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RSC - Lab Chip latest articles RSC - Lab Chip latest articles

  • Outstanding Reviewers for Lab on a Chip in 2023
    on July 14, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC90056A, EditorialWe would like to take this opportunity to highlight the Outstanding Reviewers for Lab on a Chip in 2023, as selected by the editorial team for their significant contribution to the journal.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Electric field temporal interference stimulation of neurons in vitro
    by Annika Ahtiainen on July 11, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00224E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Annika Ahtiainen, Lilly Leydolph, Jarno M. A. Tanskanen, Alexander Hunold, Jens Haueisen, Jari A. K. HyttinenIntroducing a setup for temporal interference electrical stimulation for neurons in vitro. Created with Biorender.com.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Early detection of hypo/hyperglycemia using microneedles electrode array-based biosensor for glucose ultrasensitive monitoring in interstitial fluid
    by Samar Elbahy on July 9, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00365A, PaperSamar Elbahy, Mohamed Mansour, Ahmed Soltan, Alyaa Ibrahem SalimDiabetes is a common chronic metabolic disease with a wide range of clinical symptoms and consequences and one of the main causes of death. For the management of diabetes, painless...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Multioxide combinatorial libraries: fusing synthetic approaches and additive technologies for highly orthogonal electronic noses
    by Vishalkumar Rajeshbhai Gohel on July 7, 2024 at 11:00 pm

    Lab Chip, 2024, Accepted ManuscriptDOI: 10.1039/D4LC00252K, PaperVishalkumar Rajeshbhai Gohel, Margarita Chetyrkina, Andrey Gaev, Nikolay P. Simonenko, Tatiana L Simonenko, Philipp Yu Gorobtsov, Nikita Fisenko, Darya A. Dudorova, Valeriy Zaytsev, Anna Lantsberg, Elizaveta P. Simonenko, Albert G. Nasibulin, Fedor FedorovThis study evaluates the performance advancement of electronic noses, on-chip engineered multisensor systems, exploiting a combinatorial approach. We analyze a spectrum of metal oxide semiconductor materials produced by individual methods...The content of this RSS Feed (c) The […]

  • A centrifugal-driven spiral microchannel microfiltration chip for emulsion and deformable particle sorting
    by Yongchao Cai on July 3, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00260A, PaperYongchao Cai, Zekun Li, Cuimin Sun, Xuan Zhao, Shixiong Wu, Guangyong Huang, Shengchang Tang, Peng Dai, Xiangfu Wei, Hui YouDroplet sorting and enrichment, as a prominent field within microfluidic technology, represent a pivotal stage in the manipulation of droplets and particles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Modelling the innate immune system in microphysiological systems
    by Michael J. Rupar on July 2, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC00812F, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michael J. Rupar, Hannah Hanson, Stephanie Rogers, Brianna Botlick, Steven Trimmer, James J. HickmanIntegration of an immune component moves the field closer to a physiologically relevant human-on-a-chip.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic finger-actuated mixer for ultrasensitive electrochemical measurements of protein biomarkers for point-of-care testing
    by Benjamin Utzinger on July 1, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00207E, PaperBenjamin Utzinger, Desh Deepak Dixit, Peter B. LillehojWe report a microfluidic electrochemical immunosensor that employs a unique finger-actuated mixer for rapid (<25 min), ultrasensitive (∼5 pg mL−1) measurements of protein biomarkers in human plasma using a smartphone-based diagnostic device.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Sample preparation and detection methods in point-of-care devices towards future at-home testing
    by George Adedokun on July 1, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC00943B, Critical ReviewGeorge Adedokun, Morteza Alipanah, Z. Hugh FanThis review covers recent advances in sample preparation and detection methods for point-of-care testing, aiming to accelerate progress towards at-home health monitoring for personalized healthcare in the future.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microreactor designed for efficient plasma–liquid segmented flows
    by Pierre Dedieu on July 1, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00315B, PaperPierre Dedieu, Gabriel Morand, Karine Loubière, Stéphanie Ognier, Michael TatoulianA microreactor working with gas–liquid segmented flows for controlled biphasic hydrodynamics in plasma chemical process applications.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Deformation under flow and morphological recovery of cancer cells
    by Emile Gasser on June 30, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00246F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Emile Gasser, Emilie Su, Kotryna Vaidžiulytė, Nassiba Abbade, Hamizah Cognart, Jean-Baptiste Manneville, Jean-Louis Viovy, Matthieu Piel, Jean-Yves Pierga, Kyohei Terao, Catherine VillardA novel microfluidic device dedicated to cell rheology after flow-induced deformation in constricted channel: a focus on the recovery properties of circulating tumor cells.To cite this article before page numbers are assigned, […]

  • Urine osmolality assessment through the integration of urea hydrolysis and impedance measurement
    by Tian Fook Kong on June 30, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00114A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Tian Fook Kong, Xinhui Shen, Mei Yi Sim, Jin Yong, Tze Kiat Ng, Tsung Wen Chong, MarcosWe present the development and validation of an impedance-based urine osmometer for accurate and portable measurement of urine osmolality.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Simple bioelectrical microsensor: oocyte quality prediction via membrane electrophysiological characterization
    by Peyman Palay on June 28, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D3LC01120H, PaperPeyman Palay, Davood Fathi, Hassan Saffari, Fatemeh Hassani, Samira Hajiaghalou, Rouhollah FathiIntroducing a novel electrical evaluation approach as an alternative to or an enhancer of the conventional approach for oocyte quality evaluation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Dynamic behavior of DNA molecules in microchannels: exploring deflective, elliptical, and spin motions induced by Saffman and Magnus forces
    by Zhiwei Li on June 27, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00140K, PaperZhiwei Li, Qiong Wang, Yong Niu, Ruiyu Wang, Wei Zhao, Chen Zhang, Guiren Wang, Kaige WangIn a microchannel, DNA molecules exhibit a variety of motions under certain conditions of an applied electric field, including deflected inflow, deflected outflow, rocking motion, and elliptical motion.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Quantitative reagent monitoring in paper-based electrochemical rapid diagnostic tests
    by Léonard Bezinge on June 27, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00390J, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Léonard Bezinge, Andrew J. deMello, Chih-Jen Shih, Daniel A. RichardsExploiting non-faradaic signals from electrochemical sensors to track reagent flow in rapid diagnostic tests: towards smart tests with reduced user errors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A high-sensitivity lab-on-a-chip analyzer for online monitoring of nitrite and nitrate in seawater based on liquid waveguide capillary cells
    by Zeming Yang on June 27, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3528-3535DOI: 10.1039/D4LC00248B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zeming Yang, Junxiao Zhang, Jincheng Zhao, Wen Zhou, Yuanyue Cheng, Zhantang Xu, Panpan Wei, Zihui Wang, Haorui Liang, Cai LiThe LWCC was applied for the first time to a microfluidic system for seawater nutrients in this work, providing a higher sensitivity and lower detection limit for the detection of biochemical elements in seawater based on wet-chemistry.The content of this RSS Feed (c) The Royal Society of […]

  • Functionality integration in stereolithography 3D printed microfluidics using a “print-pause-print” strategy
    by Matthieu Sagot on June 26, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3508-3520DOI: 10.1039/D4LC00147H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Matthieu Sagot, Timothée Derkenne, Perrine Giunchi, Yohan Davit, Jean-Philippe Nougayrède, Corentin Tregouet, Vincent Raimbault, Laurent Malaquin, Bastien VenzacNovel protocol for integration of object inside stereolithography-based chips and proof-of-concepts: bacteria imaging, blue energy and in-flow cell capture.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Ultra-low intensity light pulses for large cargo delivery into hard-to-transfect cells using an rGO mixed PDMS microtip device
    by Hima Harshan Padma on June 26, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00121D, PaperHima Harshan Padma, Kavitha Illath, Donia Dominic, Hwan-You Chang, Moeto Nagai, Rajdeep Ojha, Srabani Kar, Tuhin Subhra SantrarGO-polymer microtip device for uniform and contactless highly efficient intracellular delivery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic fabrication of monodisperse microcapsules with gas cores
    by Shi-Hao Yang on June 24, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3556-3567DOI: 10.1039/D4LC00443D, PaperShi-Hao Yang, Wan-Lu Song, Lin-Ling Fan, Chuan-Fu Deng, Rui Xie, Wei Wang, Zhuang Liu, Da-Wei Pan, Xiao-Jie Ju, Liang-Yin ChuA novel strategy is developed based on droplet microfluidics and interfacial polymerization for efficient and continuous fabrication of monodisperse gas-core microcapsules with controllable sizes and excellent ultrasound-induced burst performances.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Unveiling nutrient flow-mediated stress in plant roots using an on-chip phytofluidic device
    by Kaushal Agarwal on June 24, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00180J, PaperKaushal Agarwal, Sumit Kumar Mehta, Pranab Kumar MondalPRFD is a miniaturized, hydroponic, PDMS-based device for on-chip growth and real-time micrography of plant root. Off-chip anatomical study and numerical simulations were conducted for analysing both plant and mechanical stress, respectively.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic synthesis of hemin@ZIF-8 nanozyme with applications in cellular reactive oxygen species detection and anticancer drug screening
    by Yanping Wang on June 23, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3521-3527DOI: 10.1039/D4LC00290C, PaperYanping Wang, Shujun Feng, Xuyuan Wang, Chungui Tao, Yuta Liu, Yanyi Wang, Yanfeng Gao, Jinsong Zhao, Yujun SongA microfluidic chip featuring zigzag and spiral channels with sudden expansion structures was designed for enhanced reactant mixing to synthesize peroxidase-like hemin@ZIF-8 nanozyme, enabling sensitive ROS detection.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Single-molecule microfluidic assay for prostate-specific antigen based on magnetic beads and upconversion nanoparticles
    by Dorota Sklenárová on June 23, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3536-3545DOI: 10.1039/D4LC00346B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Dorota Sklenárová, Antonín Hlaváček, Jana Křivánková, Julian C. Brandmeier, Julie Weisová, Michal Řiháček, Hans H. Gorris, Petr Skládal, Zdeněk FarkaA microfluidic device for single-molecule detection of prostate-specific antigen was developed, utilizing magnetic microparticles as a solid phase and photon-upconversion nanoparticles as a label.The content of this RSS Feed (c) The Royal Society of Chemistry

  • DLM–GelMA/tumor slice sandwich structured tumor on a chip for drug efficacy testing
    by Wenqi Hu on June 23, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00278D, PaperWenqi Hu, Ho-Pan Bei, Hongwei Jiang, Di Wu, Xiaorui Yu, Xintong Zhou, Qiuwan Sun, Qinrui Lu, Qijun Du, Liangwen Wang, Zhi Luo, Guohua Wu, Xin Zhao, Shuqi WangDLM–GelMA sandwich structure tumor slice-on-a-chip could faithfully reflect the tumor microenvironment and immune response for drug efficacy screening.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Reversibly-bonded microfluidic devices for stable cell culture and rapid, gentle cell extraction
    by Xiaohan Feng on June 20, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3546-3555DOI: 10.1039/D3LC01019H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaohan Feng, Zehaoyu Wu, Lily Kwan Wai Cheng, Yang Xiang, Ryohichi Sugimura, Xuyan Lin, Angela Ruohao WuThis reversible bonding approach allows for rapid and gentle live cell extraction after long-term on-chip culturing, facilitating downstream manipulation and characterization, and opening new avenues for various applications.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Deciphering hepatoma cell resistance to tyrosine kinase inhibitors: insights from a Liver-on-a-Chip model unveiling tumor endothelial cell mechanisms
    by Madhu Shree Poddar on June 19, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00238E, PaperMadhu Shree Poddar, Yu-De Chu, Chau-Ting Yeh, Cheng-Hsien LiuTumor angiogenesis on microfluidic chips reveals treatments, advances therapeutic strategies and helps to understand tumor drug-resistance mechanisms.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Development of a self-powered digital LAMP microfluidic chip (SP-dChip) for the detection of emerging viruses
    by Tom Kasputis on June 19, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3490-3497DOI: 10.1039/D4LC00265B, PaperTom Kasputis, Po-Chen Yeh, Li Liu, Jeffrey Marano, James Weger-Lucarelli, Ke Du, Liwei Lin, Juhong ChenPoint-of-care (POC) diagnostics have emerged as a crucial technology for emerging pathogen detections to enable rapid and on-site detection of infectious diseases.The content of this RSS Feed (c) The Royal Society of Chemistry

  • In vitro vascularized liver tumor model based on a microfluidic inverse opal scaffold for immune cell recruitment investigation
    by Pingwei Xu on June 18, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3470-3479DOI: 10.1039/D4LC00341A, PaperPingwei Xu, Junjie Chi, Xiaochen Wang, Meng Zhu, Kai Chen, Qihui Fan, Fangfu Ye, Changmin ShaoA well-defined inverse opal scaffold generated by droplet microfluidics is proposed for the construction of a vascularized liver tumor model, offering insights into immune cells' recruitment.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Two-photon microscopy of acoustofluidic trapping for highly sensitive cell analysis
    by Thomas Kellerer on June 18, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3456-3469DOI: 10.1039/D4LC00144C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Thomas Kellerer, Bettina Sailer, Patrick Byers, Rune Barnkob, Oliver Hayden, Thomas HellererTwo-photon microscopy and acoustofluidics for 3D cell study close to living conditions, precise imaging, and real-time osmosis monitoring.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Reconstitution of human tissue barrier function for precision and personalized medicine
    by Jaehoon Kim on June 18, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3347-3366DOI: 10.1039/D4LC00104D, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jaehoon Kim, Taehee Yoon, Sungryeong Lee, Paul J. Kim, YongTae KimThis review highlights key design parameters for developing functional tissue barrier chips, explores recent advancements in the field, and discusses future perspectives on using these chips to realize personalized medicine.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Droplet drinking in constrictions
    by Shi Feng on June 17, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3412-3421DOI: 10.1039/D4LC00381K, PaperShi Feng, Chundong Xue, Cunliang Pan, Shengyang TaoWhen droplets pass through constrictions, they exhibit a behavior akin to cellular pinocytosis, forming intricate multiple emulsions.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An integrative temperature-controlled microfluidic system for budding yeast heat shock response analysis at the single-cell level
    by Jie Hong on June 17, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00313F, PaperJie Hong, Hao He, Yinjia Xu, Shujing Wang, Chunxiong LuoThree forms of temperature changes (step, gradient, and oscillations) were realized in a novel microfluidic platform. The feasibility of this temperature-controlled platform for studying the protein dynamic behavior of yeast cells was demonstrated.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • In-line Raman imaging of mixing by herringbone grooves in microfluidic channels
    by W. J. Niels Klement on June 16, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3498-3507DOI: 10.1039/D4LC00115J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.W. J. Niels Klement, Elia Savino, Wesley R. Browne, Elisabeth VerpoorteIn-line characterization of mixing in microchannels with high spatiotemporal resolution is challenging. Here we describe a Raman imaging approach to ascertain extent of mixing in across channels in 3D for both same- and immiscible-solvent systems.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Human induced pluripotent stem cell-derived cardiac muscle rings for biohybrid self-beating actuator
    by Tomohiro Morita on June 14, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3377-3387DOI: 10.1039/D4LC00276H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Tomohiro Morita, Minghao Nie, Shoji Takeuchi3D cardiac muscle rings are proposed as autonomously driving actuators. We develop the biohybrid self-beating actuator powered by the cardiac muscle rings and confirm its periodic antagonistic beating motion with culture.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Ultrasensitive quantification of PD-L1+ extracellular vesicles in melanoma patient plasma using a parallelized high throughput droplet digital assay
    by Hanfei Shen on June 12, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3403-3411DOI: 10.1039/D4LC00331D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hanfei Shen, Yasemin Atiyas, Zijian Yang, Andrew A. Lin, Jingbo Yang, Diao Liu, Juhwan Park, Wei Guo, David A. IssadoreWe develop a high-throughput droplet-based extracellular vesicle analysis (DEVA) assay for ultrasensitive quantification of EVs in plasma that are positive for both PD-L1 and tetraspanins.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Laser-induced microbubble as an in vivo valve for optofluidic manipulation in living Mice's microvessels
    by Meng Shao on June 12, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3480-3489DOI: 10.1039/D4LC00095A, PaperMeng Shao, Changxu Li, Chun Meng, Rui Liu, Panpan Yu, Fengya Lu, Zhensheng Zhong, Xunbin Wei, Jinhua Zhou, Min-Cheng ZhongThis study presents an optofluidic method based on microbubble valves for regulating blood microflow in vivo while assessing the apparent viscosity of leukocytes.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Acoustofluidic-based microscopic examination for automated and point-of-care urinalysis
    by Xin He on June 12, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00408F, PaperXin He, Feng Ren, Yangyang Wang, Zhiyuan Zhang, Jiming Zhou, Jian Huang, Shuye Cao, Jinying Dong, Renxin Wang, Mengxi Wu, Junshan LiuWe design an acoustofluidic-based automated and point-of-care system that can achieve urinalysis within 3 minutes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Membrane-based microfluidic systems for medical and biological applications
    by Silvia Tea Calzuola on June 12, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00251B, Tutorial ReviewSilvia Tea Calzuola, Gwenyth Newman, Thomas Feaugas, Cécile M. Perrault, Jean-Baptiste Blondé, Emmanuel Roy, Constance Porrini, Goran M. Stojanovic, Jasmina VidicMicrofluidic devices with integrated membranes for medical and biological applications have shown considerable growth over the last decade.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Optoelectronic microfluidic device for point-of-care blood plasma viscosity measurement
    by Somayyeh Bakhtiaridoost on June 12, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3305-3314DOI: 10.1039/D4LC00211C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Somayyeh Bakhtiaridoost, Cristian Musuroi, Marius Volmer, Monica FlorescuNon-contact, highly accurate and fully automated measurement of the blood plasma viscosity using the optical transparency technique at a constant temperature of 37 °C.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Impact of brain organoid-derived sEVs on metastatic adaptation and invasion of breast carcinoma cells through a microphysiological system
    by Hojjatollah Nazari on June 11, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3434-3455DOI: 10.1039/D4LC00296B, PaperHojjatollah Nazari, Ann-Na Cho, Dale Goss, Jean Paul Thiery, Majid Ebrahimi WarkianiIllustrating the hypothesis on the impact of brain sEVs on education and adaptation of breast carcinoma cells outside and then inside the brain microenvironment. Figure created with https://Biorender.com.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Periodontal disease and emerging point-of-care technologies for its diagnosis
    by Jayesh Korgaonkar on June 6, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3326-3346DOI: 10.1039/D4LC00295D, Critical ReviewJayesh Korgaonkar, Azra Yaprak Tarman, Hatice Ceylan Koydemir, Sasanka S. ChukkapalliSchematic representation of established biomarkers and various methods developed for diagnosing PD. Created with https://www.BioRender.com.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy
    by Federico Nebuloni on June 5, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3252-3264DOI: 10.1039/D4LC00107A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Federico Nebuloni, Quyen B. Do, Peter R. Cook, Edmond J. Walsh, Richard Wade-MartinsIn vivo, different neurons make directional connections; however, most in vitro models fail to capture such connectivity. We use microfluidics with fluid walls to study neuronal circuits in vitro in ways that fit into existing bio-medical workflows.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Site-specific thrombus formation: advancements in photothrombosis-on-a-chip technology
    by Kuan-Ting Liu on June 3, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3422-3433DOI: 10.1039/D4LC00216D, PaperKuan-Ting Liu, Pai-Wen Wang, Han-Yun Hsieh, Han-Chi Pan, Hsian-Jean Chin, Che-Wei Lin, Yu-Jen Huang, Yung-Chieh Liao, Ya-Chun Tsai, Shang-Ru Liu, I.-Chang Su, Yen-Fang Song, Gung-Chian Yin, Kuang-Chong Wu, Er-Yuan Chuang, Yu-Jui (Ray) Fan, Jiashing YuA photothrombosis-on-a-chip system with precise site-specific thrombus formation, controllable thrombus severity, and dual physiological environments for drug testing and thrombosis research.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Hand-held all-in-one (HAO) self-test kit for rapid and on-site detection of SARS-CoV-2 with colorimetric LAMP
    by Qingyang Wang on June 2, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3265-3275DOI: 10.1039/D4LC00199K, PaperQingyang Wang, Woong Heo, Seoyeon Choi, Woongsik Jang, Chae Seung Lim, Hyo-Il JungA hand-held all-in-one (HAO) device applied with c-LAMP for on-site SARS-CoV-2 RNA detection. Simplifying laboratory nucleic acid amplification enables sample-to-answer for distinguishing COVID-19 patients from healthy individuals in 30 min.The content of this RSS Feed (c) The Royal Society of Chemistry

  • On-demand drug delivery bioelectronics through a water-processable low dimensional highly conductive MXene layer
    by Hyeok-jin Kwon on June 2, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3294-3304DOI: 10.1039/D4LC00234B, PaperHyeok-jin Kwon, Yizhang Wu, Yuan Li, Gongkai Yuan, Rene Lopez, Ke Huang, Wubin BaiWater-processable MXene layer applied to microneedle toward on-demand drug delivery bioelectronics.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Electrolyte-gated amorphous IGZO transistors with extended gates for prostate-specific antigen detection
    by Xuemei Yin on June 2, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3284-3293DOI: 10.1039/D4LC00247D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xuemei Yin, Xingqi Ji, Wenlong Liu, Xiaoqian Li, Mingyang Wang, Qian Xin, Jiawei Zhang, Zhuocheng Yan, Aimin SongA portable biosensor combining electrolyte-gated IGZO transistors with an extended pluggable sensing pad for prostate-specific antigen (PSA) detection at low operating voltages.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Portable all-in-one microfluidic system for CRISPR–Cas13a-based fully integrated multiplexed nucleic acid detection
    by Ya Zhang on May 30, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3367-3376DOI: 10.1039/D4LC00326H, PaperYa Zhang, Yue Guo, Guozhen Liu, Shiqi Zhou, Rouyu Su, Qian Ma, Yiyue Ge, Yan-qing Lu, Lunbiao Cui, Guanghui WangA portable centrifugal microfluidic device was developed that integrates nucleic acid purification, amplification and CRISPR detection for one-step rapid multiplex diagnosis of infectious diseases in resource-limited settings.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic co-culture model for investigating colonocytes–microbiota interactions in colorectal cancer
    by Daniel Penarete-Acosta on May 30, 2024 at 11:00 pm

    Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00013G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Daniel Penarete-Acosta, Rachel Stading, Laura Emerson, Mitchell Horn, Sanjukta Chakraborty, Arum Han, Arul JayaramanChanges in the abundance of certain bacterial species within the colorectal microbiota correlate with colorectal cancer (CRC) development.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microvortex-induced turbulent mixing for reconstitution of high-density lipoprotein-mimicking nanoparticles with aggregation-prone phosphatidylcholine
    by Koji Takata on May 29, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3276-3283DOI: 10.1039/D3LC01077E, PaperKoji Takata, Shiori Shibukawa, Chika Morimoto, Shingi Hashioka, Tatsuya MurakamiLipid nanoparticles often contain a phosphatidylcholine with a long chain fatty acid, 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC).The content of this RSS Feed (c) The Royal Society of Chemistry

  • Parathyroid-on-a-chip simulating parathyroid hormone secretion in response to calcium concentration
    by Sunghan Lee on May 26, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3243-3251DOI: 10.1039/D4LC00249K, PaperSunghan Lee, Hyo-Il Jung, Jaehun Lee, Youngwon Kim, Jaewoo Chung, Han Su Kim, Jiseok Lim, Ki Chang Nam, Yun-Sung Lim, Han Seok Choi, Bong Seop KwakTonsil-derived mesenchymal stem cells were extracted and used to fabricate parathyroid organoids. By modeling both the parathyroid organoid and vasculature, this system can simulate parathyroid hormone secretion based on calcium concentration.The content of this RSS Feed (c) The Royal Society of Chemistry

  • WormSpace μ-TAS enabling automated on-chip multi-strain culturing and multi-function imaging of Caenorhabditis elegans at the single-worm level on the China Space Station
    by Qianqian Yang on May 22, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3388-3402DOI: 10.1039/D4LC00210E, PaperQianqian Yang, Runtao Zhong, Wenbo Chang, Kexin Chen, Mengyu Wang, Shuqi Yuan, Zheng Liang, Wei Wang, Chao Wang, Guanghui Tong, Tao Zhang, Yeqing SunThis paper describes a fully integrated microfluidic system (WormSpace μ-TAS) for automated on-chip multi-strain culturing and multi-function imaging of C. elegans at the single-worm level on the China Space Station.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Surface acoustic wave digital microfluidics with surface wettability gradient
    by Yaodong Zhang on May 16, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3226-3232DOI: 10.1039/D4LC00203B, PaperYaodong Zhang, Ying YangDroplets can also obey traffic rules. We propose a new method of surface acoustic wave digital microfluidic technology. Using the wetting model to select the driving object, and realize the intricate reaction among multiple droplets.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Switching to external flows: perturbations of developing vasculature within chicken chorioallantoic membrane
    by Prasanna Padmanaban on May 5, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3233-3242DOI: 10.1039/D4LC00311J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Prasanna Padmanaban, Danny van Galen, Nasim Salehi-Nik, Mariia Zakharova, Loes Segerink, Jeroen RouwkemaNot only the flow of liquid through vasculature, but also external fluid flows can affect the organization and maturation of vessels.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems
    by Alisa Ugodnikov on April 30, 2024 at 11:00 pm

    Lab Chip, 2024, 24,3199-3225DOI: 10.1039/D3LC01027A, Critical ReviewAlisa Ugodnikov, Henrik Persson, Craig A. SimmonsBiological barriers play key roles in homeostasis, disease physiology and drug delivery, highlighting a need for representative in vitro tools. We discuss advances and challenges in modeling and measuring barrier integrity in organ-on-chip systems.The content of this RSS Feed (c) The Royal Society of Chemistry

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