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Introduction to BioMEMS

Book Description

Amazon Link | CRC Press Link

Author: Albert Folch

Helping to educate the new generation of engineers and biologists, Introduction to BioMEMS explains how certain problems in biology and medicine benefit from and often require the miniaturization of devices. The book covers the whole breadth of this dynamic field, including classical microfabrication, microfluidics, tissue engineering, cell-based and noncell-based devices, and implantable systems. It focuses on high-impact, creative work encompassing all the scales of life—from biomolecules to cells, tissues, and organisms.


  • Focuses on the essentials of microfabrication
  • Presents in-depth coverage of the techniques of cell/protein micropatterning
  • Gives a thorough presentation of microfluidics, including theory, designs, and historical perspective
  • Explains how BioMEMS technology can increase the biochemical and biophysical complexity of cell culture microenvironments
  • Discusses how BioMEMS devices can improve fluid handling and increase experimentation throughput
  • Provides a good overall vision of how implantable microdevices have evolved, covering the origin of the field and the newest devices
  • Highlights fundamental concepts and defines them in an extensive glossary
  • Includes over 400 color figures, problem sets, design challenges, and key references
  • Offers downloadable PowerPoint slides for instructors

Table of Contents

How Do We Make Small Things?

  • Why Bother Making Things Small?
  • From Art to Chips
  • Photolithography
  • Micromachining
  • Micromolding
  • Soft Lithography
  • Hydrogel Devices
  • Nanofabrication Techniques
  • Fabrication Based on Self-Assembly: A “Bottom-Up” Approach

Micropatterning of Substrates and Cells

  • Interaction between Surfaces and Biomolecules
  • Surface Engineering
  • Micropatterns of SAMs
  • Micropatterns of Proteins
  • Micropatterns of Cells on Nonbiomolecular Templates
  • Micropatterns of Cells on Biomolecular Templates


  • Why Go Small?
  • Microscale Behavior of Fluids
  • Fluids in Electrical Fields
  • Fluids in Acoustic Fields
  • Fabrication of Microfluidic Channels
  • Operation of Microfluidic Channels: Practical Concerns
  • Droplet Microfluidics
  • Active Flow Control
  • Micromixers
  • Combinatorial Mixers

Molecular Biology on a Chip

  • The Importance of Miniaturizing Molecular Biology
  • The Importance of Point-of-Care Diagnostics: Where is Cost Really, Really, Really Important?
  • Sample Preparation: A Bloody Example
  • The Problem with Microfluidic Sample Separation
  • Microfluidic Immunoassays
  • Chips for Genomics and Proteomics
  • Electrospray Mass Spectrometry
  • Biochemical Analysis Using Force Sensors

 Cell-Based Chips for Biotechnology

  • Microfluidic Flow Cytometers
  • Cell Sorting
  • Cell Trapping
  • Microfluidic Cell Culture Laboratories
  • Gene Expression Cellular Microarrays (“Cellomics”)
  • Micro-Bioreactors
  • Cells on Microelectrodes
  • Patch Clamp Chips
  • Cryopreservation
  • Assisted Reproductive Technologies
  • Whole Animal Testing

 BioMEMS for Cell Biology

  • An Enabling Technology: The Hurdles
  • Cell-Substrate Signaling
  • Cell-Cell Communication
  • Cell Migration
  • BioMEMS for Cellular Neurobiology
  • Developmental Biology on a Chip
  • Yeast Biology
  • Plant Cell Biology
  • Microfluidics for Studying Cellular Dynamics

Tissue Microengineering

  • Microscaffolding
  • Micropatterned Cocultures
  • Stem Cell Engineering
  • Morphogenesis

 Implantable Microdevices

  • Dental Implants
  • Implantable Microelectrodes
  • Delivery of Soluble Signals into the Body
  • Microtools for Surgery
  • Insect Research




Product Details

  • Hardcover: 528 pages
  • Publisher: CRC Press; 1 edition (August 21, 2012)
  • Language: English
  • ISBN-10: 1439818398
  • ISBN-13: 978-1439818398
  • Product Dimensions: 9.9 x 7.3 x 0.9 inches
  • Shipping Weight: 2.8 pounds