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RSC - Lab Chip latest articles RSC - Lab Chip latest articles

  • Microfluidic approach to correlate C. elegans neuronal functional aging and underlying changes of gene expression in mechanosensation
    by Jason Wan on April 22, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D3LC01080E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jason Wan, Jimmy L. Ding, Hang LuThe aging process has broad physiological impacts, including a significant decline in sensory function, which threatens both physical health and quality of life. One ideal model to study aging, neuronal...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Drug testing of monodisperse arrays of live microdissected tumors using a valved multiwell microfluidic platform
    by Ethan J. Lockhart on April 22, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00016A, PaperEthan J. Lockhart, Lisa F. Horowitz, Adán Rodríguez, Songli Zhu, Tran Nguyen, Mehdi Mehrabi, Taranjit S. Gujral, Albert FolchA microfluidic platform was developed that hydrodynamically traps microdissected cuboids for selective drug treatments and isolates conditions with thermoplastic valves.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Automated Dynamic Inlet Microfluidics System: 3D Printer Adaptation for Cost-Effective, Low Volume, On-Demand Multi-Analyte Droplet Generator
    by Abdul Basit Zia on April 21, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00075G, PaperAbdul Basit Zia, Justin Farrell, Ian G. FouldsThe paper demonstrates an adaptation of a 3D printer (Prusa Mini+) with novel modules to develop a droplet generation system that generates combinatorial droplets from a standard 96 well plate....The content of this RSS Feed (c) The Royal Society of Chemistry

  • Correction: Direct laser writing-enabled 3D printing strategies for microfluidic applications
    by Olivia M. Young on April 21, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC90040E, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Olivia M. Young, Xin Xu, Sunandita Sarker, Ryan D. SocholTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting
    by Sunil Shrestha on April 19, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00149D, PaperSunil Shrestha, Vinod Kumar Reddy Lekkala, Prabha Acharya, Soo-Yeon Kang, Manav Goud Vanga, Moo-Yeal LeeHuman liver organoids (HLOs) hold significant potential for recapitulating the architecture and function of liver tissues in vivo. However, conventional culture methos of HLOs, forming Matrigel domes in 6-/24-well plates,...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Advanced sequencing-based high-throughput and long-read single-cell transcriptome analysis
    by Shanqing Huang on April 18, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00105B, Critical ReviewShanqing Huang, Weixiong Shi, Shiyu Li, Qian Fan, Chaoyong Yang, Jiao Cao, Lingling WuCells are the fundamental building blocks of living systems, exhibiting significant heterogeneity. The transcriptome connects the cellular genotype and phenotype, and profiling single-cell transcriptome is critical for uncovering distinct cell...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microflow sensing and control using an in-channel birefringent biomembrane
    by Nan Jia on April 18, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC00985H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nan Jia, Tianyang Deng, Charles Larouche, Tigran Galstian, André Bégin-Drolet, Jesse GreenerWe report a flow sensitive birefringent in-channel chitosan micromembrane. Using a simple cross-polarizer and a calibration curve, the membrane functions as a flow rate meter, which also works as a feedback element for a flow control system.To cite this article before page numbers are assigned, use the DOI form of citation […]

  • High-resolution low-cost LCD 3D printing for microfluidic and organ-on-a-chip devices
    by Houda Shafique on April 18, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D3LC01125A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Houda Shafique, Vahid Karamzadeh, Geunyong Kim, Molly L. Shen, Yonatan Morocz, Ahmad Sohrabi Kashani, David JunckerThe fabrication of microfluidic devices has progressed from cleanroom manufacturing to replica molding in polymers, and more recently to direct manufacturing by subtractive (e.g., laser machining) and additive (e.g., 3D...The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic microalgae detection system for cellular physiological response based on object detection algorithm
    by Shizheng Zhou on April 17, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D3LC00941F, PaperShizheng Zhou, Tianhui Chen, Edgar S. Fu, Liuyong Shi, Teng Zhou, Hong YANThe composition of species and the physiological status of microalgal cells serve as significant indicators for monitoring marine environments. Symbiotic with corals, Symbiodiniacea are more sensitive to the environmental response....The content of this RSS Feed (c) The Royal Society of Chemistry

  • Development of a microfluidic device to enrich and detect zearalenone in food using quantum dot-embedded molecularly imprinted polymers
    by Marti Z. Hua on April 16, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00193A, PaperMarti Z. Hua, Shenmiao Li, M. S. Roopesh, Xiaonan LuA QD-MIP based microfluidic device to detect mycotoxin in food.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Multiplex nanozymatic biosensing of Salmonella on a finger-actuated microfluidic chip
    by Nana Jin on April 15, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00291A, PaperNana Jin, Fan Jiang, Fengzhen Yang, Ying Ding, Ming Liao, Yanbin Li, Jianhan LinA colorimetric biosensor was elaboratively designed for fast, sensitive and multiplex bacterial detection on a single microfluidic chip.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Rocking- and diffusion-based culture of tumor spheroids-on-a-chip
    by Duomei Tian on April 14, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC01116J, PaperDuomei Tian, Zheng Mao, Li Wang, Xiaochen Huang, Wei Wang, Haoyue Luo, Juan Peng, Yong ChenTumor spheroids are cultured in hydrogel microwells with a gravity driven medium flow underneath the membrane on-a-chip. The rocking system is pumpless, powered with a rechargeable battery, and programmable with a built-in microprocess.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Portable platform for leukocyte extraction from blood using sheath-free microfluidic DLD
    by Oriana G. Chavez-Pineda on April 14, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00132J, PaperOriana G. Chavez-Pineda, Roberto Rodriguez-Moncayo, Alan M. Gonzalez-Suarez, Pablo E. Guevara-Pantoja, Jose L. Maravillas-Montero, Jose L. Garcia-CorderoA microfluidic platform isolates leukocytes from blood efficiently, offering diagnostic and immunotherapeutic potential. Enhanced by a handheld pressure controller, it enables near-patient testing and integration with downstream assays.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]

  • A paper-based dual functional biosensor for safe and user-friendly point-of-care urine analysis
    by Yujia Li on April 11, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00163J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yujia Li, Yingqi Kong, Yubing Hu, Yixuan Li, Rica Asrosa, Wenyu Zhang, Buddha Deka Boruah, Ali K. Yetisen, Andrew Davenport, Tung-Chun Lee, Bing LiA safe, accurate, and reliable sensing platform for urinary biomarkers analysis of urinary biomarkers is clinically important for the early detection and monitoring of the progression of chronic kidney disease (CKD), as it has become one of the world's most prevalent non-communicable […]

  • Screening for Urothelial Carcinoma Cells in Urine Based on Digital Holographic Flow Cytometry through Machine Learning and Deep Learning Method
    by Lu Xin on April 11, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D3LC00854A, PaperLu Xin, Xi Xiao, Wen Xiao, Ran Peng, Hao Wang, Feng PanThe incidence of urothelial carcinoma continue to rise annually, particularly among the elderly. Prompt diagnosis and treatment can significantly enhance patient survival and quality of life. Urine cytology remains a...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Operando scanning electron microscopy platform for in situ imaging of fluid evolution in nanoporous shale
    by Artur Davletshin on April 11, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D3LC01066J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Artur Davletshin, Wen SongFluid-solid interactions in nanoporous materials underlie processes fundamental to nature and the engineered environment, including the thermochemical transformation of argillaceous materials during high-level nuclear waste disposal. Operando fluid-solid resolution at...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Versatile hybrid technique for passive straight micromixer manufacturing by combining pulsed laser ablation, stereolithographic 3D printing and computational fluid dynamics
    by Bastián Carnero on April 10, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00009A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Bastián Carnero, Yago Radziunas-Salinas, Bruno K. Rodiño-Janeiro, Sylvana Varela Ballesta, M. Teresa Flores-AriasThe proposed hybrid technique for passive straight micromixer manufacturing by combining pulsed laser ablation and stereolithographic 3D printing.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Detection and Identification of Single Ribonucleotide Monophosphates using a Dual In-Plane Nanopore Sensor Made from a Thermoplastic via Replication
    by Steven A. Soper on April 9, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D3LC01062G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Steven A. Soper, Chathurika Rathnayaka, Indu Chandrasoma, Junseo Choi, Katie Childers, Maximillian Chibuike, Khurshed Akabirov, Farhad Shiri, Adam R Hall, Collin J McKinney, Matthew David Verber, Sunggook ParkWe report the generation of ~8 nm dual in-plane pores fabricated in a thermoplastic via nanoimprint lithography (NIL). These pores were connected in series with nanochannels, one of which served...The content of this […]

  • A point-of-care testing platform for on-site identification of genetically modified crops
    by Yangyang Wang on April 9, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00040D, PaperYangyang Wang, Furui Yang, Yingyi Fu, Xin He, Haowei Tian, Lili Yang, Mengxi Wu, Jijuan Cao, Junshan LiuTo fulfil the urgent needs of on-site testing, we develop a point-of-care testing platform that is able to identify 12 types of GM crops in less than 40 minutes without using laboratory settings.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic Particle Counter Visualizing Mucosal Antibody Levels against SARS-CoV-2 in the Upper Respiratory Tract for Rapid Evaluation of Immune Protection
    by Jiaheng Li on April 7, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00118D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jiaheng Li, Lok Ting CHU, Hogi Hartanto, Guihuan Guo, Lu LIU, Jianpeng WU, Minghui Wu, Chenyu Cui, Gaobo Wang, Wengang LIU, Hoi Kwan Kwong, Siying WU, Ting-Hsuan ChenMucosal antibodies at the upper respiratory tract are the earliest and most critical responders to prevent respiratory infections, providing an indication to rapidly evaluate immune protection. Here, we report a...The content of this RSS Feed (c) […]

  • Dielectrophoretic characterization and selection of non-spherical flagellate algae in parallel channels with right-angle bipolar electrodes
    by Xiaoming Chen on April 7, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00165F, PaperXiaoming Chen, Shun Liu, Mo Shen, Jishun Shi, Chungang Wu, Zhipeng Song, Yong ZhaoWe develop a microfluidic device with closed right-angle bipolar electrodes to realize dielectrophoretic characterization and selection of non-spherical flagellate algae.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Spatially controlled diffusion range of tumor-associated angiogenic factors to develop a tumor model using a microfluidic resistive circuit
    by Yu-Hsiang Hsu on April 4, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC00891F, PaperYu-Hsiang Hsu, Wen-Chih Yang, Yi-Ting Chen, Che-Yu Lin, Chiou-Fong Yang, Wei-Wen Liu, Subhashree Shivani, Pai-Chi LiThe DC-MPS device uses a velocity V-clamp to create a partition with a steep concentration gradient for simultaneously developing vasculogenic vessels and a tumor. It enables vessel–tumor interaction to develop a tumor model with angiogenic vessels.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Study on the hemodynamic effects of different pulsatile working modes of a rotary blood pump using a microfluidic platform that realizes in vitro cell culture effectively
    by Lixue Liang on April 4, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00159A, PaperLixue Liang, Xueying Wang, Dong Chen, Palaniappan Sethu, Guruprasad A. Giridharan, Yanxia Wang, Yu Wang, Kai-Rong QinThe best pulsation frequency mode of the RBP would be one that changes every 2–3 times of the cardiac cycle. The proposed in vitro microfluidic model could provide an effective platform to select the best working mode of the RBP for heart failure.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Piezoelectric and microfluidic tuning of an infrared cavity for vibrational polariton studies
    by Wei Wang on April 4, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC01101A, PaperWei Wang, Jaime de la Fuente Diez, Nicolas Delsuc, Juan Peng, Riccardo Spezia, Rodolphe Vuilleumier, Yong ChenA new method uses piezoelectric and microfluidic tuning to study vibrational polaritons in liquids under flow. This enables modifying cavity length adjustments and flexibility in experimental setups.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic-based gut-on-a-chip model containing the gut microbiota of patients with depression reveals physiological characteristics similar to depression
    by Wenxin Wang on April 3, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC01052J, PaperWenxin Wang, Yiyuan Liu, Zhikai Yao, Dengbo Chen, Yue Tang, Jingwei Cui, Jiangjiang Zhang, Hong Liu, Zikai HaoA depression-on-gut-chip (DoGC) is prepared and enables extended co-culture of aerobic human intestinal epithelial cells and anaerobic gut microbiota, and allows direct study of interactions between human gut microbiota and depression.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Direct laser writing-enabled 3D printing strategies for microfluidic applications
    by Olivia M. Young on April 3, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC00743J, Tutorial Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Olivia M. Young, Xin Xu, Sunandita Sarker, Ryan D. SocholThis Tutorial Review highlights strategies for leveraging the micron-to-submicron-scale additive manufacturing technique, “direct laser writing”, to enable 3D microfluidic technologies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • High-throughput viscoelastic characterization of cells in hyperbolic microchannels
    by Felix Reichel on April 2, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC01061A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Felix Reichel, Ruchi Goswami, Salvatore Girardo, Jochen GuckWe use hyperbolic microchannels to create a flow field with linearly increasing velocity, leading to a constant tensile stress to probe the viscoelastic properties of cells. We verify our approach on oil droplets and polyacrylamide beads.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal […]

  • Integrated high performance microfluidic organic analysis instrument for planetary and space exploration
    by Anna L. Butterworth on April 1, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00012A, PaperAnna L. Butterworth, Matin Golozar, Zachary Estlack, Jeremy McCauley, Richard A. Mathies, Jungkyu KimThis work presents the design, fabrication, and automation of our space flight-format microfabricated sample processing and capillary electrophoresis analysis instrument.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Evaluating thrombosis risk and patient-specific treatment strategy using an atherothrombosis-on-chip model
    by Fahima Akther on April 1, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00131A, PaperFahima Akther, Hedieh Fallahi, Jun Zhang, Nam-Trung Nguyen, Hang Thu TaAn atherothrombosis-on-chip model to evaluate thrombosis risk and patient-specific treatment strategy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Investigation of air bubble behaviour after gas embolism events induced in a microfluidic network mimicking microvasculature
    by Mohammad Mahdi Mardanpour on March 31, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00087K, PaperMohammad Mahdi Mardanpour, Ayyappasamy Sudalaiyadum Perumal, Zahra Mahmoodi, Karine Baassiri, Gala Montiel-Rubies, Kenneth M. LeDez, Dan V. NicolauThis study conducted in vitro experimentation using microvascular tissue-like structures to examine the dynamics of interfacial forces leading to gas bubble cessation, with the objective of providing a medical guideline for preventing gas embolism.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]

  • Development of a self-contained microfluidic chip and an internet-of-things-based point-of-care device for automated identification of respiratory viruses
    by Huynh Quoc Nguyen on March 28, 2024 at 12:00 am

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC00933E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Huynh Quoc Nguyen, Van Dan Nguyen, Vu Minh Phan, Tae Seok SeoThe COVID-19 pandemic greatly impacted the in vitro diagnostic market, leading to the development of new technologies such as point-of-care testing (POCT), multiplex testing, and digital health platforms.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Brachytherapy on-a-chip: a clinically-relevant approach for radiotherapy testing in 3d biology
    by Rodin Chermat on March 27, 2024 at 12:00 am

    Lab Chip, 2024, 24,2335-2346DOI: 10.1039/D4LC00032C, PaperRodin Chermat, Elena Refet-Mollof, Yuji Kamio, Jean-François Carrier, Philip Wong, Thomas GervaisWe introduce the first brachytherapy-on-chip device for in vitro testing of brachytherapy on naturally hypoxic tumor spheroids, for translational research and drug development.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Vascularized tissue on mesh-assisted platform (VT-MAP): a novel approach for diverse organoid size culture and tailored cancer drug response analysis
    by Jungseub Lee on March 27, 2024 at 12:00 am

    Lab Chip, 2024, 24,2208-2223DOI: 10.1039/D3LC01055D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jungseub Lee, Sangmin Jung, Hye Kyoung Hong, Hyeonsu Jo, Stephen Rhee, Ye-Lin Jeong, Jihoon Ko, Yong Beom Cho, Noo Li JeonVT-MAP, a novel in vitro platform, offers better physiological reflection through the vascularized organoid. This advancement supports drug assessment with deeper insights into cancer biology through correlation between morphology and drug effects.The content of this RSS Feed (c) The Royal Society […]

  • Development of wafer-scale multifunctional nanophotonic neural probes for brain activity mapping
    by Fu Der Chen on March 26, 2024 at 12:00 am

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC00931A, Perspective Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Fu Der Chen, Ankita Sharma, David A. Roszko, Tianyuan Xue, Xin Mu, Xianshu Luo, Hongyao Chua, Patrick Guo-Qiang Lo, Wesley D. Sacher, Joyce K. S. PoonWe explore the development of multifunctional nanophotonic neural probes, integrating microelectrodes, optical emitters, and microfluidic channels for multimodal brain mapping.To cite this article before page numbers are assigned, use the DOI form of citation above.The […]

  • A novel ratiometric design of microfluidic paper-based analytical device for the simultaneous detection of Cu2+ and Fe3+ in drinking water using a fluorescent MOF@tetracycline nanocomposite
    by Sabah H. Al-Jaf on March 26, 2024 at 12:00 am

    Lab Chip, 2024, 24,2306-2316DOI: 10.1039/D3LC01045G, PaperSabah H. Al-Jaf, Sameera Sh. Mohammed Ameen, Khalid M. OmerOn-site monitoring of ions in drinking water is essential for safeguarding public health, ensuring high water quality, and preserving the ecological balance of aquatic ecosystems.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A self-assembly and cellular migration based fabrication of high-density 3D tubular constructs of barrier forming membranes
    by Seyedaydin Jalali on March 25, 2024 at 12:00 am

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00006D, PaperSeyedaydin Jalali, Ponnambalam Ravi SelvaganapathyA scalable method for creating perfusable 3D tissue constructs using self-assembly is introduced. Unlike conventional cell injection methods, here we leverage cell migration to form tissue barriers of low permeability, mimicking in vivo environments.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A surface-engineered contact lens for tear fluid biomolecule sensing
    by Aravind M on March 22, 2024 at 12:00 am

    Lab Chip, 2024, 24,2327-2334DOI: 10.1039/D4LC00176A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Aravind M, Sajan D. GeorgeAdhesive contrast contact lens fabricated by selective lubricant grafting splits tear film on specified zone by secretion and blinking. Integrating the contact lens with the spectroscopic technique offers an efficient platform for biomolecule sensing.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Designing and prototyping a novel biosensor based on a volumetric bar-chart chip for urea detection
    by Mahdi Samadi Khezri on March 22, 2024 at 12:00 am

    Lab Chip, 2024, 24,2298-2305DOI: 10.1039/D3LC00730H, PaperMahdi Samadi Khezri, Mohammad Reza Housaindokht, Mojtaba FirouziA volumetric bar-chart chip (V-chip) is a microfluidic device based on distance-based quantitative measurement that visualizes analyte concentration without the need for apparatus or data processing.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic model to study the effects of arrhythmic flows on endothelial cells
    by Austin Lai on March 21, 2024 at 12:00 am

    Lab Chip, 2024, 24,2347-2357DOI: 10.1039/D3LC00834G, PaperAustin Lai, Adam Hawke, Mokhaled Mohammed, Peter Thurgood, Gianmarco Concilia, Karlheinz Peter, Khashayar Khoshmanesh, Sara BaratchiWe created a versatile microfluidic system for studying the effect of arrhythmic flow patterns on endothelial cells in vitro. This system provides unique opportunities to identify the molecular machineries that control endothelial biology in response to arrhythmia.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A cheaper substitute for HRP: ultra-small Cu–Au bimetallic enzyme mimics with infinitesimal steric hindrance to promote catalytic lateral flow immunodetection of clenbuterol
    by Huilan Hu on March 20, 2024 at 12:00 am

    Lab Chip, 2024, 24,2272-2279DOI: 10.1039/D3LC01079A, PaperHuilan Hu, Jiaqi Tian, Rui Shu, Huihui Liu, Shaochi Wang, Xuechi Yin, Jianlong Wang, Daohong ZhangA lateral flow immunoassay (LFIA) is developed for enzyme-catalyzed double-reading determination of clenbuterol (CLE) through the direct electrostatic adsorption of ultra-small copper–gold bimetallic enzyme mimics (USCGs) and monoclonal antibodies.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Opto-combinatorial indexing enables high-content transcriptomics by linking cell images and transcriptomes
    by Arata Tsuchida on March 20, 2024 at 12:00 am

    Lab Chip, 2024, 24,2287-2297DOI: 10.1039/D3LC00866E, PaperArata Tsuchida, Taikopaul Kaneko, Kaori Nishikawa, Mayu Kawasaki, Ryuji Yokokawa, Hirofumi ShintakuWe introduce a simple integrated analysis method that links cellular phenotypic behaviour with single-cell RNA sequencing by utilizing a combination of optical indices from cells and hydrogel beads.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Correction: Integrated biosensors for monitoring microphysiological systems
    by Lei Mou on March 19, 2024 at 12:00 am

    Lab Chip, 2024, 24,2358-2359DOI: 10.1039/D4LC90026J, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Lei Mou, Kalpana Mandal, Marvin Magan Mecwan, Ana Lopez Hernandez, Surjendu Maity, Saurabh Sharma, Rondinelli Donizetti Herculano, Satoru Kawakita, Vadim Jucaud, Mehmet Remzi Dokmeci, Ali KhademhosseiniThe content of this RSS Feed (c) The Royal Society of Chemistry

  • Effect of in-plane and out-of-plane bifurcated microfluidic channels on the flow of aggregating red blood cells
    by Amirreza Gholivand on March 18, 2024 at 12:00 am

    Lab Chip, 2024, 24,2317-2326DOI: 10.1039/D4LC00151F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Amirreza Gholivand, Olivera Korculanin, Knut Dahlhoff, Mehrnaz Babaki, Timo Dickscheid, Minne Paul LettingaTaking microfluidics to the third dimension causes scrambling of memory effects in blood flow due to out-of-plane vessel structures.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Integrated biocompatible 3D printed isoporous membranes with 7 μm pores
    by Matthew S. Viglione on March 14, 2024 at 12:00 am

    Lab Chip, 2024, 24,2202-2207DOI: 10.1039/D4LC00014E, PaperMatthew S. Viglione, Aubrianna Saxton, Dawson Downs, Adam T. Woolley, Kenneth A. Christensen, Pam M. Van Ry, Gregory P. NordinA new 3D printing method allows for fabrication of porous membranes with 7 μm pores. A device mimicking an organ-on-a-chip design is fabricated and seeded with living cells, demonstrating potential for diverse biological and mechanical applications.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Actuation for flexible and stretchable microdevices
    by Uditha Roshan on March 14, 2024 at 12:00 am

    Lab Chip, 2024, 24,2146-2175DOI: 10.1039/D3LC01086D, Critical ReviewUditha Roshan, Amith Mudugamuwa, Haotian Cha, Samith Hettiarachchi, Jun Zhang, Nam-Trung NguyenThis review paper provides a comprehensive overview of the state-of-the-art actuation mechanisms for flexible and stretchable microdevices.The content of this RSS Feed (c) The Royal Society of Chemistry

  • High-throughput 3D microfluidic chip for generation of concentration gradients and mixture combinations
    by Mingwei Zhao on March 12, 2024 at 12:00 am

    Lab Chip, 2024, 24,2280-2286DOI: 10.1039/D3LC00822C, PaperMingwei Zhao, Jing Yang, Zhenqing Li, Yuan Zeng, Chunxian Tao, Bo Dai, Dawei Zhang, Yoshinori YamaguchiConcentration gradient generation and mixed combinations of multiple solutions are of great value in the field of biomedical research.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Distance-based paper analytical device for multiplexed quantification of cytokine biomarkers using carbon dots integrated with molecularly imprinted polymer
    by Kawin Khachornsakkul on March 12, 2024 at 12:00 am

    Lab Chip, 2024, 24,2262-2271DOI: 10.1039/D4LC00055B, PaperKawin Khachornsakkul, Ruben Del-Rio-Ruiz, Lita Chheang, Wenxin Zeng, Sameer SonkusaleA carbon dots and dopamine-imprinted polymer was immobilized onto a distance-based paper channel for simultaneous detection of three cytokine biomarkers without requiring expensive reagents and instruments.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Deep learning-enabled detection of rare circulating tumor cell clusters in whole blood using label-free, flow cytometry
    by Nilay Vora on March 8, 2024 at 12:00 am

    Lab Chip, 2024, 24,2237-2252DOI: 10.1039/D3LC00694H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilay Vora, Prashant Shekar, Taras Hanulia, Michael Esmail, Abani Patra, Irene GeorgakoudiWe present a deep-learning enabled, label-free flow cytometry platform for identifying circulating tumor cell clusters in whole blood based on the endogenous scattering detected at three wavelengths. The method has potential for in vivo translation.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Synthesis and photocatalytic property of Au–TiO2 nanocomposites with controlled morphologies in microfluidic chips
    by Ziran Ye on March 7, 2024 at 12:00 am

    Lab Chip, 2024, 24,2253-2261DOI: 10.1039/D3LC01053H, PaperZiran Ye, Ping Lu, Yiben Chen, Zhixian Xu, Haixia Huang, Mingjia Zhi, Zi Ang Chen, Bo YanWe present an efficient approach for the consecutive synthesis of Au–TiO2 nanocomposites with controlled morphologies in a microfluidic chip.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Polar coordinate active-matrix digital microfluidics for high-resolution concentration gradient generation
    by Bingbing Zhang on February 27, 2024 at 12:00 am

    Lab Chip, 2024, 24,2193-2201DOI: 10.1039/D3LC00979C, PaperBingbing Zhang, Jinxin Fu, Maohua Du, Kai Jin, Qi Huang, Jiahao Li, Dongping Wang, Siyi Hu, Jinhua Li, Hanbin MaAdvancing active-matrix digital microfluidics through polar coordinates for precise concentration gradients. Demonstrated with chip photography, concentration gradient solution demo, and efficiency comparison.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Thermal segment microwell plate control for automated liquid handling setups
    by Simon Seidel on February 21, 2024 at 12:00 am

    Lab Chip, 2024, 24,2224-2236DOI: 10.1039/D3LC00714F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Simon Seidel, Katja F. Winkler, Anke Kurreck, Mariano Nicolas Cruz-Bournazou, Katharina Paulick, Sebastian Groß, Peter NeubauerThis publication introduces a thermal segment microwell plate control device, integrating smart sensor technology and standardized well-plate geometry for automated biolab setups. It is tested in a high-throughput enzymatic activity assay.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An economical in-class sticker microfluidic activity develops student expertise in microscale physics and device manufacturing
    by Priscilla Delgado on February 8, 2024 at 12:00 am

    Lab Chip, 2024, 24,2176-2192DOI: 10.1039/D3LC00912B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Priscilla Delgado, C. Alessandra Luna, Anjana Dissanayaka, Oluwamayokun Oshinowo, Jesse J. Waggoner, Sara Schley, Todd Fernandez, David R. MyersThis activity enables students to construct geometrically complex microfluidics at their desk with no specialized equipment. It can be easily transported, and helped students significantly improve their understanding of miniaturization science.The content of this RSS Feed (c) […]

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