Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D2LC00984F, PaperLaura Serioli, Lina Gruzinskyte, Giulia Zappalá, En-Te Hwu, Trygvi Laksafoss, Peter Lunding Jensen, Danilo Demarchi, Anette Müllertz, Anja Boisen, Kinga ZorIn vitro, cell-based assays are essential in diagnostics and drug development. There are ongoing efforts to establish new technologies that enable real-time detection of cell-drug interaction during culture under flow...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D2LC01168A, Communication Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Stef Broeren, Inês Figueiredo Pereira, Tongsheng Wang, Jaap den Toonder, Ye WangVarious types of passive and active micromixers have been successfully developed to address the problem of mixing in microfluidic devices. However, many applications do not need fluids to be mixed...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D3LC00052D, CommunicationMario Ochoa, Pablo Roldán-Varona, José Francisco Algorri, José Miguel López-Higuera, Luis Rodríguez-CoboIn fused silica, ultrafast laser assisted etching enables high chemical etching rates (>300 μm·h-1) by setting the light polarisation linear and perpendicular to the beam writing direction. However, for many...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D2LC01051H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Oskar E Ström, Jason Paul Beech, Jonas Olof TegenfeldtWe observe regular patterns emerging across multiple length scales with high-concentration DNA solutions in microfluidic pillar arrays at low Reynolds numbers and high Deborah. Interacting vortices between pillars lead to...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D2LC00963C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Matthew David Bourn, Safoura Zahed Mohajerani, Georgia Mavria, Nicola Ingram, P. Louise Coletta, Stephen Evans, Sally Anne PeymanThe vascular system is the primary route for the delivery of therapeutic drugs throughout the body and is an important barrier at the region of disease interest, such as a...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D3LC00060E, PaperSalih Zeki Bas, Rumeysa Cetiner, Deniz Teke, Mustafa OzmenThis study describes the fabrication of a lab-made screen-printed electrode (LabSPE) and its sensing ability for the detection of butylated hydroxyanisole (BHA) which is a synthetic antioxidant utilized widely in...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC01115H, PaperChan Kwon, Aram J. ChungWe present a novel nonlinear microfluidic cell stretching (μ-cell stretcher) platform that leverages viscoelastic fluids, i.e., methylcellulose (MC) solutions, and cell mechanoporation for highly efficient and robust intracellular mRNA delivery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC01153K, PaperBing Yang, Lu Shi, Qiaorong Tang, Wei Liu, Baoxin Li, Chaoyong Yang, Yan JinAutomated manipulation of discrete droplets by digital microfluidics (DMF) combined with chemiluminescence (CL) is promising to achieve automated and sensitive biosensing and bioanalysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D2LC00755J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Subin Mao, Catherine Fonder, Md Fazlay Rubby, Gregory J. Phillips, Donald S Sakaguchi, Long QueTo improve our understanding of how the central nervous system functions in health and disease, we report the development of an integrated chip for studying the effects of the neurotransmitters...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D2LC00973K, PaperJingjing Zheng, Xuejia Hu, Xiaoqi Gao, Yantong Liu, Shukun Zhao, Longfei Chen, Guoqing He, Jing-Wei Zhang, lei Wei, Yi YangQuick and convenient fabrication of in vitro tumor spheroids model has been pursued for clinical drug discovery and personalized therapy. Here, uniform three-dimensional (3D) tumor spheroids are quickly constructed by...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00997H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Binita Nath, Lorenzo Caprini, Claudio Maggi, Alessandra Zizzari, Valentina Arima, Ilenia Viola, Roberto Di Leonardo, Andrea PuglisiWe propose a technique for the amplification of motile sperm concentration without involving external forces or flows. Our method is validated by microfluidic experiments based on sperms in microstructures and supported by numerical simulations.To cite this article before page numbers […]

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00878E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Azim Parandakh, Oriol Ymbern, William Jogia, Johan Renault, Andy Ng, David JunckerThe ELISA chip is a capillary-driven lab-on-a-chip that automates ELISA protocol including aliquoting, flowing, and flushing of sample and reagents by structurally encoding all fluidic operations in a capillaric circuit and powering it with a paper.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]

Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D2LC00890D, Critical ReviewLihua Guo, Chang Liu, Manlin Qi, Liang Cheng, Lin Wang, Chunxia Li, Biao DongThe isolation and detection of circulating tumor cells (CTCs) play an important role in early cancer diagnosis and prognosis, providing easy access to identify metastatic cells before clinically detectable metastases....The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00926A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.S. Delshadi, M. Fratzl, O. Ramel, P. Bigotte, P. Kauffmann, D. Kirk, V. Masse, M. P. Brenier-Pinchart, H. Fricker-Hidalgo, H. Pelloux, F. Bruckert, C. Charrat, O. Cugat, N. M. Dempsey, T. Devillers, P. Halfon, A. Leroy, M. Weidenhaupt, P. N. MarcheThe magnetically localized and wash-free fluorescence immunoassay (MLFIA) is a no-wash assay for directly measuring biomolecule (antigen and antibody) concentration, […]

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00970F, PaperAdam H. Szmelter, Giulia Venturini, Rana J. Abbed, Manny O. Acheampong, David T. EddingtonClinical pressure waveforms are introduced into cell culture using a millifluidic 3D-printed platform.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00928E, Critical ReviewFrank X. Liu, Johnson Q. Cui, Zhihao Wu, Shuhuai YaoCritical development of CRISPR-based diagnostics coupled with nucleic acid amplification and amplification-free techniques; various purposes of CRISPR diagnostics including determination, quantification, multiplexed and point-of-care diagnostics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D3LC00012E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Martina Lenzuni, Silvio Bonfadini, Luigino Criante, Filippo Zorzi, Maria Summa, Rosalia Bertorelli, Giulia Suarato, Athanassia AthanassiouMicrofluidic-based dynamic assays for drug-eluting stent coatings.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00554A, Critical ReviewNavaporn Sritong, Marina Sala de Medeiros, Laud Anthony Basing, Jacqueline C. LinnesReview work on the challenges of paper-based NAATs covering sample-to-answer procedures along with the three main types of clinical samples as well as broader operational, scale up, and regulatory aspects of device development and implementation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Accepted ManuscriptDOI: 10.1039/D2LC01159J, PaperNor Syafirah Zambry, Mohd Syafiq Awang, Khi Khim Beh, Hairul H Hamzah, Yazmin Bustami, Godwin Attah Obande, Muhammad Fazli Khalid, Mehmet Ozsoz , Asrulnizam Abd Manaf, Ismail AziahThe emergence of coronavirus disease 2019 (COVID-19) motivates continuous efforts to develop robust and accurate diagnostic tests to detect the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Detection of viral nucleic...The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00693F, CommunicationNandini Debnath, Ludovic Saiveng Live, Mahla PoudinehAn integrated assay combining microfluidic passive plasma separation with surface plasmon resonance for protein biomarker detection in whole blood.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00716A, PerspectiveClaudio Parolo, Andrea Idili, Jason Heikenfeld, Kevin W. PlaxcoWe argue that the introduction of high-frequency, real-time biosensors into LoCs could be used to establish high-value feed-back control functionalities.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00799A, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ghazal Bashiri, Marshall S. Padilla, Kelsey L. Swingle, Sarah J. Shepherd, Michael J. Mitchell, Karin WangRepresentation of the influence of biological and nanoscale factors on protein corona conformation and function in a healthy versus a pathogenic biological environment.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00904H, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nan Lu, Hui Min Tay, Chayakorn Petchakup, Linwei He, Lingyan Gong, Kay Khine Maw, Sheng Yuan Leong, Wan Wei Lok, Hong Boon Ong, Ruya Guo, King Ho Holden Li, Han Wei HouThis review focuses on recent microfluidic technologies for label-free blood cell separation, detection and coupling with machine learning approaches.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of […]

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00817C, PaperKumar Abhishek, Anto Sam Crosslee Louis Sam Titus, Mai T. P. Dinh, Anton Mukhamedshin, Chandra Mohan, Sean C. Gifford, Sergey S. ShevkoplyasUsing a rosette-enabled size-based (RESIZE) approach, a desired subset of lymphocytes can be isolated from unwanted lymphocytes of the same size and other cells rapidly and with high purity and yield in a flow-through, passive microfluidic device.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of […]

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00876A, Critical ReviewZheyu Li, Qingjia Bao, Chaoyang Liu, Ying Li, Yunhuang Yang, Maili LiuMicrofluidics and NMR have their own specific features, and integration of the two approaches allows non-invasive and label-free analysis of biochemical samples.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC01045C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sebastian Shaner, Anna Savelyeva, Anja Kvartuh, Nicole Jedrusik, Lukas Matter, José Leal, Maria AsplundAn on-chip bioelectronic platform for exploring precise direct current electric field stimulation of injured keratinocytes with salt-bridgeless electrodes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00938B, PaperAmirreza Mottafegh, Gwang-Noh Ahn, Dong-Pyo KimIntroducing meta-optimizer as a new multi-model Bayesian optimization algorithm, consisting of multiple surrogate models addressing the challenge of model selection for autonomous chemical experimentation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00933A, Perspective Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Antonio Fabozzi, Francesca Della Sala, Mario di Gennaro, Marco Barretta, Gennaro Longobardo, Nicola Solimando, Maurizio Pagliuca, Assunta BorzacchielloNanoparticle systems are functional carriers that can be used in the cancer therapy field for the delivery of a variety of hydrophobic and/or hydrophilic drugs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content […]

Lab Chip, 2023, 23,475-484DOI: 10.1039/D2LC00983H, PaperDong-Hee Choi, Hui-Wen Liu, Yong Hun Jung, Jinchul Ahn, Jin-A Kim, Dongwoo Oh, Yeju Jeong, Minseop Kim, Hongjin Yoon, Byengkyu Kang, Eunsol Hong, Euijeong Song, Seok ChungA new algorithm based on deep learning analyzes angiogenic morphogenesis images taken from angiogenesis on a chip. This method can assess the morphology of angiogenesis in great depth using multiple indicators and extract 3D indices from 2D images.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,542-552DOI: 10.1039/D2LC01166B, PaperZongbao Sun, Jiahao Qi, Ye Shen, Ning Yang, Shuhua Liu, Aiying Wang, Cilin Wang, Jian TangA collection, nucleic acid release, amplification, and visualization platform for rapid field detection of rice false smut is created.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00756H, Critical ReviewXing Xu, Linfeng Cai, Shanshan Liang, Qiannan Zhang, Shiyan Lin, Mingying Li, Qizheng Yang, Chong Li, Ziyan Han, Chaoyong YangDigital microfluidic (DMF) bioassays with the benefits of automation, addressability, integration and dynamic configuration ability for nucleic acids, proteins, immunoreaction and cell analysis are presented in this review.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00804A, Critical ReviewLei Wu, Yongjian Ai, Ruoxiao Xie, Jialiang Xiong, Yu Wang, Qionglin LiangOrganoids/organs-on-a-chip contribute to mimicking intestinal surface topography, microenvironment, and various interactions, providing new frontiers of intestinal pathophysiological models.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00897A, Critical ReviewYou Jung Kang, Yingqi Xue, Jae Hee Shin, Hansang ChoIn this review, we overview designs and applications of microfluidics-based human mini-brains for reconstituting CNS disorders and expanded model systems ranging from the CNS to CNS-connecting organ axes with future perspectives.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00951J, PaperFang Wang, Chang Li, Ruotong Zhang, Yuan Liu, Haisong Lin, Lang Nan, Muhammad Ajmal Khan, Yang Xiao, Ho Cheung Shum, Hui DengThis study proposes a composition-tunable cold atmospheric plasma chip capable of producing targeted species, delivering multiple dosages, and treating multiple cell lines in a single treatment.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC01147F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Muaz S. Draz, Kevin Uning, Diego Dupouy, Martin A. M. GijsIn-plane microfluidic AC-electrothermal mixing.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00702A, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.M. Suwa, S. Tsukahara, H. WataraiThis review summarizes the recent attractive developments in the application of magnetic and electromagnetic forces in micro-analytical systems.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00930G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Francois Chesnais, Jordan Joel, Jonas Hue, Sima Shakib, Lucy Di Silvio, Agamemnon E. Grigoriadis, Trevor Coward, Lorenzo VeschiniWe present a new continuously perfusable, customisable, and matrix free vasculature on chip (VoC) platform enabling to study microvascular functions and responses to perturbations under physiologic perfusive flow.To cite this article before page numbers are assigned, use the DOI form of citation […]

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00873D, Critical ReviewHelena Muñoz-Galán, Carlos Alemán, Maria M. Pérez-MadrigalMicrocantilever-based platforms are presented as versatile lab-on-chip devices for advanced applications spanning from material characterization and environmental monitoring to energy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00811D, Critical ReviewXiaohu Zhou, Bo ZhengIn this review, we summarize the recent progress in surface modification strategies for improving the sensitivity of immunoassays, including antifouling coatings to reduce background noise and nanostructured surfaces to amplify the signals.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,466-474DOI: 10.1039/D2LC00955B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Samual C. Burnage, Jérémy Bell, Wei Wan, Evgeniia Kislenko, Knut RurackA microfluidic ratiometric detection scheme using silica nanoparticles coated with a “light-up” fluorescent molecularly imprinted polymer allows selective rapid assaying of pY-terminating peptides after in-tube/on-chip derivatisation and extraction.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,553-559DOI: 10.1039/D2LC01021F, PaperYameng Liu, Miaomiao Wang, Ruojin Liu, Feng QiuA simple label-free and non-invasive analysis method is established to detect phagocytic activity and screen medicine at single cell level.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00993E, Critical ReviewNavid Kashaninejad, Nam-Trung NguyenThe paper provides a comprehensive review on micro elastofluidic solutions for on-skin wearable devices.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00662F, PerspectiveRosanna W. Peeling, Samuel K. SiaThroughout the COVID-19 pandemic, we have witnessed the critical and expanding roles of testing.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00573E, Critical ReviewYaozhen Hou, Huaping Wang, Rongxin Fu, Xian Wang, Jiangfan Yu, Shuailong Zhang, Qiang Huang, Yu Sun, Toshio FukudaThis review covers the working mechanisms, recent progress and state-of-the-art applications of microrobots driven by optical and magnetic fields.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00493C, Critical ReviewYihe Wang, Mengqi Liu, Yu Zhang, Hong Liu, Lin HanThis review provides an overview of recent advances in droplet microfluidics for the formation and manipulation of spheroids and organoids, as well as their downstream applications in high-throughput screening and tissue engineering.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00790H, Critical ReviewJunxia Wang, Ziyi Lu, Ruisi Cai, Hanqi Zheng, Jicheng Yu, Yuqi Zhang, Zhen GuThis review summarizes state-of-the-art microneedle-based detection and sensing systems, highlighting the objective significance, sensing principles, systematic construction, and validation models of these microneedles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00856D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hiroki Matsumura, Larina Tzu-Wei Shen, Akihiro Isozaki, Hideharu Mikami, Dan Yuan, Taichi Miura, Yuto Kondo, Tomoko Mori, Yoshika Kusumoto, Masako Nishikawa, Atsushi Yasumoto, Aya Ueda, Hiroko Bando, Hisato Hara, Yuhong Liu, Yunjie Deng, Masahiro Sonoshita, Yutaka Yatomi, Keisuke Goda, Satoshi MatsusakaHeterogeneous clusters of cancer cells and leukocytes in blood were visualized by combining high-throughput and high-sensitivity […]

Lab Chip, 2023, 23,495-510DOI: 10.1039/D2LC01132H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Daniel A. Ferreira, João P. Conde, Mario Rothbauer, Peter Ertl, Pedro L. Granja, Carla OliveiraA biomimetic stomach-on-a-chip with integrated peristalsis-like motion and intra-luminal flow. Application of dynamic conditions, elicited differentiation traits that are typical of the normal gastric mucosa, but otherwise lost in 2D culture models.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,372-387DOI: 10.1039/D2LC00636G, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ahmad Ahsan Nawaz, Despina Soteriou, Catherine K. Xu, Ruchi Goswami, Maik Herbig, Jochen Guck, Salvatore GirardoReal-time morpho-rheological analysis of cells by RT-DC, combined with the improved sorting performance of an on chip FTSAW-based microactuator enables efficient label-free image-based sorting of various cell types with distinct physical properties.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,511-524DOI: 10.1039/D2LC00616B, PaperXiao Hong, Yuanhao Xu, Stella W. PangMotility and spreading of nasopharyngeal carcinoma (NPC) cells were enhanced when co-cultured with nasopharyngeal epithelial cells in microwells with different sizes and topographies, which would provide insight for the study of NPC progression.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,525-533DOI: 10.1039/D2LC00802E, PaperBryan Ang, Ankush Sookram, Citsabehsan Devendran, Vincent He, Kellie Tuck, Victor Cadarso, Adrian NeildGlass-embedded into the PDMS microchannel of the sound activated nanosieve enabled high-efficiency capture of 500 nm nanoparticles at dramatically higher flow rates due to high acoustic reflectivity and energy retention within the fluid.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00750A, PaperYoshihiro Hirade, Munehiro Kubota, Kaori Kitae, Harumi Yamamoto, Hiroko Omori, Susumu Shinoki, Takao Ohmura, Kazutake TsujikawaA novel culture system where cancer cells are grown in the presence of nanoclay in adherent plates allows preparation of malignant and dispersed spheroids compared with those formed under ultralow-adherent conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,534-541DOI: 10.1039/D2LC00840H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.André Kling, Lorin Dirscherl, Petra S. DittrichWe introduce a thermoplastic microfluidic device for the detection of cancer biomarkers by competitive immunoassays. Immobilization of different antibody-protein pairs is achieved by laser-assisted protein adsorption by photobleaching.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC01024K, PaperJeonghwan Son, Biagio Mandracchia, Aaron D. Silva Trenkle, Gabriel A. Kwong, Shu JiaImaging flow cytometry (IFC) combines conventional flow cytometry with optical microscopy, allowing for high-throughput, multi-parameter screening of single-cell specimens with morphological and spatial information.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,451-465DOI: 10.1039/D2LC00885H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Chelsey A. Smith, Megan M. Chang, Kathryn A. Kundrod, Emilie N. Novak, Sonia G. Parra, Leticia López, Celda Mavume, Cesaltina Lorenzoni, Mauricio Maza, Mila P. Salcedo, Jennifer L. Carns, Ellen Baker, Jane Montealegre, Michael Scheurer, Philip E. Castle, Kathleen M. Schmeler, Rebecca R. Richards-KortumA low-cost, user friendly 2DPN for cervical cancer screening was developed and validated for detection of high-risk HPV […]

Lab Chip, 2023, 23,251-260DOI: 10.1039/D2LC00960A, PaperDohwan Lee, Norh Asmare, A. Fatih SariogluEnzyme-linked immunosorbent assay (ELISA) is widely employed for detecting target molecules in bioassays including the serological assays that measure specific antibody titers.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,341-348DOI: 10.1039/D2LC01042A, PaperHaiying Shen, Qiliang Li, Wenqi Song, Xingyu JiangMicrofluidic on-chip valve and pump.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,330-340DOI: 10.1039/D2LC00859A, PaperOlivia S. Kanies, Katelyn R. Kremer, Brittany M. Mason, Mitchell G. Dudley, Joseph M. Hlavay, Cass T. Miller, Richard Chasen Spero, Jay K. FisherA microfluidic chip (BeadPak) containing magnetically actuatable microposts for enhanced transport was developed to improve the performance of magnetic bead-based assays in low volume applications.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, Advance ArticleDOI: 10.1039/D2LC00919F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mathias Busek, Aleksandra Aizenshtadt, Timo Koch, Anna Frank, Ludivine Delon, Mikel Amirola Martinez, Alexey Golovin, Clotilde Dumas, Justyna Stokowiec, Stefan Gruenzner, Espen Melum, Stefan KraussWe present a novel pump-less Organ-on-a-Chip (OoC) platform featuring organoid embedding, functional vascular components, and recirculation of (immune) cells in a scalable and robust configuration.To cite this article before page […]

Lab Chip, 2023, 23,388-399DOI: 10.1039/D2LC01006B, PaperXiaojun Luo, Weiling Yue, Shutong Zhang, Haopeng Liu, Zhinan Chen, Ling Qiao, Caijun Wu, Panjie Li, Yi HeA long-range SERS substrate composed of a bowtie nanoaperture array and a nanocavity is reported. The substrate demonstrated an extended probing distance, stronger E-field strength, and an excellent LOD for the SARS-CoV-2 spike and nucleocapsid proteins, respectively.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,485-494DOI: 10.1039/D2LC01008A, PaperYuqing Xu, Qinping Qiang, Yaru Zhao, Hongxing Li, Li Xu, Chong Liu, Yiya Wang, Yangkun Xu, Chengcheng Tao, Tianchun Lang, Lei Zhao, Bitao LiuThe heat-treated MXene@MS sensor not only has excellent pressure-sensing properties, but also has enhanced water resistance, resulting in good moisture sensitivity.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,349-361DOI: 10.1039/D2LC00761D, PaperGangpei Cai, Fei Xu, Bailiang Chen, Xiang Li, Jiajun Huang, Shengli MiDesigned a platform that could apply inertial forces in different directions to droplets in real time. A series of programmable controls for droplets were implemented on separate chips.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,362-371DOI: 10.1039/D2LC00891B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Claudius L. Dietsche, Elisabeth Hirth, Petra S. DittrichWe analyse signalling factors secreted by single polarized macrophages. This is achieved by using a microfluidic device with microchamber arrays for co-capturing cells in hydrodynamic traps and functionalized beads in magnetic traps.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,400-400DOI: 10.1039/D2LC90117J, Correction Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ning Yang, Taiwei Li, Sizhe Dong, Suliang Zhang, Yanwei Jia, Hanping Mao, Zhen Zhang, Fu Zhang, Xiaoqing Pan, Xiaodong Zhang, Zining DongThe content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,272-284DOI: 10.1039/D2LC00887D, PaperStephanie Y. Zhang, Gretchen J. MahlerMicrophysiological systems (MPS) are powerful predictive tools for assessing drug-induced kidney injuries.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,239-250DOI: 10.1039/D2LC00864E, PaperJohn S. Cognetti, Maya T. Moen, Matthew G. Brewer, Michael R. Bryan, Joshua D. Tice, James L. McGrath, Benjamin L. MillerIntegration of photonic sensors with tissue chips (TCs; also known as microphysiological systems or organ chips) enables real time monitoring of analytes produced by the TC or passed through a model tissue barrier.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,295-305DOI: 10.1039/D2LC00775D, PaperReza Ghaemi, Meryl Acker, Ana Stosic, Roger Jacobs, Ponnambalam Ravi SelvaganapathyA microfludic device for intact immobilization of live Drosophila larva for imaging its brain at single neuron resolution.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,318-329DOI: 10.1039/D2LC00456A, Paper Anjali, Soumen Das, Suman ChakrabortyScalable multiplex analyte detection on a paper strip with smartphone interfaced spectrometry. A portable analytical unit with embedded electronics for on-chip haemoglobin and haematocrit level determination over the entire physiological regime.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,410-420DOI: 10.1039/D2LC00895E, PaperYunjie Deng, Hui Min Tay, Yuqi Zhou, Xueer Fei, Xuke Tang, Masako Nishikawa, Yutaka Yatomi, Han Wei Hou, Ting-Hui Xiao, Keisuke GodaOptofluidic imaging on a chip is developed for studying the efficacy of antiplatelet drugs on atherosclerosis.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,421-436DOI: 10.1039/D2LC00797E, PaperYiqun Liu, Qi Yu, Le Ye, Li Yang, Yue CuiWe demonstrate a wearable, minimally invasive, fully electrochemically controlled feedback microsystem for the intelligent management of diabetes, where both the sensor and pump in the feedback system work based on electrochemical reactions.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,437-450DOI: 10.1039/D2LC00941B, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kotaro Doi, Hiroshi Kimura, Soo Hyeon Kim, Shohei Kaneda, Takehiko Wada, Tetsuhiro Tanaka, Akira Shimizu, Takanori Sano, Masamichi Chikamori, Marie Shinohara, Yukiko T. Matsunaga, Masaomi Nangaku, Teruo FujiiThe development of a filtration flow device system with precisely controlled pressure revealed the mechanobiology of filtration flow to podocytes regarding morphological and gene expression maturation and increased […]

Lab Chip, 2023, 23,306-317DOI: 10.1039/D2LC00605G, PaperKazuya Fujimoto, Scott Erickson, Masamune Nakayama, Hiroki Ihara, Kei Sugihara, Yuji Nashimoto, Koichi Nishiyama, Takashi Miura, Ryuji YokokawaShape changes of a vascular network in a microfluidic device with shear stress and/or pericytes were examined. The results showed maximum sprouting frequency within a specific range of shear stress regardless of flow rate, while pericytes constrained vessel diameter.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,229-238DOI: 10.1039/D2LC00974A, PaperSunjae Hwang, Jungil ChoiA rapid AST platform allows the use of low-density bacterial samples by concentrating bacterial cells and performing antimicrobial susceptibility testing on a single microfluidic chip.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,285-294DOI: 10.1039/D2LC00517D, PaperKyle P. McCarthy, David B. Go, Satyajyoti Senapati, Hsueh-Chia ChangAn integrated ion-exchange membrane (IEM) based device for rapid and irreversible dissociation of protein-RNA complex (ribonucleoprotein, RNP) and quantification of its associated RNA.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,261-271DOI: 10.1039/D2LC00879C, PaperKetaki Bachal, Shital Yadav, Prasanna Gandhi, Abhijit MajumderDrug testing is a vital step in the identification of the potential efficacy of any new/existing drug and/or combinations of drugs. Here, a novel diffusion based microfabricated gradient generator makes drug testing user-friendly and error free.The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2023, 23,215-228DOI: 10.1039/D2LC00812B, PaperHemin Pan, Deqing Mei, Chengyao Xu, Shuo Han, Yancheng WangBy regulating coherent SAWs in real time, polystyrene particle and yeast cell clusters can be manipulated to form specific arrays. Moreover, rapid switching, shape regulation, and directional translation among various arrays are implemented.The content of this RSS Feed (c) The Royal Society of Chemistry