy, flow control, and analysis, enabling users to create devices, run experiments, and access data online for research and education.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3528-3545DOI: 10.1039/D6LC00033A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Katharina Skoll, Maria Zobl, Elke Heiss, Barbara Braunboeck, Samuel Meerkatz, Franz Radner, Samuel Castonguay, Markus Holzner, Adriana Zbiral, Michael Wirth, Maria AnzengruberExperimental setup, sedimentation and shear stress influence cell interaction exposing the limits of static in vitro assays. The FlowCube emerges as a versatile, accessible platform that enables in vitro evaluation in a dynamic flow setting.The content of this […]

Lab Chip, 2026, 26,3703-3713DOI: 10.1039/D6LC00182C, PaperShogo Iwai, Daisuke Sasaki, Tetsutaro Kikuchi, Katsuhisa Matsuura, Kenjiro Fukuda, Sunghoon Lee, Tatsuya Shimizu, Takao Someya, Shinjiro UmezuAn ultrathin, stretchable nanomesh-based system enables contractile force measurement of cardiac tissue under mechanical stretch. It demonstrates stretch-dependent increases in contractile force and drug responses.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3735-3742DOI: 10.1039/D6LC00045B, PaperRyan Garry, Vladimir Sincari, Wentao Xu, Anurag Dhande, David A. WeitzRapid, low-cost organic solvent-compatible microfluidic device with localized surface modification for w/o/w emulsion templating of capsules and giant unilamellar vesicles.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3485-3492DOI: 10.1039/D6LC00201C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ellinor Hedberg, Jaime Sebastián-Azcona, Federico Ribet, Virginia Hernandez-Santana, Göran Stemme, Antonio Diaz Espejo, Niclas RoxhedA novel microfluidic plant sap sampling and storage device inspired by the concept of DBS, providing a practical alternative to destructive methods, supporting repeated sampling from the same plant and enabling longitudinal metabolic monitoring.The content of this RSS Feed (c) The Royal Society of […]

Lab Chip, 2026, 26,3425-3434DOI: 10.1039/D6LC00190D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Chun-Hsin Hsu, To-Wen Chen, Wei-Jen Soong, Chihchen ChenA dual-loop flow system is presented, enabling parallel, independent blood clot analogue production in hourglass-profiled channels, with integrated reagent delivery, real-time imaging, and flow-rate monitoring.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3435-3446DOI: 10.1039/D5LC01162K, PaperDoudou Ma, Nobutoshi Ota, Masaya Taniguchi, Yu-Hau Ye, Yuri Ito, Kazunori Okano, Naomi Tanga, Yoichiroh Hosokawa, Kazuya Sakai, Yo Tanaka, Koki Yamamoto, Yaxiaer YalikunPressure-tunable dynamic gap in an all-glass microfluidic device enables clog-resistant, high-throughput cell mechanotyping via defined compression, quantifying apparent Young's modulus as a robust alternative to flow-based deformability cytometry.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3670-3685DOI: 10.1039/D6LC00086J, PaperSaminu Abdullahi, Mohamed Ishag Hassan Gama, Mubashir Ali, Zhu Yang, Han Yujia, Jinzhen Li, Yuhang Liu, Xuzhong Wang, Zedong NieRapid in situ growth of enzyme–Cu hybrid nanoflowers on paper enables an ultrasensitive microfluidic dipstick for smartphone-assisted detection of normoglycemic glycosuria.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3714-3724DOI: 10.1039/D5LC00940E, PaperYing Liu, Zhixian Chen, Xiaoyu Zhao, Lin Xu, Shengli MiA highly sensitive wireless contact lens featuring an axisymmetric dual-spiral resonator enables continuous, non-invasive intraocular pressure monitoring for glaucoma management.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3725-3734DOI: 10.1039/D5LC00941C, PaperMichelle Zhang, Aida Z. Taravatfard, Mohammad Aghaamoo, Abraham P. LeeAcoustic microstreaming vortices enable high-throughput cell trapping and sequential delivery of plasmid DNA and Cas9 RNP, boosting transfection up to sevenfold by eliminating cargo competition and/or interaction.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3327-3344DOI: 10.1039/D6LC00067C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Louis P. Widom, Panteha Torabian, Michelle A. Trempel, Molly C. McCloskey, Lea V. Michel, James L. McGrath, Thomas R. GaborskiConditioned medium from macrophages stimulated with Escherichia coli-derived bacterial extracellular vesicles (BEVs) caused disruption of a human blood–brain barrier lab-on-chip, but direct BEV treatment did not cause a similar disruptive effect.The content of this RSS Feed (c) The Royal Society of […]

Lab Chip, 2026, 26,3493-3507DOI: 10.1039/D6LC00003G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ryoichi Ohta, Zhixin Zhao, Xuan Yan, Ruying Wang, Kazuma MawatariNanofluidic confinement enables instantaneous formation and hydrodynamic peel-off of surface LLPS films. In the future, this reversible 3D phase is expected to accommodate functional molecules beyond static 2D limits.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3345-3365DOI: 10.1039/D5LC01094B, PaperYue Yu, Tian Lin, Xiao Ye, Yupeng Wang, Rongrong Xiao, Baiyang Sun, Manman Zhao, Jie Song, Bo Li, Xiaobing ZhouA gut–liver-on-chip was established to conduct case studies of the toxicity–exposure relationship, time-dependent hepatotoxicity, enzyme/transporter-mediated drug–drug interaction studies, and first-pass effects.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3459-3472DOI: 10.1039/D5LC01042J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Esra Yilmaz, Zhimeng Fan, Jason P. Beech, Vinay S. Swaminathan, Jonas O. TegenfeldtCancer cells of type MDA-MB-231 were sorted based on size using deterministic lateral displacement. The results reveal differences with respect to size in morphology, adhesion dynamics, and invasion potential.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3401-3412DOI: 10.1039/D5LC00943J, PaperMahrukh A. Mir, Mahesh S. Tirumkudulu, Bhavesh RaichaWe determine the viscosity of blood from the length of blood smears. Viscosity below a threshold indicates anemia, while viscosity increase due to stiffening of red blood cells upon deoxygenation indicates sickle cell disease.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3392-3400DOI: 10.1039/D5LC00978B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Amanda C. Walls, Adrienne S. Vaughan, Kartik BalachandranA nasal airway-on-chip designed for culture of nasal epithelial and endothelial cells in co-culture with the epithelial cells in air–liquid interface culture and exposed to physiological breathing airflows.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2026, 26,3320-3326DOI: 10.1039/D5LC00821B, CommunicationGayathri Loganathan, Shubham Gurav, Khaja Moinuddin Shaik, Pirangi Srikanth, Aman Bhardwaj, Sukhendu NandiAn innovative portable point-of-care device that rapidly and accurately detects and quantifies bisphenol. This sensor ensures quick results, making it an indispensable tool for health and safety monitoring.The content of this RSS Feed (c) The Royal Society of Chemistry