Introduction to BioMEMS

Posted on August 16, 2015 by Admin

Book Description

Author: Albert Folch

Helping to educate the new generation of engineers and biologists, Introduction to BioMEMS explains how certain problems in biology and medicine benefit from and often require the miniaturization of devices. The book covers the whole breadth of this dynamic field, including classical microfabrication, microfluidics, tissue engineering, cell-based and noncell-based devices, and implantable systems. It focuses on high-impact, creative work encompassing all the scales of life—from biomolecules to cells, tissues, and organisms.

Features

Focuses on the essentials of microfabrication
Presents in-depth coverage of the techniques of cell/protein micropatterning
Gives a thorough presentation of microfluidics, including theory, designs, and historical perspective
Explains how BioMEMS technology can increase the biochemical and biophysical complexity of cell culture microenvironments
Discusses how BioMEMS devices can improve fluid handling and increase experimentation throughput
Provides a good overall vision of how implantable microdevices have evolved, covering the origin of the field and the newest devices
Highlights fundamental concepts and defines them in an extensive glossary
Includes over 400 color figures, problem sets, design challenges, and key references
Offers downloadable PowerPoint slides for instructors

Table of Contents

How Do We Make Small Things?

Why Bother Making Things Small?
From Art to Chips
Photolithography
Micromachining
Micromolding
Soft Lithography
Hydrogel Devices
Nanofabrication Techniques
Fabrication Based on Self-Assembly: A “Bottom-Up” Approach

Micropatterning of Substrates and Cells

Interaction between Surfaces and Biomolecules
Surface Engineering
Micropatterns of SAMs
Micropatterns of Proteins
Micropatterns of Cells on Nonbiomolecular Templates
Micropatterns of Cells on Biomolecular Templates

Microfluidics

Why Go Small?
Microscale Behavior of Fluids
Fluids in Electrical Fields
Fluids in Acoustic Fields
Fabrication of Microfluidic Channels
Operation of Microfluidic Channels: Practical Concerns
Droplet Microfluidics
Active Flow Control
Micromixers
Combinatorial Mixers

Molecular Biology on a Chip

The Importance of Miniaturizing Molecular Biology
The Importance of Point-of-Care Diagnostics: Where is Cost Really, Really, Really Important?
Sample Preparation: A Bloody Example
The Problem with Microfluidic Sample Separation
Microfluidic Immunoassays
Chips for Genomics and Proteomics
Electrospray Mass Spectrometry
Biochemical Analysis Using Force Sensors

Cell-Based Chips for Biotechnology