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RSC - Lab Chip latest articles RSC - Lab Chip latest articles

  • Hybrid paper and 3D-printed microfluidic device for electrochemical detection of Ag nanoparticle labels
    by Charuksha Walgama on April 6, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00276C, PaperCharuksha Walgama, Michael P. Nguyen, Lisa M. Boatner, Ian Richards, Richard M. CrooksA hybrid paper/plastic microfluidic device for detection of Ag nanoparticle labels at concentrations as low as 12 pM.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Mathematical modeling and computational analysis of centrifugal microfluidic platforms: a review
    by Masoud Madadelahi on April 2, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC00775J, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Masoud Madadelahi, Luis F. Acosta-Soto, Samira Hosseini, Sergio O. Martinez-Chapa, Marc J. MadouThis paper focuses on theory and computational modelling of lab-on-a-disc devices of relevance for novel applications discovery and optimal designs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery
    by Nicola Di Trani on April 1, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00121J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nicola Di Trani, Antonia Silvestri, Antons Sizovs, Yu Wang, Donald R. Erm, Danilo Demarchi, Xuewu Liu, Alessandro GrattoniControl of molecular diffusion through nanofluidic channels using electrostatic gating.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Monitoring Two-Dimensional Concentration Profile of Organic Vapours by Using Polymer-Stabilized Nematic Liquid Crystals in Microchannels
    by Zongdai Liu on March 31, 2020 at 11:00 pm

    Lab Chip, 2020, Accepted ManuscriptDOI: 10.1039/C9LC01021A, PaperZongdai Liu, Dan Luo, Kun-Lin YangMany volatile organic compounds (VOCs) are hazardous to human health and their concentrations need to be monitored over a large area. However, most chemical sensors can only be used for...The content of this RSS Feed (c) The Royal Society of Chemistry

  • Reconfigurable microfluidics: real-time shaping of virtual channels through hydrodynamic forces
    by David P. Taylor on March 31, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00197J, PaperDavid P. Taylor, Govind V. KaigalaVirtual microfluidic channels, formed through hydrodynamic focusing within a 2D flow cell, enable the dynamic implementation of key microfluidic functionalities, such as the precise guiding, splitting, merging and mixing of microscale flows.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Quantitatively controllable fluid flows with ballpoint-pen-printed patterns for programmable photo-paper-based microfluidic devices
    by Veasna Soum on March 30, 2020 at 11:00 pm

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00115E, PaperVeasna Soum, Sooyong Park, Albertus Ivan Brilian, Jae-Youl Choi, Yongwoo Lee, Wonjung Kim, Oh-Sun Kwon, Kwanwoo ShinA precise, simple, and inexpensive method for controlling fluid flow in a photo-paper-based microfluidic device was reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Applications of the microphysiology systems database for experimental ADME-Tox and disease models
    by Mark Schurdak on March 25, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01047E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mark Schurdak, Lawrence Vernetti, Luke Bergenthal, Quinn K. Wolter, Tong Ying Shun, Sandra Karcher, D. Lansing Taylor, Albert GoughThe Microphysiology Systems Database (MPS) is a critical tool for the design, management, analysis, and sharing of MPS study data.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic device to study flow-free chemotaxis of swimming cells
    by Nicolas Garcia-Seyda on March 24, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00045K, PaperNicolas Garcia-Seyda, Laurene Aoun, Victoria Tishkova, Valentine Seveau, Martine Biarnes-Pelicot, Marc Bajénoff, Marie-Pierre Valignat, Olivier TheodolyPermeable agarose barriers allow flow-free gradient generation, applicable to adherent and non-adherent (swimming) cells, as well as co-culture experiments.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Contact lens-based lysozyme detection in tear using a mobile sensor
    by Zachary Ballard on March 24, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01039D, PaperZachary Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, Aydogan OzcanA rapid and cost-effective method for monitoring proteins in tear-fluid is reported, which enables biomarker monitoring using contact lenses toward personalized mobile-health applications.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Rapid lipolytic oscillations in ex vivo adipose tissue explants revealed through microfluidic droplet sampling at high temporal resolution
    by Juan Hu on March 23, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00103A, PaperJuan Hu, Xiangpeng Li, Robert L. Judd, Christopher J. EasleyHigh temporal resolution sampling and quantitative detection of glycerol secretion dynamics from adipose tissue using our automated, droplet-based microfluidic system.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Scalable microfluidic droplet on-demand generator for non-steady operation of droplet-based assays
    by Kartik Totlani on March 23, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01103J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kartik Totlani, Jan-Willem Hurkmans, Walter M. van Gulik, Michiel T. Kreutzer, Volkert van SteijnWe developed a microfluidic droplet on-demand (DoD) generator that enables the production of droplets with a volume solely governed by the geometry of the generator for a range of operating conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed […]

  • Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing
    by Mario Rothbauer on March 23, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01097A, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Mario Rothbauer, Gregor Höll, Christoph Eilenberger, Sebastian R. A. Kratz, Bilal Farooq, Patrick Schuller, Isabel Olmos Calvo, Ruth A. Byrne, Brigitte Meyer, Birgit Niederreiter, Seta Küpcü, Florian Sevelda, Johannes Holinka, Oliver Hayden, Sandro F. Tedde, Hans P. Kiener, Peter ErtlWe demonstrate that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible […]

  • Droplet encapsulation improves accuracy of immune cell cytokine capture assays
    by Yuan Yuan on March 22, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01261C, PaperYuan Yuan, Julie Brouchon, J. Mauricio Calvo-Calle, Jing Xia, Li Sun, Xu Zhang, Kiera L. Clayton, Fangfu Ye, David A. Weitz, John A. HeymanIn-droplet cytokine capture assays combined with FACS to accurately identify and isolate activated immune cells.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A disposable acoustofluidic chip for nano/microparticle separation using unidirectional acoustic transducers
    by Shuaiguo Zhao on March 20, 2020 at 12:00 am

    Lab Chip, 2020, 20,1298-1308DOI: 10.1039/D0LC00106F, PaperShuaiguo Zhao, Mengxi Wu, Shujie Yang, Yuqi Wu, Yuyang Gu, Chuyi Chen, Jennifer Ye, Zhemiao Xie, Zhenhua Tian, Hunter Bachman, Po-Hsun Huang, Jianping Xia, Peiran Zhang, Heying Zhang, Tony Jun HuangA disposable acoustofluidic platform was developed for nano/microparticle separation with high versatility, precision, and biocompatibility.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery
    by Bo Wang on March 20, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00021C, CommunicationBo Wang, Ximiao Wen, Yan Cao, Shan Huang, Hoa A. Lam, Tingyi “Leo” Liu, Pei-Shan Chung, Harold G. Monbouquette, Pei-Yu Chiou, Nigel T. MaidmentPDMS thin-film transfer and enzyme microstamping enabled 3-in-1 Si/PDMS hybrid chemtrode for multi-analyte sensing and chemical delivery in vivo.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Advanced 96-microtiter plate based bioelectrochemical platform reveals molecular short cut of electron flow in cytochrome P450 enzyme
    by Ronny Frank on March 20, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01220F, PaperRonny Frank, Christoph Prönnecke, Ronny Azendorf, Heinz-Georg Jahnke, Annette G. Beck-Sickinger, Andrea A. RobitzkiWe developed a novel 96-well microtiter plate based bioelectrochemical platform with a vertical divided cell three-electrode architecture and a 96-multipotentiostat to perform fully parallelised bioelectrocatalytic screenings on redox enzymes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Multi-corneal barrier-on-a-chip to recapitulate eye blinking shear stress forces
    by Rodi Abdalkader on March 11, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01256G, PaperRodi Abdalkader, Ken-ichiro KameiHuman corneal epithelium coexists with tear fluids and shows its barrier functionality under the dynamic conditions of eye blinking. We developed a microfluidic platform enabling the dynamic culture of the human corneal barrier with recapitulation of eye blinking.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic device for digital manipulation of gaseous samples
    by A. Enel on March 11, 2020 at 12:00 am

    Lab Chip, 2020, 20,1290-1297DOI: 10.1039/C9LC01163C, PaperA. Enel, A. Bourrelier, J. Vial, D. Thiébaut, B. BourlonThe first device for digital manipulation of gaseous samples; from elementary operations to demonstration of a more complex application.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Low-frequency flexural wave based microparticle manipulation
    by Hunter Bachman on March 10, 2020 at 12:00 am

    Lab Chip, 2020, 20,1281-1289DOI: 10.1039/D0LC00072H, PaperHunter Bachman, Yuyang Gu, Joseph Rufo, Shujie Yang, Zhenhua Tian, Po-Hsun Huang, Lingyu Yu, Tony Jun HuangAn acoustofluidic particle manipulation platform that uses low frequency flexural waves produced by commercial transducers.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A liquid biopsy-guided drug release system for cancer theranostics: integrating rapid circulating tumor cell detection and precision tumor therapy
    by Chun-Miao Xu on March 10, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00149J, PaperChun-Miao Xu, Man Tang, Jiao Feng, Hou-Fu Xia, Ling-Ling Wu, Dai-Wen Pang, Gang Chen, Zhi-Ling ZhangA system integrating diagnostic and therapeutic functions for cancer is presented using magnetically controlled microfluidics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Colorimetric absorbance mapping and quantitation on paper-based analytical devices
    by Yoshiki Soda on March 10, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00028K, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yoshiki Soda, Kye J. Robinson, Thomas J. Cherubini, Eric BakkerA pixel-level colorimetric absorbance analysis can measure the total quantity of dye on paper, irrespective of shape and size.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Auto-affitech: an automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method
    by Jingjing Guo on March 9, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/D0LC00024H, PaperJingjing Guo, Li Lin, Kaifeng Zhao, Yanling Song, Mengjiao Huang, Zhi Zhu, Leiji Zhou, Chaoyong YangAn automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method that reduces the bead loss.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Optically-controlled closable microvalves for polymeric centrifugal microfluidic devices
    by M. Shane Woolf on March 6, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01187K, PaperM. Shane Woolf, Leah M. Dignan, Hannah M. Lewis, Christopher J. Tomley, Aeren Q. Nauman, James P. LandersMicrovalving is a pivotal component in many microfluidic lab-on-a-chip platforms and micro-total analysis systems (μTAS).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic approach for experimentally modelling the intercellular coupling system of a mammalian circadian clock at single-cell level
    by Kui Han on March 2, 2020 at 12:00 am

    Lab Chip, 2020, 20,1204-1211DOI: 10.1039/D0LC00140F, PaperKui Han, Long Mei, Ruoyu Zhong, Yuhong Pang, Eric Erquan Zhang, Yanyi HuangA proof-of-concept platform to reconstitute the intercellular coupling system of the central clock using uncoupled, single fibroblast cells in vitro, to mimic SCN slice cultures ex vivo and mouse behavior in vivo phenotypically.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Monolithically-integrated cytometer for measuring particle diameter in the extracellular vesicle size range using multi-angle scattering
    by Jonathan T. Butement on March 2, 2020 at 12:00 am

    Lab Chip, 2020, 20,1267-1280DOI: 10.1039/C9LC01182J, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jonathan T. Butement, Paul M. Holloway, Joshua A. Welsh, Judith A. Holloway, Nicola A. Englyst, Peter Horak, Jonathan West, James S. WilkinsonOn chip MMI-lenses combined with multi-angle waveguide collection and 3d focussing fluidics allows high performance size measurement of submicron particles.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Low-cost microphysiological systems: feasibility study of a tape-based barrier-on-chip for small intestine modeling
    by Thomas E. Winkler on March 2, 2020 at 12:00 am

    Lab Chip, 2020, 20,1212-1226DOI: 10.1039/D0LC00009D, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Thomas E. Winkler, Michael Feil, Eva F. G. J. Stronkman, Isabelle Matthiesen, Anna HerlandHigh costs are a key challenge in “democratization” of organ-chip research. We present a low-resource barrier-on-chip based on tape, and use it to model small intestine and its response to chili peppers (capsaicinoids).The content of this RSS Feed (c) The Royal Society of Chemistry

  • Highly sensitive mutation quantification by high-dynamic-range capillary-array electrophoresis (HiDy CE)
    by Takashi Anazawa on February 28, 2020 at 12:00 am

    Lab Chip, 2020, 20,1083-1091DOI: 10.1039/C9LC00853E, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Takashi Anazawa, Hiroko Matsunaga, Shuhei Yamamoto, Ryoji InabaMutant (MT) in a large excess of wild type (WT) was quantified with high-sensitivity (LOD of 0.004% MT/WT) and four-orders-of-magnitude dynamic range (0.01–100% MT/WT) by a high-dynamic-range capillary-array electrophoresis (HiDy CE).The content of this RSS Feed (c) The Royal Society of Chemistry

  • An acoustofluidic device for efficient mixing over a wide range of flow rates
    by Hunter Bachman on February 27, 2020 at 12:00 am

    Lab Chip, 2020, 20,1238-1248DOI: 10.1039/C9LC01171D, PaperHunter Bachman, Chuyi Chen, Joseph Rufo, Shuaiguo Zhao, Shujie Yang, Zhenhua Tian, Nitesh Nama, Po-Hsun Huang, Tony Jun HuangAn acoustofluidic mixer which can achieve thorough mixing across a wide range of flow rates.The content of this RSS Feed (c) The Royal Society of Chemistry

  • PRESCIENT: platform for the rapid evaluation of antibody success using integrated microfluidics enabled technology
    by Jose A. Wippold on February 24, 2020 at 12:00 am

    Lab Chip, 2020, Advance ArticleDOI: 10.1039/C9LC01165J, PaperJose A. Wippold, Han Wang, Joseph Tingling, Julian L. Leibowitz, Paul de Figueiredo, Arum HanIdentifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems
    by Matthew F. Peters on February 21, 2020 at 12:00 am

    Lab Chip, 2020, 20,1177-1190DOI: 10.1039/C9LC01107B, Critical Review Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Matthew F. Peters, Allison L. Choy, Carmen Pin, Derek J. Leishman, Annie Moisan, Lorna Ewart, Peggy J. Guzzie-Peck, Radhakrishna Sura, Douglas A. Keller, Clay W Scott, Kyle L. KolajaDrug-induced gastrointestinal toxicities (DI-GITs) are among the most common adverse events in clinical trials.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Coaxial oblique interface shearing: tunable generation and sorting of double emulsions for spatial gradient drug release
    by Fangsheng Huang on February 21, 2020 at 12:00 am

    Lab Chip, 2020, 20,1249-1258DOI: 10.1039/D0LC00111B, PaperFangsheng Huang, Zhiqiang Zhu, Ye Niu, Yi Zhao, Ting Si, Ronald X. XuWe propose a coaxial oblique interface shearing (COIS) process to one-step generate and sort double emulsions for thermal- and chemical-responsive spatial gradient releases.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Towards practical sample preparation in point-of-care testing: user-friendly microfluidic devices
    by Juhwan Park on February 20, 2020 at 12:00 am

    Lab Chip, 2020, 20,1191-1203DOI: 10.1039/D0LC00047G, Critical ReviewJuhwan Park, Dong Hyun Han, Je-Kyun ParkAn overview and future perspectives of user-friendly microfluidic devices have been reported in terms of practical sample preparation in point-of-care testing.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation
    by William Y. Wang on February 20, 2020 at 12:00 am

    Lab Chip, 2020, 20,1153-1166DOI: 10.1039/C9LC01170F, PaperWilliam Y. Wang, Daphne Lin, Evan H. Jarman, William J. Polacheck, Brendon M. BakerThe formation of functional microvasculature results from physical and soluble microenvironmental cues that balance endothelial cell migration with proliferation during multicellular sprouting morphogenesis.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic-based linear-optics label-free imager
    by Omer Wagner on February 18, 2020 at 12:00 am

    Lab Chip, 2020, 20,1259-1266DOI: 10.1039/D0LC00036A, PaperOmer Wagner, Eitan Edri, Pooria Hadikahani, Hagay Shpaisman, Zeev Zalevsky, Demetri PsaltisMicrofluidic channel flows and traps biological samples inside a water droplet along with suspended nanoparticles. Linear optics nanoscopy is then used to image the sample by decoding the scattered light from the nanoparticles in its vicinity.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Dynamic screening and printing of single cells using a microfluidic chip with dual microvalves
    by Chang Chen on February 17, 2020 at 12:00 am

    Lab Chip, 2020, 20,1227-1237DOI: 10.1039/D0LC00040J, PaperChang Chen, Dong Xu, Siwei Bai, Zhihang Yu, Yonggang Zhu, Xiao Xing, Huaying ChenInoculation of single cells into separate chambers is one of the key requirements in single-cell analysis. Here we report a three-layer microfluidic platform integrated with dual-pneumatic valves for dynamic screening and printing of single cells.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications
    by Joseph A. Fantuzzo on February 17, 2020 at 12:00 am

    Lab Chip, 2020, 20,1140-1152DOI: 10.1039/C9LC01179J, PaperJoseph A. Fantuzzo, Denise A. Robles, Vincent R. Mirabella, Ronald P. Hart, Zhiping P. Pang, Jeffrey D. ZahnDevelopment and functionality of a 96 well plate-based platform for high-throughput drug screening of compartmentalized neurocircuit models.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A microfluidic approach to micromembrane synthesis for complex release profiles of nanocarriers
    by Nan Jia on February 14, 2020 at 12:00 am

    Lab Chip, 2020, 20,1066-1071DOI: 10.1039/D0LC00039F, CommunicationNan Jia, Erica Rosella, Estelle Juère, Roxane Pouliot, Freddy Kleitz, Jesse GreenerPhysically crosslinked layered microscale biomembranes from pure chitosan are demonstrated for pH-triggered release functionalized mesoporous silica nanoparticles. The work opens the door to synthesis of complex nano-enhanced micro membranes.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An adaptable soft-mold embossing process for fabricating optically-accessible, microfeature-based culture systems and application toward liver stage antimalarial compound testing
    by Steven P. Maher on February 14, 2020 at 12:00 am

    Lab Chip, 2020, 20,1124-1139DOI: 10.1039/C9LC00921C, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Steven P. Maher, Amy J. Conway, Alison Roth, Swamy R. Adapa, Phillip Cualing, Chiara Andolina, James Hsiao, Jessica Turgeon, Victor Chaumeau, Myles Johnson, Chris Palmiotti, Naresh Singh, Samantha J. Barnes, Raahil Patel, Virginia Van Grod, Robert Carter, H.-C. Steve Sun, Jetsumon Sattabongkot, Brice Campo, François Nosten, Wajeeh M. Saadi, John H. Adams, Rays H. Y. Jiang, Dennis E. KyleAn intrahepatic Plasmodium vivax liver […]

  • Antibody-coated microstructures for selective isolation of immune cells in blood
    by Jiyu Li on February 13, 2020 at 12:00 am

    Lab Chip, 2020, 20,1072-1082DOI: 10.1039/D0LC00078G, PaperJiyu Li, Ya Liu, Jifeng Ren, Benjamin Zikai Tay, Tao Luo, Lei Fan, Dong Sun, Guannan Luo, Denvid Lau, Marcos, Raymond H. W. LamSelective immune cell isolation from diluted blood achieved with antibody-coated micropillar and micro-sieve structures in a microfluidic system.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Wide-field, high-resolution lensless on-chip microscopy via near-field blind ptychographic modulation
    by Shaowei Jiang on February 11, 2020 at 12:00 am

    Lab Chip, 2020, 20,1058-1065DOI: 10.1039/C9LC01027K, CommunicationShaowei Jiang, Jiakai Zhu, Pengming Song, Chengfei Guo, Zichao Bian, Ruihai Wang, Yikun Huang, Shiyao Wang, He Zhang, Guoan ZhengWe report a novel lensless on-chip microscopy platform based on near-field blind ptychographic modulation.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications
    by Kristin Fabre on February 10, 2020 at 12:00 am

    Lab Chip, 2020, 20,1049-1057DOI: 10.1039/C9LC01168D, PerspectiveKristin Fabre, Brian Berridge, William R. Proctor, Sherry Ralston, Yvonne Will, Szczepan W. Baran, Gorm Yoder, Terry R. Van VleetOpportunities in the drug discovery/development process for potential MPS incorporation.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Microfluidic condensation nanoparticle counter using water as the condensing liquid for assessing individual exposure to airborne nanoparticles
    by Hong-Beom Kwon on February 7, 2020 at 12:00 am

    Lab Chip, 2020, 20,1092-1102DOI: 10.1039/C9LC01003C, PaperHong-Beom Kwon, Seong-Jae Yoo, Yong-Jun KimWe present a compact, cost-efficient, water-based nanoparticle counter that can accurately monitor the personal nanoparticle exposure in real-time.The content of this RSS Feed (c) The Royal Society of Chemistry

  • An integrated microfluidic system for rapid, automatic and high-throughput staining of clinical tissue samples for diagnosis of ovarian cancer
    by Sheng-Po Huang on January 30, 2020 at 12:00 am

    Lab Chip, 2020, 20,1103-1109DOI: 10.1039/C9LC00979E, PaperSheng-Po Huang, Yuan-Jhe Chuang, Wen-Bin Lee, Yi-Cheng Tsai, Chang-Ni Lin, Keng-Fu Hsu, Gwo-Bin LeeAn integrated microfluidic platform capable of labeling ovarian cancer biomarkers within formalin-fixed, paraffin embedded tissues via aptamer probes was developed.The content of this RSS Feed (c) The Royal Society of Chemistry

  • A mini-panel PET scanner-based microfluidic radiobioassay system allowing high-throughput imaging of real-time cellular pharmacokinetics
    by Zhen Liu on January 29, 2020 at 12:00 am

    Lab Chip, 2020, 20,1110-1123DOI: 10.1039/C9LC01066A, PaperZhen Liu, Pengfei Zhang, Hao Ji, Yu Long, Boping Jing, Lu Wan, Daoming Xi, Rui An, Xiaoli LanPharmacokinetics of parallel or comparison samples can be imaged simultaneously with a mini PET scanner-based microfluidic radiobioassay system.The content of this RSS Feed (c) The Royal Society of Chemistry

  • Computational inertial microfluidics: a review
    by Sajad Razavi Bazaz on January 20, 2020 at 12:00 am

    Lab Chip, 2020, 20,1023-1048DOI: 10.1039/C9LC01022J, Critical ReviewSajad Razavi Bazaz, Ali Mashhadian, Abbas Ehsani, Suvash Chandra Saha, Timm Krüger, Majid Ebrahimi WarkianiSchematic illustration of various kinds of geometries used for inertial microfluidics.The content of this RSS Feed (c) The Royal Society of Chemistry

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  • Automated phenotyping of Caenorhabditis elegans embryos with a high-throughput-screening microfluidic platform
    by Huseyin Baris Atakan on April 6, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 06 April 2020; doi:10.1038/s41378-020-0132-8A new microfluidic approach enables the high-throughput and automated phenotyping of C. elegans embryos. Understanding the effect of osmotic stress-induced damage on cells is vital for understanding a number of biological processes. C. elegans embryos are considered ideal model systems for osmotic studies, but their phenotyping is traditionally a labor intensive and time-consuming process. Now, a team from EPFL in Switzerland led by Martin Gijs demonstrate a microfluidic platform for […]

  • Thermal scanning probe lithography—a review
    by Samuel Tobias Howell on April 6, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 06 April 2020; doi:10.1038/s41378-019-0124-8Thermal scanning probe lithography is reviewed in the context of material removal, conversion and deposition. Scanning probe lithography has long been a promising technique for direct-write nanoscale patterning on surfaces. However, while the technique is widely used in research labs, the slow write speed has limited its use in industrial settings. Instead, thermal scanning probe lithography has emerged, in which a heated tip is used to induce localized changes in the material, enabling write […]

  • Sliding walls: a new paradigm for fluidic actuation and protocol implementation in microfluidics
    by Bastien Venzac on April 6, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 06 April 2020; doi:10.1038/s41378-019-0125-7A new technology, termed “sliding walls,” has been developed for operating microfluidic devices (which function at sub-millimetre scales), whereby rigid or semi-rigid walls, hundreds of micrometres thick, slide within a microfluidic chip. Fluid control in micro-devices is currently achieved largely by expensive, bulky external valves and pumps or by valves integrated in the chip. Such internal valves or actuation methods generally have shortcomings related to performance and complex […]

  • Wafer-scale 3D shaping of high aspect ratio structures by multistep plasma etching and corner lithography
    by Shu Ni on March 23, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 23 March 2020; doi:10.1038/s41378-020-0134-6A novel 3-D silicon shaping technology has been developed that combines a multistep etching process with corner lithography. Currently, system miniaturization relies extensively on 3-D machining techniques. A team headed by Shu Ni and Niels R. Tas at the University of Twente, Netherlands developed a versatile fabrication technique for wafer-scale micro- and nano-machining using a combination of multistep etching and corner lithography (layer deposition and subsequent timed etching of the layer, […]

  • E-DNA scaffold sensors and the reagentless, single-step, measurement of HIV-diagnostic antibodies in human serum
    by Claudio Parolo on March 23, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 23 March 2020; doi:10.1038/s41378-019-0119-5A single-step, electrochemical-based device has the ability to detect and measure the amount of HIV antibodies in clinical samples. There is an ever-growing need for tools that can diagnose diseases accurately, quickly and at point-of-care. The group of Kevin Plaxco at University of California Santa Barbara has previously demonstrated an E-DNA scaffold sensor for quantifying antibodies, but it had not been tested on real clinical samples. Now, they demonstrate that it can detect several […]

  • AFM-compatible microfluidic platform for affinity-based capture and nanomechanical characterization of circulating tumor cells
    by Muhammedin Deliorman on March 23, 2020 at 12:00 am

    Microsystems & Nanoengineering, Published online: 23 March 2020; doi:10.1038/s41378-020-0131-9A microfluidic platform allows for the capture and characterization of circulating tumor cells, a major driver of invasive cancer. Circulating tumor cells (CTCs) break off from the original tumor and invade distant sites; however, they’re hard to isolate and analyze because their concentration in blood is so low. Mohammad Qasaimeh, of New York University Abu Dhabi, and his team of UAE and US scientists created a device with microfluidic channels, that traps cancer cells using targeted […]