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Recent Developments in Droplet Based Microfluidic Technologies

Application Engineer: Ashok Sinha, Dolomite Microfluidics, UK 

Introduction: 

This presentation addresses on the microfluidics market, identifies technological bottlenecks, and showcases a few successful and fast growing applications. Among these are cell encapsulation, droplet generation, high-throughput droplets & particles, double emulsions, nanoparticle synthesis, and droplets on demand.

Transcript: 

Group Introduction
Top Applications

  • Cell Encapsulation
  • Microparticle Production
  • Nanoparticle synthesis

Application:

  • Biology e.g. cell encapsulation in microdroplets and anyalysis of individual cells fom a population
  • Drug discovery e.g. drug formulaion and controlled release via biodegradable particles
  • Chemistry e.g. nanoparticle synthesis and petrochemical analysis
  • Food and cosmetics e.g. bulk precision manufacturing of emulsions and foams
  • Academia e.g. study of microfluidics and nanofluidic droplets or bubbles

Product Overview-Modules and Components

Application 1- Encapsulation of DNA/cells

  • Protein Based Assay for Surface Immobilized Antibodies
  • Compartmentalizing biochemical Reactions for Sorting by FACS
  • Density Matching Assistance Suspension(PCR)
  • Uses of Cell Encapsluation
    – Uses of polymer particles
    – Diagnostic tests and assays
    – Controlled drug release or targeted drug delivery
    – Mobile substrates with custom functionalization including magnetic particles
    – Imaging- micro-PIV (particle image velocimetry)

Application 2- Polymer Microparticle/Bead Formation

  • Batch vs. Continuous Particle Production Methods
  • Solvent extraction method of solid->liquid phase change
  • Application 3- Nanoparticle synthesis

Other Applications: 

  • Anti-solvent method of nucleation/precipitation
  • Micromixer system

Summary

 

Source: Labtube

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