News Ticker

BioMEMS: Science and Engineering Perspectives

Book Description

Amazon Link | CRC Press Link

Authors:  Simona Badilescu, Muthukumaran Packirisamy


As technological advancements widen the scope of applications for biomicroelectromechanical systems (BioMEMS or biomicrosystems), the field continues to have an impact on many aspects of life science operations and functionalities. Because BioMEMS research and development require the input of experts who use different technical languages and come from varying disciplines and backgrounds, scientists and students can avoid potential difficulties in communication and understanding only if they possess a skill set and understanding that enables them to work at the interface of engineering and biosciences.

Keeping this duality in mind throughout, BioMEMS: Science and Engineering Perspectives supports and expedites the multidisciplinary learning involved in the development of biomicrosystems. Divided into nine chapters, it starts with a balanced introduction of biological, engineering, application, and commercialization aspects of the field. With a focus on molecules of biological interest, the book explores the building blocks of cells and viruses, as well as molecules that form the self-assembled monolayers (SAMs), linkers, and hydrogels used for making different surfaces biocompatible through functionalization.

The book also discusses:

  • Different materials and platforms used to develop biomicrosystems
  • Various biological entities and pathogens (in ascending order of complexity)
  • The multidisciplinary aspects of engineering bioactive surfaces
  • Engineering perspectives, including methods of manufacturing bioactive surfaces and devices
  • Microfluidics modeling and experimentation
  • Device level implementation of BioMEMS concepts for different applications.

Because BioMEMS is an application-driven field, the book also highlights the concepts of lab-on-a-chip (LOC) and micro total analysis system (µTAS), along with their pertinence to the emerging point-of-care (POC) and point-of-need (PON) applications.


Table of Contents


  • Introduction to BioMEMS
  • Application Areas
  • Intersection of Science and Engineering
  • Evolution of Systems Based on Size
  • Commercialization, Potential, and Market

Substrate Materials Used in BioMEMS Devices

  • Metals
  • Glasses and Ceramics
  • Silicon and Silicon-Based Surfaces
  • Polymers
  • Biopolymers
  • Organic Molecules (Functional Groups) Involved in the Formation of Self-Assembled Monolayers

Biomolecules and Complex Biological Entities: Structure and Properties

  • Amino Acids
  • Polypeptides and Proteins
  • Lipids
  • Nucleotides and Nucleic Acids
  • Carbohydrates
  • Enzymes
  • Cells
  • Bacteria and Viruses

Engineering of Bioactive Surfaces

  • Plasma Treatment and Plasma-Mediated Surface Modification
  • Surface Modifications Mediated by Self-Assembled Monolayers (SAMs)
  • Langmuir-Blodgett and Layer-by-Layer Assembly
  • Biosmart Hydrogels
  • Immobilization and Detection of Biomolecules by Using Gold Nanoparticles: Case Studies
  • Biomimetic Surface Engineering
  • Attachment of Proteins to Surfaces
  • Surface Modification of Biomaterials for Tissue Engineering Applications
  • Temperature-Responsive Intelligent Interfaces

Methods of Study and Characterization of Surface-Modified Substrates

  • Contact Angle
  • Atomic Force Microscopy (AFM)
  • X-Ray Photoelectron Spectroscopy
  • Confocal Fluorescence Microscopy
  • Attenuated Total Reflection (Internal Reflection) Infrared Spectroscopy
  • Mechanical Methods: Use of Micro- and Nanocantilevers for Characterization of Surfaces

Biosensing Fundamentals

  • Biosensors
  • Immunoassays
  • Comparison between Biosensors and ELISA Immunoassays

Fabrication of BioMEMS Devices

  • Basic Microfabrication Processes
  • Micromachining
  • Soft Micromachining
  • Microfabrication Techniques for Biodegradable Polymers
  • Nanofabrication Methods

Introduction to Microfluidics

  • Fluid Physics at the Microscale
  • Methods for Enhancing Diffusive Mixing between Two Laminar Flows
  • Controlling Flow and Transport in Microfluidic Channels
  • Modeling Microchannel Flow
  • Experimental Methods

BioMEMS: Life Science Applications

  • Introduction to Microarrays
  • Microarrays Based on DNA
  • Polymerase Chain Reaction (PCR)
  • Protein Microarrays
  • Cell and Tissue-Based Assays on a Chip
  • Microreactors
  • Micro Total Analysis Systems (μTAS) and Lab-on-a-Chip (LOC)
  • Lab-on-a-Chip: Conclusion and Outlook
  • Microcantilever BioMEMS

Product Details

  • Hardcover: 368 pages
  • Publisher: CRC Press; 1 edition (April 25, 2011)
  • Language: English
  • ISBN-10: 1439816999
  • ISBN-13: 978-1439816998
  • Product Dimensions: 0.8 x 7 x 10 inches
  • Shipping Weight: 1.8 pounds