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Fabrication of All Glass Bifurcation Microfluidic Chip for Blood Plasma Separation


An all-glass bifurcation microfluidic chip for blood plasma separation was fabricated by a cost-effective glass molding process using an amorphous carbon (AC) mold, which in turn was fabricated by the carbonization of a replicated furan precursor. To compensate for the shrinkage during AC mold fabrication, an enlarged photoresist pattern master was designed, and an AC mold with a dimensional error of 2.9% was achieved; the dimensional error of the master pattern was 1.6%. In the glass molding process, a glass microchannel plate with negligible shape errors (~1.5%) compared to AC mold was replicated. Finally, an all-glass bifurcation microfluidic chip was realized by micro drilling and thermal fusion bonding processes. A separation efficiency of 74% was obtained using the fabricated all-glass bifurcation microfluidic chip. View Full-Text

Keywords: glass molding; amorphous carbon mold; microfluidics; blood plasma separation; bifurcation microfluidic chip
Hyungjun Jang 1,  ,Muhammad Refatul Haq,Jonghyun Ju 1,Youngkyu Kim,Seok-min Kim 1,* and Jiseok Lim 2,*
 1 School of Mechanical Engineering, Chung-Ang University, Seoul 06974, Korea
School of Mechanical Engineering, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do 38541, Korea
Micromachines 2017, 8(3), 67; doi:10.3390/mi8030067

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