Drug Screening

CRISPR Meets Single-cell Sequencing in New Screening Method

February 18, 2017

Microfluidic droplets capture single, genome-edited cells and barcode their transcriptome. (Image Credit: Paul Datlinger/CeMM) Genome editing using CRISPR/Cas9 “gene scissors” is a powerful tool for biological discovery and for [more...]

3D-printed Heart-on-a-chip with Integrated Sensors

November 6, 2016

Harvard University researchers have made the first entirely 3D-printed organ-on-a-chip with integrated sensing. Built by a fully automated, digital manufacturing procedure, the 3D-printed heart-on-a-chip can be quickly fabricated and [more...]

Scaling Up Tissue Engineering

March 18, 2016

Confocal microscopy image showing a cross-section of a 3D-printed, 1-centimeter-thick vascularized tissue construct showing stem cell differentiation towards development of bone cells, following one month of active perfusion of fluids, [more...]

Insulin-Producing Pancreatic Cells Created from Human Skin Cells

January 7, 2016

Functioning human pancreatic cells after they’ve been transplanted into a mouse. [Image credit: Saiyong Zhu] Scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF) have successfully converted human [more...]

LumaCyte’s Radiance Instrument for Label-free Single Cell Analysis and Sorting

August 2, 2015

LumaCyte’s mission is to provide scientists and researchers with transformational research tools that accelerate biological and pharmaceutical discovery through a novel, label-free approach to single-cell analysis and sorting. A Need for [more...]

3-D Organoids Grown from Patient Tumors Could Personalize Drug Screening

July 4, 2015

Cancer in 3-D (Image Credit: Wellcome Trust Sanger Institute) Three-dimensional cultures (or “organoids”) derived from the tumors of cancer patients closely replicate key properties of the original tumors, reveals a study [more...]

Heartbeat On a Chip

June 21, 2015

Heartbeat Chip Test (Image credit: Michigan Engineering) The ability to accurately test drugs and therapies for human use is a goal we desperately need to reach. Often animals are used to test drugs intended for human use, which not only [more...]

Johnson & Johnson to Deploy Emulate' s Organs-on-Chips Platform in Drug Development Process

June 21, 2015

New Thrombosis-on-Chip (Image credit: EmulateBio) Emulate, whose president Geraldine Hamilton will speak at the first Organ-on-a-Chip World Congress 8-9 July 2015, said the alliance was intended to improve Janssen’s drug development [more...]

Microfluidics for Accelerated Drug Assays

April 12, 2015

Multiple microwells on Yevgeny Berdichevsky’s assay chips make it possible to test up to 18 drug candidates at a time. (Image Credit: Linda Nye) Approximately 125,000 Americans each year develop epilepsy, a brain disease marked by [more...]

$17 million from NIH funds next phase of Tissue Chip for Drug Screening

September 24, 2014

A neurovascular unit on a chip being developed by Vanderbilt University researchers. (Vanderbilt University Photo/ John Wikswo). The National Institutes of Health will award funds to support the next phase of its Tissue Chip for Drug [more...]